Are psychological interventions effective on anxiety in cancer patients? A systematic review and meta-analyses
Abstract
OBJECTIVE: The aims of this meta-analysis were to estimate the overall effect size (ES) of psychological interventions on anxiety in patients with cancer and extract sample and intervention characteristics that influence effectiveness. METHODS: PubMed, Scopus, PsycINFO, Embase, Medline, and CINAHL were searched using Medical Subject Heading keywords 'cancer' AND 'anxiety' AND 'psychological intervention' AND 'counselling' AND 'psycho*' AND 'psychotherapy' AND 'psychosocial' AND 'therapy' between January 1993 and June 2017. RESULTS: Seventy-one studies were eligible for the systematic review; among them, 51 studies were included in the meta-analysis calculations. The overall ES was -0.21 (95% confidence interval; -0.30 to -0.13) in favour of the intervention. From subgroup analyses, studies conducted in Asia, enrolling inpatients, focussing on relaxation, of <6-week intervention duration, <30-minute intervention dose per session, and <4 hours of total time of intervention showed moderate ESs ranging from -0.40 to -0.55. Only 2 studies restricted enrolment to prescreened patients with clinically elevated level of anxiety and showed moderate ES of -0.58. CONCLUSIONS: Low psychological distress at baseline and nonevidence-based interventions were the main factors identified for low effectiveness. Screening and assessment to determine clinical levels of anxiety in patients with cancer should be considered in future trials as an inclusion criterion before providing psychological interventions. Systematic review registration: PROSPERO: International Prospective Register of Systematic Reviews: CRD42017056132.
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Our findings differ from recent meta-analyses investigating the efficacy of anxiety-based psychological interventions on anxiety in patients with cancer, which found an overall pooled effect size in the small range.
“Our findings differ from recent meta-analyses investigating the efficacy of anxiety-based psychological interventions on anxiety in patients with cancer, which found an overall pooled effect size in the small range (Sanjida et al., 2018).”
From Do non-pharmacological sleep interventions affect anxiety symptoms? A meta-analysis (2022) · cites this paper as Sanjida et al., 2018
Recent meta-analyses showed psychotherapy overall produced a moderate decrease in depression and a small effect on anxiety, with those with more severe symptoms benefiting most.
“Many psychotherapeutic modalities are used to assist those living with advanced cancer in managing depression and/or anxiety (Watson and Kissane, 2011) and recent meta-analyses showed that psychotherapy overall produced a moderate decrease in depression (Okuyama et al., 2017) and a small effect on anxiety (Sanjida et al., 2018) with both reviews noting that those with the more severe symptoms bene”
From A mixed methods pilot and feasibility open trial of internet-delivered cognitive behaviour therapy (iCanADAPT Advanced) for people with advanced cancer with depression and/or anxiety (2021) · cites this paper as Sanjida et al., 2018
Sanjida et al. found a small but significant effect size in managing anxiety in people with advanced cancer.
“Sanjida et al. (57) hallaron un tamaño del efecto pequeño pero significativo en el manejo de la ansiedad en personas con cáncer avanzado.”
From AVANZACT: protocolo e intervención psicoterapéutica en cáncer avanzado basados en Terapia de Aceptación y Compromiso. (2025) · cites this paper as Sanjida et al. (57)
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Randomized Trial of a Social Networking Intervention for Cancer-Related Distress
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Flagged first, then by citations
Cited by
Sorted by citations
Ugalde, A., Gaskin, C. J., Rankin, N. M., Schofield, P. E., Boltong, A. G., Aranda, S. K., Chambers, S. K., Krishnasamy, M., & Livingston, P. M. (2019) · Psycho-Oncology · doi:10.1002/pon.5018 · Cited by 127 · see citing works
“A recent systematic review and meta‐analysis exploring the efficacy of psychological interventions on anxiety in cancer patients found that low psychological distress at baseline was a key reason for low effectiveness, with authors advocating for screening and assessment of anxiety as an inclusion criterion before enr…”
BackgroundDeshields, T. L., Gregorio, S. W., Flowers, S. R., Irwin, K. E., Nipp, R. D., Padgett, L. S., & Zebrack, B. (2021) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.21672 · Cited by 116 · see citing works
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“In contrast, the effect sizes for treatment of anxiety in people with chronic physical conditions in the context of illness are considerably smaller, such as for cancer (Cohen’s d = 0.21; Sanjida et al., 2018), and for cardiovascular disease (Cohen’s d = 0.42; Klainin-Yobas et al., 2016).”
