The myofibroblast, a key cell in normal and pathological tissue repair

Myofibroblasts and mechano-regulation of connective tissue remodelling

Tomasek, J. J., Gabbiani, G., Hinz, B., Chaponnier, C., & Brown, R. A. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm809 · Cited by 4,290 · see citing works

J. Submicrosc. Cytol. Pathol.

Thomas, A. C., & Campbell, J. H. (2000) · Cited by 2,800 · see citing works

Effects of substrate stiffness on cell morphology, cytoskeletal structure, and adhesion

Yeung, T., Georges, P. C., Flanagan, L. A., Marg, B., Ortiz, M., Funaki, M., Zahir, N., Ming, W., Weaver, V., & Janmey, P. A. (2005) · Cell Motility and the Cytoskeleton · doi:10.1002/cm.20041 · Cited by 2,325 · see citing works

TGF-β signaling and the fibrotic response

Leask, A., & Abraham, D. J. (2004) · The FASEB Journal · doi:10.1096/fj.03-1273rev · Cited by 2,319 · see citing works

Pericyte Loss and Microaneurysm Formation in PDGF-B-Deficient Mice

Lindahl, P., Johansson, B. R., Levéen, P., & Betsholtz, C. (1997) · Science · doi:10.1126/science.277.5323.242 · Cited by 2,226 · see citing works

Transforming growth factor-beta 1 induces alpha-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts

Desmoulière, A., Geinoz, A., Gabbiani, F., & Gabbiani, G. (1993) · The Journal of Cell Biology · doi:10.1083/jcb.122.1.103 · Cited by 2,226 · see citing works

The extracellular matrix modulates the hallmarks of cancer

Pickup, M. W., Mouw, J. K., & Weaver, V. M. (2014) · EMBO Reports · doi:10.15252/embr.201439246 · Cited by 2,014 · see citing works

Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesis.

Yu, Q., & Stamenkovic, I. (2000) · PubMed · Cited by 1,952 · see citing works

Evidence that fibroblasts derive from epithelium during tissue fibrosis

Iwano, M., Plieth, D., Danoff, T. M., Xue, C., Okada, H., & Neilson, E. G. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15518 · Cited by 1,809 · see citing works

Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-β and promotes tumor invasion and angiogenesis

Yu, Q., & Stamenkovic, I. (2000) · Genes & Development · doi:10.1101/gad.14.2.163 · Cited by 1,754 · see citing works

A monoclonal antibody against alpha-smooth muscle actin: a new probe for smooth muscle differentiation.

Skalli, O., Ropraz, P., Trzeciak, A. M., Benzonana, G., Gillessen, D., & Gabbiani, G. (1986) · The Journal of Cell Biology · doi:10.1083/jcb.103.6.2787 · Cited by 1,622 · see citing works

Evidence that fibroblasts derive from epithelium during tissue fibrosis

Iwano, M., Plieth, D., Danoff, T. M., Xue, C., Okada, H., & Neilson, E. G. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215518 · Cited by 1,589 · see citing works

Remodeling and homeostasis of the extracellular matrix: implications for fibrotic diseases and cancer

Cox, T. R., & Erler, J. T. (2011) · Disease Models & Mechanisms · doi:10.1242/dmm.004077 · Cited by 1,569 · see citing works

Presence of modified fibroblasts in granulation tissue and their possible role in wound contraction

Gabbiani, G., Ryan, G. B., & Majno, G. (1971) · Experientia · doi:10.1007/bf02147594 · Cited by 1,485 · see citing works

Hypertrophic Scarring and Keloids: Pathomechanisms and Current and Emerging Treatment Strategies

Gauglitz, G. G., Korting, H. C., Pavicic, T., Ruzicka, T., & Jeschke, M. G. (2011) · Molecular Medicine · doi:10.2119/molmed.2009.00153 · Cited by 1,462 · see citing works

Fate Tracing Reveals the Pericyte and Not Epithelial Origin of Myofibroblasts in Kidney Fibrosis

