Metabolic Engineering for Pentose Utilization in Saccharomyces cerevisiae

Bio-ethanol – the fuel of tomorrow from the residues of today

Hahn-Hägerdal, B., Galbe, M., Gorwa-Grauslund, M. F., Lidén, G., & Zacchi, G. (2006) · Trends in Biotechnology · doi:10.1016/j.tibtech.2006.10.004 · Cited by 1,513

Inhibition of ethanol-producing yeast and bacteria by degradation products produced during pre-treatment of biomass

Klinke, H. B., Thomsen, A. B., & Ahring, B. K. (2004) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-004-1642-2 · Cited by 1,484

Towards industrial pentose-fermenting yeast strains

Hahn-Hägerdal, B., Karhumaa, K., Fonseca, C., Spencer-Martins, I., & Gorwa-Grauslund, M. F. (2007) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-006-0827-2 · Cited by 783

Yeast Physiology and Biotechnology

Walker, G. M. (1998) · Medical Entomology and Zoology · Cited by 637

An interlaboratory comparison of physiological and genetic properties of four Saccharomyces cerevisiae strains

van Dijken, J. P., Bauer, J., Brambilla, L., Duboc, P., Francois, J. M., Gancedo, C., Giuseppin, M. L. F., Heijnen, J. J., Hoare, M., Lange, H. C., et al. (2000) · Enzyme and Microbial Technology · doi:10.1016/s0141-0229(00)00162-9 · Cited by 598

Yeast Physiology and Biotechnology

Pompon, D. (1999) · Biofutur · doi:10.1016/s0294-3506(99)80418-9 · Cited by 540

Genetically Engineered Saccharomyces Yeast Capable of Effective Cofermentation of Glucose and Xylose

Ho, N. W. Y., Chen, Z., & Brainard, A. P. (1998) · Applied and Environmental Microbiology · doi:10.1128/aem.64.5.1852-1859.1998 · Cited by 540

Xylose fermentation by Saccharomyces cerevisiae

K�tter, P., & Ciriacy, M. (1993) · Applied Microbiology and Biotechnology · doi:10.1007/bf00167144 · Cited by 509

Metabolic engineering of a xylose-isomerase-expressing strain for rapid anaerobic xylose fermentation

KUYPER, M., HARTOG, M., TOIRKENS, M., ALMERING, M., WINKLER, A., VANDIJKEN, J., & PRONK, J. (2005) · FEMS Yeast Research · doi:10.1016/j.femsyr.2004.09.010 · Cited by 404

Anaerobic Xylose Fermentation by Recombinant Saccharomyces cerevisiae Carrying XYL1 , XYL2 , and XKS1 in Mineral Medium Chemostat Cultures

Eliasson, A., Christensson, C., Wahlbom, C. F., & Hahn-Hägerdal, B. (2000) · Applied and Environmental Microbiology · doi:10.1128/aem.66.8.3381-3386.2000 · Cited by 392

In silico aided metabolic engineering of Saccharomyces cerevisiae for improved bioethanol production

BRO, C., REGENBERG, B., FORSTER, J., & NIELSEN, J. (2006) · Metabolic Engineering · doi:10.1016/j.ymben.2005.09.007 · Cited by 367

High-level functional expression of a fungal xylose isomerase: the key to efficient ethanolic fermentation of xylose by ?

KUYPER, M., HARHANGI, H., STAVE, A., WINKLER, A., JETTEN, M., DELAAT, W., DENRIDDER, J., OPDENCAMP, H., VANDIJKEN, J., & PRONK, J. (2003) · FEMS Yeast Research · doi:10.1016/s1567-1356(03)00141-7 · Cited by 366

NADH-linked aldose reductase: the key to anaerobic alcoholic fermentation of xylose by yeasts

Bruinenberg, P. M., de Bot, P. H. M., van Dijken, J. P., & Scheffers, W. A. (1984) · Applied Microbiology and Biotechnology · doi:10.1007/bf00251847 · Cited by 349

Evolutionary engineering of mixed-sugar utilization by a xylose-fermenting strain

KUYPER, M., TOIRKENS, M., DIDERICH, J., WINKLER, A., VANDIJKEN, J., & PRONK, J. (2005) · FEMS Yeast Research · doi:10.1016/j.femsyr.2005.04.004 · Cited by 341

