Apoptotic and necrotic cell death induced by death domain receptors

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

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Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade

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Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c

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Apoptosis by Death Factor

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Cleavage of BID by Caspase 8 Mediates the Mitochondrial Damage in the Fas Pathway of Apoptosis

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Molecular characterization of mitochondrial apoptosis-inducing factor

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BCL-2 family members and the mitochondria in apoptosis

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Bid, a Bcl2 Interacting Protein, Mediates Cytochrome c Release from Mitochondria in Response to Activation of Cell Surface Death Receptors

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Smac, a Mitochondrial Protein that Promotes Cytochrome c–Dependent Caspase Activation by Eliminating IAP Inhibition

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A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD

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Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF.

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Apaf-1, a Human Protein Homologous to C. elegans CED-4, Participates in Cytochrome c–Dependent Activation of Caspase-3

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Two CD95 (APO‐1/Fas) signaling pathways

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Mammalian Caspases: Structure, Activation, Substrates, and Functions During Apoptosis

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Programmed Cell Death in Animal Development

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The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme

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The mitochondrial permeability transition

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Identification of DIABLO, a Mammalian Protein that Promotes Apoptosis by Binding to and Antagonizing IAP Proteins

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Noxa, a BH3-Only Member of the Bcl-2 Family and Candidate Mediator of p53-Induced Apoptosis

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THE MITOCHONDRIAL DEATH/LIFE REGULATOR IN APOPTOSIS AND NECROSIS

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Ordering the Cytochrome c–initiated Caspase Cascade: Hierarchical Activation of Caspases-2, -3, -6, -7, -8, and -10 in a Caspase-9–dependent Manner

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Intracellular adenosine triphosphate (ATP) concentration: A switch in the decision between apoptosis and necrosis

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Genetic control of programmed cell death in the nematode C. elegans

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Movement of Bax from the Cytosol to Mitochondria during Apoptosis

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Cell Death in Development

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Chromatin cleavage in apoptosis: Association with condensed chromatin morphology and dependence on macromolecular synthesis

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A receptor for phosphatidylserine-specific clearance of apoptotic cells

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The mitochondrial permeability transition in cell death: a common mechanism in necrosis, apoptosis and autophagy

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Bcl-xL Regulates the Membrane Potential and Volume Homeostasis of Mitochondria

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TUMOR NECROSIS FACTOR RECEPTOR AND Fas SIGNALING MECHANISMS

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Bid-induced Conformational Change of Bax Is Responsible for Mitochondrial Cytochrome c Release during Apoptosis

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Intracellular ATP levels determine cell death fate by apoptosis or necrosis.

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Immature Dendritic Cells Phagocytose Apoptotic Cells via αvβ5 and CD36, and Cross-present Antigens to Cytotoxic T Lymphocytes

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C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2

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Activation of Interferon-γ Inducing Factor Mediated by Interleukin-1β Converting Enzyme

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Bcl-2 inhibits the mitochondrial release of an apoptogenic protease.

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Autoactivation of Procaspase-9 by Apaf-1-Mediated Oligomerization

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Enforced dimerization of BAX results in its translocation, mitochondrial dysfunction and apoptosis

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The coordinate release of cytochrome c during apoptosis is rapid, complete and kinetically invariant

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The Proapoptotic Activity of the Bcl-2 Family Member Bim Is Regulated by Interaction with the Dynein Motor Complex

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Investigation of the subcellular distribution of the bcl-2 oncoprotein: residence in the nuclear envelope, endoplasmic reticulum, and outer mitochondrial membranes.

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Cytotoxic activity of tumor necrosis factor is mediated by early damage of mitochondrial functions. Evidence for the involvement of mitochondrial radical generation.

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Bax interacts with the permeability transition pore to induce permeability transition and cytochrome c release in isolated mitochondria

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Caspase activation: The induced-proximity model

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Inhibition of Caspases Increases the Sensitivity of L929 Cells to Necrosis Mediated by Tumor Necrosis Factor

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Calpain and caspase: can you tell the difference?

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Poly(ADP-ribose) polymerase is a mediator of necrotic cell death by ATP depletion

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Role of Poly(ADP-ribose) Polymerase (PARP) Cleavage in Apoptosis

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Nitric oxide inhibits apoptosis by preventing increases in caspase-3-like activity via two distinct mechanisms

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More than one way to die: apoptosis, necrosis and reactive oxygen damage

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Structural and biochemical basis of apoptotic activation by Smac/DIABLO

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Distinct Caspase Cascades Are Initiated in Receptor-mediated and Chemical-induced Apoptosis

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Dose‐dependent induction of apoptosis in human tumour cell lines by widely diverging stimuli

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Checkpoints of dueling dimers foil death wishes

