The GRID-HAMD: standardization of the Hamilton Depression Rating Scale
Abstract
This report describes the GRID-Hamilton Depression Rating Scale (GRID-HAMD), an improved version of the Hamilton Depression Rating Scale that was developed through a broad-based international consensus process. The GRID-HAMD separates the frequency of the symptom from its intensity for most items, refines several problematic anchors, and integrates both a structured interview guide and consensus-derived conventions for all items. Usability was established in a small three-site sample of convenience, evaluating 29 outpatients, with most evaluators finding the scale easy to use. Test-retest (4-week) and interrater reliability were established in 34 adult outpatients with major depressive disorder, as part of an ongoing clinical trial. In a separate study, interrater reliability was found to be superior to the Guy version of the HAMD, and as good as the Structured Interview Guide for the Hamilton Depression Rating Scale (SIGH-D), across 30 interview pairs. Finally, using the SIGH-D as the criterion standard, the GRID-HAMD demonstrated high concurrent validity. Overall, these data suggest that the GRID-HAMD is an improvement over the original Guy version as well as the SIGH-D in its incorporation of innovative features and preservation of high reliability and validity.
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Participants were randomly assigned to the two groups with a computer-generated random number sequence stratified according to recruitment centre and participants' symptomatic status at randomisation using the GRID-Hamilton Rating Scale for Depression (GRID-HAMD) cutoff of less than 8 being asymptomatic and greater than or equal to 8 being partially symptomatic.
“Patients were randomly assigned to the two groups with a computer-generated random number sequence stratifi ed according to recruitment centre and partici pants' symptomatic status at randomisation using the GRID-Hamilton Rating Scale for Depression (GRID-HAMD) 16 cutoff of less than 8 being asymptomatic and greater than or equal to 8 being partially symp tomatic.17”
The GRID-HAMD is reliable and valid in the general population.
“It is a 17-item clinician-administered interview that has been found to be reliable and valid in the general population”
From Guided self-help for depression in autistic adults: The ADEPT feasibility RCT (2019) · cites this paper as [54]
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- Authors
- Williams, J. B. W., Kobak, K. A., Bech, P., Engelhardt, N., Evans, K., Lipsitz, J., Olin, J., Pearson, J., & Kalali, A.
- Affiliations
- Columbia University (US)
- Merck & Co., Inc., Rahway, NJ, USA (United States) (US)
- University of California San Diego (US)
- Corresponding author
- Williams, Janet B.W.
- Venue
- International Clinical Psychopharmacology
- Published
- 2008-05
- Volume
- 23
- Issue
- 3
- Pages
- 120-129
- ISSN
- 0268-1315 (ISSN-L)
- OpenAlex
- W2030962294
- Cited by
- 295
- References
- 26
- Citations by year
- 2026: 17 · 2025: 18 · 2024: 18 · 2023: 26 · 2022: 25 · 2021: 19 · 2020: 25 · 2019: 29 · 2018: 13 · 2017: 18 · 2016: 18 · 2015: 14 · 2014: 16 · 2013: 8 · 2012: 8
- FWCI
- 10.43
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Clinical Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Social Sciences › Decision Sciences › Management Science and Operations Research › Psychometric Methodologies and Testing
- Keywords
- Hamilton Depression Rating Scale, major depressive disorder, inter-rater reliability, test-retest reliability, concurrent validity, consensus building, outpatients
- MeSH terms
- Adult, Consensus Statements as Topic, Major Depressive Disorder, Humans, International Cooperation, Interview, Psychological, Pilot Projects, Predictive Value of Tests, Psychiatric Status Rating Scales, Psychometrics, Surveys and Questionnaires, United States, Reproducibility of Results, Observer Variation, Treatment Outcome
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