Inflammaging and the Lung

The Hallmarks of Aging

López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982 · see citing works

Macrophage activation and polarization: nomenclature and experimental guidelines

Murray, P. J., Allen, J. E., Biswas, S. K., Fisher, E. A., Gilroy, D. W., Goerdt, S., Gordon, S., Hamilton, J. A., Ivashkiv, L. B., Lawrence, T., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.06.008 · Cited by 6,337 · see citing works

Macrophage plasticity and polarization: in vivo veritas

Sica, A., & Mantovani, A. (2012) · Journal of Clinical Investigation · doi:10.1172/jci59643 · Cited by 6,335 · see citing works

Inflamm‐aging: An Evolutionary Perspective on Immunosenescence

FRANCESCHI, C., BONAFÈ, M., VALENSIN, S., OLIVIERI, F., DE LUCA, M., OTTAVIANI, E., & DE BENEDICTIS, G. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06651.x · Cited by 5,358 · see citing works

Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases

Franceschi, C., & Campisi, J. (2014) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glu057 · Cited by 3,891 · see citing works

Gut microbiota composition correlates with diet and health in the elderly

Claesson, M. J., Jeffery, I. B., Conde, S., Power, S. E., O’Connor, E. M., Cusack, S., Harris, H. M. B., Coakley, M., Lakshminarayanan, B., O’Sullivan, O., et al. (2012) · Nature · doi:10.1038/nature11319 · Cited by 3,314 · see citing works

Macrophage plasticity and polarization in tissue repair and remodelling

Mantovani, A., Biswas, S. K., Galdiero, M. R., Sica, A., & Locati, M. (2013) · The Journal of Pathology · doi:10.1002/path.4133 · Cited by 2,384 · see citing works

Composition, variability, and temporal stability of the intestinal microbiota of the elderly

Claesson, M. J., Cusack, S., O'Sullivan, O., Greene-Diniz, R., de Weerd, H., Flannery, E., Marchesi, J. R., Falush, D., Dinan, T., Fitzgerald, G., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000097107 · Cited by 1,754 · see citing works

Regulation of Tight Junction Permeability by Intestinal Bacteria and Dietary Components1,2

Ulluwishewa, D., Anderson, R. C., McNabb, W. C., Moughan, P. J., Wells, J. M., & Roy, N. C. (2011) · The Journal of Nutrition · doi:10.3945/jn.110.135657 · Cited by 1,177 · see citing works

An unrestrained proinflammatory M1 macrophage population induced by iron impairs wound healing in humans and mice

Sindrilaru, A., Peters, T., Wieschalka, S., Baican, C., Baican, A., Peter, H., Hainzl, A., Schatz, S., Qi, Y., Schlecht, A., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci44490 · Cited by 1,100 · cited 1× · see citing works

Age-dependent dysregulation of innate immunity

Shaw, A. C., Goldstein, D. R., & Montgomery, R. R. (2013) · Nature Reviews Immunology · doi:10.1038/nri3547 · Cited by 1,061 · see citing works

Cytoskeletal regulation of pulmonary vascular permeability

Dudek, S. M., & Garcia, J. G. N. (2001) · Journal of Applied Physiology · doi:10.1152/jappl.2001.91.4.1487 · Cited by 985 · see citing works

Proteostasis and aging

Kaushik, S., & Cuervo, A. M. (2015) · Nature Medicine · doi:10.1038/nm.4001 · Cited by 899 · see citing works

Macrophage activation switching: an asset for the resolution of inflammation

Porcheray, F., Viaud, S., Rimaniol, A.-C., Léone, C., Samah, B., Dereuddre-Bosquet, N., Dormont, D., & Gras, G. (2005) · Clinical and Experimental Immunology · doi:10.1111/j.1365-2249.2005.02934.x · Cited by 840 · see citing works

Monocyte and Macrophage Plasticity in Tissue Repair and Regeneration

Das, A., Sinha, M., Datta, S., Abas, M., Chaffee, S. M., Sen, C. K., & Roy, S. (2015) · American Journal Of Pathology · doi:10.1016/j.ajpath.2015.06.001 · Cited by 747 · see citing works

Gut Bifidobacteria Populations in Human Health and Aging

Arboleya, S., Watkins, C., Stanton, C., & Ross, R. P. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.01204 · Cited by 683 · see citing works

