Berberis Vulgaris and Berberine: An Update Review

Treatment of Type 2 Diabetes and Dyslipidemia with the Natural Plant Alkaloid Berberine

Zhang, Y., Li, X., Zou, D., Liu, W., Yang, J., Zhu, N., Huo, L., Wang, M., Hong, J., Wu, P., et al. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-2404 · Cited by 573 · cited 3×

Berberine suppresses proinflammatory responses through AMPK activation in macrophages

Jeong, H. W., Hsu, K. C., Lee, J.-W., Ham, M., Huh, J. Y., Shin, H. J., Kim, W. S., & Kim, J. B. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90599.2008 · Cited by 454

The Crosstalk Between Nrf2 and AMPK Signal Pathways Is Important for the Anti-Inflammatory Effect of Berberine in LPS-Stimulated Macrophages and Endotoxin-Shocked Mice

Mo, C., Wang, L., Zhang, J., Numazawa, S., Tang, H., Tang, X., Han, X., Li, J., Yang, M., Wang, Z., et al. (2014) · Antioxidants & Redox Signaling · doi:10.1089/ars.2012.5116 · Cited by 443

Berberine lowers blood glucose in type 2 diabetes mellitus patients through increasing insulin receptor expression

Zhang, H., Wei, J., Xue, R., Wu, J.-D., Zhao, W., Wang, Z.-Z., Wang, S.-K., Zhou, Z.-X., Song, D.-Q., Wang, Y.-M., et al. (2010) · Metabolism · doi:10.1016/j.metabol.2009.07.029 · Cited by 440

Berberine activates thermogenesis in white and brown adipose tissue

Zhang, Z., Zhang, H., Li, B., Meng, X., Wang, J., Zhang, Y., Yao, S., Ma, Q., Jin, L., Yang, J., et al. (2014) · Nature Communications · doi:10.1038/ncomms6493 · Cited by 438

Bioavailability study of berberine and the enhancing effects of TPGS on intestinal absorption in rats

Chen, W., Miao, Y.-Q., Fan, D.-J., Yang, S.-S., Lin, X., Meng, L.-K., & Tang, X. (2011) · AAPS PharmSciTech · doi:10.1208/s12249-011-9632-z · Cited by 363

Extensive intestinal first-pass elimination and predominant hepatic distribution of berberine explain its low plasma levels in rats

Liu, Y.-T., Hao, H.-P., Xie, H.-G., Lai, L., Wang, Q., Liu, C.-X., & Wang, G.-J. (2010) · Drug Metabolism and Disposition · doi:10.1124/dmd.110.033936 · Cited by 356

Hepatocyte Nuclear Factor 1α Plays a Critical Role in PCSK9 Gene Transcription and Regulation by the Natural Hypocholesterolemic Compound Berberine

Li, H., Dong, B., Park, S. W., Lee, H.-S., Chen, W., & Liu, J. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.052407 · Cited by 348

Berberine: a potential phytochemical with multispectrum therapeutic activities

Vuddanda, P. R., Chakraborty, S., & Singh, S. (2010) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.2010.517745 · Cited by 316

Tissue Distribution of Berberine and Its Metabolites after Oral Administration in Rats

Tan, X.-S., Ma, J.-Y., Feng, R., Ma, C., Chen, W.-J., Sun, Y.-P., Fu, J., Huang, M., He, C.-Y., Shou, J.-W., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0077969 · Cited by 266

Application of Berberine on Treating Type 2 Diabetes Mellitus

Pang, B., Zhao, L.-H., Zhou, Q., Zhao, T.-Y., Wang, H., Gu, C.-J., & Tong, X.-L. (2015) · International Journal of Endocrinology · doi:10.1155/2015/905749 · Cited by 251

Berberine improves lipid dysregulation in obesity by controlling central and peripheral AMPK activity

Kim, W. S., Lee, Y. S., Cha, S. H., Jeong, H. W., Choe, S. S., Lee, M.-R., Oh, G. T., Park, H.-S., Lee, K.-U., Lane, M. D., et al. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90710.2008 · Cited by 239

Acute toxicity of berberine and its correlation with the blood concentration in mice

Kheir, M. M., Wang, Y., Hua, L., Hu, J., Li, L., Lei, F., & Du, L. (2010) · Food and Chemical Toxicology · doi:10.1016/j.fct.2010.01.033 · Cited by 235

Berberine decreases PCSK9 expression in HepG2 cells

Cameron, J., Ranheim, T., Kulseth, M. A., Leren, T. P., & Berge, K. E. (2008) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2008.02.004 · Cited by 233

Efficacy of Berberine in Patients with Non-Alcoholic Fatty Liver Disease

Yan, H.-M., Xia, M.-F., Wang, Y., Chang, X.-X., Yao, X.-Z., Rao, S.-X., Zeng, M.-S., Tu, Y.-F., Feng, R., Jia, W.-P., et al. (2015) · PLOS ONE · doi:10.1371/journal.pone.0134172 · Cited by 229

Berberine in the treatment of type 2 diabetes mellitus: A systemic review and meta-analysis

Dong, H., Wang, N., Zhao, L., & Lu, F. (2012) · Evidence-Based Complementary and Alternative Medicine · doi:10.1155/2012/591654 · Cited by 225

TNFα-induced and berberine-antagonized tight junction barrier impairment via tyrosine kinase, Akt and NFκB signaling

Amasheh, M., Fromm, A., Krug, S. M., Amasheh, S., Andres, S., Zeitz, M., Fromm, M., & Schulzke, J.-D. (2010) · Journal of Cell Science · doi:10.1242/jcs.070896 · Cited by 224

On the mechanism of antidepressant-like action of berberine chloride

Kulkarni, S. K., & Dhir, A. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2008.05.043 · Cited by 222

Genetic Evidence for Inhibition of Bacterial Division Protein FtsZ by Berberine

Boberek, J. M., Stach, J., & Good, L. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013745 · Cited by 209

Efficacy and safety of berberine for congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy

Zeng, X.-H., Zeng, X.-J., & Li, Y.-Y. (2003) · The American Journal of Cardiology · doi:10.1016/s0002-9149(03)00533-2 · Cited by 191

Berberine exerts nephroprotective effect against cisplatin-induced kidney damage through inhibition of oxidative/nitrosative stress, inflammation, autophagy and apoptosis

Domitrović, R., Cvijanović, O., Pernjak-Pugel, E., Škoda, M., Mikelić, L., & Crnčević-Orlić, Ž. (2013) · Food and Chemical Toxicology · doi:10.1016/j.fct.2013.09.003 · Cited by 190

Berberine alleviates ox-LDL induced inflammatory factors by up-regulation of autophagy via AMPK/mTOR signaling pathway

Fan, X., Wang, J., Hou, J., Lin, C., Bensoussan, A., Chang, D., Liu, J., & Wang, B. (2015) · Journal of Translational Medicine · doi:10.1186/s12967-015-0450-z · Cited by 184

Effects and Action Mechanisms of Berberine and Rhizoma coptidis on Gut Microbes and Obesity in High-Fat Diet-Fed C57BL/6J Mice

Xie, W., Gu, D., Li, J., Cui, K., & Zhang, Y. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024520 · Cited by 183

Hepatoprotective activity of berberine is mediated by inhibition of TNF-α, COX-2, and iNOS expression in CCl4-intoxicated mice

Domitrović, R., Jakovac, H., & Blagojević, G. (2011) · Toxicology · doi:10.1016/j.tox.2010.11.005 · Cited by 183

Neuroprotective effects of berberine on stroke models in vitro and in vivo

Zhou, X.-Q., Zeng, X.-N., Kong, H., & Sun, X.-L. (2008) · Neuroscience Letters · doi:10.1016/j.neulet.2008.09.064 · Cited by 173

Berberine on metabolic and cardiovascular risk factors: An analysis from preclinical evidences to clinical trials

Derosa, G., Maffioli, P., & Cicero, A. F. (2012) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.2012.704014 · Cited by 171

