The role of cognition in classical and operant conditioning
Abstract
For the past 35 years, learning theorists have been providing models that depend on mental representations, even in their most simple, deterministic, and mechanistic approaches. Hence, cognitive involvement (typically thought of as expectancy) is assumed for most instances of classical and operant conditioning, with current theoretical differences concerning the level of cognition that is involved (e.g., simple association vs. rule learning), rather than its presence. Nevertheless, many psychologists not in the mainstream of learning theory continue to think of cognitive and conditioning theories as rival families of hypotheses. In this article, the data pertaining to the role of higher‐order cognition in conditioning is reviewed, and a theoretical synthesis is proposed that provides a role for both automatic and cognitively mediated processes. © 2004 Wiley Periodicals, Inc. J Clin Psychol.
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Animals can behaviorally respond at certain intervals (seconds to minutes) according to a programmed stimulus.
“Studies in training animals with classical and operant conditioning have shown that animals can behaviorally respond at certain intervals (seconds to minutes) according to the programmed stimulus (Kirsch et al., 2004; Kyd et al., 2008)”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Kirsch et al., 2004
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The Biological Effects of Childhood Trauma
De Bellis, M. D., & Zisk, A. (2014) · Child and Adolescent Psychiatric Clinics of North America · doi:10.1016/j.chc.2014.01.002 · Cited by 892 · see citing works
The neuroscience of placebo effects: connecting context, learning and health
Wager, T. D., & Atlas, L. Y. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn3976 · Cited by 844 · see citing works
Colloca, L., & BARSKY, A. J. (2020) · New England Journal of Medicine · doi:10.1056/nejmra1907805 · Cited by 695 · see citing works
The Placebo Effect: Dissolving the Expectancy Versus Conditioning Debate.
Stewart‐Williams, S., & Podd, J. (2004) · Psychological Bulletin · doi:10.1037/0033-2909.130.2.324 · Cited by 664 · see citing works
Placebo and the New Physiology of the Doctor-Patient Relationship
Benedetti, F. (2013) · Physiological Reviews · doi:10.1152/physrev.00043.2012 · Cited by 492 · see citing works
How Placebos Change the Patient's Brain
Benedetti, F., Carlino, E., & Pollo, A. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2010.81 · Cited by 446 · see citing works
How prior experience shapes placebo analgesia
Colloca, L., & Benedetti, F. (2006) · Pain · doi:10.1016/j.pain.2006.04.005 · Cited by 443 · see citing works
The role of learning in nocebo and placebo effects
Colloca, L., Sigaudo, M., & Benedetti, F. (2008) · Pain · doi:10.1016/j.pain.2008.02.006 · Cited by 411 · see citing works
Nonconscious activation of placebo and nocebo pain responses
Jensen, K. B., Kaptchuk, T. J., Kirsch, I., Raicek, J., Lindstrom, K. M., Berna, C., Gollub, R. L., Ingvar, M., & Kong, J. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1202056109 · Cited by 305 · see citing works
Self-citationHow the number of learning trials affects placebo and nocebo responses
Colloca, L., Petrovic, P., Wager, T. D., Ingvar, M., & Benedetti, F. (2010) · Pain · doi:10.1016/j.pain.2010.08.007 · Cited by 300 · see citing works
Errorless Learning in the Rehabilitation of Memory Impairment: A Critical Review
Clare, L., & Jones, R. S. P. (2008) · Neuropsychology Review · doi:10.1007/s11065-008-9051-4 · Cited by 291 · see citing works
Laferton, J. A. C., Kube, T., Salzmann, S., Auer, C. J., & Shedden-Mora, M. C. (2017) · Frontiers in Psychology · doi:10.3389/fpsyg.2017.00233 · Cited by 267 · see citing works
Relieving patients' pain with expectation interventions: a meta-analysis
Peerdeman, K. J., van Laarhoven, A. I. M., Keij, S. M., Vase, L., Rovers, M. M., Peters, M. L., & Evers, A. W. M. (2016) · Pain · doi:10.1097/j.pain.0000000000000540 · Cited by 239 · see citing works
Learning potentiates neurophysiological and behavioral placebo analgesic responses
Colloca, L., Tinazzi, M., Recchia, S., Le Pera, D., Fiaschi, A., Benedetti, F., & Valeriani, M. (2008) · Pain · doi:10.1016/j.pain.2008.04.021 · Cited by 180 · see citing works
Dissociable Influences of Opiates and Expectations on Pain
Atlas, L. Y., Whittington, R. A., Lindquist, M. A., Wielgosz, J., Sonty, N., & Wager, T. D. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.0383-12.2012 · Cited by 172 · see citing works
Placebo psychotherapy: Synonym or oxymoron?
