Cited by 117Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchFunctional Brain Connectivity Studies

In vivo characterization of the early states of the amyloid-beta network

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Sepulcre, Jorge, Sabuncu, Mert R., Becker, Alex, Sperling, Reisa, Johnson, Keith A.·2013·Brain

Abstract

Alzheimer's disease is a neurodegenerative disease that is associated with the abnormal accumulation of amyloid-β. Much is known about regional brain atrophy in Alzheimer's disease, yet our knowledge about the network nature of Alzheimer's disease-associated amyloid-β accumulation is limited. We use stepwise connectivity analysis of Pittsburgh Compound B positron emission tomography images to reveal the network properties of amyloid-β deposits in normal elderly subjects and clinical patients with Alzheimer's disease. We found that amyloid-β accumulation in the medial temporal lobe is associated with accumulation in cortical regions such as orbitofrontal, lateral temporal and precuneus/posterior cingulate cortices in Alzheimer's disease. In normal subjects, there was a predominant association between amyloid-β deposits in the hippocampus and the midline prefrontal/orbitofrontal regions, even in those with very low amyloid-β burden. Moreover, the orbitofrontal cortex, amygdala nucleus and hippocampus exhibit hub properties in the amyloid-β network that may be critical to understanding the putative spreading mechanisms of Alzheimer's disease pathology in early stages.

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Crossref · 10.1093/brain/awt146

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Authors
Sepulcre, J., Sabuncu, M. R., Becker, A., Sperling, R., & Johnson, K. A.
Affiliations
Harvard University (US)
Venue
Brain
Published
2013-06-22
Volume
136
Issue
7
Pages
2239-2252
ISSN
  • 0006-8950 (ISSN-L)
  • 1460-2156
OpenAlex
W2057401494
Cited by
117
References
113
Citations by year
2026: 2 · 2025: 4 · 2024: 8 · 2023: 12 · 2022: 5 · 2021: 6 · 2020: 8 · 2019: 12 · 2018: 11 · 2017: 17 · 2016: 9 · 2015: 15 · 2014: 7 · 2013: 1
FWCI
7.43
Type
journal article
Language
en
Open access
Locations
  • Brain (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Harvard University
  • National Institute on Aging (K24AG035007, P50-AG00513421, R01AG027435, R01AG037497, R01AG027435-S1, P50AG005134, P01AG036694)
  • National Institute of Biomedical Imaging and Bioengineering (K25EB013649)
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
Keywords
Alzheimer's disease, amyloid-beta deposition, network hubs, Pittsburgh compound B PET, medial temporal lobe, hippocampus, orbitofrontal cortex, amygdala, posterior cingulate cortex, regional brain atrophy, early Alzheimer's disease
MeSH terms
Aged, Aged, 80 and over, Alzheimer Disease, Aniline Compounds, Brain, Brain Mapping, Carbon Isotopes, Female, Humans, Image Processing, Computer-Assisted, Longitudinal Studies, Magnetic Resonance Imaging, Male, Neural Pathways, Oxygen, Thiazoles, Amyloid beta-Peptides, Positron-Emission Tomography

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