Amelioration of IFN-γ and TNF-α-Induced Intestinal Epithelial Barrier Dysfunction by Berberine via Suppression of MLCK-MLC Phosphorylation Signaling Pathway

Cao, M., Wang, P., Sun, C., He, W., & Wang, F. (2013) · PLoS ONE · doi:10.1371/journal.pone.0061944 · Cited by 168

Berberine Ameliorates Intestinal Epithelial Tight-Junction Damage and Down-regulates Myosin Light Chain Kinase Pathways in a Mouse Model of Endotoxinemia

Gu, L., Li, N., Gong, J., Li, Q., Zhu, W., & Li, J. (2011) · The Journal of Infectious Diseases · doi:10.1093/infdis/jir147 · Cited by 166

Combination of simvastatin with berberine improves the lipid-lowering efficacy

Kong, W.-J., Wei, J., Zuo, Z.-Y., Wang, Y.-M., Song, D.-Q., You, X.-F., Zhao, L.-X., Pan, H.-N., & Jiang, J.-D. (2008) · Metabolism · doi:10.1016/j.metabol.2008.01.037 · Cited by 162

Antibacterial activity and mechanism of berberine against Streptococcus agalactiae.

Peng, L., Kang, S., Yin, Z., Jia, R., Song, X., Li, L., Li, Z., Zou, Y., Liang, X., Li, L., et al. (2015) · PubMed · Cited by 159

Berberine prevents nigrostriatal dopaminergic neuronal loss and suppresses hippocampal apoptosis in mice with Parkinson’s disease

Kim, M., Cho, K., Shin, M., Lee, J. M., Cho, H.-S., Kim, C., SHIN, D.-H., & Yang, H. J. (2014) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2014.1656 · Cited by 159

Berberine reduces methylation of the MTTP promoter and alleviates fatty liver induced by a high-fat diet in rats

Chang, X., Yan, H., Jing, F., Jiang, M., Zhu, H., Lu, D., & Gao, X. (2010) · Journal of Lipid Research · doi:10.1194/jlr.m001958 · Cited by 157

A clinical study on the short-term effect of berberine in comparison to metformin on the metabolic characteristics of women with polycystic ovary syndrome

Wei, W., Zhao, H., Wang, A., Sui, M., Liang, K., Deng, H., Ma, Y., Zhang, Y., Zhang, H., & Guan, Y. (2012) · European Journal of Endocrinology · doi:10.1530/eje-11-0616 · Cited by 155

Berberine inhibits RANKL-induced osteoclast formation and survival through suppressing the NF-κB and Akt pathways

Hu, J.-P., Nishishita, K., Sakai, E., Yoshida, H., Kato, Y., Tsukuba, T., & Okamoto, K. (2007) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.11.013 · Cited by 153

Berberine suppresses neuroinflammatory responses through AMP‐activated protein kinase activation in BV‐2 microglia

Lu, D., Tang, C., Chen, Y., & Wei, I. (2010) · Journal of Cellular Biochemistry · doi:10.1002/jcb.22580 · Cited by 151

Approaches to Improve the Oral Bioavailability and Effects of Novel Anticancer Drugs Berberine and Betulinic Acid

Godugu, C., Patel, A. R., Doddapaneni, R., Somagoni, J., & Singh, M. S. (2014) · PLoS ONE · doi:10.1371/journal.pone.0089919 · Cited by 150

Lipid-lowering effect of berberine in human subjects and rats

Hu, Y., Ehli, E. A., Kittelsrud, J. M., Ronan, P. J., Munger, K. A., Downey, T., Bohlen, K., Callahan, L. B., Munson, V., Jahnke, M., et al. (2012) · Phytomedicine · doi:10.1016/j.phymed.2012.05.009 · Cited by 139

Repeated administration of berberine inhibits cytochromes P450 in humans

Guo, Y., Chen, Y., Tan, Z.-R., Klaassen, C. D., & Zhou, H.-H. (2012) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-011-1108-2 · Cited by 137

Berberine attenuates bleomycin induced pulmonary toxicity and fibrosis via suppressing NF-κB dependant TGF-β activation: A biphasic experimental study

Palanivel, C., Gowrikumar, S., Manikandan, R., & Sudhandiran, G. (2013) · Toxicology Letters · doi:10.1016/j.toxlet.2013.03.009 · Cited by 133

Berberine Promotes Osteoblast Differentiation by Runx2 Activation With p38 MAPK

Lee, H. W., Suh, J. H., Kim, H.-N., Kim, A., Park, S. Y., Shin, C. S., Choi, J., & Kim, J. B. (2008) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.080325 · Cited by 130

Berberine Inhibits Doxorubicin-Triggered Cardiomyocyte Apoptosis via Attenuating Mitochondrial Dysfunction and Increasing Bcl-2 Expression

Lv, X., Yu, X., Wang, Y., Wang, F., Li, H., Wang, Y., Lu, D., Qi, R., & Wang, H. (2012) · PLoS ONE · doi:10.1371/journal.pone.0047351 · Cited by 127

Berberine Moderates Glucose and Lipid Metabolism through Multipathway Mechanism

Zhang, Q., Xiao, X., Feng, K., Wang, T., Li, W., Yuan, T., Sun, X., Sun, Q., Xiang, H., & Wang, H. (2010) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2011/924851 · Cited by 124

Berberine prevents nitric oxide-induced rat chondrocyte apoptosis and cartilage degeneration in a rat osteoarthritis model via AMPK and p38 MAPK signaling

Zhou, Y., Liu, S., Yu, L., He, B., Wu, S.-H., Zhao, Q., Xia, S., & Mei, H. (2015) · APOPTOSIS · doi:10.1007/s10495-015-1152-y · Cited by 123

Preventive effect of Coptis chinensis and berberine on intestinal injury in rats challenged with lipopolysaccharides

Zhang, Q., Piao, X., Piao, X., Lu, T., Wang, D., & Kim, S. W. (2010) · Food and Chemical Toxicology · doi:10.1016/j.fct.2010.09.032 · Cited by 122

Regulation of Th1 and Th17 Cell Differentiation and Amelioration of Experimental Autoimmune Encephalomyelitis by Natural Product Compound Berberine

Qin, X., Guo, B.-S., Wan, B., Fang, L., Lü, L., Wu, L., Zang, Y. Q., & Zhang, J. Z. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0903853 · Cited by 122

Therapeutic Effect of Berberine on Huntington’s Disease Transgenic Mouse Model

Jiang, W., Wei, W., Gaertig, M. A., Li, S., & Li, X.-J. (2015) · PLoS ONE · doi:10.1371/journal.pone.0134142 · Cited by 119

Berberine improves pressure overload-induced cardiac hypertrophy and dysfunction through enhanced autophagy

Li, M., Zhang, Y., Yu, Y., Yang, S., Iqbal, J., Mi, Q., Li, B., Wang, Z., Mao, W., Xie, H., et al. (2014) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2014.01.061 · Cited by 117

Berberine Protects against Neuronal Damage via Suppression of Glia-Mediated Inflammation in Traumatic Brain Injury

Chen, C.-C., Hung, T., Lee, C. Y., Wang, L.-F., Wu, C., Ke, C., & Chen, S. (2014) · PLoS ONE · doi:10.1371/journal.pone.0115694 · Cited by 114

Berberine reverts hepatic mitochondrial dysfunction in high-fat fed rats: A possible role for SirT3 activation

Teodoro, J. S., Duarte, F. V., Gomes, A. P., Varela, A. T. I. F., Peixoto, F., Rolo, A. P., & Palmeira, C. M. (2013) · Mitochondrion · doi:10.1016/j.mito.2013.09.002 · Cited by 113

Proteomic Analysis Reveals a Synergistic Mechanism of Fluconazole and Berberine against Fluconazole-Resistant Candida albicans: Endogenous ROS Augmentation