Kirsch, I. (2005) · Journal of Clinical Psychology · doi:10.1002/jclp.20126 · Cited by 164 · see citing works
Self-citationChao, O. Y., de Souza Silva, M. A., Yang, Y.-M., & Huston, J. P. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.04.007 · Cited by 158 · see citing works
Assessing learning and memory in pigs
Gieling, E. T., Nordquist, R. E., & van der Staay, F. J. (2011) · Animal Cognition · doi:10.1007/s10071-010-0364-3 · Cited by 154 · see citing works
Neural bases of conditioned placebo analgesia
Lui, F., Colloca, L., Duzzi, D., Anchisi, D., Benedetti, F., & Porro, C. A. (2010) · Pain · doi:10.1016/j.pain.2010.09.021 · Cited by 149 · see citing works
“how externally reinforced stimuli are modulated to induce learned placebo analgesic responses [17].”
BackgroundA Neural Mechanism for Nonconscious Activation of Conditioned Placebo and Nocebo Responses
Jensen, K., Kaptchuk, T., Chen, X., Kirsch, I., Ingvar, M., Gollub, R., & Kong, J. (2014) · Cerebral Cortex · doi:10.1093/cercor/bhu275 · Cited by 140 · see citing works
Self-citationThe top‐down influence of ergogenic placebos on muscle work and fatigue
Pollo, A., Carlino, E., & Benedetti, F. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06344.x · Cited by 146 · see citing works
Christiansen, S., Oettingen, G., Dahme, B., & Klinger, R. (2010) · Pain · doi:10.1016/j.pain.2009.12.015 · Cited by 141 · see citing works
Operant Learning Theory in Pain and Chronic Pain Rehabilitation
Gatzounis, R., Schrooten, M. G. S., Crombez, G., & Vlaeyen, J. W. S. (2012) · Current Pain and Headache Reports · doi:10.1007/s11916-012-0247-1 · Cited by 128 · see citing works
Technological adjuncts to increase adherence to therapy: A review
Clough, B. A., & Casey, L. M. (2011) · Clinical Psychology Review · doi:10.1016/j.cpr.2011.03.006 · Cited by 125 · see citing works
Utilizing placebo mechanisms for dose reduction in pharmacotherapy
Doering, B. K., & Rief, W. (2012) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2011.12.001 · Cited by 125 · see citing works
An integrative review of the influence of expectancies on pain
Peerdeman, K. J., Laarhoven, A. I. M. V., Peters, M. L., & Evers, A. W. M. (2016) · Frontiers in Psychology · doi:10.3389/fpsyg.2016.01270 · Cited by 122 · see citing works
The Placebo Puzzle: Putting Together the Pieces.
Stewart‐Williams, S. (2004) · Health Psychology · doi:10.1037/0278-6133.23.2.198 · Cited by 119 · see citing works
Conditioned Placebo Analgesia Persists When Subjects Know They Are Receiving a Placebo
Schafer, S. M., Colloca, L., & Wager, T. D. (2015) · The Journal of Pain · doi:10.1016/j.jpain.2014.12.008 · Cited by 117 · see citing works
Cognitive testing of pigs (Sus scrofa) in translational biobehavioral research
Kornum, B. R., & Knudsen, G. M. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.05.004 · Cited by 110 · see citing works
Conditioning, Expectancy, and the Placebo Effect: Comment on Stewart-Williams and Podd (2004).
