Cited by 222Neuroscience and Neuropharmacology ResearchNeural dynamics and brain functionMemory and Neural Mechanisms

The DOI matches its Crossref record; 110 of the 110 references it cites were found in a registry or an index.

The decade of the dendritic NMDA spike

Open access

Antic, Srdjan D., Zhou, Wen‐Liang, Moore, Anna R., Short, Shaina M., Ikonomu, Katerina D.·2010·Journal of Neuroscience Research

DOI 10.1002/jnr.22444PMC PMC5643072

Open this paper in CoChat — free account

Abstract

In the field of cortical cellular physiology, much effort has been invested in understanding thick apical dendrites of pyramidal neurons and the regenerative sodium and calcium spikes that take place in the apical trunk. Here we focus on thin dendrites of pyramidal cells (basal, oblique, and tuft dendrites), and we discuss one relatively novel form of an electrical signal ("NMDA spike") that is specific for these branches. Basal, oblique, and apical tuft dendrites receive a high density of glutamatergic synaptic contacts. Synchronous activation of 10-50 neighboring glutamatergic synapses triggers a local dendritic regenerative potential, NMDA spike/plateau, which is characterized by significant local amplitude (40-50 mV) and an extraordinary duration (up to several hundred milliseconds). The NMDA plateau potential, when it is initiated in an apical tuft dendrite, is able to maintain a good portion of that tuft in a sustained depolarized state. However, if NMDA-dominated plateau potentials originate in proximal segments of basal dendrites, they regularly bring the neuronal cell body into a sustained depolarized state, which resembles a cortical Up state. At each dendritic initiation site (basal, oblique, and tuft) an NMDA spike creates favorable conditions for causal interactions of active synaptic inputs, including the spatial or temporal binding of information, as well as processes of short-term and long-term synaptic modifications (e.g., long-term potentiation or long-term depression). Because of their strong amplitudes and durations, local dendritic NMDA spikes make up the cellular substrate for multisite independent subunit computations that enrich the computational power and repertoire of cortical pyramidal cells. We propose that NMDA spikes are likely to play significant roles in cortical information processing in awake animals (spatiotemporal binding, working memory) and during slow-wave sleep (neuronal Up states, consolidation of memories).