Characterization of the xylose-transporting properties of yeast hexose transporters and their influence on xylose utilization

Hamacher, T., Becker, J., Gárdonyi, M., Hahn-Hägerdal, B., & Boles, E. (2002) · Microbiology · doi:10.1099/00221287-148-9-2783 · Cited by 317

Evolutionary Engineering of Industrially Important Microbial Phenotypes

Sauer, U. (2001) · Advances in Biochemical Engineering/Biotechnology · doi:10.1007/3-540-45300-8_7 · Cited by 295

Isolation and characterization of the Pichia stipitis xylitol dehydrogenase gene, XYL2, and construction of a xylose-utilizing Saccharomyces cerevisiae transformant

Kötter, P., Amore, R., Hollenberg, C. P., & Ciriacy, M. (1990) · Current Genetics · doi:10.1007/bf00327019 · Cited by 283

Simultaneous saccharification and co-fermentation of glucose and xylose in steam-pretreated corn stover at high fiber content with Saccharomyces cerevisiae TMB3400

Öhgren, K., Bengtsson, O., Gorwa-Grauslund, M. F., Galbe, M., Hahn-Hägerdal, B., & Zacchi, G. (2006) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2006.05.001 · Cited by 280

Oxygen requirements of yeasts

Visser, W., Scheffers, W. A., Batenburg-van der Vegte, W. H., & van Dijken, J. P. (1990) · Applied and Environmental Microbiology · doi:10.1128/aem.56.12.3785-3792.1990 · Cited by 267

The role of redox balances in the anaerobic fermentation of xylose by yeasts

Bruinenberg, P. M., Bot, P. H. M., Dijken, J. P., & Scheffers, W. A. (1983) · European Journal of Applied Microbiology and Biotechnology · doi:10.1007/bf00500493 · Cited by 264

Minimal metabolic engineering of for efficient anaerobic xylose fermentation: a proof of principle

KUYPER, M., WINKLER, A., VANDIJKEN, J., & PRONK, J. (2004) · FEMS Yeast Research · doi:10.1016/j.femsyr.2004.01.003 · Cited by 261

Regulation of the l-arabinose operon of Escherichia coli

Schleif, R. (2000) · Trends in Genetics · doi:10.1016/s0168-9525(00)02153-3 · Cited by 260

A Modified Saccharomyces cerevisiae Strain That Consumes l -Arabinose and Produces Ethanol

Becker, J., & Boles, E. (2003) · Applied and Environmental Microbiology · doi:10.1128/aem.69.7.4144-4150.2003 · Cited by 253

Ethanolic fermentation of xylose with Saccharomyces cerevisiae harboring the Thermus thermophilus xylA gene, which expresses an active xylose (glucose) isomerase

Walfridsson, M., Bao, X., Anderlund, M., Lilius, G., Bülow, L., & Hahn-Hägerdal, B. (1996) · Applied and Environmental Microbiology · doi:10.1128/aem.62.12.4648-4651.1996 · Cited by 252

Evolutionary Engineering of Saccharomyces cerevisiae for Anaerobic Growth on Xylose

Sonderegger, M., & Sauer, U. (2003) · Applied and Environmental Microbiology · doi:10.1128/aem.69.4.1990-1998.2003 · Cited by 251

Conversion of Xylose to Ethanol by Recombinant Saccharomyces cerevisiae: Importance of Xylulokinase (XKS1) and Oxygen Availability

Toivari, M. H., Aristidou, A., Ruohonen, L., & Penttilä, M. (2001) · Metabolic Engineering · doi:10.1006/mben.2000.0191 · Cited by 247

The danger of metabolic pathways with turbo design

Teusink, B., Walsh, M. C., van Dam, K., & Westerhoff, H. V. (1998) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(98)01205-5 · Cited by 246

Bioconversion of forest and agricultural plant residues

Hobson, P. N. (1994) · Bioresource Technology · doi:10.1016/0960-8524(94)90160-0 · Cited by 246

Role of cultivation media in the development of yeast strains for large scale industrial use

Hahn-Hägerdal, B., Karhumaa, K., Larsson, C. U., Gorwa-Grauslund, M., Görgens, J., & van Zyl, W. H. (2005) · Microbial Cell Factories · doi:10.1186/1475-2859-4-31 · Cited by 235

