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Cited by 349

The DOI matches its Crossref record; 151 of the 151 references it cites were found in a registry or an index.

Interstitial guidance of cancer invasion

Open access
G. Gritsenko, Pavlo, Ilina, Olga, Friedl, Peter·2012·The Journal of Pathology
DOI 10.1002/path.3031
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Abstract

Cancer cell invasion into healthy tissues develops preferentially along pre‐existing tracks of least resistance, followed by secondary tissue remodelling and destruction. The tissue scaffolds supporting or preventing guidance of invasion vary in structure and molecular composition between organs. In the brain, the guidance is provided by myelinated axons, astrocyte processes, and blood vessels which are used as invasion routes by glioma cells. In the human breast, containing interstitial collagen‐rich connective tissue, disseminating breast cancer cells preferentially invade along bundled collagen fibrils and the surface of adipocytes. In both invasion types, physical guidance prompted by interfaces and space is complemented by molecular guidance. Generic mechanisms shared by most, if not all, tissues include (i) guidance by integrins towards fibrillar interstitial collagen and/or laminins and type IV collagen in basement membranes decorating vessels and adipocytes, and, likely, CD44 engaging with hyaluronan; (ii) haptotactic guidance by chemokines and growth factors; and likely (iii) physical pushing mechanisms. Tissue‐specific, resticted guidance cues include ECM proteins with restricted expression (tenascins, lecticans), cell–cell interfaces, and newly secreted matrix molecules decorating ECM fibres (laminin‐332, thrombospondin‐1, osteopontin, periostin). We here review physical and molecular guidance mechanisms in interstitial tissue and brain parenchyma and explore shared principles and organ‐specific differences, and their implications for experimental model design and therapeutic targeting of tumour cell invasion. Copyright © 2011 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

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Metadata

Authors
G. Gritsenko, P., Ilina, O., & Friedl, P.
Venue
The Journal of Pathology
Publisher
Wiley
Published
2011-12
Volume
226
Issue
2
Pages
185-199
ISSN
  • 0022-3417 (ISSN-L)
  • 1096-9896
DOI
10.1002/path.3031
OpenAlex
W1964292350
Cited by
349
References
151
FWCI
9.67
Type
journal article
Language
en
Open access
bronze

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