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1002/jnr.22444

Cites

110 of 110 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Short-Term Synaptic Plasticity
Zucker, R. S., & Regehr, W. G. (2002) · Annual Review of Physiology · doi:10.1146/annurev.physiol.64.092501.114547 · Cited by 5,068
Magnesium gates glutamate-activated channels in mouse central neurones
Nowak, L. M., Bregestovski, P. D., Ascher, P., Herbet, A., & Prochiantz, A. (1984) · Nature · doi:10.1038/307462a0 · Cited by 4,116
The memory function of sleep
Diekelmann, S., & Born, J. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2762 · Cited by 3,760
Voltage-dependent block by Mg2+ of NMDA responses in spinal cord neurones
Mayer, M. L., Westbrook, G. L., & Guthrie, P. B. (1984) · Nature · doi:10.1038/309261a0 · Cited by 2,941
Mnemonic coding of visual space in the monkey's dorsolateral prefrontal cortex
Funahashi, S., Bruce, C. J., & Goldman-Rakic, P. S. (1989) · Journal of Neurophysiology · doi:10.1152/jn.1989.61.2.331 · Cited by 2,685
Structural basis of long-term potentiation in single dendritic spines
Matsuzaki, M., Honkura, N., Ellis-Davies, G. C. R., & Kasai, H. (2004) · Nature · doi:10.1038/nature02617 · Cited by 2,483
Pyramidal neurons: dendritic structure and synaptic integration
Spruston, N. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2286 · Cited by 1,688
Dissociation of Object and Spatial Processing Domains in Primate Prefrontal Cortex
Wilson, F. A. W., Scalaidhe, S. P., & Goldman, P. S. (1993) · Science · doi:10.1126/science.8316836 · Cited by 1,408
Active propagation of somatic action potentials into neocortical pyramidal cell dendrites
Stuart, G. J., & Sakmann, B. (1994) · Nature · doi:10.1038/367069a0 · Cited by 1,289
Morphological Changes in Dendritic Spines Associated with Long-Term Synaptic Plasticity
Yuste, R., & Bonhoeffer, T. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.1071 · Cited by 1,269
Structure and function of dendritic spines
Nimchinsky, E. A., Sabatini, B. L., & Svoboda, K. (2002) · Annual Review of Physiology · doi:10.1146/annurev.physiol.64.081501.160008 · Cited by 1,208
Stably maintained dendritic spines are associated with lifelong memories
Yang, G., Pan, F., & Gan, W.-B. (2009) · Nature · doi:10.1038/nature08577 · Cited by 1,182
Odor cues during slow-wave sleep prompt declarative memory consolidation
Rasch, B., Büchel, C., Gais, S., & Born, J. (2007) · Science · doi:10.1126/science.1138581 · Cited by 1,181
A new cellular mechanism for coupling inputs arriving at different cortical layers
Larkum, M. E., Zhu, J. J., & Sakmann, B. (1999) · Nature · doi:10.1038/18686 · Cited by 1,180
The high-conductance state of neocortical neurons in vivo
Alain Destexhe, A., Rudolph, M., & Paré, D. (2003) · Nature reviews. Neuroscience · doi:10.1038/nrn1198 · Cited by 1,062
Turning on and off recurrent balanced cortical activity
Shu, Y., Hasenstaub, A., & McCormick, D. A. (2003) · Nature · doi:10.1038/nature01616 · Cited by 1,054
Communication between neocortex and hippocampus during sleep in rodents
Sirota, A., Csicsvari, J., Buhl, D., & Buzsáki, G. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0437938100 · Cited by 930
Intracellular analysis of relations between the slow (< 1 Hz) neocortical oscillation and other sleep rhythms of the electroencephalogram
Steriade, M., Nunez, A., & Amzica, F. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-08-03266.1993 · Cited by 894
Activity-Dependent Action Potential Invasion and Calcium Influx into Hippocampal CA1 Dendrites
Spruston, N., Schiller, Y., Stuart, G. J., & Sakmann, B. J. (1995) · Science · doi:10.1126/science.7716524 · Cited by 839
Computational subunits in thin dendrites of pyramidal cells
Polsky, A., Mel, B. W., & Schiller, J. (2004) · Nature Neuroscience · doi:10.1038/nn1253 · Cited by 817
