Cited by 138Circadian rhythm and melatoninNeurotransmitter Receptor Influence on BehaviorSubstance Abuse Treatment and Outcomes

Circadian clock gene polymorphisms in alcohol use disorders and alcohol consumption

Kovanen, L., Saarikoski, S. T., Haukka, J., Pirkola, S., Aromaa, A., Lonnqvist, J., Partonen, T.·2010·Alcohol and Alcoholism

Abstract

AIMS: Circadian clock genes are involved in the development of drug-induced behaviors and regulate neurotransmission pathways in addiction. Our aim was to study whether circadian clock gene polymorphisms predispose to alcohol dependence or abuse or other alcohol-related characteristics. METHODS: The study sample comprised of 512 individuals having alcohol dependence or alcohol abuse (according to Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV)) and their 511 age- and sex-matched controls. This population-based sample was drawn from a cohort (n = 7415), representative of the Finnish general population aged 30 and over. Altogether 42 single-nucleotide polymorphisms of 19 genes related to the circadian pacemaker system were genotyped. RESULTS: ARNTL rs6486120 T(+) allelic status (P = 0.0007, q = 0.17), ADCYAP1 rs2856966 GG genotype (P = 0.0006, q = 0.17) and VIP CC haplotype (rs3823082-rs688136) (P = 0.0006) were suggestively associated with alcohol consumption in socially drinking controls. ARNTL2 GT haplotype (rs7958822-rs4964057) associated suggestively with alcohol abuse diagnosis (P = 0.0013). Earlier findings on the associations of DRD2 and NPY with alcohol dependence were supported: DRD2/ANKK1 Taq1A(1) increased (P = 0.04) and NPY Pro7 decreased (P = 0.01) the risk of alcohol dependence. CONCLUSIONS: ARNTL, ARNTL2, VIP and ADCYAP1 were indicated as having influence on alcohol use or abuse. The role of DRD2 and NPY on alcohol dependence was also supported.

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Crossref · 10.1093/alcalc/agq035

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  • CLOCK variants, particularly the CLOCK 3111T/C polymorphism, are associated with alcohol dependence and increased risk for comorbid depression and alcohol use disorders.

    “CLOCK variants, particularly the CLOCK 3111T/C polymorphism, are associated with alcohol dependence (138), and increased risk for comorbid depression and alcohol use disorders (139).”

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Authors
Kovanen, L., Saarikoski, S. T., Haukka, J., Pirkola, S., Aromaa, A., Lonnqvist, J., & Partonen, T.
Affiliations
  • Finnish Institute for Health and Welfare (FI)
  • Helsinki University Hospital (FI)
Corresponding author
Kovanen, L.
Venue
Alcohol and Alcoholism
Published
2010-06-16
Volume
45
Issue
4
Pages
303-311
ISSN
  • 0735-0414 (ISSN-L)
  • 1464-3502
OpenAlex
W2139275514
Cited by
138
References
80
Citations by year
2026: 9 · 2025: 4 · 2024: 7 · 2023: 6 · 2022: 7 · 2021: 15 · 2020: 11 · 2019: 12 · 2018: 12 · 2017: 11 · 2016: 7 · 2015: 14 · 2014: 6 · 2013: 12 · 2012: 4
FWCI
2.47
Type
journal article
Language
en
Open access
closed
Locations
  • Alcohol and Alcoholism (publishedVersion)
  • PubMed (publishedVersion)
  • STM:n Hallinnonalan avoin julkaisuarkisto (Julkari) (submittedVersion)
Funders
Yrjö Jahnssonin Säätiö
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Keywords
clock genes, alcoholism, alcohol abuse, alcohol consumption, single nucleotide polymorphisms, Bmal1, ARNTL2, ADCYAP1, VIP, DRD2, neuropeptide Y, genetic susceptibility, haplotypes, addiction genetics
MeSH terms
Adult, Alcohol Drinking, Alcoholism, Circadian Rhythm, Female, Gene Frequency, Genotype, Humans, Interview, Psychological, Male, Middle Aged, Vasoactive Intestinal Peptide, Polymorphism, Single Nucleotide, Pituitary Adenylate Cyclase-Activating Polypeptide, CLOCK Proteins, ARNTL Transcription Factors

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