Neutrophils: Between Host Defence, Immune Modulation, and Tissue Injury

Krüger, P., Saffarzadeh, M., Weber, A. N. R., Rieber, N. P., Radsak, M. P., von Bernuth, H., Benarafa, C., Roos, D., Skokowa, J., & Hartl, D. (2015) · PLoS Pathogens · doi:10.1371/journal.ppat.1004651 · Cited by 663 · see citing works

Cutting edge: impaired toll-like receptor expression and function in aging

Renshaw, M., Rockwell, J., Engleman, C., Gewirtz, A., Katz, J., & Sambhara, S. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.9.4697 · Cited by 626 · see citing works

Diverse macrophage populations mediate acute lung inflammation and resolution

Aggarwal, N. R., King, L. S., & D’Alessio, F. R. (2014) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00341.2013 · Cited by 583 · see citing works

Innate immunosenescence: Effect of aging on cells and receptors of the innate immune system in humans

Solana, R., Tarazona, R., Gayoso, I., Lesur, O., Dupuis, G., & Fulop, T. (2012) · Seminars in Immunology · doi:10.1016/j.smim.2012.04.008 · Cited by 567 · see citing works

Physiological regulation of epithelial tight junctions is associated with myosin light-chain phosphorylation

Turner, J. R., Rill, B. K., Carlson, S. L., Carnes, D., Kerner, R., Mrsny, R. J., & Madara, J. (1997) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1997.273.4.c1378 · Cited by 553 · see citing works

Aging is associated with chronic innate immune activation and dysregulation of monocyte phenotype and function

Hearps, A. C., Martin, G. E., Angelovich, T. A., Cheng, W., Maisa, A., Landay, A. L., Jaworowski, A., & Crowe, S. M. (2012) · Aging Cell · doi:10.1111/j.1474-9726.2012.00851.x · Cited by 547 · see citing works

Molecular Basis of Epithelial Barrier Regulation

Turner, J. R. (2006) · American Journal Of Pathology · doi:10.2353/ajpath.2006.060681 · Cited by 542 · see citing works

Toll-like receptors: Activation, signalling and transcriptional modulation

Nardo, D. D. (2015) · Cytokine · doi:10.1016/j.cyto.2015.02.025 · Cited by 459 · see citing works

Effect of age on human neutrophil function

Wenisch, C., Patruta, S., Daxböck, F., Krause, R., & Hörl, W. H. (2000) · Journal of Leukocyte Biology · doi:10.1002/jlb.67.1.40 · Cited by 452 · see citing works

Microbial shifts in the aging mouse gut

Langille, M. G., Meehan, C. J., Koenig, J. E., Dhanani, A. S., Rose, R. A., Howlett, S. E., & Beiko, R. G. (2014) · Microbiome · doi:10.1186/s40168-014-0050-9 · Cited by 437 · see citing works

Senescence in innate immune responses: reduced neutrophil phagocytic capacity and CD16 expression in elderly humans

Butcher, S. K., Chahal, H., Nayak, L., Sinclair, A., Henriquez, N. V., Sapey, E., O'Mahony, D., & Lord, J. M. (2001) · Journal of Leukocyte Biology · doi:10.1189/jlb.70.6.881 · Cited by 436 · see citing works

Innate immunity in aging: impact on macrophage function

Plowden, J., Renshaw‐Hoelscher, M., Engleman, C., Katz, J. M., & Sambhara, S. R. (2004) · Aging Cell · doi:10.1111/j.1474-9728.2004.00102.x · Cited by 430 · see citing works

Intestinal Permeability Defects: Is It Time to Treat?

Odenwald, M. A., & Turner, J. R. (2013) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2013.07.001 · Cited by 366 · see citing works

Gut-origin sepsis: evolution of a concept

Deitch, E. A. (2012) · The Surgeon · doi:10.1016/j.surge.2012.03.003 · Cited by 359 · see citing works

Phosphoinositide 3-kinase inhibition restores neutrophil accuracy in the elderly: toward targeted treatments for immunosenescence

Sapey, E., Greenwood, H., Walton, G., Mann, E., Love, A., Aaronson, N., Insall, R. H., Stockley, R. A., & Lord, J. M. (2014) · Blood · doi:10.1182/blood-2013-08-519520 · Cited by 358 · see citing works

Inflammaging decreases adaptive and innate immune responses in mice and humans

Frasca, D., & Blomberg, B. B. (2016) · Biogerontology · doi:10.1007/s10522-015-9578-8 · Cited by 357 · see citing works