Engineering Redox Cofactor Regeneration for Improved Pentose Fermentation in Saccharomyces cerevisiae

Verho, R., Londesborough, J., Penttilä, M., & Richard, P. (2003) · Applied and Environmental Microbiology · doi:10.1128/aem.69.10.5892-5897.2003 · Cited by 227

Xylose-metabolizing Saccharomyces cerevisiae strains overexpressing the TKL1 and TAL1 genes encoding the pentose phosphate pathway enzymes transketolase and transaldolase

Walfridsson, M., Hallborn, J., Penttil�, M., Ker�nen, S., & Hahn-H�gerdal, B. (1995) · Applied and Environmental Microbiology · doi:10.1128/aem.61.12.4184-4190.1995 · Cited by 219

Investigation of limiting metabolic steps in the utilization of xylose by recombinant Saccharomyces cerevisiae using metabolic engineering

Karhumaa, K., Hahn‐Hägerdal, B., & Gorwa‐Grauslund, M. (2005) · Yeast · doi:10.1002/yea.1216 · Cited by 213

Ethanol fermentation from lignocellulosic hydrolysate by a recombinant xylose- and cellooligosaccharide-assimilating yeast strain

Katahira, S., Mizuike, A., Fukuda, H., & Kondo, A. (2006) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-006-0402-x · Cited by 211

Xylose transport studies with xylose-utilizing Saccharomyces cerevisiae strains expressing heterologous and homologous permeases

Saloheimo, A., Rauta, J., Stasyk, O. V., Sibirny, A. A., Penttilä, M., & Ruohonen, L. (2007) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-006-0747-1 · Cited by 210

Furfural, 5‐hydroxymethyl furfural, and acetoin act as external electron acceptors during anaerobic fermentation of xylose in recombinant Saccharomyces cerevisiae

Wahlbom, C. F., & Hahn–Hägerdal, B. (2002) · Biotechnology and Bioengineering · doi:10.1002/bit.10188 · Cited by 209

Effect of Oxygenation on Xylose Fermentation by Pichia stipitis

Skoog, K., & Hahn-Hägerdal, B. (1990) · Applied and Environmental Microbiology · doi:10.1128/aem.56.11.3389-3394.1990 · Cited by 206

Production of Ethanol from d -Xylose by Using d -Xylose Isomerase and Yeasts

Gong, C., Chen, L., Flickinger, M. C., Chiang, L., & Tsao, G. T. N. (1981) · Applied and Environmental Microbiology · doi:10.1128/aem.41.2.430-436.1981 · Cited by 203

Production of Ethanol from Cellulosic Biomass Hydrolysates Using Genetically Engineered Saccharomyces Yeast Capable of Cofermenting Glucose and Xylose

Sedlak, M., & Ho, N. W. Y. (2004) · Applied Biochemistry and Biotechnology · doi:10.1385/abab:114:1-3:403 · Cited by 199

Bioconversion of Forest and Agricultural Plant Residues

Saddler, J. N. (1993) · Medical Entomology and Zoology · Cited by 196

Genetic Analysis of a Novel Pathway for d -Xylose Metabolism in Caulobacter crescentus

Stephens, C., Christen, B., Fuchs, T., Sundaram, V., Watanabe, K., & Jenal, U. (2007) · Journal of Bacteriology · doi:10.1128/jb.01438-06 · Cited by 194

Characterization of the effectiveness of hexose transporters for transporting xylose during glucose and xylose co‐fermentation by a recombinant Saccharomyces yeast

Sedlak, M., & Ho, N. W. Y. (2004) · Yeast · doi:10.1002/yea.1060 · Cited by 192

Reduced Oxidative Pentose Phosphate Pathway Flux in Recombinant Xylose-Utilizing Saccharomyces cerevisiae Strains Improves the Ethanol Yield from Xylose

Jeppsson, M., Johansson, B., Hahn-Hägerdal, B., & Gorwa-Grauslund, M. F. (2002) · Applied and Environmental Microbiology · doi:10.1128/aem.68.4.1604-1609.2002 · Cited by 186

Optimal Growth and Ethanol Production from Xylose by Recombinant Saccharomyces cerevisiae Require Moderate d -Xylulokinase Activity