Pyramidal Neuron as Two-Layer Neural Network
Poirazi, P., Brannon, T., & Mel, B. W. (2003) · Neuron · doi:10.1016/s0896-6273(03)00149-1 · Cited by 803
Action potential initiation and backpropagation in neurons of the mammalian CNS
Stuart, G., Spruston, N., Sakmann, B., & Häusser, M. (1997) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)10075-8 · Cited by 768
Dendritic Excitability and Synaptic Plasticity
Sjöström, P. J., Rancz, E. A., Roth, A., & Häusser, M. (2008) · Physiological Reviews · doi:10.1152/physrev.00016.2007 · Cited by 740
NMDA spikes in basal dendrites of cortical pyramidal neurons
Schiller, J., Major, G., Koester, H. J., & Schiller, Y. (2000) · Nature · doi:10.1038/35005094 · Cited by 720
Visual discrimination learning requires sleep after training
Stickgold, R., James, L., & Hobson, J. A. (2000) · Nature Neuroscience · doi:10.1038/81756 · Cited by 715
Origin of Slow Cortical Oscillations in Deafferented Cortical Slabs
Timofeev, I. (2000) · Cerebral Cortex · doi:10.1093/cercor/10.12.1185 · Cited by 710
Interaction of sensory responses with spontaneous depolarization in layer 2/3 barrel cortex
Petersen, C. C. H., Hahn, T. T. G., Mehta, M. R., Grinvald, A., & Sakmann, B. J. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2235811100 · Cited by 679
Synaptic integration in tuft dendrites of layer 5 pyramidal neurons: a new unifying principle
Larkum, M. E., Nevian, T., Sandler, M., Polsky, A., & Schiller, J. (2009) · Science · doi:10.1126/science.1171958 · Cited by 677
Synaptic plasticity and dynamic modulation of the postsynaptic membrane
Lüscher, C., Nicoll, R. A., Malenka, R. C., & Müller, D. (2000) · Nature Neuroscience · doi:10.1038/75714 · Cited by 662
Integrative Properties of Radial Oblique Dendrites in Hippocampal CA1 Pyramidal Neurons
Losonczy, A., & Magee, J. C. (2006) · Neuron · doi:10.1016/j.neuron.2006.03.016 · Cited by 641
Dendritic spikes as a mechanism for cooperative long-term potentiation
Golding, N. L., Staff, N. P., & Spruston, N. (2002) · Nature · doi:10.1038/nature00854 · Cited by 623
Synchrony Unbound
Shadlen, M. N., & Movshon, J. A. (1999) · Neuron · doi:10.1016/s0896-6273(00)80822-3 · Cited by 606
Impact of Active Dendrites and Structural Plasticity on the Memory Capacity of Neural Tissue
Poirazi, P., & Mel, B. W. (2001) · Neuron · doi:10.1016/s0896-6273(01)00252-5 · Cited by 601
Compartmentalized dendritic plasticity and input feature storage in neurons
Losonczy, A., Makara, J. K., & Magee, J. C. (2008) · Nature · doi:10.1038/nature06725 · Cited by 598
Characterization of single voltage‐gated Na+ and Ca2+ channels in apical dendrites of rat CA1 pyramidal neurons.
Magee, J., & Johnston, D. (1995) · Journal of Physiology · doi:10.1113/jphysiol.1995.sp020862 · Cited by 577
Spontaneous firing patterns and axonal projections of single corticostriatal neurons in the rat medial agranular cortex
Cowan, R. L., & Wilson, C. J. (1994) · Journal of Neurophysiology · doi:10.1152/jn.1994.71.1.17 · Cited by 540
Calcium action potentials restricted to distal apical dendrites of rat neocortical pyramidal neurons
Schiller, J., Schiller, Y., Stuart, G. J., & Sakmann, B. J. (1997) · The Journal of Physiology · doi:10.1111/j.1469-7793.1997.605ba.x · Cited by 528
Synaptic background activity influences spatiotemporal integration in single pyramidal cells.
Bernander, Ö., Douglas, R. J., Martin, K. A. C., & Koch, C. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.24.11569 · Cited by 518
Rapid Neocortical Dynamics: Cellular and Network Mechanisms
Haider, B., & McCormick, D. A. (2009) · Neuron · doi:10.1016/j.neuron.2009.04.008 · Cited by 441
Synchronous Membrane Potential Fluctuations in Neurons of the Cat Visual Cortex
Lampl, I., Reichova, I., & Ferster, D. (1999) · Neuron · doi:10.1016/s0896-6273(00)81096-x · Cited by 435