Untitled work

(1999) · PubMed · Cited by 354 · see citing works

Redefining the gut as the motor of critical illness

Mittal, R., & Coopersmith, C. M. (2013) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2013.08.004 · Cited by 342 · see citing works

Hallmarks of the ageing lung

Meiners, S., Eickelberg, O., & Königshoff, M. (2015) · European Respiratory Journal · doi:10.1183/09031936.00186914 · Cited by 340 · see citing works

Inflammation, But Not Telomere Length, Predicts Successful Ageing at Extreme Old Age: A Longitudinal Study of Semi-supercentenarians

Arai, Y., Martin-Ruiz, C. M., Takayama, M., Abe, Y., Takebayashi, T., Koyasu, S., Suematsu, M., Hirose, N., & von Zglinicki, T. (2015) · EBioMedicine · doi:10.1016/j.ebiom.2015.07.029 · Cited by 333 · see citing works

Acute Lung Injury: How Macrophages Orchestrate Resolution of Inflammation and Tissue Repair

Herold, S., Mayer, K., & Lohmeyer, J. (2011) · Frontiers in Immunology · doi:10.3389/fimmu.2011.00065 · Cited by 331 · see citing works

The Effect of Aging on Nasal Mucociliary Clearance, Beat Frequency, and Ultrastructure of Respiratory Cilia

HO, J. C., CHAN, K. N., HU, W. H., LAM, W. K., ZHENG, L., TIPOE, G. L., SUN, J., LEUNG, R., & TSANG, K. W. (2001) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.163.4.9909121 · Cited by 324 · see citing works

When two is better than one: macrophages and neutrophils work in concert in innate immunity as complementary and cooperative partners of a myeloid phagocyte system

Silva, M. T. (2009) · Journal of Leukocyte Biology · doi:10.1189/jlb.0809549 · Cited by 321 · see citing works

Impaired neutrophil extracellular trap formation: a novel defect in the innate immune system of aged individuals

Hazeldine, J., Harris, P., Chapple, I., Grant, M. M., Greenwood, H. L., Livesey, A., Sapey, E., & Lord, J. M. (2014) · Aging Cell · doi:10.1111/acel.12222 · Cited by 297 · see citing works

Nutrition and the gut microbiome in the elderly

Salazar, N., Valdés-Varela, L., González, S., Gueimonde, M., & de los Reyes-Gavilán, C. G. (2017) · Gut Microbes · doi:10.1080/19490976.2016.1256525 · Cited by 282 · see citing works

Burns, Bacterial Translocation, Gut Barrier Function, and Failure

Magnotti, L. J., & Deitch, E. A. (2005) · Journal of Burn Care & Rehabilitation · doi:10.1097/01.bcr.0000176878.79267.e8 · Cited by 277 · see citing works

Current Concept and Update of the Macrophage Plasticity Concept: Intracellular Mechanisms of Reprogramming and M3 Macrophage “Switch” Phenotype

Malyshev, I. Y., & Malyshev, Y. (2015) · BioMed Research International · doi:10.1155/2015/341308 · Cited by 276 · see citing works

Age-dependent decrease in Toll-like receptor 4-mediated proinflammatory cytokine production and mitogen-activated protein kinase expression

Boehmer, E. D., Góral, J., Faunce, D. E., & Kovacs, E. J. (2003) · Journal of Leukocyte Biology · doi:10.1189/jlb.0803389 · Cited by 266 · see citing works

Gastrointestinal mucosal barrier function and diseases

Oshima, T., & Miwa, H. (2016) · Journal of Gastroenterology · doi:10.1007/s00535-016-1207-z · Cited by 250 · see citing works

Dysbiosis of upper respiratory tract microbiota in elderly pneumonia patients

de Steenhuijsen Piters, W. A. A., Huijskens, E. G. W., Wyllie, A. L., Biesbroek, G., van den Bergh, M. R., Veenhoven, R. H., Wang, X., Trzciński, K., Bonten, M. J., Rossen, J. W. A., et al. (2016) · The ISME Journal · doi:10.1038/ismej.2015.99 · Cited by 235 · see citing works

Culture and molecular-based profiles show shifts in bacterial communities of the upper respiratory tract that occur with age

Stearns, J. C., Davidson, C. J., McKeon, S., Whelan, F. J., Fontes, M. E., Schryvers, A. B., Bowdish, D. M. E., Kellner, J. D., & Surette, M. G. (2015) · The ISME Journal · doi:10.1038/ismej.2014.250 · Cited by 234 · see citing works

Bacterial translocation or lymphatic drainage of toxic products from the gut: What is important in human beings?

