Increased sensitivity to amphetamine and reward-related stimuli following social isolation in rats: possible disruption of dopamine-dependent mechanisms of the nucleus accumbens

Jones, G. H.; Marsden, C. A.; Robbins, T. W.

doi:10.1007/bf02244105

Cited by 232Neurotransmitter Receptor Influence on BehaviorStress Responses and CortisolNeuroscience and Neuropharmacology Research

Increased sensitivity to amphetamine and reward-related stimuli following social isolation in rats: possible disruption of dopamine-dependent mechanisms of the nucleus accumbens

Jones, G. H., Marsden, C. A., Robbins, T. W.·1990·Psychopharmacology

DOI 10.1007/bf02244105

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Abstract

These experiments compared isolation-reared and socially-reared rats in two complementary paradigms for measuring responding to signals of reward, both undrugged and following either systemic or intraaccumbens d-amphetamine (AMPH). In experiment 1, locomotor activity conditioned to food presentation was measured in rats exposed to a restricted feeding schedule. The interaction between this conditioned activity, AMPH administration (0.5, 2.0, 3.5, 5.0 mg/kg IP) and motivational state was measured. In experiment 2, hungry rats were trained to associate a compound light/noise stimulus with sucrose reward and were then implanted with guide cannulae in the nucleus accumbens. In the test phase, responding on one of two novel levers produced the compound stimulus (conditioned reinforcer; CR). Responses on the other lever had no effect. Each rat received four counterbalanced intra-accumbens infusions of AMPH (0, 3, 10, 20 micrograms). In both experiments, isolated rats responded more with stimuli associated with reward and this differential rearing effect was further exaggerated by AMPH. The isolation-induced sensitivity to these stimuli and to AMPH was critically dependent on motivational variables. Thus, in experiment 1 there were no differences between the groups when sated or during extinction and in experiment 2 the increased responding was restricted to the lever providing CR. Measurements of the locomotor response to intra-accumbens AMPH (0, 3, 10 micrograms) also revealed that isolated rats were more sensitive to a low dose of the drug when tested food-deprived in a relatively novel environment. These results suggest that the experience of isolation-rearing interacts either directly or indirectly with dopamine-dependent mechanisms of the nucleus accumbens to enhance the effects of reward-related stimuli.

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Social isolation increases indices of approach motivation, including enhanced responding for increasing sucrose concentrations and greater conditioned responses to sucrose-related stimuli.
“Increased indices of approach motivation are also found following social isolation, with evidence of enhanced responding for increasing concentrations of sucrose (Cuenya et al., 2015; Hall et al., 1997), as well as greater conditioned responses to sucrose-related stimuli (Jones et al., 1990).”
From The effects of early life stress on reward processing (2018) · cites this paper as Jones et al., 1990

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Authors: Jones, G. H., Marsden, C. A., & Robbins, T. W.
Affiliations: University of Cambridge (GB)
University of Nottingham (GB)
ORCID: Robbins, T. W.
Venue: Psychopharmacology
Publisher: Springer Science and Business Media LLC
Published: 1990-11
Volume: 102
Issue: 3
Pages: 364-372
ISSN: 0033-3158 (ISSN-L)
1432-2072
DOI: 10.1007/bf02244105
OpenAlex: W2017838119
Cited by: 232
References: 61
Citations by year: 2026: 1 · 2025: 1 · 2024: 1 · 2023: 4 · 2022: 1 · 2021: 4 · 2020: 1 · 2019: 5 · 2018: 6 · 2017: 5 · 2016: 6 · 2015: 11 · 2014: 4 · 2013: 8 · 2012: 7
FWCI: 3.26
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Psychopharmacology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: social isolation, amphetamine sensitivity, nucleus accumbens, dopamine, reward, conditioned reinforcer, sucrose reward, food deprivation, locomotor activity, motivational states
MeSH terms: Animals, Conditioning, Operant, Dextroamphetamine, Dopamine, Dose-Response Relationship, Drug, Female, Injections, Motor Activity, Nucleus Accumbens, Reward, Social Isolation, Stereotaxic Techniques, Sucrose, Rats

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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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Increased sensitivity to amphetamine and reward-related stimuli following social isolation in rats: possible disruption of dopamine-dependent mechanisms of the nucleus accumbens

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