Single Synaptic Events Evoke NMDA Receptor–Mediated Release of Calcium from Internal Stores in Hippocampal Dendritic Spines
Emptage, N. J., Bliss, T., & Fine, A. (1999) · Neuron · doi:10.1016/s0896-6273(00)80683-2 · Cited by 429
Dendritic mechanisms underlying the coupling of the dendritic with the axonal action potential initiation zone of adult rat layer 5 pyramidal neurons
Larkum, M. E., Zhu, J., & Sakmann, B. J. (2001) · The Journal of Physiology · doi:10.1111/j.1469-7793.2001.0447a.x · Cited by 425
Spine-Neck Geometry Determines NMDA Receptor-Dependent Ca2+ Signaling in Dendrites
Noguchi, J., Matsuzaki, M., Ellis-Davies, G. C. R., & Kasai, H. (2005) · Neuron · doi:10.1016/j.neuron.2005.03.015 · Cited by 419
Properties of basal dendrites of layer 5 pyramidal neurons: a direct patch-clamp recording study.
Nevian, T., Larkum, M. E., Polsky, A., & Schiller, J. (2007) · Nature Neuroscience · doi:10.1038/nn1826 · Cited by 406
Photostimulation using caged glutamate reveals functional circuitry in living brain slices.
Callaway, E. M., & Katz, L. C. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.16.7661 · Cited by 401
In vivo dendritic calcium dynamics in deep-layer cortical pyramidal neurons
Helmchen, F., Svoboda, K., Denk, W. T., & Tank, D. W. (1999) · Nature Neuroscience · doi:10.1038/14788 · Cited by 387
Consciousness and the Binding Problem
SINGER, W. (2001) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2001.tb05712.x · Cited by 367
State-Dependent Calcium Signaling in Dendritic Spines of Striatal Medium Spiny Neurons
Carter, A. G., & Sabatini, B. L. (2004) · Neuron · doi:10.1016/j.neuron.2004.10.013 · Cited by 347
On the Initiation and Propagation of Dendritic Spikes in CA1 Pyramidal Neurons
Gasparini, S., Migliore, M., & Magee, J. C. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.2520-04.2004 · Cited by 340
Pathway Interactions and Synaptic Plasticity in the Dendritic Tuft Regions of CA1 Pyramidal Neurons
Takahashi, H., & Magee, J. C. (2009) · Neuron · doi:10.1016/j.neuron.2009.03.007 · Cited by 321
Persistent neural activity: prevalence and mechanisms
Major, G., & Tank, D. (2004) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2004.10.017 · Cited by 320
Apical dendrites of the neocortex: correlation between sodium- and calcium-dependent spiking and pyramidal cell morphology
Kim, H., & Connors, B. W. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-12-05301.1993 · Cited by 305
Ca2+ accumulations in dendrites of neocortical pyramidal neurons: An apical band and evidence for two functional compartments
Yuste, R., Gutnick, M. J., Saar, D., Delaney, K. R., & Tank, D. W. (1994) · Neuron · doi:10.1016/0896-6273(94)90457-x · Cited by 298
Precise Long-Range Synchronization of Activity and Silence in Neocortical Neurons during Slow-Wave Sleep
Volgushev, M., Chauvette, S., Mukovski, M., & Timofeev, I. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.0279-06.2006 · Cited by 289
Ventral Tegmental Area Afferents to the Prefrontal Cortex Maintain Membrane Potential 'Up' States in Pyramidal Neurons via D1 Dopamine Receptors
Lewis, B. L. (2000) · Cerebral Cortex · doi:10.1093/cercor/10.12.1168 · Cited by 287
Synaptic integration in dendritic trees.
Gulledge, A. T., Kampa, B., & Stuart, G. (2005) · Journal of Neurobiology · doi:10.1002/neu.20144 · Cited by 276
Submillisecond Precision of the Input-Output Transformation Function Mediated by Fast Sodium Dendritic Spikes in Basal Dendrites of CA1 Pyramidal Neurons
Ariav, G., Poleg-Polsky, A., & Schiller, J. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-21-07750.2003 · Cited by 276
Dendritic morphology of pyramidal neurones of the visual cortex of the rat: III. Spine distributions
Larkman, A. U. (1991) · The Journal of Comparative Neurology · doi:10.1002/cne.903060209 · Cited by 274
