Cited by 31Stress Responses and CortisolNeurotransmitter Receptor Influence on BehaviorNeuroendocrine regulation and behavior

Neurobehavioural sequelae of social deprivation in rodents revisited: Modelling social adversity for developmental neuropsychiatric disorders

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Robbins, TW·2016·Journal of Psychopharmacology

Abstract

The significance of investigating effects of deprivation of social experience in rodents is reviewed in the context of the review by Robbins et al. (1996) in the Journal of Psychopharmacology (10: 39-47). The early development of the paradigm by which rats were reared post-weaning in social isolation is described and compared with other early experience manipulations. The specification of the neural and behavioural phenotype of the isolate is brought up-to-date, focusing on changes in motivation and cognitive function, as well as on contrasting changes in the dopamine and serotonin systems, and in cortical (including hippocampal) structure and function. The relevance of the isolate for animal models of psychiatric disorders such as attention deficit hyperactivity disorder and schizophrenia is reviewed, and it is considered that the paradigm best exemplifies a manipulation that can be applied to test effects of certain forms of social adversity during adolescence on brain development and behaviour.

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Crossref · 10.1177/0269881116664450

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  • Isolation during adolescence results in cognitive flexibility deficits impairing reward learning, reversal learning, and attention shifting.

    “Particularly, isolation during adolescence results in cognitive flexibility deficits that impair reward learning,47 reversal learning,48 and attention shifting.49”
  • By depriving animals of play experiences that normally guide cortical development, post-weaning social isolation is conceptualized as a rodent model of adolescent adversity with long-lasting effects on neurobiology and behavior.

    “By depriving animals of the play experiences that normally guide cortical development, post-weaning social isolation is conceptualized as a rodent model of adolescent adversity with long-lasting effects on neurobiology and behavior (Fone and Porkess, 2008; Lukkes et al., 2009; Robbins, 2016).”

    From The effects of early life stress on reward processing (2018) · cites this paper as Robbins, 2016

  • Social isolation after weaning leads to cognitive flexibility deficits that disrupt reward learning.

    “In line with the developmental sensitivity of the prefrontal cortex during adolescence, post-weaning social isolation results in deficits in cognitive flexibility that impair reward learning processes (Fone and Porkess, 2008; Robbins, 2016).”

    From The effects of early life stress on reward processing (2018) · cites this paper as Robbins, 2016

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Authors
Robbins, T.
Affiliations
Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK
Venue
Journal of Psychopharmacology
Published
2016-09-28
Volume
30
Issue
11
Pages
1082-1089
ISSN
  • 0269-8811 (ISSN-L)
  • 1461-7285
OpenAlex
W2524348813
Cited by
31
References
70
Citations by year
2026: 1 · 2025: 1 · 2023: 1 · 2022: 2 · 2021: 3 · 2020: 7 · 2019: 5 · 2018: 6 · 2017: 4 · 2016: 1
FWCI
0.55
Type
journal article
Language
en
Open access
Locations
  • Journal of Psychopharmacology (publishedVersion)
  • PubMed (publishedVersion)
  • Apollo (University of Cambridge) (submittedVersion)
  • Apollo
Funders
  • Wellcome Trust (093875/Z/10/Z, 093875)
  • Medical Research Council (MR/J012084/1)
Topics
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
Keywords
social isolation, social deprivation, early life experience, motivation, cognitive function, dopaminergic system, serotonergic system, hippocampus, cortical structure, animal models of psychiatric disorders, attention deficit hyperactivity disorder, schizophrenia, adolescence, brain development
MeSH terms
Animals, Attention Deficit Disorder with Hyperactivity, Behavior, Animal, Mental Disorders, Cognition, Dopamine, Hippocampus, Humans, Motivation, Rodentia, Schizophrenia, Serotonin, Social Isolation

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