Immune senescence, epigenetics and autoimmunity

Ray, Donna; Yung, Raymond

doi:10.1016/j.clim.2018.04.002

Cited by 219Epigenetics and DNA MethylationT-cell and B-cell ImmunologyTelomeres, Telomerase, and Senescence

Immune senescence, epigenetics and autoimmunity

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Ray, Donna, Yung, Raymond·2018·Clinical Immunology

DOI 10.1016/j.clim.2018.04.002PMC PMC6548177

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Abstract

Aging of the immune system in humans and animals is characterized by a decline in both adaptive and innate immune responses. Paradoxically, aging is also associated with a state of chronic inflammation ("inflammaging") and an increased likelihood of developing autoimmune diseases. Epigenetic changes in non-dividing and dividing cells, including immune cells, due to environmental factors contribute to the inflammation and autoimmunity that characterize both the state and diseases of aging. Here, we review the epigenetic mechanisms involved in the development of immune senescence and autoimmunity in old age.

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Autoantibodies and inflammatory cytokines or chemokines are associated with immune senescence.
“Autoantibodies and inflammatory cytokines or chemokines are associated with immune senescence 17 .”
From Age-related immune response heterogeneity to SARS-CoV-2 vaccine BNT162b2 (2021) · cites this paper as [17]

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Senescent cell clearance by the immune system: Emerging therapeutic opportunities
Prata, L. G. P. L., Ovsyannikova, I. G., Tchkonia, T., & Kirkland, J. L. (2018) · Seminars in Immunology · doi:10.1016/j.smim.2019.04.003 · Cited by 497 · see citing works

Authors: Ray, D., & Yung, R.
Affiliations: University of Michigan (US)
Corresponding author: Yung, Raymond
ORCID: Yung, Raymond
Venue: Clinical Immunology
Publisher: Elsevier BV
Published: 2018-11
Volume: 196
Pages: 59-63
ISSN: 1521-6616 (ISSN-L)
DOI: 10.1016/j.clim.2018.04.002
PMC: PMC6548177
OpenAlex: W2797192791
Cited by: 219
References: 106
Citations by year: 2026: 8 · 2025: 33 · 2024: 41 · 2023: 46 · 2022: 30 · 2021: 40 · 2020: 9 · 2019: 5 · 2018: 7
FWCI: 5.51
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Clinical Immunology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Deep Blue (University of Michigan) (submittedVersion)
University of Michigan Library
Funders: NIH (AG020628, AG024824, AI110502)
Geriatrics Research, Education and Clinical Care Center
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
Keywords: immunosenescence, epigenetics, autoimmunity, inflammaging, aging, chronic inflammation, adaptive immunity, innate immunity, immune cells, environmental factors
MeSH terms: Immunosenescence, Aging, Autoimmune Diseases, Humans, Immunity, Innate, Inflammation, Autoimmunity, Epigenesis, Genetic, Adaptive Immunity

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