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Advancing the science of distress screening and management in cancer care
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“There is also evidence that patients with high levels of distress who are properly referred and who receive psychological intervention benefit from screening while those with mild distress do not (Sanjida et al ., 2018).”
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“Failure to specifically recruit participants requiring supportive care interventions has also been identified as an issue in several previous systematic reviews of supportive care interventions in cancer [26,53].”
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Do non-pharmacological sleep interventions affect anxiety symptoms? A meta-analysis
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“Moreover, research has found in newly diagnosed cancer patients, that the estimated prevalence of insomnia is between 30 and 50% (Savard & Morin, 2001).”
BackgroundIntegrative Approaches to Stress Management
Carlson, L. E., Toivonen, K., & Subnis, U. B. (2019) · The Cancer Journal · doi:10.1097/ppo.0000000000000395 · Cited by 32 · see citing works
Sharpe, L., Richmond, B., Todd, J., Dudeney, J. E., Dear, B. F., Szabó, M., Sesel, A.-L., Forrester, M. A., & Menzies, R. E. (2023) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2023.111514 · Cited by 26 · see citing works
van der Donk, L. J., Tovote, K. A., Links, T. P., Roodenburg, J. L. N., Kluin‐Nelemans, H. C., Arts, H. J. G., Mul, V. E. M., van Ginkel, R. J., Baas, P. C., Hoff, C., et al. (2019) · Psycho-Oncology · doi:10.1002/pon.5029 · Cited by 22 · see citing works
“Cancer survivors in our trial were consecutively screened on depressive symptoms as a part of standard care, as recommended by the current clinical screening guidelines(7,8) and regarded as a quality standard in setting up an RCT.(14,15) Yet, the screening procedure was not efficient (ie, resulting in low uptake).”
MethodInfluentialAustin, J., Drossaert, C. H. C., van Dijk, J., Sanderman, R., Børøsund, E., Mirković, J., Schotanus-Dijkstra, M., Peeters, N. J., Klooster, J. W. J. R. V. '., Schroevers, M. J., et al. (2022) · JMIR Cancer · doi:10.2196/37502 · Cited by 23 · see citing works
“Psychological interventions for people with cancer are effective in reducing symptoms of distress and improving well-being and are mostly delivered face to face in an individual or group format [7-10].”
BackgroundPsychosocial Care for Adult Cancer Patients: Guidelines of the Italian Medical Oncology Association
Caminiti, C., Diodati, F., Annunziata, M. A., Giulio, P. D., Isa, L., Mosconi, P., Nanni, M. G., Patrini, A., Piredda, M., Santangelo, C., et al. (2021) · Cancers · doi:10.3390/cancers13194878 · Cited by 20 · see citing works
“A large systematic review and meta-analysis of 71 RCTs (13,098 patients) [30] estimated the overall ES of psychological interventions on anxiety and distress in cancer patients.”
Belluomini, L., Avancini, A., Sposito, M., Pontolillo, L., Tregnago, D., Trestini, I., Insolda, J., Carbognin, L., Milella, M., Bria, E., et al. (2024) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2024.104444 · Cited by 21 · see citing works
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“faced with psychological distress and loss of control [5].”