Jin, Y.-S., Ni, H., Laplaza, J. M., & Jeffries, T. W. (2003) · Applied and Environmental Microbiology · doi:10.1128/aem.69.1.495-503.2003 · Cited by 181

Saccharomyces cerevisiae Engineered for Xylose Metabolism Exhibits a Respiratory Response

Jin, Y.-S., Laplaza, J. M., & Jeffries, T. W. (2004) · Applied and Environmental Microbiology · doi:10.1128/aem.70.11.6816-6825.2004 · Cited by 178

Construction of xylose-assimilating Saccharomyces cerevisiae

Tantirungkij, M., Nakashima, N., Seki, T., & Yoshida, T. (1993) · Journal of Fermentation and Bioengineering · doi:10.1016/0922-338x(93)90214-s · Cited by 171

Two glucose/xylose transporter genes from the yeast Candida intermedia: first molecular characterization of a yeast xylose–H+ symporter

Leandro, M. J., Gonçalves, P., & Spencer-Martins, I. (2006) · Biochemical Journal · doi:10.1042/bj20051465 · Cited by 166

Fermentations with New Recombinant Organisms

Bothast, R. J., Nichols, N. N., & Dien, B. S. (1999) · Biotechnology Progress · doi:10.1021/bp990087w · Cited by 161

Expression of the Escherichia coli xylose isomerase gene in Saccharomyces cerevisiae

Sarthy, A. V., McConaughy, B. L., Lobo, Z., Sundstrom, J. A., Furlong, C. E., & Hall, B. D. (1987) · Applied and Environmental Microbiology · doi:10.1128/aem.53.9.1996-2000.1987 · Cited by 160

Metabolic-Flux Profiling of the Yeasts Saccharomyces cerevisiae and Pichia stipitis

Fiaux, J., Çakar, Z. P., Sonderegger, M., Wüthrich, K., Szyperski, T., & Sauer, U. (2003) · Eukaryotic Cell · doi:10.1128/ec.2.1.170-180.2003 · Cited by 160

Deletion of the GRE3 Aldose Reductase Gene and Its Influence on Xylose Metabolism in Recombinant Strains of Saccharomyces cerevisiae Expressing the xylA and XKS1 Genes

Träff, K. L., Otero, R. R. C., van Zyl, W. H., et al. (2001) · Applied and Environmental Microbiology · doi:10.1128/aem.67.12.5668-5674.2001 · Cited by 159

Generation of the improved recombinant xylose-utilizing TMB 3400 by random mutagenesis and physiological comparison with CBS 6054

Wahlbom, C. F., van Zyl, W. H., Jönsson, L. J., Hahn‐Hägerdal, B., & Otero, R. R. C. (2003) · FEMS Yeast Research · doi:10.1016/s1567-1356(02)00206-4 · Cited by 153

High activity of xylose reductase and xylitol dehydrogenase improves xylose fermentation by recombinant Saccharomyces cerevisiae

Karhumaa, K., Fromanger, R., Hahn‐Hägerdal, B., & Gorwa‐Grauslund, M. F. (2006) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-006-0575-3 · Cited by 151

Co-utilization of L-arabinose and D-xylose by laboratory and industrial Saccharomyces cerevisiae strains

Karhumaa, K., Wiedemann, B., Hahn‐Hägerdal, B., Boles, E., & Gorwa‐Grauslund, M. F. (2006) · Microbial Cell Factories · doi:10.1186/1475-2859-5-18 · Cited by 149

The expression of a Pichia stipitis xylose reductase mutant with higher KM for NADPH increases ethanol production from xylose in recombinant Saccharomyces cerevisiae

Jeppsson, M., Bengtsson, O., Franke, K., Lee, H., Hahn‐Hägerdal, B., & Gorwa‐Grauslund, M. F. (2005) · Biotechnology and Bioengineering · doi:10.1002/bit.20737 · Cited by 148

Improvement of Xylose Uptake and Ethanol Production in Recombinant Saccharomyces cerevisiae through an Inverse Metabolic Engineering Approach

Jin, Y., Alper, H. S., Yang, Y.-T., & Stephanopoulos, G. N. (2005) · Applied and Environmental Microbiology · doi:10.1128/aem.71.12.8249-8256.2005 · Cited by 148