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Mitochondrio‐nuclear translocation of AIF in apoptosis and necrosis

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The role of phosphatidylserine in recognition of apoptotic cells by phagocytes

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Mitochondria and cell death: Mechanistic aspects and methodological issues

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Mitochondria Are Excitable Organelles Capable of Generating and Conveying Electrical and Calcium Signals

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Fas-Induced Caspase Denitrosylation

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The morphology of various types of cell death in prenatal tissues

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Dual regulation of caspase activity by hydrogen peroxide: implications for apoptosis

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The Central Executioner of Apoptosis: Multiple Connections between Protease Activation and Mitochondria in Fas/APO-1/CD95- and Ceramide-induced Apoptosis

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Regulated Targeting of BAX to Mitochondria

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Direct evidence for tumor necrosis factor-induced mitochondrial reactive oxygen intermediates and their involvement in cytotoxicity.

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Differential Modulation of Apoptosis Sensitivity in CD95 Type I and Type II Cells

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Serotonin and Octopamine in the Nematode Caenorhabditis elegans

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Depletion of the mitochondrial electron transport abrogates the cytotoxic and gene-inductive effects of TNF.

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Inhibition of apoptosis induced by ischemia-reperfusion prevents inflammation

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Dual Signaling of the Fas Receptor: Initiation of Both Apoptotic and Necrotic Cell Death Pathways

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Inhibition of Ced-3/ICE-related Proteases Does Not Prevent Cell Death Induced by Oncogenes, DNA Damage, or the Bcl-2 Homologue Bak

McCarthy, N. J., Whyte, M. K. B., Gilbert, C. S., & Evan, G. I. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.136.1.215 · Cited by 543

The 40-kDa subunit of DNA fragmentation factor induces DNA fragmentation and chromatin condensation during apoptosis

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Bcl-X L interacts with Apaf-1 and inhibits Apaf-1-dependent caspase-9 activation

Hu, Y., Benedict, M. A., Wu, D., Inohara, N., & Núñez, G. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.8.4386 · Cited by 529

Nitric Oxide Reversibly Inhibits Seven Members of the Caspase Family via S-Nitrosylation

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The CARD domain: a new apoptotic signalling motif

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Modulation of cell death by Bcl-x L through caspase interaction

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Bcl-xL Prevents Cell Death following Growth Factor Withdrawal by Facilitating Mitochondrial ATP/ADP Exchange

Heiden, M. G. V., Chandel, N. S., Schumacker, P. T., & Thompson, C. B. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80307-x · Cited by 505

Tumor necrosis factor-induced hepatocyte apoptosis precedes liver failure in experimental murine shock models.

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The permeability transition pore as a mitochondrial calcium release channel: A critical appraisal

Bernardi, P., & Petronilli, V. (1996) · Journal of Bioenergetics and Biomembranes · doi:10.1007/bf02110643 · Cited by 467

Cathepsin D protease mediates programmed cell death induced by interferon-gamma, Fas/APO-1 and TNF-alpha.

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Intracellular K+ Suppresses the Activation of Apoptosis in Lymphocytes

Hughes, F. M., Bortner, C. D., Purdy, G. D., & Cidlowski, J. A. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.48.30567 · Cited by 460

Interleukin 1 is processed and released during apoptosis.

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Role of cytochrome c and dATP/ATP hydrolysis in Apaf-1-mediated caspase-9 activation and apoptosis

Hu, Y. (1999) · The EMBO Journal · doi:10.1093/emboj/18.13.3586 · Cited by 452

S-nitrosylation regulates apoptosis

Melino, G., Bernassola, F., Knight, R. A., Corasaniti, M. T., Nistic, G., & Finazzi-Agr, A. (1997) · Nature · doi:10.1038/41237 · Cited by 446

BH4 domain of antiapoptotic Bcl-2 family members closes voltage-dependent anion channel and inhibits apoptotic mitochondrial changes and cell death

Shimizu, S., Konishi, A., Kodama, T., & Tsujimoto, Y. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.7.3100 · Cited by 433

Nitric Oxide Inhibits Caspase-3 by S-Nitrosationin Vivo

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Acinus is a caspase-3-activated protein required for apoptotic chromatin condensation

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Requirement for GD3 Ganglioside in CD95- and Ceramide-Induced Apoptosis

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Subcellular and submitochondrial mode of action of Bcl-2-like oncoproteins

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The permeability transition pore. Control points of a cyclosporin A-sensitive mitochondrial channel involved in cell death

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Bcl-2 prevents apoptotic mitochondrial dysfunction by regulating proton flux

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Programmed cell death—II. Endocrine potentiation of the breakdown of the intersegmental muscles of silkmoths

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The domains of death: evolution of the apoptosis machinery

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