Deitch, E. A. (2002) · Surgery · doi:10.1067/msy.2002.116408 · Cited by 233 · see citing works

Infection in an aging population

Kline, K. A., & Bowdish, D. M. E. (2015) · Current Opinion in Microbiology · doi:10.1016/j.mib.2015.11.003 · Cited by 229 · see citing works

Airway epithelial regulation of pulmonary immune homeostasis and inflammation

Hallstrand, T. S., Hackett, T., Altemeier, W. A., Matute‐Bello, G., Hansbro, P. M., & Knight, D. A. (2013) · Clinical Immunology · doi:10.1016/j.clim.2013.12.003 · Cited by 223 · see citing works

Advanced Age Impairs Macrophage Polarization

Mahbub, S., Deburghgraeve, C. R., & Kovacs, E. J. (2012) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2011.0058 · Cited by 222 · see citing works

Dysregulation of human Toll-like receptor function in aging

Shaw, A. C., Panda, A., Joshi, S. R., Qian, F., Allore, H. G., & Montgomery, R. R. (2011) · Ageing Research Reviews · doi:10.1016/j.arr.2010.10.007 · Cited by 215 · see citing works

The Loss of Topography in the Microbial Communities of the Upper Respiratory Tract in the Elderly

Whelan, F. J., Verschoor, C. P., Stearns, J. C., Rossi, L., Luinstra, K., Loeb, M., Smieja, M., Johnstone, J., Surette, M. G., & Bowdish, D. M. E. (2014) · Annals of the American Thoracic Society · doi:10.1513/annalsats.201310-351oc · Cited by 205 · see citing works

Ageing and the neutrophil: no appetite for killing?

Butcher, S. K., Chahel, H., & Lord, J. M. (2000) · Immunology · doi:10.1046/j.1365-2567.2000.00079.x · Cited by 200 · see citing works

Gut microbiota lipopolysaccharide accelerates inflamm-aging in mice

Kim, K.-A., Jeong, J.-J., Yoo, S.-Y., & Kim, D.-H. (2016) · BMC Microbiology · doi:10.1186/s12866-016-0625-7 · Cited by 196 · see citing works

Age-associated modifications of intestinal permeability and innate immunity in human small intestine.

Man, A., Bertelli, E., Rentini, S., Regoli, M., Briars, G., Marini, M., Watson, A., & Nicoletti, C. (2015) · Clinical science · doi:10.1042/cs20150046 · Cited by 189 · see citing works

Reduced Neutrophil Chemotaxis and Infiltration Contributes to Delayed Resolution of Cutaneous Wound Infection with Advanced Age

Brubaker, A. L., Rendon, J. L., Ramirez, L., Choudhry, M. A., & Kovacs, E. J. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1201213 · Cited by 181 · see citing works

Aging Delays Resolution of Acute Inflammation in Mice: Reprogramming the Host Response with Novel Nano-Proresolving Medicines

Arnardottir, H. H., Dalli, J., Colas, R. A., Shinohara, M., & Serhan, C. N. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1401313 · Cited by 171 · see citing works

Aging negatively skews macrophage TLR2- and TLR4-mediated pro-inflammatory responses without affecting the IL-2-stimulated pathway

Boehmer, E. D., Meehan, M. J., Cutro, B. T., & Kovacs, E. J. (2005) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2005.07.009 · Cited by 170 · see citing works

Aging impairs peritoneal but not bone marrow‐derived macrophage phagocytosis

Linehan, E., Dombrowski, Y., Snoddy, R., Fallon, P. G., Kissenpfennig, A., & Fitzgerald, D. C. (2014) · Aging Cell · doi:10.1111/acel.12223 · Cited by 169 · see citing works

Ageing is associated with diminished apoptotic cell clearancein vivo

Aprahamian, T. R., Takemura, Y., Goukassian, D. A., & Walsh, K. (2008) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2008.03658.x · Cited by 168 · see citing works

Targeting macrophages rescues age‐related immune deficiencies in C57<scp>BL</scp>/6J geriatric mice

Jackaman, C., Radley‐Crabb, H. G., Soffe, Z., Shavlakadze, T., Grounds, M. D., & Nelson, D. J. (2013) · Aging Cell · doi:10.1111/acel.12062 · Cited by 162 · see citing works

Aging reduces the functionality of anti-pneumococcal antibodies and the killing of Streptococcus pneumoniae by neutrophil phagocytosis.