Genomic adaptation of ethanologenic yeast to biomass conversion inhibitors

Liu, Z. L. (2006) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-006-0567-3 · Cited by 147

Properties of the sugar carrier in baker's yeast

Kotyk, A. (1967) · Folia Microbiologica · doi:10.1007/bf02896872 · Cited by 146

Fermentation performance of engineered and evolved xylose‐fermenting Saccharomyces cerevisiae strains

Sonderegger, M., Jeppsson, M., Larsson, C., Gorwa‐Grauslund, M. F., Boles, E., Lisbeth Olsson, A., Spencer‐Martins, I., Hahn‐Hägerdal, B., & Sauer, U. (2004) · Biotechnology and Bioengineering · doi:10.1002/bit.20094 · Cited by 144

Plasmid stability in recombinant Saccharomyces cerevisiae

Zhang, Z., Moo‐Young, M., & Chisti, Y. (1996) · Biotechnology Advances · doi:10.1016/s0734-9750(96)00033-x · Cited by 143

Xylose metabolism in the anaerobic fungus Piromyces sp. strain E2 follows the bacterial pathway

Harhangi, H. R., Akhmanova, A. S., Emmens, R., van der DRIFT, C., de Laat, W. T. A. M., van Dijken, J. P., Jetten, M. S. M., Pronk, J. T., & den Camp, H. J. M. O. (2003) · Archives of Microbiology · doi:10.1007/s00203-003-0565-0 · Cited by 140

Molecular Basis for Anaerobic Growth of Saccharomyces cerevisiae on Xylose, Investigated by Global Gene Expression and Metabolic Flux Analysis

Sonderegger, M., Jeppsson, M., Hahn‐Hägerdal, B., & Sauer, U. (2004) · Applied and Environmental Microbiology · doi:10.1128/aem.70.4.2307-2317.2004 · Cited by 140

Xylulokinase Overexpression in Two Strains ofSaccharomyces cerevisiaeAlso Expressing Xylose Reductase and Xylitol Dehydrogenase and Its Effect on Fermentation of Xylose and Lignocellulosic Hydrolysate

Johansson, B., Christensson, C., Hobley, T. J., & Hahn‐Hägerdal, B. (2001) · Applied and Environmental Microbiology · doi:10.1128/aem.67.9.4249-4255.2001 · Cited by 137

Ethanol from lignocellulosics: A review of the economy

von Sivers, M., & Zacchi, G. (1996) · Bioresource Technology · doi:10.1016/0960-8524(96)00018-1 · Cited by 137

Fermentation of a pentose by yeasts

Wang, P. Y., Shopsis, C. S., & Schneider, H. (1980) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(80)80213-0 · Cited by 133

Metabolic Engineering of a Phosphoketolase Pathway for Pentose Catabolism in Saccharomyces cerevisiae

Sonderegger, M., Schümperli, M., & Sauer, U. (2004) · Applied and Environmental Microbiology · doi:10.1128/aem.70.5.2892-2897.2004 · Cited by 129

The fermentation of xylose ?an analysis of the expression of Bacillus and Actinoplanes xylose isomerase genes in yeast

Amore, R., Wilhelm, M., & Hollenberg, C. P. (1989) · Applied Microbiology and Biotechnology · doi:10.1007/bf00296623 · Cited by 122

Expression of a cytoplasmic transhydrogenase inSaccharomyces cerevisiae results in formation of 2-oxoglutarate due to depletion of the NADPH pool

Nissen, T. L., Anderlund, M., Nielsen, J., Villadsen, J., & Kielland‐Brandt, M. C. (2000) · Yeast · Cited by 121

Production of ethanol from -arabinose by containing a fungal -arabinose pathway

Richard, P., Verho, R., PUTKONEN, M., Londesborough, J., & Penttilä, M. E. (2003) · FEMS Yeast Research · doi:10.1016/s1567-1356(02)00184-8 · Cited by 120

Molecular Analysis of a Saccharomyces cerevisiae Mutant with Improved Ability To Utilize Xylose Shows Enhanced Expression of Proteins Involved in Transport, Initial Xylose Metabolism, and the Pentose Phosphate Pathway

Wahlbom, C. F., Otero, R. R. C., van Zyl, W. H., Hahn‐Hägerdal, B., & Jönsson, L. J. (2003) · Applied and Environmental Microbiology · doi:10.1128/aem.69.2.740-746.2003 · Cited by 120