Xu, Y., Wang, Y., Yan, L., Liang, R.-M., Dai, B.-D., Tang, R.-J., Gao, P.-H., & Jiang, Y.-Y. (2009) · Journal of Proteome Research · doi:10.1021/pr9005074 · Cited by 113

Berberine improves endothelial function by reducing endothelial microparticles-mediated oxidative stress in humans

Cheng, F., Wang, Y., Li, J., Su, C., Wu, F., Xia, W., Yang, Z., Yu, B., Qiu, Y., & Tao, J. (2012) · International Journal of Cardiology · doi:10.1016/j.ijcard.2012.03.090 · Cited by 112

Effects of berberine on lipid profile in subjects with low cardiovascular risk

Derosa, G., D'Angelo, A., Bonaventura, A., Bianchi, L., Romano, D., & Maffioli, P. (2013) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.2013.776037 · Cited by 112

Berberine decreases cholesterol levels in rats through multiple mechanisms, including inhibition of cholesterol absorption

Wang, Y., Yi, X., Ghanam, K., Zhang, S., Zhao, T.-T., & Zhu, X. (2014) · Metabolism · doi:10.1016/j.metabol.2014.05.013 · Cited by 111

Berberine Attenuates Experimental Autoimmune Encephalomyelitis in C57 BL/6 Mice

Ma, X., Jiang, Y., Wu, A., Chen, X., Pi, R., Liu, M., & Liu, Y. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013489 · Cited by 111

Berberine Ameliorates Collagen-Induced Arthritis in Rats Associated with Anti-inflammatory and Anti-angiogenic Effects

Wang, Z., Chen, Z., Yang, S., Wang, Y., Huang, Z., Gao, J., Tu, S., & Rao, Z. (2014) · Inflammation · doi:10.1007/s10753-014-9909-y · Cited by 109

Bioactivities of berberine metabolites after transformation through CYP450 isoenzymes

Li, Y., Ren, G., Wang, Y.-X., Kong, W.-J., Yang, P., Wang, Y.-M., Li, Y.-H., Yi, H., Li, Z.-R., Song, D.-Q., et al. (2011) · Journal of Translational Medicine · doi:10.1186/1479-5876-9-62 · Cited by 109

Berberine inhibits NADPH oxidase mediated superoxide anion production in macrophagesThis article is one of a selection of papers published in a Special Issue on Oxidative Stress in Health and Disease.

Sarna, L. K., Wu, N., Hwang, S., Siow, Y. L., & Karmin, O. (2010) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y09-136 · Cited by 108

Excretion of Berberine and Its Metabolites in Oral Administration in Rats

Ma, J., Feng, R., Tan, X., Ma, C., Shou, J., Fu, J., Huang, M., He, C., Chen, S., Zhao, Z., et al. (2013) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.23718 · Cited by 107

Berberine was neuroprotective against an in vitro model of brain ischemia: Survival and apoptosis pathways involved

Pires, E. N. S., Frozza, R. L., Hoppe, J. B., Menezes, B. D. M., & Salbego, C. G. (2014) · Brain Research · doi:10.1016/j.brainres.2014.02.021 · Cited by 107

The use of berberine for women with polycystic ovary syndrome undergoing IVF treatment

An, Y., Sun, Z., Zhang, Y., Liu, B., Guan, Y., & Lu, M. (2014) · Clinical Endocrinology · doi:10.1111/cen.12294 · Cited by 105

The neuroprotective effect of berberine in mercury-induced neurotoxicity in rats

Moneim, A. E. A. (2015) · Metabolic Brain Disease · doi:10.1007/s11011-015-9652-6 · Cited by 103

Oxidative demethylenation and subsequent glucuronidation are the major metabolic pathways of berberine in rats

Liu, Y., Hao, H., Xie, H., Lv, H., Liu, C., & Wang, G. (2009) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.21721 · Cited by 101

Berberine ameliorates inflammation in patients with acute coronary syndrome following percutaneous coronary intervention

Meng, S., Wang, L., Huang, Z., Zhou, Q., Sun, Y., Cao, J., Li, Y., & Wang, C. (2012) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2012.05670.x · Cited by 99

Berberine Hydrochloride Prevents Postsurgery Intestinal Adhesion and Inflammation in Rats

Zhang, Y., Li, X., Zhang, Q., Li, J., Ju, J., Du, N., Liu, X., Chen, X., Cheng, F., Yang, L., et al. (2014) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.114.212795 · Cited by 98

Berberine Protects 6-Hydroxydopamine-Induced Human Dopaminergic Neuronal Cell Death through the Induction of Heme Oxygenase-1

Bae, J., Lee, D., Kim, Y. K., Gil, M., Lee, J., & Lee, K. J. (2013) · Molecules and Cells · doi:10.1007/s10059-013-2298-5 · Cited by 97

Preparation of an anhydrous reverse micelle delivery system to enhance oral bioavailability and anti-diabetic efficacy of berberine

Wang, T., Wang, N., Song, H., Xi, X., Wang, J., Hao, A., & Li, T. (2011) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2011.06.015 · Cited by 96

Protective effect of berberine against myocardial ischemia reperfusion injury: role of Notch1/Hes1-PTEN/Akt signaling

Yu, L., Li, F., Zhao, G., Yang, Y., Jin, Z., Zhai, M., Yu, W., Zhao, L., Chen, W., Duan, W., et al. (2015) · APOPTOSIS · doi:10.1007/s10495-015-1122-4 · Cited by 94

Berberine improves endothelial function by inhibiting endoplasmic reticulum stress in the carotid arteries of spontaneously hypertensive rats

Liu, L., Liu, J., Huang, Z., Yu, X., Zhang, X., Dou, D., & Huang, Y. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.02.028 · Cited by 93

Berberine inhibits TPA-induced MMP-9 and IL-6 expression in normal human keratinocytes

Kim, S.-M., Kim, Y., Kim, J. E., Cho, K. H., & Chung, J. H. (2007) · Phytomedicine · doi:10.1016/j.phymed.2007.09.011 · Cited by 92

Berberine inhibits the expression of TNFα, MCP-1, and IL-6 in AcLDL-stimulated macrophages through PPARγ pathway

Chen, F. L., Yang, Z.-J., Liu, Y., Li, L. X., Liang, W. C., Wang, X. C., Zhou, W. B., Yang, Y., & Hu, R. (2008) · Endocrine · doi:10.1007/s12020-008-9089-3 · Cited by 91

Effects of berberine on the blood concentration of cyclosporin A in renal transplanted recipients: Clinical and pharmacokinetic study

Wu, X., Li, Q., Xin, H., Yu, A., & Zhong, M. (2005) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-005-0952-3 · Cited by 90

Inhibition of H1N1 influenza A virus growth and induction of inflammatory mediators by the isoquinoline alkaloid berberine and extracts of goldenseal (Hydrastis canadensis)

Cecil, C., Davis, J. M., Cech, N. B., & Laster, S. M. (2011) · International Immunopharmacology · doi:10.1016/j.intimp.2011.06.002 · Cited by 90

Berberine reducing insulin resistance by up-regulating IRS-2 mRNA expression in nonalcoholic fatty liver disease (NAFLD) rat liver

Xing, L., Zhang, L. R., Liu, T., Hua, Y., Zheng, P., & Ji, G. (2011) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2011.07.036 · Cited by 90

Berberine attenuates pro-inflammatory cytokine-induced tight junction disruption in an in vitro model of intestinal epithelial cells

Li, N., Gu, L., Qu, L., Gong, J., Li, Q., Zhu, W., & Li, J. (2010) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2010.02.001 · Cited by 89

Hepatoprotective effects of berberine on carbon tetrachloride-induced acute hepatotoxicity in rats

Feng, Y., Siu, K.-Y., Ye, X., Wang, N., Yuen, M., Leung, C., Tong, Y., & Kobayashi, S. (2010) · Chinese Medicine · doi:10.1186/1749-8546-5-33 · Cited by 88