Humphreys, B. D., Lin, S., Kobayashi, A., Hudson, T. E., Nowlin, B. T., Bonventre, J. V., Valerius, M. T., McMahon, A. P., & Duffield, J. S. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2010.090517 · Cited by 1,447 · see citing works

Fate tracing reveals hepatic stellate cells as dominant contributors to liver fibrosis independent of its aetiology

Mederacke, I., Hsu, C. C., Troeger, J. S., Huebener, P., Mu, X., Dapito, D. H., Pradere, J.-P., & Schwabe, R. F. (2013) · Nature Communications · doi:10.1038/ncomms3823 · Cited by 1,443 · see citing works

Myofibroblast contraction activates latent TGF-β1 from the extracellular matrix

Wipff, P.-J., Rifkin, D. B., Meister, J.-J., & Hinz, B. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200704042 · Cited by 1,346 · see citing works

Interactions between cancer stem cells and their niche govern metastatic colonization

Malanchi, I., Santamaria-Martínez, A., Susanto, E., Peng, H., Lehr, H.-A., Delaloye, J.-F., & Huelsken, J. (2012) · Nature · doi:10.1038/nature10694 · Cited by 1,339 · see citing works

Alpha-smooth muscle actin is transiently expressed by myofibroblasts during experimental wound healing.

Darby, I. A., Skalli, O., & Gabbiani, G. (1990) · PubMed · Cited by 1,180 · see citing works

Apoptosis mediates the decrease in cellularity during the transition between granulation tissue and scar.

Desmoulière, A., Redard, M., Darby, I. A., & Gabbiani, G. (1995) · Europe PMC (PubMed Central) · Cited by 1,173 · see citing works

Identification and characterization of a fibroblast marker: FSP1.

Strutz, F. M., Okada, H., Lo, C. W., Danoff, T. M., Carone, R. L., Tomaszewski, J. E., & Neilson, E. G. (1995) · The Journal of Cell Biology · doi:10.1083/jcb.130.2.393 · Cited by 1,075 · see citing works

Human breast cancer invasion and aggression correlates with ECM stiffening and immune cell infiltration

Acerbi, I., Cassereau, L., Dean, I. S., Shi, Q., Au, A., Park, C., Chen, Y. Y., Liphardt, J., Hwang, E. S., & Weaver, V. M. (2015) · Integrative Biology · doi:10.1039/c5ib00040h · Cited by 1,062 · see citing works

miR-21 mediates fibrogenic activation of pulmonary fibroblasts and lung fibrosis

Liu, G., Friggeri, A., Yang, Y., Milosevic, J., Ding, Q., Thannickal, V. J., Kaminski, N., & Abraham, E. (2010) · Journal of Experimental Medicine · doi:10.1084/jem.20100035 · Cited by 935 · see citing works

PDGF-A signaling is a critical event in lung alveolar myofibroblast development and alveogenesis

Boström, H., Willetts, K., Pekny, M., Levéen, P., Lindahl, P., Hedstrand, H., Pekna, M., Hellström, M., Gebre-Medhin, S., Schalling, M., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81270-2 · Cited by 864 · see citing works

NADPH oxidase-4 mediates myofibroblast activation and fibrogenic responses to lung injury

Hecker, L., Vittal, R., Jones, T., Jagirdar, R., Luckhardt, T. R., Horowitz, J. C., Pennathur, S., Martinez, F. J., & Thannickal, V. J. (2009) · Nature Medicine · doi:10.1038/nm.2005 · Cited by 852 · see citing works

Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis

Kisseleva, T., Cong, M., Paik, Y., Scholten, D., Jiang, C., Benner, C., Iwaisako, K., Moore-Morris, T., Scott, B., Tsukamoto, H., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1201840109 · Cited by 805 · see citing works

