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Cited by 915

The DOI matches its Crossref record; 125 of the 125 references it cites were found in a registry or an index.

Mesenchymal Stromal Cells: Current Understanding and Clinical Status

Open access
Salem, Husein K., Thiemermann, Chris·2010·Stem Cells
DOI 10.1002/stem.269
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Abstract

Multipotent mesenchymal stromal cells (MSCs) represent a rare heterogeneous subset of pluripotent stromal cells that can be isolated from many different adult tissues that exhibit the potential to give rise to cells of diverse lineages. Numerous studies have reported beneficial effects of MSCs in tissue repair and regeneration. After culture expansion and in vivo administration, MSCs home to and engraft to injured tissues and modulate the inflammatory response through synergistic downregulation of proinflammatory cytokines and upregulation of both prosurvival and antiinflammatory factors. In addition, MSCs possess remarkable immunosuppressive properties, suppressing T-cell, NK cell functions, and also modulating dentritic cell activities. Tremendous progress has been made in preclinical studies using MSCs, including the ability to use allogeneic cells, which has driven the application of MSCs toward the clinical setting. This review highlights our current understanding into the biology of MSCs with particular emphasis on the cardiovascular and renal applications, and provides a brief update on the clinical status of MSC-based therapy.

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Crossref · 10.1002/stem.269

Cites

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Citations

Cites

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Cited by

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Metadata

Authors
Salem, H. K., & Thiemermann, C.
Venue
Stem Cells
Publisher
Oxford University Press (OUP)
Published
2009-12-04
Volume
28
Issue
3
Pages
585-596
ISSN
  • 1066-5099 (ISSN-L)
  • 1549-4918
DOI
10.1002/stem.269
OpenAlex
W1978370369
Cited by
915
References
125
FWCI
30.38
Type
journal article
Language
en
Open access
bronze

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Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.