Response to different environmental stress conditions of industrial and laboratory Saccharomyces cerevisiae strains

Garay‐Arroyo, A., Covarrubias, A. A., Clark, I., Ni�o, I., Gosset, G., & Martı́nez, A. (2004) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-003-1414-4 · Cited by 118

Metabolic flux analysis of xylose metabolism in recombinant Saccharomyces cerevisiae using continuous culture

Pitkänen, J., Aristidou, A. A., Salusjärvi, L., Ruohonen, L., & Penttilä, M. E. (2003) · Metabolic Engineering · doi:10.1016/s1096-7176(02)00012-5 · Cited by 117

Successful Design and Development of Genetically Engineered Saccharomyces Yeasts for Effective Cofermentation of Glucose and Xylose from Cellulosic Biomass to Fuel Ethanol

Ho, N. W. Y., Chen, Z., Brainard, A. P., & Sedlák, M. (1999) · Advances in biochemical engineering, biotechnology · doi:10.1007/3-540-49194-5_7 · Cited by 116

Fermentation performance and intracellular metabolite patterns in laboratory and industrial xylose-fermenting Saccharomyces cerevisiae

Zaldivar, J., Borges, A., Johansson, B., Smits, H., as, S. V.-B. X. F., Nielsen, J., & Lisbeth Olsson, A. (2002) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-002-1056-y · Cited by 114

Metabolic Engineering of Ammonium Assimilation in Xylose-Fermenting Saccharomyces cerevisiae Improves Ethanol Production

Roca, C., Nielsen, J., & Lisbeth Olsson, A. (2003) · Applied and Environmental Microbiology · doi:10.1128/aem.69.8.4732-4736.2003 · Cited by 113

Evidence that the gene YLR070c of Saccharomyces cerevisiae encodes a xylitol dehydrogenase

Richard, P., Toivari, M. H., & Penttilä, M. E. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)01016-9 · Cited by 106

The non-oxidative pentose phosphate pathway controls the fermentation rate of xylulose but not of xylose inSaccharomyces cerevisiaeTMB3001

Johansson, B., & Hähn‐Hägerdal, B. (2002) · FEMS Yeast Research · doi:10.1111/j.1567-1364.2002.tb00095.x · Cited by 105

Cofactor Dependence in Furan Reduction by Saccharomyces cerevisiae in Fermentation of Acid-Hydrolyzed Lignocellulose

Nilsson, A., Gorwa‐Grauslund, M. F., Hahn‐Hägerdal, B., & Lidén, G. (2005) · Applied and Environmental Microbiology · doi:10.1128/aem.71.12.7866-7871.2005 · Cited by 105

An interlaboratory comparison of the performance of ethanol-producing micro-organisms in a xylose-rich acid hydrolysate

Hahn-H�gerdal, B., Jeppsson, H., Lisbeth Olsson, A., & Mohagheghi, A. (1994) · Applied Microbiology and Biotechnology · doi:10.1007/bf00166083 · Cited by 102

The xylose reductase/xylitol dehydrogenase/xylulokinase ratio affects product formation in recombinant xylose-utilising Saccharomyces cerevisiae

Lantz, A. E., Hofmeyr, J. S., Pedler, S., & Hahn‐Hägerdal, B. (2001) · Enzyme and Microbial Technology · doi:10.1016/s0141-0229(01)00386-6 · Cited by 98

Use of population genetics to derive nonrecombinantSaccharomyces cerevisiaestrains that grow using xylose as a sole carbon source

Attfield, P. V., & Bell, P. (2006) · FEMS Yeast Research · doi:10.1111/j.1567-1364.2006.00098.x · Cited by 96

Effect of enhanced xylose reductase activity on xylose consumption and product distribution in xylose-fermenting recombinant

Jeppsson, M., Träff, K. L., JOHANSSON, B., Hahn‐Hägerdal, B., & Gorwa‐Grauslund, M. F. (2003) · FEMS Yeast Research · doi:10.1016/s1567-1356(02)00186-1 · Cited by 92

Control of xylose consumption by xylose transport in recombinant Saccharomyces cerevisiae