Micro-RNA profiling reveals a role for miR-29 in human and murine liver fibrosis

Roderburg, C., Urban, G.-W., Bettermann, K., Vucur, M., Zimmermann, H. W., Schmidt, S., Janssen, J., Koppe, C., Knolle, P. A., Castoldi, M., et al. (2010) · Hepatology · doi:10.1002/hep.23922 · Cited by 802 · see citing works

NAD(P)H Oxidase 4 Mediates Transforming Growth Factor-β1–Induced Differentiation of Cardiac Fibroblasts Into Myofibroblasts

Cucoranu, I., Clempus, R., Dikalova, A., Phelan, P. J., Ariyan, S., Dikalov, S., & Sorescu, D. (2005) · Circulation Research · doi:10.1161/01.res.0000187457.24338.3d · Cited by 786 · see citing works

Aberrant Wnt/β-Catenin Pathway Activation in Idiopathic Pulmonary Fibrosis

Chilosi, M., Poletti, V., Zamò, A., Lestani, M., Montagna, L., Piccoli, P., Pedron, S., Bertaso, M., Scarpa, A., Murer, B., et al. (2003) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)64282-4 · Cited by 708 · see citing works

Focal adhesion size controls tension-dependent recruitment of α-smooth muscle actin to stress fibers

Goffin, J. M., Pittet, P., Csúcs, G., Lussi, J. W., Meister, J.-J., & Hinz, B. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200506179 · Cited by 703 · see citing works

The myofibroblast: Paradigm for a mechanically active cell

Hinz, B. (2009) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2009.09.020 · Cited by 695 · see citing works

Myofibroblast-mediated mechanisms of pathological remodelling of the heart

Weber, K. T., Sun, Y., Bhattacharya, S. K., Ahokas, R. A., & Gerling, I. (2012) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2012.158 · Cited by 670 · see citing works

Neuronal Control of Skin Function: The Skin as a Neuroimmunoendocrine Organ

Roosterman, D., Goerge, T., Schneider, S. W., Bunnett, N. W., & Steinhoff, M. S. (2006) · Physiological Reviews · doi:10.1152/physrev.00026.2005 · Cited by 667 · see citing works

Mechanical Tension Controls Granulation Tissue Contractile Activity and Myofibroblast Differentiation

Hinz, B., Mastrangelo, D., Iselin, C. E., Chaponnier, C., & Gabbiani, G. (2001) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)61776-2 · Cited by 638 · see citing works

Localized scleroderma-response to 1,25-dihydroxyvitamin D3

Humbert, P. G., DUPOND, J. L., ROCHEFORT, A., VASSELET, R., LUCAS, A., Laurent, R., & Agache, P. G. (1990) · Clinical and Experimental Dermatology · doi:10.1111/j.1365-2230.1990.tb02127.x · Cited by 633 · see citing works

Antifibrotic and anti-inflammatory activity of the tyrosine kinase inhibitor nintedanib in experimental models of lung fibrosis

Wollin, L., Maillet, I., Quesniaux, V., Holweg, A., & Ryffel, B. (2014) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.113.208223 · Cited by 633 · see citing works

Neuroinflammation and the generation of neuropathic pain

Ellis, A., & Bennett, D. (2013) · British Journal of Anaesthesia · doi:10.1093/bja/aet128 · Cited by 610 · see citing works

Fibroblast Differentiation in Wound Healing and Fibrosis

Darby, I. A., & Hewitson, T. D. (2007) · International review of cytology · doi:10.1016/s0074-7696(07)57004-x · Cited by 605 · see citing works

Looking Older: Fibroblast Collapse and Therapeutic Implications

Fisher, G. J., Varani, J., & Voorhees, J. J. (2008) · Archives of Dermatology · doi:10.1001/archderm.144.5.666 · Cited by 540 · see citing works

Morphological and immunochemical differences between keloid and hypertrophic scar.