CYP2D plays a major role in berberine metabolism in liver of mice and humans

Guo, Y., Li, F., Ma, X., Cheng, X., Zhou, H., & Klaassen, C. D. (2011) · Xenobiotica · doi:10.3109/00498254.2011.597456 · Cited by 86

Berberine sensitizes mutliple human cancer cells to the anticancer effects of doxorubicin in vitro

Tong, N., ZHANG, J., Chen, Y., Li, Z., Luo, Y., Zuo, H., & Zhao, X. (2012) · Oncology Letters · doi:10.3892/ol.2012.644 · Cited by 83

Effects of β-cyclodextrin on the intestinal absorption of berberine hydrochloride, a P-glycoprotein substrate

Zhang, Y., Cui, Y., Gao, L., & Jiang, H.-L. (2013) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2013.04.074 · Cited by 83

Effect of Berberine on Depression- and Anxiety-Like Behaviors and Activation of the Noradrenergic System Induced by Development of Morphine Dependence in Rats

Lee, B., Sur, B., Yeom, M., Shim, I., Lee, H., & Hahm, D. (2012) · Korean Journal of Physiology and Pharmacology · doi:10.4196/kjpp.2012.16.6.379 · Cited by 83

PROTECTION BY AND ANTI‐OXIDANT MECHANISM OF BERBERINE AGAINST RAT LIVER FIBROSIS INDUCED BY MULTIPLE HEPATOTOXIC FACTORS

Zhang, B., Xu, D., Guo, Y., Ping, J., Chen, L., & Wang, H. (2007) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2007.04819.x · Cited by 83

Hypoxia-inducible factor 1 mediates the anti-apoptosis of berberine in neurons during hypoxia/ischemia

Zhang, Q., Qian, Z., Pan, L., Li, H., & Zhu, H. (2012) · Acta Physiologica Hungarica · doi:10.1556/aphysiol.99.2012.3.8 · Cited by 82

A metabolomic and pharmacokinetic study on the mechanism underlying the lipid-lowering effect of orally administered berberine

Gu, S., Cao, B., Sun, R., Tang, Y., Paletta, J. L., Wu, X., Liu, L., Zha, W., Zhao, C., Li, Y., et al. (2014) · Molecular BioSystems · doi:10.1039/c4mb00500g · Cited by 82

Berberine Exerts Neuroprotective Actions against in Vitro Ischemia-Induced Neuronal Cell Damage in Organotypic Hippocampal Slice Cultures: Involvement of B-Cell Lymphoma 2 Phosphorylation Suppression

Cui, H.-S., Matsumoto, K., Murakami, Y., Hori, H., Zhao, Q., & Obi, R. (2009) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.32.79 · Cited by 81

Metformin and Berberine Prevent Olanzapine-Induced Weight Gain in Rats

Hu, Y., Young, A. J., Ehli, E. A., Nowotny, D., Davies, P. S., Droke, E. A., Soundy, T. J., & Davies, G. E. (2014) · PLoS ONE · doi:10.1371/journal.pone.0093310 · Cited by 80

Fluconazole Assists Berberine To Kill Fluconazole-Resistant Candida albicans

Li, D., Xu, Y., Zhang, D., Quan, H., Mylonakis, E. E., Hu, D., Li, M.-B., Zhao, L., Liang-hua, Z. H. U., Wang, Y., et al. (2013) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00499-13 · Cited by 80

Berberine induces dendritic cell apoptosis and has therapeutic potential for rheumatoid arthritis

Hu, Z., Jiao, Q., Ding, J., Liu, F., Liu, R., Shan, L., Zeng, H., Zhang, J., & Zhang, W. (2010) · Arthritis & Rheumatism · doi:10.1002/art.30202 · Cited by 79

Nutraceutical pill containing berberine versus ezetimibe on plasma lipid pattern in hypercholesterolemic subjects and its additive effect in patients with familial hypercholesterolemia on stable cholesterol-lowering treatment

Pisciotta, L., Bellocchio, A., & Bertolini, S. (2012) · Lipids in Health and Disease · doi:10.1186/1476-511x-11-123 · Cited by 79

Dose-response of berberine on hepatic cytochromes P450 mRNA expression and activities in mice

Guo, Y., Pope, C., Cheng, X., Zhou, H., & Klaassen, C. D. (2011) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2011.08.058 · Cited by 77

Berberine, an Isoquinoline Alkaloid in Herbal Plants, Protects Pancreatic Islets and Serum Lipids in Nonobese Diabetic Mice

Chueh, W.-H., & Lin, J. (2011) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf201627w · Cited by 76

PI3K p55γ promoter activity enhancement is involved in the anti-apoptotic effect of berberine against cerebral ischemia–reperfusion

Hu, J., Chai, Y., Wang, Y., Kheir, M. M., Li, H., Yuan, Z., Wan, H., Xing, D., Fan, L., & Du, L. (2011) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2011.11.014 · Cited by 75

The antibacterial mechanism of berberine againstActinobacillus pleuropneumoniae

Kang, S., Moalin, M., Yin, Z., Jia, R., Song, X., Li, L., Chen, Z., Peng, L., Qu, J., Hu, Z., et al. (2015) · Natural Product Research · doi:10.1080/14786419.2014.1001388 · Cited by 74

Berberine protects against lipopolysaccharide-induced intestinal injury in mice via alpha 2 adrenoceptor-independent mechanisms

Li, H., Wang, Y., Wang, H., Cao, W., Yu, X., Lu, D., Qi, R., Hu, C., & Yan, Y. (2011) · Acta Pharmacologica Sinica · doi:10.1038/aps.2011.102 · Cited by 73

Anti‐atherogenic effect of berberine on LXRα‐ABCA1‐dependent cholesterol efflux in macrophages

Lee, T., Pan, C.-C., Peng, C., Kou, Y. R., Chen, C., Ching, L., Tsai, T., Chen, S., Lyu, P. C., & Shyue, S. (2010) · Journal of Cellular Biochemistry · doi:10.1002/jcb.22667 · Cited by 73

Antidiabetic Properties of Berberine: From Cellular Pharmacology to Clinical Effects

Cicero, A. F. G., & Tartagni, E. (2012) · Hospital Practice · doi:10.3810/hp.2012.04.970 · Cited by 72

Berberine promotes the development of atherosclerosis and foam cell formation by inducing scavenger receptor A expression in macrophage

Li, K., Yao, W., Zheng, X., & Liao, K. (2009) · Cell Research · doi:10.1038/cr.2009.76 · Cited by 72

Inhibitory Effects of Isoquinoline Alkaloid Berberine on Ischemia-Induced Apoptosis via Activation of Phosphoinositide 3-Kinase/Protein Kinase B Signaling Pathway

Kim, M., Shin, M. S., Lee, J. M., Cho, H. S., Kim, C., Kim, Y., Choi, H., & Jeon, J. W. (2014) · International Neurourology Journal · doi:10.5213/inj.2014.18.3.115 · Cited by 71

Berberine induces heme oxygenase-1 up-regulation through phosphatidylinositol 3-kinase/AKT and NF-E2-related factor-2 signaling pathway in astrocytes

Chen, J., Huang, S.-M., Tan, T., Lin, H., Chen, P., Yeh, W., Chou, S.-C., Tsai, C., Wei, I., & Lu, D. (2011) · International Immunopharmacology · doi:10.1016/j.intimp.2011.10.019 · Cited by 69

Berberine via suppression of transient receptor potential vanilloid 4 channel improves vascular stiffness in mice

Wang, J., Guo, T., Peng, Q., Yue, S., & Wang, S. (2015) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.12645 · Cited by 68

Berberine attenuates adverse left ventricular remodeling and cardiac dysfunction after acute myocardial infarction in rats: Role of autophagy

Zhang, Y., Yang, S., Li, M., Iqbal, J., Bourantas, C. V., Mi, Q., Yu, Y., Li, J., Zhao, S., Tian, N., et al. (2014) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.12309 · Cited by 67