Glutamate receptor channels in isolated patches from CA1 and CA3 pyramidal cells of rat hippocampal slices.
Jonas, P., & Sakmann, B. (1992) · The Journal of Physiology · doi:10.1113/jphysiol.1992.sp019294 · Cited by 271
Unique Roles of SK and Kv4.2 Potassium Channels in Dendritic Integration
Cai, X., Liang, C. W., Muralidharan, S., Kao, J. P. Y., Tang, C., & Thompson, S. M. (2004) · Neuron · doi:10.1016/j.neuron.2004.09.026 · Cited by 266
Synaptic clustering by dendritic signalling mechanisms
Larkum, M. E., & Nevian, T. (2008) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2008.08.013 · Cited by 265
Postsynaptic depolarization requirements for LTP and LTD: a critique of spike timing-dependent plasticity
Lisman, J. E., & Spruston, N. (2005) · Nature Neuroscience · doi:10.1038/nn0705-839 · Cited by 257
Dendritic Spikes Are Enhanced by Cooperative Network Activity in the Intact Hippocampus
Kamondi, A., Acsády, L., & Buzsáki, G. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-10-03919.1998 · Cited by 253
Amyloid precursor protein promotes post‐developmental neurite arborization in the Drosophila brain
Leyssen, M., Ayaz, D., Hébert, S. S., Reeve, S. P., Strooper, B. D., & Hassan, B. A. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600757 · Cited by 249
Calcium concentration dynamics produced by synaptic activation of CA1 hippocampal pyramidal cells
Regehr, W. G., & Tank, D. W. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-11-04202.1992 · Cited by 230
Spatial profile of dendritic calcium transients evoked by action potentials in rat neocortical pyramidal neurones.
Schiller, J., Helmchen, F., & Sakmann, B. J. (1995) · The Journal of Physiology · doi:10.1113/jphysiol.1995.sp020902 · Cited by 223
Spatiotemporally Graded NMDA Spike/Plateau Potentials in Basal Dendrites of Neocortical Pyramidal Neurons
Major, G., Poleg-Polsky, A., Denk, W. T., Schiller, J., & Tank, D. W. (2008) · Journal of Neurophysiology · doi:10.1152/jn.00011.2008 · Cited by 222
Cortical area and species differences in dendritic spine morphology
Benavides-Piccione, R., Ballesteros-Yáñez, I., DeFelipe, J., & Yuste, R. (2002) · Journal of Neurocytology · doi:10.1023/a:1024134312173 · Cited by 207
Compartmentalized and Binary Behavior of Terminal Dendrites in Hippocampal Pyramidal Neurons
Wei, D.-S., Mei, Y., Bagal, A. A., Kao, J. P. Y., Thompson, S. M., & Tang, C. (2001) · Science · doi:10.1126/science.1061198 · Cited by 199
Backpropagating action potentials in neurones: measurement, mechanisms and potential functions
Waters, J., Schaefer, A., & Sakmann, B. (2005) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2004.06.009 · Cited by 192
Chemical Two-Photon Uncaging: a Novel Approach to Mapping Glutamate Receptors
Pettit, D. L., Wang, S. S. ‐., Gee, K. R., & Augustine, G. J. (1997) · Neuron · doi:10.1016/s0896-6273(00)80361-x · Cited by 180
Dendritic spikes induce single-burst long-term potentiation
Remy, S., & Spruston, N. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0707919104 · Cited by 179
Background Synaptic Activity Is Sparse in Neocortex
Waters, J., & Helmchen, F. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.2152-06.2006 · Cited by 177
Robust Persistent Neural Activity in a Model Integrator with Multiple Hysteretic Dendrites per Neuron
Goldman, M. S. (2003) · Cerebral Cortex · doi:10.1093/cercor/bhg095 · Cited by 169
Plasticity compartments in basal dendrites of neocortical pyramidal neurons
Gordon, U., Polsky, A., & Schiller, J. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.3502-06.2006 · Cited by 157
A model for intradendritic computation of binocular disparity
Archie, K. A., & Mel, B. W. (2000) · Nature Neuroscience · doi:10.1038/71125 · Cited by 138
Regulation of NMDA receptor Ca2+ signalling and synaptic plasticity