Gárdonyi, M., Jeppsson, M., Lidén, G., Gorwa‐Grauslund, M. F., & Hahn‐Hägerdal, B. (2003) · Biotechnology and Bioengineering · doi:10.1002/bit.10631 · Cited by 92

Cloning and expression of the Clostridium thermosulfurogenes D-xylose isomerase gene (xyLA) in Saccharomyces cerevisiae

Moes, C. J., Pretorius, I. S., & van Zyl, W. H. (1996) · Biotechnology Letters · doi:10.1007/bf00142943 · Cited by 92

Strategies for Manipulating Metabolic Fluxes in Biotechnology

Cornish-Bowden, A. J., Hofmeyr, J. H., & Cárdenas, M. L. (1995) · Bioorganic Chemistry · doi:10.1006/bioo.1995.1030 · Cited by 86

Arabinose utilization by xylose-fermenting yeasts and fungi

McMillan, J. D., & Boynton, B. L. (1994) · Applied Biochemistry and Biotechnology · doi:10.1007/bf02941831 · Cited by 86

Galactose Transport in Saccharomyces cerevisiae II. Characteristics of Galactose Uptake and Exchange in Galactokinaseless Cells

Kou, S.-C., Christensen, M. S., & Cirillo, V. P. (1970) · Journal of Bacteriology · doi:10.1128/jb.103.3.671-678.1970 · Cited by 83

Contaminant occurrence, identification and control in a pilot-scale corn fiber to ethanol conversion process

Schell, D. J., Dowe, N., Ibsen, K. N., Riley, C. J., Ruth, M. F., & Lumpkin, R. E. (2006) · Bioresource Technology · doi:10.1016/j.biortech.2006.10.002 · Cited by 81

Identification and Characterization of l-Arabonate Dehydratase, l-2-Keto-3-deoxyarabonate Dehydratase, and l-Arabinolactonase Involved in an Alternative Pathway of l-Arabinose Metabolism

Watanabe, S., Shimada, N., Tajima, K., Kodaki, T., & Makino, K. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m606727200 · Cited by 79

Xylose fermentation by genetically modified Saccharomyces cerevisiae 259ST in spent sulfite liquor

Helle, S. S., Murray, A., Lam, J., et al. (2003) · Bioresource Technology · doi:10.1016/j.biortech.2003.08.011 · Cited by 78

Comparative metabolic network analysis of two xylose fermenting recombinant Saccharomyces cerevisiae strains

Grotkjær, T., Christakopoulos, P., Nielsen, J., & Lisbeth Olsson, A. (2005) · Metabolic Engineering · doi:10.1016/j.ymben.2005.07.003 · Cited by 72

The Streptomyces rubiginosus xylose isomerase is misfolded when expressed in Saccharomyces cerevisiae

Gárdonyi, M., & Hahn‐Hägerdal, B. (2002) · Enzyme and Microbial Technology · doi:10.1016/s0141-0229(02)00285-5 · Cited by 72

Xylose chemostat isolates of Saccharomyces cerevisiae show altered metabolite and enzyme levels compared with xylose, glucose, and ethanol metabolism of the original strain

Pitkänen, J., Rintala, E., Aristidou, A. A., Ruohonen, L., & Penttilä, M. E. (2005) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-004-1798-9 · Cited by 72

Identification of the First Fungal NADP-GAPDH from Kluyveromyces lactis

Verho, R., Richard, P., Jonson, P. H., et al. (2002) · Biochemistry · doi:10.1021/bi0265325 · Cited by 71

Screening forl-arabinose fermenting yeasts

Dien, B. S., Kurtzman, C. P., Badal Chandra, S. A. H. A., & Bothast, R. J. (1996) · Applied Biochemistry and Biotechnology · doi:10.1007/bf02941704 · Cited by 69

Expression of E. coli araBAD operon encoding enzymes for metabolizing L-arabinose in Saccharomyces cerevisiae

Sedlák, M., & Ho, N. W. Y. (2001) · Enzyme and Microbial Technology · doi:10.1016/s0141-0229(00)00282-9 · Cited by 66

High capacity xylose transport in Candida intermedia PYCC 4715

Gárdonyi, M., OSTERBERG, M., Rodrigues, C., Spencer‐Martins, I., & Hähn‐Hägerdal, B. (2003) · FEMS Yeast Research · doi:10.1111/j.1567-1364.2003.tb00137.x · Cited by 65