Berberine reduces both MMP-9 and EMMPRIN expression through prevention of p38 pathway activation in PMA-induced macrophages

Huang, Z., Wang, L., Meng, S., Wang, Y., Chen, T., & Wang, C. (2009) · International Journal of Cardiology · doi:10.1016/j.ijcard.2009.06.023 · Cited by 65

Inhibition of organic cation transporter 2 and 3 may be involved in the mechanism of the antidepressant-like action of berberine

Sun, S., Wang, K., Lei, H., Li, L., Tu, M., Zeng, S., Zhou, H., & Jiang, H. (2013) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2013.11.005 · Cited by 65

Effect of berberine on the pharmacokinetics of substrates of CYP3A and P-gp

Qiu, W., Jiang, X. H., Liu, C. X., Ju, Y., & Jin, J. X. (2009) · Phytotherapy Research · doi:10.1002/ptr.2808 · Cited by 64

The effects of berberine on the pharmacokinetics of ciclosporin A in healthy volunteers

Xin, H.-W., Wu, X.-C., Li, Q., Yu, A.-R., & Zhong, M.-Y. (2006) · Methods and Findings in Experimental and Clinical Pharmacology · doi:10.1358/mf.2006.28.1.962774 · Cited by 63 · cited 3×

Berberine ameliorates COX-2 expression in rat small intestinal mucosa partially through PPARγ pathway during acute endotoxemia

Feng, A., Gao, W., Zhou, G., Ren, Y., Li, N., Huang, X., Li, Q., & Li, J. (2011) · International Immunopharmacology · doi:10.1016/j.intimp.2011.11.009 · Cited by 62

Berberine Inhibits Hepatic Stellate Cell Proliferation and Prevents Experimental Liver Fibrosis

Sun, X., Zhang, X., Hu, H., Lu, Y., Chen, J., Yasuda, K., & Wang, H. (2009) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.32.1533 · Cited by 61

Berberine increases the expression of NHE3 and AQP4 in sennosideA-induced diarrhoea model

Zhang, Y., Wang, X., Sha, S., Liang, S., Zhao, L., Liu, L., Chai, N., Wang, H., & Wu, K. (2012) · Fitoterapia · doi:10.1016/j.fitote.2012.05.015 · Cited by 60

Neurotoxic effects of berberine on long-term l-DOPA administration in 6-hydroxydopamine-lesioned rat model of Parkinson’s disease

Shin, K. S., Choi, H. S., Zhao, T., Suh, K. H., Kwon, I. H., Choi, S. O., & Lee, M. K. (2013) · Archives of Pharmacal Research · doi:10.1007/s12272-013-0051-4 · Cited by 60

Enhanced circulating PCSK9 concentration by berberine through SREBP-2 pathway in high fat diet-fed rats

Jia, Y., Xu, R.-X., Sun, J., Tang, Y., & Li, J. (2014) · Journal of Translational Medicine · doi:10.1186/1479-5876-12-103 · Cited by 60

Immunotoxicity induced in mice by subacute exposure to berberine

Mahmoudi, M., Rabe, S. Z. T., Balali‐Mood, M., Karimi, G., Memar, B., Rahnama, M., Tabasi, N. S., Khazaee, M., & Riahi‐Zanjani, B. (2015) · Journal of Immunotoxicology · doi:10.3109/1547691x.2015.1058306 · Cited by 59

Inhibition of respiratory syncytial virus replication and virus-induced p38 kinase activity by berberine

Shin, H.-B., Choi, M.-S., Yi, C.-M., Lee, J. H., Kim, N., & Inn, K. (2015) · International Immunopharmacology · doi:10.1016/j.intimp.2015.04.045 · Cited by 59

Protective Effects of Berberine in an Experimental Rat Osteoarthritis Model

Hu, P., Chen, W., Tang, J., Bao, J., & Wu, L. (2010) · Phytotherapy Research · doi:10.1002/ptr.3359 · Cited by 58

Berberine prevents UV-induced MMP-1 and reduction of type I procollagen expression in human dermal fibroblasts

Kim, S., & Chung, J. H. (2008) · Phytomedicine · doi:10.1016/j.phymed.2007.11.004 · Cited by 57

Berberis vulgaris root bark extract prevents hyperoxaluria induced urolithiasis in rats

Bashir, S., Gilani, A. H., Siddiqui, A. A., et al. (2010) · Phytotherapy Research · doi:10.1002/ptr.3196 · Cited by 57

The effect of berberine in vitro on tight junctions in human Caco-2 intestinal epithelial cells

Gu, L., Li, N., Li, Q., Zhang, Q., Wang, C., Zhu, W., & Li, J. (2009) · Fitoterapia · doi:10.1016/j.fitote.2009.02.005 · Cited by 57

Berberine Suppresses Th17 and Dendritic Cell Responses

Yang, Y., Qi, J., Wang, Q., Du, L., Zhou, Y. N., Yu, H., Kijlstra, A., & Yang, P. (2013) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.12-11217 · Cited by 56

Berberine attenuates cardiac dysfunction in hyperglycemic and hypercholesterolemic rats

Dong, S., Hong, Y., Liu, M. R., Hao, Y., Yu, H.-S., Liu, Y., & Sun, J. (2011) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2011.03.024 · Cited by 56

Organic cation transporter-mediated drug-drug interaction potential between berberine and metformin

Kwon, M., Choi, Y. A., Choi, M.-K., & Song, I.-S. (2015) · Archives of Pharmacal Research · doi:10.1007/s12272-014-0510-6 · Cited by 56

Protective Effects of Berberine on Isoproterenol‐Induced Acute Myocardial Ischemia in Rats through Regulating HMGB1‐TLR4 Axis

Zhang, T., Yang, S., & Du, J. (2014) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2014/849783 · Cited by 56

Berberine Attenuates Ischemia-Reperfusion Injury Via Regulation of Adenosine-5′-monophosphate Kinase Activity in Both Non-ischemic and Ischemic Areas of the Rat Heart

Chang, W., Zhang, M., Li, J., Meng, Z., Xiao, D., Wei, S., Chen, L., Wang, C., & Hatch, G. M. (2012) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-012-6422-0 · Cited by 56

Berberine Ameliorates Pro-inflammatory Cytokine-Induced Endoplasmic Reticulum Stress in Human Intestinal Epithelial Cells In Vitro

Hao, X., Yao, A., Gong, J., Zhu, W., Li, N., & Li, J. (2011) · Inflammation · doi:10.1007/s10753-011-9385-6 · Cited by 55

Cyclosporine and Herbal Supplement Interactions

Colombo, D., Lunardon, L., & Bellia, G. (2014) · Journal of Toxicology · doi:10.1155/2014/145325 · Cited by 55

The anti-atherogenic effects of berberine on foam cell formation are mediated through the upregulation of sirtuin 1

Chi, L., Peng, L., PAN, N., Hu, X., & Zhang, Y. (2014) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2014.1868 · Cited by 54

Effects of berberine on human rheumatoid arthritis fibroblast-like synoviocytes

Wang, X., Jiang, S., & Sun, Q. (2011) · Experimental Biology and Medicine · doi:10.1258/ebm.2011.010366 · Cited by 54

Berberine‐induced Haemolysis Revisited: Safety of Rhizoma coptidis and Cortex phellodendri in Chronic Haematological Diseases

Linn, Y. C., Lü, J., Lim, L. C., Sun, H., Sun, J., Zhou, Y., & Ng, H. (2011) · Phytotherapy Research · doi:10.1002/ptr.3617 · Cited by 54

Enhancement of Sodium Caprate on Intestine Absorption and Antidiabetic Action of Berberine

Lv, X., Li, J., Zhang, M., Wang, C., Fan, Z., Wang, C., & Chen, L. (2010) · AAPS PharmSciTech · doi:10.1208/s12249-010-9386-z · Cited by 53