Lau, C. G., Takeuchi, K., Rodenas-Ruano, A., Takayasu, Y., Murphy, J., Bennett, M. V. L., & Zukin, R. S. (2009) · Biochemical Society Transactions · doi:10.1042/bst0371369 · Cited by 138
Action Potentials in Basal and Oblique Dendrites of Rat Neocortical Pyramidal Neurons
Antic, S. D. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2002.033746 · Cited by 136
Self-citation
Spatial Segregation and Interaction of Calcium Signalling Mechanisms in Rat Hippocampal CA1 Pyramidal Neurons
Nakamura, T., Lasser‐Ross, N., Nakamura, K. M., & Ross, W. N. (2002) · The Journal of Physiology · doi:10.1113/jphysiol.2002.020362 · Cited by 123
Activity-Dependent Plasticity of the NMDA-Receptor Fractional Ca2+ Current
Sobczyk, A., & Svoboda, K. (2007) · Neuron · doi:10.1016/j.neuron.2006.11.016 · Cited by 111
The Properties and Implications of NMDA Spikes in Neocortical Pyramidal Cells
Rhodes, P. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.3791-05.2006 · Cited by 105
Propagating dendritic action potential mediates synaptic transmission in CA1 pyramidal cells in situ
Herreras, Ó. (1990) · Journal of Neurophysiology · doi:10.1152/jn.1990.64.5.1429 · Cited by 99
Up and down states
Wilson, C. J. (2008) · Scholarpedia · doi:10.4249/scholarpedia.1410 · Cited by 95
Beyond bistability: Biophysics and temporal dynamics of working memory
Durstewitz, D., & Seamans, J. K. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.06.094 · Cited by 94
Activity-Dependent Control of Neuronal Output by Local and Global Dendritic Spike Attenuation
Remy, S., Csicsvari, J., & Beck, H. (2009) · Neuron · doi:10.1016/j.neuron.2009.01.032 · Cited by 88
Single‐shock LTD by local dendritic spikes in pyramidal neurons of mouse visual cortex
Holthoff, K., Kovalchuk, Y., Yuste, R., & Konnerth, A. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2004.072678 · Cited by 83
States of High Conductance in a Large-Scale Model of the Visual Cortex
Shelley, M., McLaughlin, D. W., Shapley, R. M., & Wielaard, J. (2002) · Journal of Computational Neuroscience · doi:10.1023/a:1020158106603 · Cited by 81
Intracellular long-wavelength voltage-sensitive dyes for studying the dynamics of action potentials in axons and thin dendrites
Zhou, W., Yan, P., Wuskell, J. P., Loew, L. M., & Antic, S. D. (2007) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2007.05.002 · Cited by 80
Self-citation
Dendritic signals from rat hippocampal CA1 pyramidal neurons during coincident pre‐ and post‐synaptic activity: a combined voltage‐ and calcium‐imaging study
Canepari, M., Djurisic, M. R., & Zečević, D. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2006.125005 · Cited by 78
Rapid time course of action potentials in spines and remote dendrites of mouse visual cortex neurons: Optical recording of APs in dendritic spines
Holthoff, K., Zecevic, D., & Konnerth, A. (2010) · The Journal of Physiology · doi:10.1113/jphysiol.2009.184960 · Cited by 76
Exercise normalizes levels of MAG and Nogo‐A growth inhibitors after brain trauma
Chytrova, G., Ying, Z., & Gómez‐Pinilla, F. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05982.x · Cited by 75
Burst generation in rat pyramidal neurones by regenerative potentials elicited in a restricted part of the basilar dendritic tree
Milojkovic, B. A., Radojicic, M. S., Goldman‐Rakic, P. S., & Antic, S. D. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2004.061416 · Cited by 75
Self-citation
Active Dendrites Enhance Neuronal Dynamic Range
Gollo, L. L., Kinouchi, O., & Copelli, M. (2009) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1000402 · Cited by 72
A Strict Correlation between Dendritic and Somatic Plateau Depolarizations in the Rat Prefrontal Cortex Pyramidal Neurons
