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Cited by 217Virus-based gene therapy researchParvovirus B19 Infection StudiesRNA Interference and Gene Delivery

The DOI matches its Crossref record; 192 of the 195 references it cites were found in a registry or an index.

AAV Capsid Structure and Cell Interactions

Agbandje-McKenna, Mavis, Kleinschmidt, Jürgen·2012·Methods in Molecular Biology
DOI 10.1007/978-1-61779-370-7_3
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Abstract

The Adeno-associated viruses (AAVs) are not associated with any diseases, and their ability to package non-genomic DNA and to transduce different cell/tissue populations has generated significant interest in understanding their basic biology in efforts to improve their utilization for corrective gene delivery. This includes their capsid structure, cellular tropism and interactions for entry, uncoating, replication, DNA packaging, capsid assembly, and antibody neutralization. The human and nonhuman primate AAVs are clustered into serologically distinct genetic clade and serotype groups, which have distinct cellular/tissue tropisms and transduction efficiencies. These properties are highly dependent upon the AAV capsid amino acid sequence, their capsid structure, and their interactions with host cell factors, including cell surface receptors, co-receptors, signaling molecules, proteins involved in host DNA replication, and host-derived antibodies. This chapter reviews the current structural information on AAV capsids and the capsid viral protein regions playing a role in the cellular interactions conferring an infective phenotype, which are then used to annotate the functional regions of the capsid. Based on the current data, the indication is that the AAVs, like other members of the Parvoviridae and other ssDNA viruses that form a T = 1 capsid, have evolved a multifunctional capsid with conserved core regions as is required for efficient capsid trafficking, capsid assembly, and genome packaging. Disparate surface loop structures confer differential receptor recognition and are involved in antibody recognition. The role of structural regions in capsid uncoating remains to be elucidated.

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Citations

Cites

Research works printed but not linked: 6

  1. Chapman, M. S., and Agbandje-McKenna, M. (2006) Atomic structure if viral particles., in Parvoviruses (Kerr, J. R., Cotmore, S. F., Bloom, M. E., Linden, R. M., and Parrish, C. R., Eds.), pp 107–123, Edward Aenold Ltd. New York, New York.
  2. Akache, B., Grimm, D., Pandey, K., Yant, S. R., Xu, H., and Kay, M. A. (2006) The 37/67-kilodalton laminin receptor is a receptor for adeno-associated virus serotypes 8, 2, 3, and 9, J Virol 80, 9831–9836. · DOI
  3. Hansen, J., Qing, K., and Srivastava, A. (2001) Adeno-associated virus type 2-mediated gene transfer: altered endocytic processing enhances transduction efficiency in murine fibroblasts, J Virol 75, 4080–4090. · DOI · Paper page
  4. Xiao, W., Warrington, K. H., Jr., Hearing, P., Hughes, J., and Muzyczka, N. (2002) Adenovirus-facilitated nuclear translocation of adeno-associated virus type 2, J Virol 76, 11505–11517. · DOI
  5. Knipe, D. M., and Howley, P. M. H. (2001) Fields Viroloy, Lippincott Williams&Wilkins, Philadelphia, USA.
  6. Sonntag et al (2010) PNAS 107, 10220–10225. · DOI · Paper page

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Metadata

Authors
Agbandje-McKenna, M., & Kleinschmidt, J.
Affiliations
German Cancer Research Center (DE)
Venue
Methods in Molecular Biology
Publisher
Humana Press
Published
2011-09-27
Volume
807
Pages
47-92
ISSN
  • 1064-3745 (ISSN-L)
  • 1940-6029
DOI
10.1007/978-1-61779-370-7_3
OpenAlex
W124314106
Cited by
215
References
195
Citations by year
2026: 12 · 2025: 16 · 2024: 19 · 2023: 19 · 2022: 17 · 2021: 15 · 2020: 13 · 2019: 17 · 2018: 14 · 2017: 11 · 2016: 10 · 2015: 12 · 2014: 16 · 2013: 12 · 2012: 12
FWCI
32.78
Type
book chapter
Language
en
Open access
closed
Licence
Locations
  • Methods in molecular biology (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of General Medical Sciences (R01GM082946)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Virus-based gene therapy research
  • Health Sciences › Medicine › Infectious Diseases › Parvovirus B19 Infection Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
Keywords
adeno-associated virus, capsid structure, capsid assembly, DNA packaging, cell tropism, receptor recognition, capsid uncoating, antibody neutralization, serotypes, gene delivery vectors, host cell interactions
MeSH terms
Dependovirus, Antibody Formation, Capsid, Humans, Models, Molecular, Endosomes, Viral Proteins, Protein Structure, Secondary

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