The DOI matches its Crossref record; 125 of the 125 references it cites were found in a registry or an index.
Mesenchymal Stromal Cells: Current Understanding and Clinical Status
Open accessAbstract
Multipotent mesenchymal stromal cells (MSCs) represent a rare heterogeneous subset of pluripotent stromal cells that can be isolated from many different adult tissues that exhibit the potential to give rise to cells of diverse lineages. Numerous studies have reported beneficial effects of MSCs in tissue repair and regeneration. After culture expansion and in vivo administration, MSCs home to and engraft to injured tissues and modulate the inflammatory response through synergistic downregulation of proinflammatory cytokines and upregulation of both prosurvival and antiinflammatory factors. In addition, MSCs possess remarkable immunosuppressive properties, suppressing T-cell, NK cell functions, and also modulating dentritic cell activities. Tremendous progress has been made in preclinical studies using MSCs, including the ability to use allogeneic cells, which has driven the application of MSCs toward the clinical setting. This review highlights our current understanding into the biology of MSCs with particular emphasis on the cardiovascular and renal applications, and provides a brief update on the clinical status of MSC-based therapy.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
1 retracted
Spontaneous Human Adult Stem Cell Transformation
Rubio, D., Garcia-Castro, J., Martín, M. C., de la Fuente, R., Cigudosa, J. C., Lloyd, A. C., & Bernad, A. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-4194 · Cited by 1,036
RetractedMultilineage potential of adult human mesenchymal stem cells
Pittenger, M. F., Mackay, A. M., Beck, S. C., Jaiswal, R. K., Douglas, R., Mosca, J. D., Moorman, M. A., Simonetti, D. W., Craig, S., & Marshak, D. R. (1999) · Science · doi:10.1126/science.284.5411.143 · Cited by 21,052
Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors
Takahashi, K., Tanabe, K., Ohnuki, M., Narita, M., Ichisaka, T., Tomoda, K., & Yamanaka, S. (2007) · Cell · doi:10.1016/j.cell.2007.11.019 · Cited by 20,221
Caplan, A. I. (1991) · Journal of Orthopaedic Research · doi:10.1002/jor.1100090504 · Cited by 6,548
Marrow Stromal Cells as Stem Cells for Nonhematopoietic Tissues
Prockop, D. J. (1997) · Science · doi:10.1126/science.276.5309.71 · Cited by 4,629
Human mesenchymal stem cells modulate allogeneic immune cell responses
Aggarwal, S., & Pittenger, M. F. (2005) · Blood · doi:10.1182/blood-2004-04-1559 · Cited by 4,511
Getting to the site of inflammation: the leukocyte adhesion cascade updated
Ley, K., Laudanna, C., Cybulsky, M. I., & Nourshargh, S. (2007) · Nature Reviews Immunology · doi:10.1038/nri2156 · Cited by 4,354
Mesenchymal stem cells reside in virtually all post-natal organs and tissues
Meirelles, L. D. S., Chagastelles, P. C., & Nardi, N. B. (2006) · Journal of Cell Science · doi:10.1242/jcs.02932 · Cited by 2,485
Chamberlain, G., Fox, J., Ashton, B., & Middleton, J. (2007) · Stem Cells · doi:10.1634/stemcells.2007-0197 · Cited by 2,381
Wollert, K. C., Meyer, G. P., Lotz, J., Ringes Lichtenberg, S., Lippolt, P., Breidenbach, C., Fichtner, S., Korte, T., Hornig, B., Messinger, D., et al. (2004) · The Lancet · doi:10.1016/s0140-6736(04)16626-9 · Cited by 2,191
Cited by
Eggenhofer, E., Benseler, V., Kroemer, A., Popp, F. C., Geissler, E. K., Schlitt, H. J., Baan, C. C., Dahlke, M. H., & Hoogduijn, M. J. (2012) · Frontiers in Immunology · doi:10.3389/fimmu.2012.00297 · Cited by 804
Mesenchymal stem cell: An efficient mass producer of exosomes for drug delivery
Yeo, R. W. Y., Lai, R. C., Zhang, B., Tan, S. S., Yin, Y., Teh, B. J., & Lim, S. K. (2013) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.07.001 · Cited by 746
Reinders, M. E. J., de Fijter, J. W., Roelofs, H., Bajema, I. M., de Vries, D. K., Schaapherder, A. F., Claas, F. H. J., van Miert, P. P. M. C., Roelen, D. L., van Kooten, C., et al. (2013) · Stem Cells Translational Medicine · doi:10.5966/sctm.2012-0114 · Cited by 339
Cryopreservation of Human Stem Cells for Clinical Application: A Review