BackgroundDeckx, L., Chow, K. H., Askew, D. A., van Driel, M., Mitchell, G. K., & van den Akker, M. (2020) · Psycho-Oncology · doi:10.1002/pon.5612 · Cited by 17 · see citing works
“This is in line with another review on psychosocial interventions in cancer survivors.(7) Different types of interventions were compared in this review, for example, relaxation, psycho-”
BackgroundResultMurphy, M. J., Newby, J. M., Butow, P., Joubert, A., Kirsten, L., Shaw, J., Shepherd, H. L., & Andrews, G. (2021) · Internet Interventions · doi:10.1016/j.invent.2021.100449 · Cited by 15 · see citing works
Ardizzone, A., Bavetta, D., Garo, M. L., Santangelo, D., Bongiorno, A., & Bono, M. (2022) · Healthcare · doi:10.3390/healthcare10040629 · Cited by 16 · see citing works
“A recent meta-analysis conducted by Sanjida et al. (2018), which evaluated the effects of psychological interventions in anxiety and distress reduction and analyzed the characteristics of the sample and the interventions that influenced effectiveness, showed that psychological interventions and…”
BackgroundMethodInfluentialHuynh, N. T. T., Fan, S.-Y., & Kao, C. (2022) · Supportive Care in Cancer · doi:10.1007/s00520-022-07085-4 · Cited by 15 · see citing works
“Patients’ anxiety may be different based on their needs or specific concerns, and individual interventions including individual meetings or telephonic counselling are shown to be the most suitable and the most effective [9].”
BackgroundResultInfluentialHaydon, M. D., Walsh, L. C., Fritz, M. M., Rahal, D., Lyubomirsky, S., & Bower, J. E. (2022) · The Journal of Positive Psychology · doi:10.1080/17439760.2022.2093786 · Cited by 15 · see citing works
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“Current evidence also calls for psycho-oncological care to be patient-centred, with anxiety-relieving approaches based on the patient's individual coping strategies, although these are common among cancer patients and could be streamlined across different groups (Sanjida et al., 2018).”
BackgroundSohanpal, R., Pinnock, H., Steed, L., Heslop-Marshall, K., Kelly, M. J., Chan, C. L., Wileman, V., Barradell, A. C., Dibao-Dina, C., Gilabert, P. F., et al. (2023) · Health Technology Assessment · doi:10.3310/pawa7221 · Cited by 13 · see citing works
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Suicide and Suicidal Ideation Among Survivors of Childhood Cancer
Tan, J. Y., Ge, G., Low, C. E., Rana, S., Tan, T. Y. Z., Fang, N. B. J., Teo, J. Y. Y., Yap, Y. T., Yau, C. E., Lee, A. R. Y. B., et al. (2025) · JAMA Network Open · doi:10.1001/jamanetworkopen.2024.57544 · Cited by 12 · see citing works
Lapid, M. I., Pagali, S. R., Randall, A., Donovan, K. A., Bronars, C. A., Gauthier, T. A., Bock, J., Lim, S. D., Carey, E. C., Sokolowski, E. I., et al. (2025) · Palliative & Supportive Care · doi:10.1017/s147895152500032x · Cited by 11 · see citing works
“Research regarding the effectiveness of these interventions demonstrates low to moderate effect sizes (Faller et al. 2013; Park et al. 2019; Sanijda et al. 2018).”
The fear of cancer recurrence and progression in patients with pancreatic cancer
Pijnappel, E. N., Dijksterhuis, W. P. M., Sprangers, M. A. G., Augustinus, S., de Vos‐Geelen, J., de Hingh, I. H. J. T., Molenaar, I. Q., Busch, O. R., Besselink, M. G., Wilmink, J. W., et al. (2022) · Supportive Care in Cancer · doi:10.1007/s00520-022-06887-w · Cited by 12 · see citing works
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“Meta-analyses and systematic reviews show a moderate effect size of 0.36 for anxiety and 0.19–0.21 for depression in favor of the interventions (Sanjida et al., 2018; Sheard & Maguire, 1999).”
