Delipidating effect of resveratrol metabolites in 3 T 3‐L 1 adipocytes
Abstract
Scope: Due to the low bioavailability of resveratrol, determining whether its metabolites exert any beneficial effect is an interesting issue. Methods and results: 3 T 3‐L 1 maturing pre‐adipocytes were treated from day 0 to day 8 of differentiation and mature adipocytes for 24 h on day 12 with 1, 10, or 25 μM of resveratrol or its metabolites. Triacylglycerols were assessed by spectrophotometry and gene expression by real time RT‐PCR. Resveratrol, trans‐resveratrol‐4′‐O‐glucuronide and trans‐resveratrol‐3‐O‐sulfate reduced triacylglycerol content in maturing pre‐adipocytes at 25 μM. In mature adipocytes, both resveratrol and its glucuronide metabolites, though not sulfate metabolite, reduced triacylglycerol content, although resveratrol was more effective than them. Resveratrol and the three metabolites reduced C/EBP β m RNA levels. Trans‐resveratrol‐3‐O‐sulfate also reduced C/EBP‐α, peroxisome proliferator‐activated receptor γ (PPAR‐γ), and lipoprotein lipase (LPL) expression. In mature adipocytes, resveratrol increased ATGL, CPT‐1, deacetylase sirtuin 1 (SIRT‐1), and PGC 1‐α expression. Trans‐resveratrol‐3‐O‐glucuronide reduced m RNA levels of FASN and increased those of SIRT‐1. Trans‐resveratrol‐4′‐O‐glucuronide increased HSL and SIRT‐1 m RNA levels. Trans‐resveratrol‐3‐O‐sulfate did not change gene expression. Conclusion: The present study shows for the first time the delipidating effect of (i) resveratrol metabolites in maturing pre‐adipocytes and (ii) glucuronide metabolites in mature adipocytes. This suggests that both resveratrol and resveratrol metabolites may be involved in the anti‐obesity effect of this polyphenol.
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Resveratrol has an inhibitory effect on lipoprotein lipase.
“Hence, these results suggest the presence of an inhibitory effect of resveratrol on lipoprotein lipase [18].”
From The Role of Resveratrol Administration in Human Obesity (2021) · cites this paper as [18]
Lasa et al. reported that incubating pre-adipocyte cells with increasing concentrations of resveratrol (1, 10, and 25 μM) for 24 h decreased triacylglycerol content and lower expression of ACC.
“Lasa and colleagues [18] incubated pre-adipocyte cells with increasing concentrations of resveratrol (1, 10, and 25 µM) for 24 h, reporting a decrease in triacylglycerol content and a lower expression of acetyl-CoA carboxylase (ACC).”
From The Role of Resveratrol Administration in Human Obesity (2021) · cites this paper as [18]
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- Authors
- Lasa, A., Churruca, I., Eseberri, I., Andrés‐Lacueva, C., & Portillo, M. P.
- Affiliations
- University of the Basque Country (ES)
- Universitat de Barcelona (ES)
- Corresponding author
- Portillo, María P.
- Venue
- Molecular Nutrition & Food Research
- Publisher
- Wiley
- Published
- 2012-09-04
- Volume
- 56
- Issue
- 10
- Pages
- 1559-1568
- ISSN
- 1613-4125 (ISSN-L)
- 1613-4133
- OpenAlex
- W2054003772
- Cited by
- 103
- References
- 49
- Citations by year
- 2026: 2 · 2025: 8 · 2024: 7 · 2023: 9 · 2022: 2 · 2021: 3 · 2020: 13 · 2019: 7 · 2018: 7 · 2017: 5 · 2016: 5 · 2015: 8 · 2014: 13 · 2013: 13
- FWCI
- 5.33
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular Nutrition & Food Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministerio de Ciencia e Innovación (AGL2008-01005-ALI)
- Ministerio de Economía y Competitividad (AGL2011-27406-ALI)
- Government of País Vasco (IT386-10, MICRORES S-PE11UN094)
- University of the Basque Country UPV/EHU (ELDUNANOTEK UFI11/32)
- Instituto de Salud Carlos III
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Keywords
- resveratrol, resveratrol metabolites, adipocytes, adipogenesis, lipolysis, C/EBPβ, PPARγ, lipoprotein lipase, SIRT1, PGC-1α, adipose triglyceride lipase, HSL, fatty acid synthase, anti-obesity, polyphenols
- MeSH terms
- Resveratrol, Animals, Cell Differentiation, Gene Expression Regulation, Lipoprotein Lipase, RNA, Messenger, Stilbenes, Triglycerides, Adipocytes, Anti-Obesity Agents, Glucuronides, 3T3-L1 Cells, PPAR gamma, Mice, Real-Time Polymerase Chain Reaction, Fatty Acid Synthases
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