Milojkovic, B. A., Radojicic, M. S., & Antic, S. D. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.5314-04.2005 · Cited by 70
Self-citation
Oscillatory neuronal activity related to visual short-term memory in monkey temporal pole
Nakamura, K., Mikami, A., & Kubota, K. (1992) · Neuroreport · doi:10.1097/00001756-199201000-00031 · Cited by 69
Voltage and calcium transients in basal dendrites of the rat prefrontal cortex
Milojkovic, B. A., Zhou, W., & Antic, S. D. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2007.142315 · Cited by 66
Self-citation
Initiation of Sodium Spikelets in Basal Dendrites of Neocortical Pyramidal Neurons
Milojkovic, B. A., Wuskell, J. P., Loew, L. M., & Antic, S. D. (2005) · The Journal of Membrane Biology · doi:10.1007/s00232-005-0827-7 · Cited by 64
Self-citation
Synaptically Activated Ca2+ Release From Internal Stores in CNS Neurons
Ross, W. N., Nakamura, T., Watanabe, S., Larkum, M. E., & Lasser‐Ross, N. (2005) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-005-3060-0 · Cited by 54
Quantitative Assessment of the Distributions of Membrane Conductances Involved in Action Potential Backpropagation Along Basal Dendrites
Acker, C. D., & Antic, S. D. (2009) · Journal of Neurophysiology · doi:10.1152/jn.00651.2007 · Cited by 51
Self-citation
Dynamics of action potential backpropagation in basal dendrites of prefrontal cortical pyramidal neurons
Zhou, W., Yan, P., Wuskell, J. P., Loew, L. M., & Antic, S. D. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06075.x · Cited by 48
Self-citation
Distribution of spontaneous currents along the somato-dendritic axis of rat hippocampal CA1 pyramidal neurons
Cossart, R., Hirsch, J. C., Cannon, R. C., Dinoncourt, C., Wheal, H. V., Ben‐Ari, Y., Esclapez, M., & Bernard, C. (2000) · Neuroscience · doi:10.1016/s0306-4522(00)00231-1 · Cited by 45
Dendritic spikes and activity-dependent synaptic plasticity
Holthoff, K., Kovalchuk, Y., & Konnerth, A. (2006) · Cell and Tissue Research · doi:10.1007/s00441-006-0263-8 · Cited by 42
Dendritic Calcium Spikes in Layer 5 Pyramidal Neurons Amplify and Limit Transmission of Ligand-Gated Dendritic Current to Soma
Oakley, J. C., Schwindt, P. C., & Crill, W. E. (2001) · Journal of Neurophysiology · doi:10.1152/jn.2001.86.1.514 · Cited by 40
Coherence and recurrency: maintenance, control and integration in working memory
Wolters, G., & Raffone, A. (2007) · Cognitive Processing · doi:10.1007/s10339-007-0185-8 · Cited by 31
Possible Role of Dendritic Compartmentalization in the Spatial Working Memory Circuit
Morita, K. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.0059-08.2008 · Cited by 31
Hyperexcitability of Distal Dendrites in Hippocampal Pyramidal Cells after Chronic Partial Deafferentation
Cai, X., Wei, D.-S., Gallagher, S. E., Bagal, A. A., Mei, Y., Kao, J. P. Y., Thompson, S. M., & Tang, C. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.4502-06.2007 · Cited by 28
A plateau potential mediated by the activation of extrasynaptic NMDA receptors in rat hippocampal CA1 pyramidal neurons
Suzuki, T., Kodama, S., Hoshino, C., Izumi, T., & Miyakawa, H. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06324.x · Cited by 28
Initiation and Propagation of Regenerative Ca 2+ -Dependent Potentials in Dendrites of Layer 5 Pyramidal Neurons
Oakley, J. C., Schwindt, P. C., & Crill, W. E. (2001) · Journal of Neurophysiology · doi:10.1152/jn.2001.86.1.503 · Cited by 26
Infrared-Interference Videomicroscopy of Living Brain Slices
Dodt, H. (1993) · Advances in experimental medicine and biology · doi:10.1007/978-1-4899-2468-1_22 · Cited by 24
Frontal cortex ablation reversibly decreases striatal zif/268 and junB expression: Temporal correspondence with sensory neglect and its spontaneous recovery
Vargo, J. M., & Marshall, J. F. (1996) · Synapse · doi:10.1002/(sici)1098-2396(199604)22:4 · Cited by 24