Ehrlich, H. P., Desmoulière, A., Diegelmann, R. F., Cohen, I. K., Compton, C. C., Garner, W. L., Kapançi, Y., & Gabbiani, G. (1994) · PubMed Central · Cited by 532 · see citing works

Mechanical load initiates hypertrophic scar formation through decreased cellular apoptosis

Aarabi, S., Bhatt, K. A., Shi, Y., Paterno, J., Chang, E. I.-F., Loh, S. A., Holmes, J. W., Longaker, M. T., Yee, H. T., & Gurtner, G. C. (2007) · The FASEB Journal · doi:10.1096/fj.07-8218com · Cited by 516 · see citing works

Integrins and the activation of latent transforming growth factor β1 – An intimate relationship

Wipff, P., & Hinz, B. (2008) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2008.01.012 · Cited by 514 · see citing works

Induction of alpha-smooth muscle actin by transforming growth factor-beta 1 in quiescent human breast gland fibroblasts. Implications for myofibroblast generation in breast neoplasia.

Rønnov‐Jessen, L., & PETERSEN, O. W. (1993) · PubMed · Cited by 514 · see citing works

Integrin αVβ6-mediated activation of latent TGF-β requires the latent TGF-β binding protein-1

Annes, J. P., Chen, Y., Munger, J. S., & Rifkin, D. B. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200312172 · Cited by 500 · see citing works

The cutaneous sensory system

McGlone, F. P., & Reilly, D. M. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.08.004 · Cited by 470 · see citing works

Thrombospondin causes activation of latent transforming growth factor- beta secreted by endothelial cells by a novel mechanism [published erratum appears in J Cell Biol 1993 Sep;122(5):following 1143]

Schultz‐Cherry, S. (1993) · The Journal of Cell Biology · doi:10.1083/jcb.122.4.923 · Cited by 468 · see citing works

Myofibroblasts

Hinz, B. (2016) · Experimental Eye Research · doi:10.1016/j.exer.2015.07.009 · Cited by 424 · see citing works

Partial Inhibition of Integrin αvβ6 Prevents Pulmonary Fibrosis without Exacerbating Inflammation

Horan, G. S., Wood, S., Ona, V., Li, D. J., Lukashev, M. E., Weinreb, P. H., Simon, K. J., Hahm, K., Allaire, N. E., Rinaldi, N. J., et al. (2008) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200706-805oc · Cited by 420 · see citing works

Lineage tracing and genetic ablation of ADAM12(+) perivascular cells identify a major source of profibrotic cells during acute tissue injury

Dulauroy, S., Di Carlo, S. E., Langa, F., Eberl, G., & Peduto, L. (2012) · Nature Medicine · doi:10.1038/nm.2848 · Cited by 418 · see citing works

Epithelial cell α3β1 integrin links β-catenin and Smad signaling to promote myofibroblast formation and pulmonary fibrosis

Kim, K. K., Wei, Y., Szekeres, C. K., Kugler, M. C., Wolters, P. J., Hill, M. L., Frank, J. A., Brumwell, A. N., Wheeler, S. E., Kreidberg, J. A., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci36940 · Cited by 399 · see citing works

Tubular epithelial-myofibroblast transdifferentiation in progressive tubulointerstitial fibrosis in 5/6 nephrectomized rats

Ng, Y.-Y., Huang, T., Yang, W.-C., Chen, Z.-P., Yang, A., Mu, W., Nikolic‐Paterson, D. J., Atkins, R. C., & Lan, H. Y. (1998) · Kidney International · doi:10.1046/j.1523-1755.1998.00076.x · Cited by 396 · see citing works

Tenascin-C induced signaling in cancer

Orend, G., & Chiquet-Ehrismann, R. (2006) · Cancer Letters · doi:10.1016/j.canlet.2006.02.017 · Cited by 384 · see citing works

Effect of pirfenidone on proliferation, TGF-β-induced myofibroblast differentiation and fibrogenic activity of primary human lung fibroblasts

Conte, E., Gili, E., Fagone, E., Fruciano, M., Iemmolo, M., & Vancheri, C. (2014) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2014.02.014 · Cited by 368 · see citing works