Kirsch, I. (2004) · Psychological Bulletin · doi:10.1037/0033-2909.130.2.341 · Cited by 111 · see citing works
Self-citationPlacebo analgesia: Clinical applications
Klinger, R., Colloca, L., Bingel, U., & Flor, H. (2013) · Pain · doi:10.1016/j.pain.2013.12.007 · Cited by 98 · see citing works
Spatial Learning and Memory in HIV-1 Transgenic Rats
Vigorito, M., LaShomb, A. L., & Chang, S. L. (2007) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-007-9078-y · Cited by 93 · see citing works
Self-citationPlacebo mechanisms across different conditions: from the clinical setting to physical performance
Pollo, A., Carlino, E., & Benedetti, F. (2011) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2010.0381 · Cited by 95 · see citing works
Teaching neurons to respond to placebos
Benedetti, F., Frisaldi, E., Carlino, E., Giudetti, L., Pampallona, A., Zibetti, M., Lanotte, M., & Lopiano, L. (2016) · The Journal of Physiology · doi:10.1113/jp271322 · Cited by 100 · see citing works
Sailer, M., Maier, R., Berger, S., Kastorff, T., & Stegmann, K. (2024) · Learning and Individual Differences · doi:10.1016/j.lindif.2024.102446 · Cited by 137 · see citing works
Olfactory-induced synesthesias: A review and model.
Stevenson, R. J., & Tomiczek, C. (2007) · Psychological Bulletin · doi:10.1037/0033-2909.133.2.294 · Cited by 86 · see citing works
Pavlovian Conditioning of Immunological and Neuroendocrine Functions
Hadamitzky, M., Lückemann, L., Pacheco‐López, G., & Schedlowski, M. (2019) · Physiological Reviews · doi:10.1152/physrev.00033.2018 · Cited by 87 · see citing works
Classical conditioning without verbal suggestions elicits placebo analgesia and nocebo hyperalgesia
Bąbel, P., Bajcar, E. A., Adamczyk, W. M., Kicman, P., Lisińska, N., Swider, K. J., & Colloca, L. (2017) · PLoS ONE · doi:10.1371/journal.pone.0181856 · Cited by 80 · see citing works
Development of a dynamic computational model of social cognitive theory
Riley, W. T., Martín, C. A., Rivera, D. E., Hekler, E. B., Adams, M. A., Buman, M. P., Misha Pavel, C., & King, A. C. (2015) · Translational Behavioral Medicine · doi:10.1007/s13142-015-0356-6 · Cited by 78 · see citing works
Fish Cognition and Consciousness
Allen, C. (2011) · Journal of Agricultural and Environmental Ethics · doi:10.1007/s10806-011-9364-9 · Cited by 77 · see citing works
The placebo effect revisited: Lessons learned to date
Kirsch, I. (2013) · Complementary Therapies in Medicine · doi:10.1016/j.ctim.2012.12.003 · Cited by 73 · see citing works
Self-citationClinical Use of Placebo Effects in Patients With Pain Disorders
Klinger, R., Stuhlreyer, J., Schwartz, M., Schmitz, J., & Colloca, L. (2018) · International review of neurobiology · doi:10.1016/bs.irn.2018.07.015 · Cited by 73 · see citing works
Odour aversion after olfactory conditioning of the sting extension reflex in honeybees
Carcaud, J., Roussel, E., Giurfa, M., & Sandoz, J. (2009) · Journal of Experimental Biology · doi:10.1242/jeb.026641 · Cited by 71 · see citing works
Klinger, R., Kothe, R., Schmitz, J., Kamping, S., & Flor, H. (2017) · Pain · doi:10.1097/j.pain.0000000000000977 · Cited by 63 · see citing works
Placebo and nocebo effects across symptoms: from pain to fatigue, dyspnea, nausea, and itch
Wolters, F., Peerdeman, K. J., & Evers, A. W. M. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00470 · Cited by 57 · see citing works
Chemotherapy-induced Nausea and Vomiting
Mustian, K. M., Darling, T. V., Janelsins, M. C., Jean‐Pierre, P., Roscoe, J. A., & Morrow, G. R. (2008) · touchREVIEWS in Oncology & Haematology · doi:10.17925/ohr.2008.04.1.19 · Cited by 58 · see citing works
Is phenomenal force sufficient for immediate perceptual justification?