Flagged first, then by citations

Research works printed but not linked: 1

Antic SD, 2007, Mechanisms of spontaneous active states in the neocortex, mechanisms of spontaneous active states in the neocortex, 45

Sorted by citations

Active properties of neocortical pyramidal neuron dendrites
Major, G., Larkum, M. E., & Schiller, J. (2013) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-062111-150343 · Cited by 443
Why Neurons Have Thousands of Synapses, a Theory of Sequence Memory in Neocortex
Hawkins, J., & Ahmad, S. (2016) · Frontiers in Neural Circuits · doi:10.3389/fncir.2016.00023 · Cited by 442
Neural dynamics as sampling: a model for stochastic computation in recurrent networks of spiking neurons
Buesing, L., Bill, J., Nessler, B., & Maass, W. (2011) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1002211 · Cited by 384
NMDA spikes enhance action potential generation during sensory input
Palmer, L. M., Shai, A. S., Reeve, J. E., Anderson, H. L., Paulsen, O., & Larkum, M. E. (2014) · Nature Neuroscience · doi:10.1038/nn.3646 · Cited by 333
Power-efficient neural network with artificial dendrites
Li, X., Tang, J., Zhang, Q., Gao, B., Yang, J. J., Song, S., Wu, W., Zhang, W., Yao, P., Deng, N., et al. (2020) · Nature Nanotechnology · doi:10.1038/s41565-020-0722-5 · Cited by 262

See all 222

Authors: Antic, S. D., Zhou, W., Moore, A. R., Short, S. M., & Ikonomu, K. D.
Affiliations: UConn Health (US)
Corresponding author: Antic, Srdjan D.
ORCID: Antic, Srdjan D.
Zhou, Wen‐Liang
Moore, Anna R.
Short, Shaina M.
Venue: Journal of Neuroscience Research
Publisher: Wiley
Published: 2010-06-11
Volume: 88
Issue: 14
Pages: 2991-3001
ISSN: 0360-4012 (ISSN-L)
1097-4547
DOI: 10.1002/jnr.22444
PMC: PMC5643072
OpenAlex: W1971335223
Cited by: 222
References: 110
Citations by year: 2026: 5 · 2025: 22 · 2024: 15 · 2023: 18 · 2022: 16 · 2021: 20 · 2020: 11 · 2019: 13 · 2018: 13 · 2017: 13 · 2016: 15 · 2015: 14 · 2014: 15 · 2013: 20 · 2012: 6
FWCI: 0.92
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Journal of Neuroscience Research (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
OpenCommons - UConn (University of Connecticut) (submittedVersion)
Funders: National Institute of Mental Health (MH063503, R01MH063503)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords: pyramidal neurons, basal dendrites, glutamatergic synapses, working memory, long-term potentiation, long-term depression, slow-wave sleep, memory consolidation, cortical processing
MeSH terms: Action Potentials, Animals, Cerebral Cortex, Dendrites, Humans, Receptors, N-Methyl-D-Aspartate, Pyramidal Cells

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The decade of the dendritic NMDA spike

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks