p600/UBR4 in the central nervous system
Open accessAbstract
A decade ago, the large 600 kDa mammalian protein p600 (also known as UBR4) was discovered as a multifunctional protein with roles in anoikis, viral transformation and protein degradation. Recently, p600 has emerged as a critical protein in the mammalian brain with roles in neurogenesis, neuronal migration, neuronal signaling and survival. How p600 integrates these apparently unrelated functions to maintain tissue homeostasis and murine survival remains unclear. The common molecular basis underlying many of the actions of p600 suggests, however, certain conservation and transposition of these functions across systems. In this review, we summarize the central nervous system functions of p600 and propose new perspectives on its biological complexity in neuronal physiology and neurological diseases.
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UBR4 encodes a ubiquitin ligase that regulates neurogenesis in the developing neocortex and promotes neuronal migration, among other roles.
“UBR4 encodes a ubiquitin ligase that regulates neurogenesis in the developing neocortex and promotes neuronal migration, among other roles [26].”
From Neandertal Introgression Sheds Light on Modern Human Endocranial Globularity (2019) · cites this paper as [26]
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Self-citation
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Neandertal Introgression Sheds Light on Modern Human Endocranial Globularity
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“UBR4 encodes a ubiquitin ligase that regulates neurogenesis in the developing neocortex and promotes neuronal migration, among other roles [26].”
- Authors
- Parsons, K., Nakatani, Y., & Nguyen, M. D.
- Affiliations
- University of Calgary (CA)
- Harvard University (US)
- Corresponding author
- Nguyen, Minh Dang
- ORCID
- Nguyen, Minh Dang
- Venue
- Cellular and Molecular Life Sciences
- Published
- 2014-11-26
- Volume
- 72
- Issue
- 6
- Pages
- 1149-1160
- ISSN
- 1420-682X (ISSN-L)
- 1420-9071
- PMC
- PMC11113099
- OpenAlex
- W2048310301
- Cited by
- 35
- References
- 109
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 2 · 2023: 4 · 2022: 3 · 2021: 1 · 2020: 3 · 2019: 1 · 2018: 7 · 2017: 5 · 2016: 1 · 2015: 1
- FWCI
- 0.24
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Cellular and Molecular Life Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Alberta Innovates - Health Solutions
- Canadian Institutes of Health Research
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- P600, UBR4, central nervous system, neurogenesis, neuronal migration, neuronal signaling, neuronal survival, protein degradation, anoikis, viral transformation, neurological disorders, tissue homeostasis
- MeSH terms
- Animals, Calmodulin-Binding Proteins, Central Nervous System, Cytoskeletal Proteins, Gene Expression Regulation, Humans, Neurons, Protein Structure, Tertiary, Neurodegenerative Diseases, Calcium Signaling, Ubiquitin-Protein Ligases, Neurogenesis
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