BackgroundInfluentialCurran, L., Sharpe, L., & Butow, P. N. (2020) · Behavioural and Cognitive Psychotherapy · doi:10.1017/s1352465820000697 · Cited by 9 · see citing works
“Unfortunately, interventions for cancer-related anxiety have, on average, only demonstrated small effect sizes (Sanjida et al., 2018).”
BackgroundThe association between anxiety and esophageal cancer: A nationwide population‐based study
Zhu, J. L., Zhou, Y., Ma, S., Chen, R., Xie, S., Liu, Z., Li, X., & Wei, W. (2020) · Psycho-Oncology · doi:10.1002/pon.5580 · Cited by 9 · see citing works
“Therefore, healthcare providers and policy‐makers should address this important issue, which can be accomplished by enacting psychological surveillance, necessary counseling, and psychotherapy.(48,49)”
BackgroundIgelström, H., Carlsson, M. E., Hauffman, A., von Essén, L., Grönqvist, H., Johansson, B., & Olsson, E. M. G. (2023) · Internet Interventions · doi:10.1016/j.invent.2023.100625 · Cited by 13 · see citing works
“This is an example of the floor-effect seen in previous studies (Sanjida et al., 2018).”
BackgroundResultPsychoonkologischer Versorgungsbedarf in Krebszentren
(DKG), V. D. A. P. (. D. D. K., Mehnert, A., (DKG), B. D. A. P. (. D. D. K., Faller, H., Herschbach, P., Hönig, K., Hornemann, B., Petermann‐Meyer, A., & Zimmermann, T. (2019) · Der Onkologe · doi:10.1007/s00761-019-00689-2 · Cited by 8 · see citing works
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Burden of depression and anxiety disorders per disease codes in patients with lymphoma in Germany
Tilch, M., Galle, P. R., Schattenberg, J. M., Kostev, K., & Labenz, C. (2021) · Supportive Care in Cancer · doi:10.1007/s00520-021-06677-w · Cited by 6 · see citing works
“Additionally, a metaanalytic review suggested that psychological interventions may assist some cancer patients in reducing levels of anxiety [26].”
BackgroundBenton, J., Bergerot, C., Woodruff, P., Williams, S., Wallis, C., & Klaassen, Z. (2021) · Cancer · doi:10.1002/cncr.33901 · Cited by 4 · see citing works
“A more recent review focusing on the effect of psychologic interventions on anxiety with stricter inclusion criteria found a smaller effect size than previously observed, and noted that most trials failed to screen patients appropriately before intervention.(14) A Cochrane review of 16 studies found a low certainty of…”
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Predictors of emotional distress in uveal melanoma survivors: a systematic review
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“Further exploration of psychological constructs such as resilience and worry, which are modifiable through psychological intervention is imperative to inform the design and implementation of such support [58, 59].”
BackgroundWu, Z., Luo, F., Wang, S., hu, X., & Chen, M. (2025) · JMIR Cancer · doi:10.2196/64754 · Cited by 4 · see citing works
“…a previous study demonstrating that psychosocial interventions on relaxation, of 6-week intervention duration, 30-minute intervention dose per session, and 4 hours of total time of intervention showed moderate effects, where a short time is necessary for timely and intensive intervention [53].”
Joseph, J., Rani, R., & Dhankhar, R. (2022) · Medical Journal of Dr D Y Patil Vidyapeeth · doi:10.4103/mjdrdypu.mjdrdypu_319_21 · Cited by 4 · see citing works
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“Therefore, the pain and anxiety of patients with gynecologic oncology needs to be managed effectively [4].”
