Circadian clock gene polymorphisms in alcohol use disorders and alcohol consumption
Abstract
AIMS: Circadian clock genes are involved in the development of drug-induced behaviors and regulate neurotransmission pathways in addiction. Our aim was to study whether circadian clock gene polymorphisms predispose to alcohol dependence or abuse or other alcohol-related characteristics. METHODS: The study sample comprised of 512 individuals having alcohol dependence or alcohol abuse (according to Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV)) and their 511 age- and sex-matched controls. This population-based sample was drawn from a cohort (n = 7415), representative of the Finnish general population aged 30 and over. Altogether 42 single-nucleotide polymorphisms of 19 genes related to the circadian pacemaker system were genotyped. RESULTS: ARNTL rs6486120 T(+) allelic status (P = 0.0007, q = 0.17), ADCYAP1 rs2856966 GG genotype (P = 0.0006, q = 0.17) and VIP CC haplotype (rs3823082-rs688136) (P = 0.0006) were suggestively associated with alcohol consumption in socially drinking controls. ARNTL2 GT haplotype (rs7958822-rs4964057) associated suggestively with alcohol abuse diagnosis (P = 0.0013). Earlier findings on the associations of DRD2 and NPY with alcohol dependence were supported: DRD2/ANKK1 Taq1A(1) increased (P = 0.04) and NPY Pro7 decreased (P = 0.01) the risk of alcohol dependence. CONCLUSIONS: ARNTL, ARNTL2, VIP and ADCYAP1 were indicated as having influence on alcohol use or abuse. The role of DRD2 and NPY on alcohol dependence was also supported.
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CLOCK variants, particularly the CLOCK 3111T/C polymorphism, are associated with alcohol dependence and increased risk for comorbid depression and alcohol use disorders.
“CLOCK variants, particularly the CLOCK 3111T/C polymorphism, are associated with alcohol dependence (138), and increased risk for comorbid depression and alcohol use disorders (139).”
From Impact of Sleep and Circadian Rhythms on Addiction Vulnerability in Adolescents (2018) · cites this paper as [138]
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- Authors
- Kovanen, L., Saarikoski, S. T., Haukka, J., Pirkola, S., Aromaa, A., Lonnqvist, J., & Partonen, T.
- Affiliations
- Finnish Institute for Health and Welfare (FI)
- Helsinki University Hospital (FI)
- Corresponding author
- Kovanen, L.
- Venue
- Alcohol and Alcoholism
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-06-16
- Volume
- 45
- Issue
- 4
- Pages
- 303-311
- ISSN
- 0735-0414 (ISSN-L)
- 1464-3502
- OpenAlex
- W2139275514
- Cited by
- 138
- References
- 80
- Citations by year
- 2026: 9 · 2025: 4 · 2024: 7 · 2023: 6 · 2022: 7 · 2021: 15 · 2020: 11 · 2019: 12 · 2018: 12 · 2017: 11 · 2016: 7 · 2015: 14 · 2014: 6 · 2013: 12 · 2012: 4
- FWCI
- 2.47
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Alcohol and Alcoholism (publishedVersion)
- PubMed (publishedVersion)
- STM:n Hallinnonalan avoin julkaisuarkisto (Julkari) (submittedVersion)
- Funders
- Yrjö Jahnssonin Säätiö
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Keywords
- clock genes, alcoholism, alcohol abuse, alcohol consumption, single nucleotide polymorphisms, Bmal1, ARNTL2, ADCYAP1, VIP, DRD2, neuropeptide Y, genetic susceptibility, haplotypes, addiction genetics
- MeSH terms
- Adult, Alcohol Drinking, Alcoholism, Circadian Rhythm, Female, Gene Frequency, Genotype, Humans, Interview, Psychological, Male, Middle Aged, Vasoactive Intestinal Peptide, Polymorphism, Single Nucleotide, Pituitary Adenylate Cyclase-Activating Polypeptide, CLOCK Proteins, ARNTL Transcription Factors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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