Preparation and evaluation of a microemulsion for oral delivery of berberine

Gui, S., Gui, S. Y., Gui, S. Y., et al. (2008) · Die Pharmazie · doi:10.31083/ph.2008.8018 · Cited by 52

Berberine protects endothelial progenitor cell from damage of TNF-α via the PI3K/AKT/eNOS signaling pathway

Xiao, M., Men, L. N., Xu, M. G., Wang, G. B., Lv, H. T., & Liu, C. (2014) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2014.09.024 · Cited by 52

The Effect of Berberis Vulgaris Extract on Transaminase Activities in Non-Alcoholic Fatty Liver Disease

Kashkooli, R. I., Najafi, S. S., Sharif, F., Hamedi, A., Asl, M. K. H., Kalyani, M. N., & Birjandi, M. (2015) · Hepatitis Monthly · doi:10.5812/hepatmon.25067 · Cited by 51

Antifungal activity of berberine hydrochloride and palmatine hydrochloride against Microsporum canis -induced dermatitis in rabbits and underlying mechanism

Xiao, C., Ji, Q., Wei, Q., Liú, Y., & Bao, G. (2015) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-015-0680-x · Cited by 50

Berberine elicits anti‐arrhythmic effects via IK1/Kir2.1 in the rat type 2 diabetic myocardial infarction model

Wang, L., Yu, C., Fu, Y. H., Li, Q., & Sun, Y. (2010) · Phytotherapy Research · doi:10.1002/ptr.3097 · Cited by 50

The Anticonvulsant and Antioxidant Effects of Berberine in Kainate-induced Temporal Lobe Epilepsy in Rats.

Mojarad, T. B., & Roghani, M. (2014) · Europe PMC (PubMed Central) · Cited by 50

Correction: A metabolomic and pharmacokinetic study on the mechanism underlying the lipid-lowering effect of orally administered berberine

Gu, S., Cao, B., Sun, R., Tang, Y., Paletta, J. L., Wu, X., Liu, L., Zha, W., Zhao, C., Li, Y., et al. (2014) · Molecular BioSystems · doi:10.1039/c4mb90042a · Cited by 49

Berberine attenuates cAMP-induced lipolysis via reducing the inhibition of phosphodiesterase in 3T3-L1 adipocytes

Zhou, L., Wang, X., Yang, Y., Wu, L., Li, F., Zhang, R., Yuan, G., Wang, N., Chen, M., & Ning, G. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2010.10.001 · Cited by 49

Berberine, a natural lipid-lowering drug, exerts prothrombotic effects on vascular cells

Holy, E. W., Akhmedov, A., Lüscher, T. F., & Tanner, F. C. (2008) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2008.10.011 · Cited by 48

Berberine Up-Regulates Hepatic Low-Density Lipoprotein Receptor through Ras-Independent but AMP-Activated Protein Kinase-Dependent Raf-1 Activation

Li, Z., Jiang, J., & Kong, W. (2014) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b14-00412 · Cited by 48

Effects of Berberine on Expression of LOX-1 and SR-BI in Human Macrophage-Derived Foam Cells Induced by ox-LDL

Guan, S., Wang, B., Li, W., Guan, J., & Fang, X. (2010) · The American Journal of Chinese Medicine · doi:10.1142/s0192415x10008548 · Cited by 47

Inhibitory effects of berberine on lipopolysaccharide-induced inducible nitric oxide synthase and the high-mobility group box 1 release in macrophages

Lee, D., Bae, J., Kim, Y. K., et al. (2013) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2012.12.143 · Cited by 46

Effect of berberine on expressions of uncoupling protein-2 mRNA and protein in hepatic tissue of non-alcoholic fatty liver disease in rats

Yang, Q., Hu, S., Zhang, Y., Xie, W., Li, N., Ji, G., Qiao, N.-L., Xiu-feng, L. I. N., Chen, T.-Y., & Liu, H. (2011) · Chinese Journal of Integrative Medicine · doi:10.1007/s11655-011-0668-4 · Cited by 45

Berberine-induced decline in circulating CD31+/CD42− microparticles is associated with improvement of endothelial function in humans

Wang, J.-M., Yang, Z., Xu, M.-G., Chen, L., Wang, Y., Su, C., & Tao, J. (2009) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2009.04.037 · Cited by 45

The protective effect of berberine against neuronal damage by inhibiting matrix metalloproteinase-9 and laminin degradation in experimental autoimmune encephalomyelitis

Jiang, Y., Wu, A., Zhu, C., Pi, R., Chen, S., Liu, Y., Ma, L., Zhu, D., & Chen, X. (2013) · Neurological Research · doi:10.1179/1743132812y.0000000156 · Cited by 45

Protective effects of berberine against doxorubicin-induced cardiotoxicity in rats by inhibiting metabolism of doxorubicin

Hao, G., Yu, Y., Gu, B., et al. (2015) · Xenobiotica · doi:10.3109/00498254.2015.1034223 · Cited by 45

Berberine Attenuates Doxorubicin-Induced Cardiotoxicity in Mice

Zhao, X., Zhang, J., Tong, N., Liao, X., Wang, E., Li, Z., Luo, Y., & Zuo, H. (2011) · Journal of International Medical Research · doi:10.1177/147323001103900514 · Cited by 44

Anti-hypertensive and renoprotective effects of berberine in spontaneously hypertensive rats

Guo, Z., Sun, H., Zhang, H., & Zhang, Y. (2015) · Clinical and Experimental Hypertension · doi:10.3109/10641963.2014.972560 · Cited by 44

Aqueous Extract of Dried Fruit ofBerberis vulgaris L.in Acne vulgaris, a Clinical Trial

Fouladi, R. F. (2012) · Journal of Dietary Supplements · doi:10.3109/19390211.2012.726702 · Cited by 44

Berberine-Induced Upregulation of Circulating Endothelial Progenitor Cells Is Related to Nitric Oxide Production in Healthy Subjects

Xu, M.-G., Wang, J., Chen, L., Wang, Y., Yang, Z., & Tao, J. (2008) · Cardiology · doi:10.1159/000157336 · Cited by 43

Anticonvulsant Effect of Berberis integerrima L. Root Extracts in Mice

Hosseinzadeh, H., Ramezani, M., Shafaei, H., & Taghiabadi, E. (2012) · Journal of Acupuncture and Meridian Studies · doi:10.1016/j.jams.2012.07.018 · Cited by 42

Inhibition of Retinoblastoma mRNA Degradation through Poly (A) Involved in the Neuroprotective Effect of Berberine against Cerebral Ischemia

Chai, Y., Yuan, Z.-Y., Fan, L., Wang, Y. G., Hu, J., Du, F., Lü, X., Jiang, J.-F., Xing, D. M., & Du, L. J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0090850 · Cited by 42

Berberine Reduces Leukocyte Adhesion to Lps-Stimulated Endothelial Cells and Vcam-1 Expression Both In Vivo and In Vitro

Wu, Y., Chuang, S.-Y., Hong, W.-C., Lai, Y., Chang, G.-J., & Pang, J. S. (2012) · International Journal of Immunopathology and Pharmacology · doi:10.1177/039463201202500320 · Cited by 40

Activity of berberine on Shigella dysenteriae investigated by microcalorimetry and multivariate analysis

Kong, W., Li, Z., Xiao, X., Zhao, Y., & Zhang, P. (2010) · Journal of Thermal Analysis and Calorimetry · doi:10.1007/s10973-010-0778-9 · Cited by 40

Berberine Inhibits the Release of Glutamate in Nerve Terminals from Rat Cerebral Cortex

Lin, T., Lin, Y.-W., Lü, C.-W., Huang, S.-K., & Wang, S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0067215 · Cited by 40

Inhibitory Effect of Berberis vulgaris Aqueous Extract on Acquisition and Reinstatement Effects of Morphine in Conditioned Place Preferences (CPP) in Mice

Imenshahidi, M., Qaredashi, R., Hashemzaei, M., & Hosseinzadeh, H. (2014) · Jundishapur Journal of Natural Pharmaceutical Products · doi:10.17795/jjnpp-16145 · Cited by 40