Teng, L. (2016) · Synthese · doi:10.1007/s11229-016-1233-7 · Cited by 56 · see citing works
Treatment of Nausea and Vomiting During Chemotherapy
Mustian, K. M., Devine, K. A., Ryan, J. L., Janelsins, M. C., Sprod, L. K., Peppone, L. J., Candelario, G. D., Mohile, S. G., & Morrow, G. R. (2011) · touchREVIEWS in Oncology & Haematology · doi:10.17925/ohr.2011.07.2.91 · Cited by 56 · see citing works
Classical Conditioning as a Distinct Mechanism of Placebo Effects
Bąbel, P. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00449 · Cited by 55 · see citing works
A new understanding of the cognitive reappraisal technique: an extension based on the schema theory
Wang, Y., & Yin, B. (2023) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2023.1174585 · Cited by 54 · see citing works
Behavioral Interventions in Treating Anticipatory Nausea and Vomiting
Figueroa-Moseley, C., Jean‐Pierre, P., Roscoe, J. A., Ryan, J. L., Kohli, S., Palesh, O. G., Ryan, E. P., Carroll, J. K., & Morrow, G. R. (2007) · Journal of the National Comprehensive Cancer Network · doi:10.6004/jnccn.2007.0006 · Cited by 53 · see citing works
Ellingsen, D., Napadow, V., Protsenko, E., Mawla, I., Kowalski, M., Swensen, D., O'Dwyer-Swensen, D., Edwards, R. R., Kettner, N. W., & Loggia, M. L. (2018) · Journal of Pain · doi:10.1016/j.jpain.2018.05.012 · Cited by 48 · see citing works
Role of explicit verbal information in conditioned analgesia
Carlino, E., Torta, D. M. E., Piedimonte, A., Frisaldi, E., Vighetti, S., & Benedetti, F. (2014) · European Journal of Pain · doi:10.1002/ejp.579 · Cited by 47 · see citing works
Preventing motor training through nocebo suggestions
Pollo, A., Carlino, E., Vase, L., & Benedetti, F. (2012) · European Journal of Applied Physiology · doi:10.1007/s00421-012-2333-9 · Cited by 49 · see citing works
The principle of parity: the ‘placebo effect’ and physician communication
Blease, C. (2011) · Journal of Medical Ethics · doi:10.1136/medethics-2011-100177 · Cited by 46 · see citing works
A biomimetic afferent nervous system based on the flexible artificial synapse
Wang, K., Jia, Y., & Yan, X. (2022) · Nano Energy · doi:10.1016/j.nanoen.2022.107486 · Cited by 45 · see citing works
Harms, P. D., Vanhove, A. J., & Luthans, F. (2016) · Applied Psychology · doi:10.1111/apps.12077 · Cited by 44 · see citing works
Schmitz, J., Müller, M., Stork, J., Eichler, I., Zöllner, C., Flor, H., & Klinger, R. (2019) · Psychotherapy and Psychosomatics · doi:10.1159/000501385 · Cited by 43 · see citing works
Balmuth, E. A., Luan, D., Jannat‐Khah, D., Evans, A. T., Wong, T., & Scales, D. A. (2024) · PLoS ONE · doi:10.1371/journal.pone.0298665 · Cited by 40 · see citing works
The role of learning in nocebo and placebo effects
Colloca, L., Sigaudo, M., & Benedetti, F. (2008) · Acute Pain · doi:10.1016/j.acpain.2008.05.028 · Cited by 40 · see citing works
Considering the Role of Conditioning in Sexual Orientation
Hoffmann, H. (2012) · Archives of Sexual Behavior · doi:10.1007/s10508-012-9915-9 · Cited by 33 · see citing works
Situating Human Sexual Conditioning
Hoffmann, H. (2017) · Archives of Sexual Behavior · doi:10.1007/s10508-017-1030-5 · Cited by 34 · see citing works
Operant conditioning as a new mechanism of placebo effects
Bąbel, P. (2020) · European Journal of Pain · doi:10.1002/ejp.1544 · Cited by 31 · see citing works
Social expectations in depression
Kirchner, L., Κube, T., Berg, M., Eckert, A.-L., Straube, B., Endres, D., & Rief, W. (2024) · Nature Reviews Psychology · doi:10.1038/s44159-024-00386-x · Cited by 31 · see citing works
Wiemer, J., & Pauli, P. (2016) · Journal of Anxiety Disorders · doi:10.1016/j.janxdis.2016.07.003 · Cited by 31 · see citing works
The Placebo Phenomenon: A Narrow Focus on Psychological Models
Peiris, N., Blasini, M., Wright, T. B., & Colloca, L. (2018) · Perspectives in biology and medicine · doi:10.1353/pbm.2018.0051 · Cited by 29 · see citing works
The ABC of academic procrastination: Functional analysis of a detrimental habit
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The Effects of Manipulating Verbal Suggestions on Physical Performance
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Thoughts on Experimental Psychopathology
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Modulation of the Motor System by Placebo and Nocebo Effects.