Hunt, C. J. (2011) · Transfusion Medicine and Hemotherapy · doi:10.1159/000326623 · Cited by 329
Paracrine Effect of Mesenchymal Stem Cells Derived from Human Adipose Tissue in Bone Regeneration
Linero, I., & Chaparro, O. (2014) · PLoS ONE · doi:10.1371/journal.pone.0107001 · Cited by 323
Lin, Z., Wu, Y., Xu, Y., Li, G., Li, Z., & Liu, T. (2022) · Molecular Cancer · doi:10.1186/s12943-022-01650-5 · Cited by 297
A novel marker of human endometrial mesenchymal stem-like cells
Masuda, H., Anwar, S. S., Bühring, H.-J., Rao, J. R., & Gargett, C. E. (2012) · Cell Transplantation · doi:10.3727/096368911x637362 · Cited by 294
Zaim, M., Karaman, S., Cetin, G., & Isik, S. (2012) · Annals of Hematology · doi:10.1007/s00277-012-1438-x · Cited by 294
Raab, M., Swift, J., P. Dingal, P. C. D., Shah, P., Shin, J.-W., & Discher, D. E. (2012) · Journal of Cell Biology · doi:10.1083/jcb.201205056 · Cited by 285
Concise Review: Mesenchymal Stem Cells in Neurodegenerative Diseases
Volkman, R., & Offen, D. (2017) · Stem Cells · doi:10.1002/stem.2651 · Cited by 222
Teratomas from pluripotent stem cells: A clinical hurdle
Fong, C., Gauthaman, K., & Bongso, A. (2010) · Journal of Cellular Biochemistry · doi:10.1002/jcb.22775 · Cited by 222
PDE3A mutations cause autosomal dominant hypertension with brachydactyly
Maass, P. G., Aydin, A., Luft, F. C., Schächterle, C., Weise, A., Stricker, S., Lindschau, C., Vaegler, M., Qadri, F., Toka, H. R., et al. (2015) · Nature Genetics · doi:10.1038/ng.3302 · Cited by 166
Genetic Engineering of Mesenchymal Stem Cells and Its Application in Human Disease Therapy
Hodgkinson, C. P., Gomez, J. A., Mirotsou, M., & Dzau, V. J. (2010) · Human Gene Therapy · doi:10.1089/hum.2010.165 · Cited by 150
Potential implications of mesenchymal stem cells in cancer therapy
Dai, L.-J., Moniri, M. R., Zeng, Z.-R., Zhou, J. X., Rayat, J., & Warnock, G. L. (2011) · Cancer Letters · doi:10.1016/j.canlet.2011.02.012 · Cited by 99
Mesenchymal stem/stromal cells in post-menopausal endometrium
Ulrich, D., Tan, K. S., Deane, J., Schwab, K., Cheong, A., Rosamilia, A., & Gargett, C. E. (2014) · Human Reproduction · doi:10.1093/humrep/deu159 · Cited by 91
Lee, S. C., Jeong, H. J., Lee, S. K., & Kim, S.-J. (2015) · Stem Cell Research & Therapy · doi:10.1186/s13287-015-0072-7 · Cited by 82
Belmar-Lopez, C., Mendoza, G., Oberg, D., Burnet, J., Simon, C., Cervello, I., Iglesias, M., Ramirez, J. C., Lopez-Larrubia, P., Quintanilla, M., et al. (2013) · BMC Medicine · doi:10.1186/1741-7015-11-139 · Cited by 71
Russell, K. C., Tucker, H. A., Bunnell, B. A., Andreeff, M., Schober, W., Gaynor, A. S., Strickler, K. L., Lin, S., Lacey, M. R., & O'Connor, K. C. (2013) · Tissue Engineering Part A · doi:10.1089/ten.tea.2012.0649 · Cited by 56
Maiso, P., Mogollón, P., Ocio, E. M., & Garayoa, M. (2021) · Cancers · doi:10.3390/cancers13112542 · Cited by 48
Hao, T., Chen, J., Zhi, S., Zhang, Q., Chen, G., & Yu, F. (2017) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2017.5333 · Cited by 47
Recent advances in exosome-based immunotherapy applied to cancer
Xie, J., Zheng, Z., Tuo, L., Deng, X., Tang, H., Peng, C., & Zou, Y. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1296857 · Cited by 40
Conese, M., Piro, D., Carbone, A., Castellani, S., & Di Gioia, S. (2014) · The Scientific World Journal · doi:10.1155/2014/859817 · Cited by 28
Yarahmadi, A., Dorri Giv, M., Hosseininejad, R., Rezaie, A., Mohammadi, N., Afkhami, H., & Farokhi, A. (2025) · Frontiers in Neurology · doi:10.3389/fneur.2025.1472679 · Cited by 21
The role of mesenchymal stem cells in oncology and regenerative medicine
Maliha, K., Syeda Ezze Rukhshan, A., & Amanda L, O. (2017) · Future Oncology · doi:10.2217/fon-2016-0264 · Cited by 5
Metadata
- Authors
- Salem, H. K., & Thiemermann, C.
- Venue
- Stem Cells
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-12-04
- Volume
- 28
- Issue
- 3
- Pages
- 585-596
- ISSN
- 1066-5099 (ISSN-L)
- 1549-4918
- OpenAlex
- W1978370369
- Cited by
- 915
- References
- 125
- FWCI
- 30.38
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