Effects of berberine on hippocampal neuronal damage and matrix metalloproteinase‐9 activity following transient global cerebral ischemia

Hong, J., Chu, Y., Lee, H., Ahn, B., Park, J., Kim, M., Lee, S., Ryoo, H., Jang, J., Lee, S., et al. (2011) · Journal of Neuroscience Research · doi:10.1002/jnr.22756 · Cited by 39

The natural compound berberine positively affects macrophage functions involved in atherogenesis

Zimetti, F., Adorni, M. P., Ronda, N., Gatti, R., Bernini, F., & Favari, E. (2014) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2014.08.004 · Cited by 39

Co-administration of berberine and plant stanols synergistically reduces plasma cholesterol in rats

Jia, X., Chen, Y., Zidichouski, J. A., Zhang, J., Sun, C., & Wang, Y. (2008) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2008.03.008 · Cited by 39

Berberine-induced mobilization of circulating endothelial progenitor cells improves human small artery elasticity

Xu, M.-G., Wang, J.-M., Chen, L., Wang, Y., Yang, Z., & Tao, J. (2007) · Journal of Human Hypertension · doi:10.1038/sj.jhh.1002311 · Cited by 38

Suppression of oxLDL‐Induced MMP‐9 and EMMPRIN Expression by Berberine via Inhibition of NF‐κB Activation in Human THP‐1 Macrophages

Huang, Z., Meng, S., Wang, L., Wang, Y., Chen, T., & Wang, C. (2011) · The Anatomical Record · doi:10.1002/ar.21489 · Cited by 38

Berberine inhibits Staphylococcus Epidermidis adhesion and biofilm formation on the surface of titanium alloy

Wang, X., Qiu, S., Xiao, Y., Tang, T., Dai, K., & Zhu, Z. (2009) · Journal of Orthopaedic Research® · doi:10.1002/jor.20917 · Cited by 37

Berberine inhibits SREBP‐1‐related clozapine and risperidone induced adipogenesis in 3T3‐L1 cells

Hu, Y., Kutscher, E. C., & Davies, G. E. (2010) · Phytotherapy Research · doi:10.1002/ptr.3204 · Cited by 36

Role of JNK and c-Jun signaling pathway in regulation of human serum paraoxonase 1 gene transcription by berberine in human HepG2 cells

Cheng, C., Hsueh, C., Liang, K., Ting, C.-T., Wen, C.-L., & Hsu, S. (2010) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2010.10.051 · Cited by 34

Effect of berberine on insulin resistance in women with polycystic ovary syndrome: study protocol for a randomized multicenter controlled trial

Li, Y., Ma, H., Zhang, Y., Kuang, H., Ng, E. H. Y., Hou, L., & Wu, X. (2013) · Trials · doi:10.1186/1745-6215-14-226 · Cited by 34

Berberine exerts anti-adipogenic activity through up-regulation of C/EBP inhibitors, CHOP and DEC2

Pham, T. P. T., Kwon, J., & Shin, J. (2011) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2011.08.110 · Cited by 33

Berberine combined with atorvastatin downregulates LOX-1 expression through the ET-1 receptor in monocyte/macrophages

Chi, L., Peng, L., Hu, X., PAN, N., & Zhang, Y. (2014) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2014.1748 · Cited by 33

Berberine reduces Toll-like receptor-mediated macrophage migration by suppression of Src enhancement

Cheng, W.-E., Chang, M. Y., Wei, J.-Y., Chen, Y.-J., Maa, M., & Leu, T. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.03.013 · Cited by 31

In vitro studies of berberine metabolism and its effect of enzyme induction on HepG2 cells

Cui, H., Zhang, Q., Wang, J., Chen, J., Zhang, Y., & Tong, X. (2014) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2014.10.018 · Cited by 30

The Anti-Apoptotic Role of Berberine in Preimplantation Embryo In Vitro Development through Regulation of miRNA-21

Zhang, C., Shi, Y., Liu, X., Cao, Y., Zhen, D., Jia, Z.-Y., Jiang, J.-Q., Tian, J., & Gao, J. (2015) · PLoS ONE · doi:10.1371/journal.pone.0129527 · Cited by 29

Berberine Attenuates Isoniazid-Induced Hepatotoxicity by Modulating Peroxisome Proliferator-Activated Receptor γ, Oxidative Stress and Inflammation

Mahmoud, A. M., Germoush, M. O., & Soliman, A. S. (2014) · International Journal of Pharmacology · doi:10.3923/ijp.2014.451.460 · Cited by 29

Effect of berberine and Berberis aetnensis C. Presl. alkaloid extract on glutamate‐evoked tissue transglutaminase up‐regulation in astroglial cell cultures

Campisi, A., Acquaviva, R., Mastrojeni, S., Raciti, G., Vanella, A., Pasquale, R. D., Puglisi, S., & Iauk, L. (2010) · Phytotherapy Research · doi:10.1002/ptr.3340 · Cited by 28

Letrozole, berberine, or their combination for anovulatory infertility in women with polycystic ovary syndrome: study design of a double-blind randomised controlled trial

Li, Y., Kuang, H., Shen, W., Ma, H., Zhang, Y., Stener‐Victorin, E., Hung, E., Ng, E. H. Y., Liu, J., Kuang, H., et al. (2013) · BMJ Open · doi:10.1136/bmjopen-2013-003934 · Cited by 28

Drug–drug Interactions between Ketoconazole and Berberine in Rats: Pharmacokinetic Effects Benefit Pharmacodynamic Synergism

Zhou, Y., He, P., Liu, A., Zhang, L., Liu, Y., & Dai, R. (2011) · Phytotherapy Research · doi:10.1002/ptr.3621 · Cited by 26

Protection of Gastrointestinal Mucosa from Acute Heavy Alcohol Consumption: The Effect of Berberine and Its Correlation with TLR2, 4/IL1β-TNFα Signaling

Wang, X.-P., Fan, L., Du, F., Chai, Y.-S., Jiang, J.-F., Wang, Y.-G., Yu, X., Yan, X.-J., Xing, D.-M., & Du, L. (2015) · PLoS ONE · doi:10.1371/journal.pone.0134044 · Cited by 26

Effect of Berberine on Cell Survival in the Developing Rat Brain Damaged by MK-801

Lee, T., Heo, H., & Kwon, Y. K. (2010) · Experimental Neurobiology · doi:10.5607/en.2010.19.3.140 · Cited by 26

Berberine reverses abnormal expression of L-type pyruvate kinase by DNA demethylation and histone acetylation in the livers of the non-alcoholic fatty disease rat.

Zhang, Y., Chang, X., Song, X., Chen, C., Chen, H., Lu, Z., Gao, X., & Lu, D. (2015) · Europe PMC (PubMed Central) · Cited by 26

Berberine suppresses in vitro migration of human aortic smooth muscle cells through the inhibitions of MMP-2/9, u-PA, AP-1, and NF-κB

Liu, S.-J., Yin, C.-X., Ding, M., et al. (2014) · BMB Reports · doi:10.5483/bmbrep.2014.47.7.186 · Cited by 25

Effects of berberine on serum levels of inflammatory factors and inflammatory signaling pathway in obese mice induced by high fat diet

Wenbin, S. (2010) · China Journal of Chinese Materia Medica · doi:10.4268/cjcmm20101125 · Cited by 24

Berberine inhibits tumor necrosis factor-α-induced expression of inflammatory molecules and activation of nuclear factor-κB via the activation of AMPK in vascular endothelial cells

Liu, S.-J., YIN, C.-X., Ding, M., WANG, Y., & WANG, H. (2015) · Molecular Medicine Reports · doi:10.3892/mmr.2015.4061 · Cited by 23

Berberine attenuates spontaneous action potentials in sinoatrial node cells and the currents of human HCN4 channels expressed in Xenopus laevis oocytes