Interstitial fluid flow induces myofibroblast differentiation and collagen alignment in vitro

Ng, C. P., Hinz, B., & Swartz, M. A. (2005) · Journal of Cell Science · doi:10.1242/jcs.02605 · Cited by 360 · see citing works

Angiotensin II Stimulated Expression of Transforming Growth Factor-β1in Cardiac Fibroblasts and Myofibroblasts

Campbell, S. E., & Katwa, L. C. (1997) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.1997.0435 · Cited by 357 · see citing works

Inhibition of Myofibroblast Apoptosis by Transforming Growth Factor β1

Zhang, H. Y., & Phan, S. H. (1999) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.21.6.3720 · Cited by 354 · see citing works

Stromal Myofibroblasts Predict Disease Recurrence for Colorectal Cancer

辻野, 督., Seshimo, I., Yamamoto, H., Ngan, C. Y., Ezumi, K., Takemasa, I., Ikeda, M., Sekimoto, M., Matsuura∥, N., & Monden, M. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-2191 · Cited by 352 · see citing works

Platelet-derived growth factor receptor signaling activates pericyte–myofibroblast transition in obstructive and post-ischemic kidney fibrosis

Chen, Y., Chang, F., Wu, C.-F., Chou, Y., Hsu, H., Chiang, W., Shen, J., Chen, Y., Wu, K., Tsai, T., et al. (2011) · Kidney International · doi:10.1038/ki.2011.208 · Cited by 341 · see citing works

Transforming growth factor β as a therapeutic target in systemic sclerosis

Varga, J., & Pasche, B. (2009) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2009.26 · Cited by 295 · see citing works

The Nano-Scale Mechanical Properties of the Extracellular Matrix Regulate Dermal Fibroblast Function

Achterberg, V., Buscemi, L., Diekmann, H., Smith-Clerc, J., Schwengler, H., Meister, J.-J., Wenck, H., Gallinat, S., & Hinz, B. (2014) · Journal of Investigative Dermatology · doi:10.1038/jid.2014.90 · Cited by 288 · see citing works

Histopathological Differential Diagnosis of Keloid and Hypertrophic Scar

Lee, J. Y., Yang, C., Chao, S., & Wong, T. (2004) · American Journal of Dermatopathology · doi:10.1097/00000372-200410000-00006 · Cited by 281 · see citing works

Mechanical force regulation of myofibroblast differentiation in cardiac fibroblasts

Wang, J., Chen, H., Seth, A. K., & McCulloch, C. A. (2003) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00387.2003 · Cited by 269 · see citing works

A Case of Multiple Spontaneous Keloid Scars

Jfri, A. H., Rajeh, N., & Karkashan, E. M. (2015) · Case Reports in Dermatology · doi:10.1159/000437249 · Cited by 263 · see citing works

The Single-Molecule Mechanics of the Latent TGF-β1 Complex

Buscemi, L., Ramonet, D., Klingberg, F., Formey, A., Smith-Clerc, J., Meister, J.-J., & Hinz, B. (2011) · Current Biology · doi:10.1016/j.cub.2011.11.037 · Cited by 257 · see citing works

The myofibroblast: phenotypic characterization as a prerequisite to understanding its functions in translational medicine

Eyden, B. P. (2007) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2007.00213.x · Cited by 252 · see citing works

Smoothelin, a novel cytoskeletal protein specific for smooth muscle cells.

van der Loop, F. T. L., Schaart, G., Timmer, E. D. J., Ramaekers, F. C. S., & van Eys, G. J. J. M. (1996) · The Journal of Cell Biology · doi:10.1083/jcb.134.2.401 · Cited by 251 · see citing works

Emerging Concepts in the Pathogenesis of Lung Fibrosis

Hardie, W. D., Glasser, S. W., & Hagood, J. S. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2009.081170 · Cited by 239 · see citing works