Fiorio, M. (2018) · International review of neurobiology · doi:10.1016/bs.irn.2018.07.012 · Cited by 21 · see citing works
Placebo effect in children: the role of expectation and learning
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The response set theory of hypnosis reconsidered: toward an integrative model
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Gaming the gamer? – The ethics of exploiting psychological research in video games
Søraker, J. H. (2016) · Journal of Information Communication and Ethics in Society · doi:10.1108/jices-02-2015-0003 · Cited by 25 · see citing works
An Analysis of the Basic Processes of Formation and Change of Placebo Expectations
Geers, A. L., Briñol, P., & Petty, R. E. (2018) · Review of General Psychology · doi:10.1037/gpr0000171 · Cited by 26 · see citing works
Toward a common theory for learning from reward, affect, and motivation: the SIMON framework
Madan, C. (2013) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2013.00059 · Cited by 21 · see citing works
Individual Differences Are More Than a Gene × Environment Interaction: The Role of Learning
Byrom, N., & Murphy, R. (2018) · Journal of Experimental Psychology: Animal Learning and Cognition · doi:10.1037/xan0000157 · Cited by 20 · see citing works
Examining the effect of perceived availability on craving for alcohol: A quasi-experimental approach
MacKillop, J. M., & Lisman, S. A. (2007) · Addiction Research & Theory · doi:10.1080/16066350701407104 · Cited by 22 · see citing works
The role of patients' response expectancies in side effect development and control.
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Startle induces early initiation of classically conditioned postural responses
Campbell, A. D., Chua, R., Inglis, J. T., & Carpenter, M. G. (2012) · Journal of Neurophysiology · doi:10.1152/jn.01157.2011 · Cited by 20 · see citing works
Socially Intelligent Interfaces for Increased Energy Awareness in the Home
Jussi Karlgren, C., Fahlén, L. E., Wallberg, A., Hansson, P., Ståhl, O., Söderberg, J., & Åkesson, K.-P. (2008) · Springer eBooks · doi:10.1007/978-3-540-78731-0_17 · Cited by 20 · see citing works
Sharing clinical notes, and placebo and nocebo effects: Can documentation affect patient health?
Blease, C., Delbanco, T., Torous, J. B., Pontén, M., DesRoches, C. M., Hägglund, M., Walker, J., & Kirsch, I. (2020) · Journal of Health Psychology · doi:10.1177/1359105320948588 · Cited by 18 · see citing works
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A metacognitive account of phenomenal force
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Placebo analgesia persists during sleep: An experimental study
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- Authors
- Kirsch, I., Lynn, S. J., Vigorito, M., & Miller, R. R.
- Affiliations
- University of Connecticut (US)
- Binghamton University (US)
- Seton Hall University (US)
- Venue
- Journal of Clinical Psychology
- Publisher
- Wiley
- Published
- 2004-02-12
- Volume
- 60
- Issue
- 4
- Pages
- 369-392
- ISSN
- 0021-9762 (ISSN-L)
- 1097-4679
- OpenAlex
- W2121568298
- Cited by
- 192
- References
- 120
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 15 · 2023: 13 · 2022: 8 · 2021: 6 · 2020: 12 · 2019: 10 · 2018: 13 · 2017: 8 · 2016: 10 · 2015: 9 · 2014: 12 · 2013: 7 · 2012: 11
- FWCI
- 0.37
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Clinical Psychology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Social Sciences › Psychology › Developmental and Educational Psychology › Behavioral and Psychological Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Keywords
- classical conditioning, operant conditioning, higher-order cognition, expectancy, mental representation, rule induction, automatic processes, cognitive mediation, learning theory
- MeSH terms
- Cognition, Conditioning, Classical, Conditioning, Operant, Humans, Immunosuppression Therapy, Psychological Theory, Sublimation, Psychological
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