Engineering of carbon catabolite repression in recombinant xylose fermenting Saccharomyces cerevisiae

Roca, C., Haack, M. B., & Lisbeth Olsson, A. (2004) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-003-1408-2 · Cited by 61

Different internal metabolites trigger the induction of glycolytic gene expression in Saccharomyces cerevisiae

Müller, S., Boles, E., May, M., & Zimmermann, F. K. (1995) · Journal of Bacteriology · doi:10.1128/jb.177.15.4517-4519.1995 · Cited by 59

Microbial Pentose Metabolism

Hahn‐Hägerdal, B., & Pamment, N. B. (2004) · Applied Biochemistry and Biotechnology · doi:10.1385/abab:116:1-3:1207 · Cited by 57

Endogenous NADPH‐dependent aldose reductase activity influences product formation during xylose consumption in recombinant Saccharomyces cerevisiae

Träff‐Bjerre, K. L., Jeppsson, M., Hahn‐Hägerdal, B., & Gorwa‐Grauslund, M. F. (2003) · Yeast · doi:10.1002/yea.1072 · Cited by 53

Effects of increased transaldolase activity on D-xylulose and D-glucose metabolism in Saccharomyces cerevisiae cell extracts

Senac, T., & Hahn‐Hägerdal, B. (1991) · Applied and Environmental Microbiology · doi:10.1128/aem.57.6.1701-1706.1991 · Cited by 36

Expression of Vitreoscilla hemoglobin improves the metabolism of xylose in recombinant yeast Saccharomyces cerevisiae under low oxygen conditions

Ruohonen, L., Aristidou, A. A., Frey, A. D., Penttilä, M. E., & Kallio, P. T. (2005) · Enzyme and Microbial Technology · doi:10.1016/j.enzmictec.2005.06.024 · Cited by 36

High capacity xylose transport in PYCC 4715

Gárdonyi, M., OSTERBERG, M., Rodrigues, C., Spencer‐Martins, I., & Hahn‐Hägerdal, B. (2003) · FEMS Yeast Research · doi:10.1016/s1567-1356(02)00137-x · Cited by 24

A constitutive catabolite repression mutant of a recombinantSaccharomyces cerevisiae strain improves xylose consumption during fermentation

Gururajan, V. T., Gorwa‐Grauslund, M. F., Hahn‐Hägerdal, B., Pretorius, I. S., & Otero, R. R. C. (2007) · Annals of Microbiology · doi:10.1007/bf03175055 · Cited by 16

Engineered Saccharomyces cerevisiae capable of simultaneous cellobiose and xylose fermentation

Ha, S.-J., Galazka, J. M., Rin Kim, S., Choi, J.-H., Yang, X., Seo, J.-H., Louise Glass, N., Cate, J. H. D., & Jin, Y.-S. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1010456108 · Cited by 466

Recent advances in second generation bioethanol production: An insight to pretreatment, saccharification and fermentation processes

Rastogi, M., & Shrivastava, S. (2017) · Renewable and Sustainable Energy Reviews · doi:10.1016/j.rser.2017.05.225 · Cited by 459

Development of a D-xylose fermenting and inhibitor tolerant industrial Saccharomyces cerevisiae strain with high performance in lignocellulose hydrolysates using metabolic and evolutionary engineering

Demeke, M. M., Dietz, H., Li, Y., Foulquié-Moreno, M. R., Mutturi, S., Deprez, S., Den Abt, T., Bonini, B. M., Liden, G., Dumortier, F., et al. (2013) · Biotechnology for Biofuels · doi:10.1186/1754-6834-6-89 · Cited by 331

Xylose isomerase overexpression along with engineering of the pentose phosphate pathway and evolutionary engineering enable rapid xylose utilization and ethanol production by Saccharomyces cerevisiae

Zhou, H., Cheng, J.-S., Wang, B. L., Fink, G. R., & Stephanopoulos, G. (2012) · Metabolic Engineering · doi:10.1016/j.ymben.2012.07.011 · Cited by 287

Simultaneous consumption of pentose and hexose sugars: an optimal microbial phenotype for efficient fermentation of lignocellulosic biomass

Kim, J.-H., Block, D. E., & Mills, D. A. (2010) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-010-2839-1 · Cited by 287