Outpatient multidisciplinary cancer rehabilitation in Switzerland: a status assessment
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Thyroid Cancer Survivorship: Contemporary Themes
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NURSING INTERVENTIONS FOR MANAGING ANXIETY IN PATIENTS UNDERGOING CHEMOTHERAPY
ALZain, A. A., Theabi, S. D. A. T. D. A., Zain, T. A. A., Alzain, S. A. A., Alsalman, A. M., Alsalman, D., Almoomen, F. A., Aloqaili, N. A., & Alqahtani, H. A. (2022) · Journal of Population Therapeutics and Clinical Pharmacology · doi:10.53555/jptcp.v29i04.5751
An intervention module for caregivers of children with acute lymphoblastic leukemia (ALL)
Chong, A. S. S., Ahmad, M., Alias, H., Hussain, R. I., Lateh, A., & Chan, C. M. H. (2024) · Journal of Psychosocial Oncology · doi:10.1080/07347332.2024.2364670
“37 Low levels of distress at baseline may indicate that perceived social support is sufficient, hence limiting the impact of intervention.”
Psychotherapeutic interventions in neuro-oncology
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“PO interventions have proven effective in alleviating distress in these patients (Guo et al. 2013; Holland 2018; Sanjida et al. 2018).”
Fornaro, M., Lorenzo, C. D., Berardis, D. D., Stubbs, B., Veronese, N., Calati, R., Primavera, D., Carta, M. G., & Solmi, M. (2026) · Psychiatry Research · doi:10.1016/j.psychres.2026.117228
PSYCHOSOCIAL CARE COMPETENCIES OF NURSES AND INFLUENCING FACTORS
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Reframing distress in oncology: the potential of psychedelic-assisted therapy
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Health psychology for more sustainable healthcare: a systems-oriented framework
Grignoli, N., Büchel, J., Favre, O., Keller, R., Isenschmid, M., Martin, T., Petrocchi, S., Soelch, C. M., & Inauen, J. (2026) · Health Psychology and Behavioral Medicine · doi:10.1080/21642850.2026.2745672
“Psycho-oncology similarly applies health psychology principles to address psychosocial needs alongside cancer care (Holland et al., 2021), including fear of recurrence for which psychological interventions have demonstrated benefit (Sanjida et al., 2018).”
- Authors
- Sanjida, S., McPhail, S. M., Shaw, J., Couper, J., Kissane, D., Price, M. A., & Janda, M.
- Affiliations
- Queensland University of Technology (AU)
- The University of Sydney (AU)
- Australian National University (AU)
- Monash University (AU)
- Venue
- Psycho-Oncology
- Publisher
- Wiley
- Published
- 2018-07-16
- Volume
- 27
- Issue
- 9
- Pages
- 2063-2076
- ISSN
- 1057-9249 (ISSN-L)
- 1099-1611
- OpenAlex
- W2807448195
- Cited by
- 74
- References
- 100
- Citations by year
- 2026: 6 · 2025: 7 · 2024: 9 · 2023: 9 · 2022: 15 · 2021: 12 · 2020: 5 · 2019: 9 · 2018: 2
- FWCI
- 0.73
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psycho-Oncology (publishedVersion)
- PubMed (publishedVersion)
- ANU Open Research (Australian National University) (submittedVersion)
- Minerva Access (University of Melbourne) (submittedVersion)
- Funders
- National Health and Medical Research Council (#11051021, #1090440)
- Advance Queensland
- Topics
- Health Sciences › Medicine › Oncology › Cancer survivorship and care
- Social Sciences › Psychology › Social Psychology › Music Therapy and Health
- Social Sciences › Psychology › Clinical Psychology › Mindfulness and Compassion Interventions
- Keywords
- psychological intervention, anxiety, cancer patients, psychotherapy, relaxation training, psychosocial interventions, intervention effectiveness, hospitalized patients
- MeSH terms
- Anxiety, Anxiety Disorders, Humans, Inpatients, Neoplasms, Prospective Studies, Psychotherapy, Psychotherapy, Group, Quality of Life, Stress, Psychological
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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