Chen, H., Chen, Y., TANG, Y., Yang, J., Wang, D., Yu, T., & Huang, C. (2014) · Molecular Medicine Reports · doi:10.3892/mmr.2014.2377 · Cited by 23

Changes in Botrytis cinerea Conidia Caused by Berberis vulgaris Extract

Pârvu, M., Pârvu, A. E., Crăciun, C., Barbu–Tudoran, L., Vlase, L., Tămaş, M., Roşca-Casian, O., Persecă, O., & Molnar, A. (2010) · Notulae Botanicae Horti Agrobotanici Cluj-Napoca · doi:10.15835/nbha3834741 · Cited by 21

Berberine reduces the hypoxic-ischemic insult in rat pup brain

Benaissa, F., Rad, H. M., Rahimi‐Moghaddam, P., & Mahmoudian, M. (2009) · Acta Physiologica Hungarica · doi:10.1556/aphysiol.96.2009.2.6 · Cited by 21

Effects of berberine and red yeast on proinflammatory cytokines IL-6 and TNF-α in peripheral blood mononuclear cells (PBMCs) of human subjects

Spatuzza, C., Postiglione, L., Covelli, B., Ricciardone, M., Benvenuti, C., Mondola, P., & Belfiore, A. (2014) · Frontiers in Pharmacology · doi:10.3389/fphar.2014.00230 · Cited by 19

Inhibitory Effects of Coptidis rhizoma and Berberine on Cocaine‐Induced Sensitization

Lee, B., Yang, C. H., Hahm, D., Choe, E. S., Lee, H., Pyun, K.-H., & Shim, I. (2007) · Evidence-based Complementary and Alternative Medicine · doi:10.1093/ecam/nem070 · Cited by 19

Antihistaminic and Anticholinergic Activity of Methanolic Extract of Barberry Fruit (Berberis vulgaris) in the Guinea- Pig Ileum

Khosrokhavar, R., Ahmadiani, A., & Shamsa, F. (2010) · DOAJ (DOAJ: Directory of Open Access Journals) · Cited by 17

Effects of berberine on differentiation and bone resorption of osteoclasts derived from rat bone marrow cells

Wei, P. (2009) · Journal of Chinese Integrative Medicine · doi:10.3736/jcim20090408 · Cited by 16

[Effects of different dose berberine on hemodynamic parameters and [Ca2+]i of cardiac myocytes of diastolic heart failure rat model].

Zhang, X., Ren, H.-M., & Liu, L. (2008) · PubMed · Cited by 15

Berberine protects against Schistosoma mansoni-induced oxidative damage in renal and testicular tissues of mice.

Dkhil, M. A., Moneim, A. E. A., & Al-Quraishy, S. (2014) · Pakistan Journal of Zoology · Cited by 14

New Oral Delivery System to Improve Absorption of Berberine: Likely Interaction of Cationized Chitosan with PG-P Pump.

Fratter, A., Servi, B. D., & Vitro Screen, M. (2014) · International Journal of Drug Delivery Technology · doi:10.25258/ijddt.v5i1.8866 · Cited by 14

[Effects of ginseng total saponins with berberine on plasma brain natriuretic peptide and Ca2+ concentration in experimental rats with chronic congestive heart failure].

Li, Y., Chen, X., Liu, H., et al. (2009) · PubMed · Cited by 13

Protective Effects of Berberine on Oxygen-Glucose Deprivation/Reperfusion on Oligodendrocyte Cell Line (OLN-93).

Nadjafi, S., Ebrahimi, S.-A., & Rahbar‐Roshandel, N. (2014) · Europe PMC (PubMed Central) · Cited by 13

Berberine protects C57BL/6J mice against ethanol withdrawal‐induced hyperexcitability

Bhutada, P., Mundhada, Y. R., Bansod, K. U., Hiware, R., Rathod, S., Dixit, P. V., & Mundhada, D. R. (2010) · Phytotherapy Research · doi:10.1002/ptr.3272 · Cited by 8

Berberis vulgaris Juice and Acne Vulgaris: A Placebo-Controlled Study

Johnson, M. E., & Rafikhah, N. (2014) · Asian Journal of Clinical Nutrition · doi:10.3923/ajcn.2014.47.52 · Cited by 7

Abstracts: The effects of Coptis japonica root extract and its key component, berberine, on human subcutaneous adipocytes

Yashiki(Tohi), K., Kiso, A., Zhou, Y. Y., Iwasaki, D., Kambara, T., & Mizutani, K. (2010) · International Journal of Cosmetic Science · doi:10.1111/j.1468-2494.2010.00583_5.x · Cited by 6

[Intervention of berberine on lipid deposition in liver cells of non-alcoholic fatty liver disease rats induced by high fat diet].

Li, H., Yang, Q.-H., Zhang, Y., et al. (2015) · PubMed · Cited by 6

Effect of berberine on pharmacokinetics of digoxin after oral administration to rats

Ju, Y. (2011) · China Journal of Chinese Materia Medica · doi:10.4268/cjcmm20110721 · Cited by 5

The Protective Effect of Medicinal Herbs Extracts Including Cynara scolymus L., Cichorium intybus L. Taraxacum officinal L. and Berberis vulgaris L. in Single and in Combination Form in CCl4 Induced Rat Liver Toxicity

Huseini, H. F., Mahmoudabadi, A. Z., Badi, H. N., Alavian, S. M., Savadroodbari, R. M., & Mehdizadeh, M. (2012) · DOAJ (DOAJ: Directory of Open Access Journals) · Cited by 5

Berberine Disturbs the Expression of Sex-hormone Regulated Genes in β-naphthoflavone-induced Mice

Lao‐ong, T., Chatuphonprasert, W., & Jarukamjorn, K. (2013) · Journal of Biological Sciences · doi:10.3923/jbs.2013.271.276 · Cited by 3

Effect of Berberine on Lipid Metabolism and Expressions of Low Density Lipoprotein Receptor and Scavenger Receptor Class-B Type 1 Genes in Livers of Hyperlipidemic Rabbits

Yang, J. (2010) · Zhongguo shengwuzhipinxue zazhi · Cited by 2

The effect of berberine on arrhythmia caused by stretch of myocardium, in vitro, of rats after myocardial ischemia

Cao, J., & Fu, L. (2012) · Zhonghua jizhen yixue zazhi · doi:10.3760/cma.j.issn.1671-0282.2012.07.003 · Cited by 2

Caloric Restriction Mimetics against Age-Associated Disease: Targets, Mechanisms, and Therapeutic Potential

Madeo, F., Carmona-Gutierrez, D., Hofer, S. J., & Kroemer, G. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.01.018 · Cited by 630

Berberine in Cardiovascular and Metabolic Diseases: From Mechanisms to Therapeutics

Feng, X., Sureda, A., Jafari, S., Memariani, Z., Tewari, D., Annunziata, G., Barrea, L., Hassan, S. T. S., Šmejkal, K., Malaník, M., et al. (2019) · Theranostics · doi:10.7150/thno.30787 · Cited by 465

Naturally Occurring Acetylcholinesterase Inhibitors and Their Potential Use for Alzheimer's Disease Therapy

Santos, T. C. D., Gomes, T. M., Pinto, B. A. S., Camara, A. L., & Paes, A. M. D. A. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.01192 · Cited by 389

Natural Deep Eutectic Solvents (NADES) to Enhance Berberine Absorption: An In Vivo Pharmacokinetic Study

Sut, S., Faggian, M., Baldan, V., Poloniato, G., Castagliuolo, I., Grabnar, I., Perissutti, B., Brun, P., Maggi, F., Voinovich, D., et al. (2017) · Molecules · doi:10.3390/molecules22111921 · Cited by 120

Berberine, a Herbal Metabolite in the Metabolic Syndrome: The Risk Factors, Course, and Consequences of the Disease

Och, A., Och, M., Nowak, R., Podgórska, D., & Podgórski, R. (2022) · Molecules · doi:10.3390/molecules27041351 · Cited by 104