Cited by 35Neurogenesis and neuroplasticity mechanismsUbiquitin and proteasome pathwaysGenetics and Neurodevelopmental Disorders

p600/UBR4 in the central nervous system

Open access
Parsons, Kari, Nakatani, Yoshihiro, Nguyen, Minh Dang·2015·Cellular and Molecular Life Sciences

Abstract

A decade ago, the large 600 kDa mammalian protein p600 (also known as UBR4) was discovered as a multifunctional protein with roles in anoikis, viral transformation and protein degradation. Recently, p600 has emerged as a critical protein in the mammalian brain with roles in neurogenesis, neuronal migration, neuronal signaling and survival. How p600 integrates these apparently unrelated functions to maintain tissue homeostasis and murine survival remains unclear. The common molecular basis underlying many of the actions of p600 suggests, however, certain conservation and transposition of these functions across systems. In this review, we summarize the central nervous system functions of p600 and propose new perspectives on its biological complexity in neuronal physiology and neurological diseases.

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Crossref · 10.1007/s00018-014-1788-8

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109 of 109 references verified0 citation errors · 0 not checkable

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  • UBR4 encodes a ubiquitin ligase that regulates neurogenesis in the developing neocortex and promotes neuronal migration, among other roles.

    “UBR4 encodes a ubiquitin ligase that regulates neurogenesis in the developing neocortex and promotes neuronal migration, among other roles [26].”

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Authors
Parsons, K., Nakatani, Y., & Nguyen, M. D.
Affiliations
  • University of Calgary (CA)
  • Harvard University (US)
Corresponding author
Nguyen, Minh Dang
Venue
Cellular and Molecular Life Sciences
Published
2014-11-26
Volume
72
Issue
6
Pages
1149-1160
ISSN
  • 1420-682X (ISSN-L)
  • 1420-9071
OpenAlex
W2048310301
Cited by
35
References
109
Citations by year
2026: 3 · 2025: 4 · 2024: 2 · 2023: 4 · 2022: 3 · 2021: 1 · 2020: 3 · 2019: 1 · 2018: 7 · 2017: 5 · 2016: 1 · 2015: 1
FWCI
0.24
Type
journal article
Language
en
Open access
Locations
  • Cellular and Molecular Life Sciences (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Alberta Innovates - Health Solutions
  • Canadian Institutes of Health Research
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Keywords
P600, UBR4, central nervous system, neurogenesis, neuronal migration, neuronal signaling, neuronal survival, protein degradation, anoikis, viral transformation, neurological disorders, tissue homeostasis
MeSH terms
Animals, Calmodulin-Binding Proteins, Central Nervous System, Cytoskeletal Proteins, Gene Expression Regulation, Humans, Neurons, Protein Structure, Tertiary, Neurodegenerative Diseases, Calcium Signaling, Ubiquitin-Protein Ligases, Neurogenesis

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