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Cited by 872

The DOI matches its Crossref record; 95 of the 95 references it cites were found in a registry or an index.

Concise Review: Evidence for CD34 as a Common Marker for Diverse Progenitors

Open access
Sidney, Laura E., Branch, Matthew J., Dunphy, Siobhán E., Dua, Harminder S., Hopkinson, Andrew·2014·Stem Cells
DOI 10.1002/stem.1661
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Abstract

CD34 is a transmembrane phosphoglycoprotein, first identified on hematopoietic stem and progenitor cells. Clinically, it is associated with the selection and enrichment of hematopoietic stem cells for bone marrow transplants. Due to these historical and clinical associations, CD34 expression is almost ubiquitously related to hematopoietic cells, and it is a common misconception that CD34-positive (CD34+) cells in nonhematopoietic samples represent hematopoietic contamination. The prevailing school of thought states that multipotent mesenchymal stromal cells (MSC) do not express CD34. However, strong evidence demonstrates CD34 is expressed not only by MSC but by a multitude of other nonhematopoietic cell types including muscle satellite cells, corneal keratocytes, interstitial cells, epithelial progenitors, and vascular endothelial progenitors. In many cases, the CD34+ cells represent a small proportion of the total cell population and also indicate a distinct subset of cells with enhanced progenitor activity. Herein, we explore common traits between cells that express CD34, including associated markers, morphology and differentiation potential. We endeavor to highlight key similarities between CD34+ cells, with a focus on progenitor activity. A common function of CD34 has yet to be elucidated, but by analyzing and understanding links between CD34+ cells, we hope to be able to offer an insight into the overlapping properties of cells that express CD34. Stem Cells 2014;32:1380–1389

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Metadata

Authors
Sidney, L. E., Branch, M. J., Dunphy, S. E., Dua, H. S., & Hopkinson, A.
Venue
Stem Cells
Publisher
Oxford University Press (OUP)
Published
2014-05-23
Volume
32
Issue
6
Pages
1380-1389
ISSN
  • 1066-5099 (ISSN-L)
  • 1549-4918
DOI
10.1002/stem.1661
OpenAlex
W1521262132
Cited by
872
References
95
FWCI
20.86
Type
journal article
Language
en
Open access
hybrid

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