Simell, B., Vuorela, A., Ekström, N., Palmu, A., Reunanen, A., Meri, S., Käyhty, H., & Väkeväinen, M. (2011) · Vaccine · doi:10.1016/j.vaccine.2010.12.121 · Cited by 155 · see citing works

Neutrophils and Macrophages: the Main Partners of Phagocyte Cell Systems

Silva, M. T., & Correia‐Neves, M. (2012) · Frontiers in Immunology · doi:10.3389/fimmu.2012.00174 · Cited by 153 · see citing works

Molecular basis of age-associated cytokine dysregulation in LPS-stimulated macrophages

Chelvarajan, R. L., Liu, Y., Popa, D., Getchell, M. L., Getchell, T. V., Stromberg, A. J., & Bondada, S. (2006) · Journal of Leukocyte Biology · doi:10.1189/jlb.0106024 · Cited by 151 · see citing works

Long-term clearance from small airways decreases with age

Svartengren, M., Falk, R., & Philipson, K. (2005) · European Respiratory Journal · doi:10.1183/09031936.05.00002105 · Cited by 144 · see citing works

Age‐Associated Inflammation and Toll‐Like Receptor Dysfunction Prime the Lungs for Pneumococcal Pneumonia

Hinojosa, E., Boyd, A. R., & Orihuela, C. J. (2009) · The Journal of Infectious Diseases · doi:10.1086/600870 · Cited by 143 · see citing works

Changes in apoptosis of human polymorphonuclear granulocytes with aging

Fülöp Jr, T., Fouquet, C., Allaire, P., Perrin, N., Lacombe, G., Stankova, J., Rola-Pleszczynski, M., Gagné, D., Wagner, J. R., Khalil, A., et al. (1997) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(96)01881-7 · Cited by 141 · see citing works

The unresponsiveness of aged mice to polysaccharide antigens is a result of a defect in macrophage function

Chelvarajan, R. L., Collins, S. M., Van Willigen, J. M., & Bondada, S. (2005) · Journal of Leukocyte Biology · doi:10.1189/jlb.0804449 · Cited by 141 · see citing works

The Impact of Immunosenescence on Pulmonary Disease

Murray, M., & Chotirmall, S. H. (2015) · Mediators of Inflammation · doi:10.1155/2015/692546 · Cited by 124 · see citing works

Cellular senescence increases expression of bacterial ligands in the lungs and is positively correlated with increased susceptibility to pneumococcal pneumonia

Shivshankar, P., Boyd, A. R., Le Saux, C. J., Yeh, I., & Orihuela, C. J. (2011) · Aging Cell · doi:10.1111/j.1474-9726.2011.00720.x · Cited by 117 · see citing works

Age-related defects in TLR2 signaling diminish the cytokine response by alveolar macrophages during murine pneumococcal pneumonia

Boyd, A. R., Shivshankar, P., Jiang, S., Berton, M. T., & Orihuela, C. J. (2012) · Experimental Gerontology · doi:10.1016/j.exger.2012.04.004 · Cited by 117 · see citing works

The impact of ageing on the intestinal epithelial barrier and immune system

Man, A., Gicheva, N., & Nicoletti, C. (2014) · Cellular Immunology · doi:10.1016/j.cellimm.2014.04.001 · Cited by 114 · see citing works

Molecular composition of the alveolar lining fluid in the aging lung

Moliva, J. I., Rajaram, M. V. S., Sidiki, S., Sasindran, S. J., Guirado, E., Pan, X. J., Wang, S.-H., Ross, P., Lafuse, W. P., Schlesinger, L. S., et al. (2014) · AGE · doi:10.1007/s11357-014-9633-4 · Cited by 114 · see citing works

Innate Immune Dysfunctions in Aged Mice Facilitate the Systemic Dissemination of Methicillin-Resistant S. aureus

Tseng, C. W., Kyme, P. A., Arruda, A., Ramanujan, V. K., Tawackoli, W., & Liu, G. Y. (2012) · PLoS ONE · doi:10.1371/journal.pone.0041454 · Cited by 112 · see citing works

Advanced age exacerbates the pulmonary inflammatory response after lipopolysaccharide exposure

Gómez, C. R., Hirano, S. A., Cutro, B. T., Birjandi, S. Z., Baila, H., Nomellini, V., & Kovacs, E. J. (2006) · Critical Care Medicine · doi:10.1097/01.ccm.0000251639.05135.e0 · Cited by 111 · see citing works

Advanced Age Alters Monocyte and Macrophage Responses

Albright, J. M., Dunn, R. C., Shults, J. A., Boe, D. M., Afshar, M., & Kovacs, E. J. (2016) · Antioxidants and Redox Signaling · doi:10.1089/ars.2016.6691 · Cited by 104 · see citing works

The impact of glial activation in the aging brain.

