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Cited by 323

The DOI matches its Crossref record; 122 of the 122 references it cites were found in a registry or an index.

New insights into form and function of fibronectin splice variants

Open access
White, ES, Baralle, FE, Muro, AF·2008·The Journal of Pathology

Abstract

The extracellular matrix (ECM) is a highly dynamic structure that not only provides a physical framework for cells within connective tissues, but also imparts instructive signals for development, tissue homeostasis and basic cell functions through its composition and ability to exert mechanical forces. The ECM of tissues is composed of, in addition to proteoglycans and hyaluronic acid, a number of proteins, most of which are generated after alternative splicing of their pre‐mRNA. However, the precise function of these protein isoforms is still obscure in most cases. Fibronectin (FN), one of the main components of the ECM, is also one of the best‐known examples of a family of proteins generated by alternative splicing, having at least 20 different isoforms in humans. Over the last few years, considerable progress on elucidating the functions of the alternatively spliced FN isoforms has been achieved with the essential development of key engineered mouse strains. Here we summarize the phenotypes of the mouse strains having targeted mutations in the FN gene, which may lead to novel insights linking function of alternatively spliced isoforms of fibronectin to human pathologies. Copyright © 2008 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

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Crossref · 10.1002/path.2388

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Metadata

Authors
White, E., Baralle, F., & Muro, A.
Venue
The Journal of Pathology
Publisher
Wiley
Published
2008-08-04
Volume
216
Issue
1
Pages
1-14
ISSN
  • 0022-3417 (ISSN-L)
  • 1096-9896
OpenAlex
W2114534122
Cited by
323
References
122
FWCI
12.35
Type
journal article
Language
en
Open access
bronze

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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