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An overview of microRNAs: Biology, functions, therapeutics, and analysis methods

Saliminejad, Kioomars, Khorram Khorshid, Hamid Reza, Soleymani Fard, Shahrzad, Ghaffari, Seyed Hamidollah·2019·Journal of Cellular Physiology

DOI 10.1002/jcp.27486

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Abstract

MicroRNAs (miRNAs) are a class of small noncoding RNAs, which function in posttranscriptional regulation of gene expression. They are powerful regulators of various cellular activities including cell growth, differentiation, development, and apoptosis. They have been linked to many diseases, and currently miRNA‐mediated clinical trial has shown promising results for treatment of cancer and viral infection. This review provides an overview and update on miRNAs biogenesis, regulation of miRNAs expression, their biological functions, and role of miRNAs in epigenetics and cell–cell communication. In addition, alteration of miRNAs following exercise, their association with diseases, and therapeutic potential will be explained. Finally, miRNA bioinformatics tools and conventional methods for miRNA detection and quantification will be discussed.

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“Another miRNAs that have been targeted using miRNA mimics in preclinical studies are miR‐200/26a/506/520 and 15/16 cluster (Rupaimoole & Slack, 2017).”
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Paul, P., Chakraborty, A., Sarkar, D., Langthasa, M., Rahman, M., Bari, M., Singha, R. S., Malakar, A. K., & Chakraborty, S. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.25854 · Cited by 420 · cited 1×
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Background
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Authors: Saliminejad, K., Khorram Khorshid, H. R., Soleymani Fard, S., & Ghaffari, S. H.
Affiliations: Hematology, Oncology and Stem Cell Transplantation Research Center Shariati Hospital, Tehran University of Medical Sciences Tehran Iran
Genetics Research Center University of Social Welfare and Rehabilitation Sciences Tehran Iran
ORCID: Ghaffari, Seyed Hamidollah
Venue: Journal of Cellular Physiology
Publisher: Wiley
Published: 2018-11-23
Volume: 234
Issue: 5
Pages: 5451-5465
ISSN: 0021-9541
1097-4652
DOI: 10.1002/jcp.27486
Cited by: 1,872
References: 6
Language: en
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)

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An overview of microRNAs: Biology, functions, therapeutics, and analysis methods

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