Lynch, A. M., Murphy, K. J., Deighan, B. F., O’Reilly, J.-A., Gun’ko, Y. K., Cowley, T. R., González-Reyes, R. E., & Lynch, M. A. (2010) · Europe PMC (PubMed Central) · Cited by 103 · see citing works

The inflammatory status of the elderly: The intestinal contribution

Schiffrin, E. J., Morley, J. E., Donnet‐Hughes, A., & Guigoz, Y. (2009) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2009.07.011 · Cited by 103 · see citing works

Granulocyte and natural killer activity in the elderly

Lorenzo, G. D., Balistreri, C. R., Candore, G., Cigna, D., Colombo, A., Romano, G. C., Colucci, A. T., Gervasi, F., Listı̀, F., Potestio, M., et al. (1999) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(98)00156-0 · Cited by 103 · see citing works

Non-specific immunity in aging: Deficiency of monocyte and polymorphonuclear cell-mediated functions

Antonaci, S., Jirillo, E., Ventura, M. T., Garofalo, A. R., & Bonomo, L. (1984) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(84)90121-0 · Cited by 103 · see citing works

Neutrophils of Centenarians Show Function Levels Similar to Those of Young Adults

Alonso‐Fernández, P., Puerto, M., Maté, I., Ribera, J. M., & De La Fuente, M. (2008) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2008.02018.x · Cited by 100 · see citing works

Age-dependent alterations of Fc gamma receptor-mediated effector functions of human polymorphonuclear leucocytes.

Fülöp, T., Fóris, G., Wórum, I., & Leovey, A. (1985) · PubMed Central · Cited by 99 · see citing works

Aging and the mucosal immune system in the intestine

Mabbott, N. A., Kobayashi, A., Sehgal, A., Bradford, B. M., Pattison, M., & Donaldson, D. S. (2015) · Biogerontology · doi:10.1007/s10522-014-9498-z · Cited by 95 · see citing works

Immunosenescence of Polymorphonuclear Neutrophils

Weßels, I., Jansen, J., Rink, L., & Uciechowski, P. (2010) · The Scientific World JOURNAL · doi:10.1100/tsw.2010.14 · Cited by 89 · see citing works

Age-related alterations in innate immune receptor expression and ability of macrophages to respond to pathogen challenge in vitro

Liang, S., Domon, H., Hosur, K. B., Wang, M., & Hajishengallis, G. (2009) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2009.06.006 · Cited by 81 · see citing works

An age-associated increase in pulmonary inflammation after burn injury is abrogated by CXCR2 inhibition

Nomellini, V., Faunce, D. E., Gómez, C. R., & Kovacs, E. J. (2008) · Journal of Leukocyte Biology · doi:10.1189/jlb.1007672 · Cited by 78 · see citing works

Effects of aging on triggering receptor expressed on myeloid cells (TREM)‐1‐induced PMN functions

Fortin, C. F., Lesur, O., & Fülöp, T. (2007) · FEBS Letters · doi:10.1016/j.febslet.2007.02.029 · Cited by 75 · see citing works

Polymorphonuclear leucocytes selectively produce anti‐inflammatory interleukin‐1 receptor antagonist and chemokines, but fail to produce pro‐inflammatory mediators

Schröder, A., von der Ohe, M., Kolling, U., Altstaedt, J., Uciechowski, P., Fleischer, D., Dalhoff, K., Ju, X., Zenke, M., Heussen, N. M., et al. (2006) · Immunology · doi:10.1111/j.1365-2567.2006.02435.x · Cited by 73 · see citing works

Small intestinal permeability in older adults

Valentini, L., Ramminger, S., Haas, V., Postrach, E., Werich, M., Fischer, A., Koller, M., Swidsinski, A., Bereswill, S., Lochs, H., et al. (2014) · Physiological Reports · doi:10.1002/phy2.281 · Cited by 73 · see citing works

Age-associated changes of the intestinal epithelial barrier: local and systemic implications

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