Novel mechanisms for the antifibrotic action of nintedanib

Rangarajan, S., Kurundkar, A., Kurundkar, D., Bernard, K., Sanders, Y. Y., Ding, Q., Antony, V. B., Zhang, J., Zmijewski, J., & Thannickal, V. J. (2016) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2014-0445oc · Cited by 238 · see citing works

miR-21 promotes renal fibrosis in diabetic nephropathy by targeting PTEN and SMAD7

McClelland, A., Herman‐Edelstein, M., Komers, R., Jha, J. C., Winbanks, C. E., Hagiwara, S., Gregorevic, P., Kantharidis, P., & Cooper, M. E. (2015) · Clinical Science · doi:10.1042/cs20150427 · Cited by 236 · see citing works

Myofibroblast development is characterized by specific cell-cell adherens junctions

Hinz, B., Pittet, P., Smith-Clerc, J., Chaponnier, C., & Meister, J.-J. (2004) · Molecular Biology of the Cell · doi:10.1091/mbc.e04-05-0386 · Cited by 231 · see citing works

The NH2-terminal peptide of α–smooth muscle actin inhibits force generation by the myofibroblast in vitro and in vivo

Hinz, B., Gabbiani, G., & Chaponnier, C. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200201049 · Cited by 226 · see citing works

Prestress in the extracellular matrix sensitizes latent TGF-β1 for activation

Klingberg, F., Chow, M. L., Koehler, A., Boo, S., Buscemi, L., Quinn, T. M., Costell, M., Alman, B. A., Genot, E. M., & Hinz, B. (2014) · The Journal of Cell Biology · doi:10.1083/jcb.201402006 · Cited by 222 · see citing works

Increased formation of pyridinoline cross-links due to higher telopeptide lysyl hydroxylase levels is a general fibrotic phenomenon

van der Slot, A. J., Zuurmond, A., van den Bogaerdt, A. J., Ulrich, M. M. W., Middelkoop, E., BOERS, W., Ronday, H. K., DeGroot, J., Huizinga, T. W. J., & Bank, R. A. (2004) · Matrix Biology · doi:10.1016/j.matbio.2004.06.001 · Cited by 214 · see citing works

Expression of α-Smooth Muscle Actin Determines the Fate of Mesenchymal Stromal Cells

Talele, N. P., Fradette, J., Davies, J. E., Kapùs, A., & Hinz, B. (2015) · Stem Cell Reports · doi:10.1016/j.stemcr.2015.05.004 · Cited by 210 · see citing works

Inhibition of focal adhesion kinase prevents experimental lung fibrosis and myofibroblast formation

Lagares, D., Busnadiego, Ó., García-Fernández, R. A., Kapoor, M., Liu, S., Carter, D. E., Abraham, D., Shiwen, X., Carreira, P. E., Fontaine, B. A., et al. (2011) · Arthritis & Rheumatism · doi:10.1002/art.33482 · Cited by 192 · see citing works

Neurotrophins in Skin Biology and Pathology

Botchkarev, V. A., Yaar, M., Peters, E. M. J., Raychaudhuri, S. P., Botchkareva, N. V., Marconi, A., Raychaudhuri, S. K., Paus, R., & Pincelli, C. (2006) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700270 · Cited by 191 · see citing works

Studies on Wound Healing, with Special Reference to the Phenomenon of Contracture in Experimental Wounds in Rabbitsʼ Skin*

Billingham, R. E., & Russell, P. S. (1956) · Annals of Surgery · doi:10.1097/00000658-195612000-00005 · Cited by 181 · see citing works

Pruritus, pain, and small nerve fiber function in keloids: A controlled study

Lee, S.-S., Yosipovitch, G., Chan, Y.-H., & Goh, C. (2004) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2004.07.054 · Cited by 180 · see citing works

Differences in the Regulation of Fibroblast Contraction of Floating Versus Stressed Collagen Matrices

Grinnell, F., Ho, C.-H., Lin, Y., & Skuta, G. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.2.918 · Cited by 178 · see citing works

Increased Expression of Integrin αvβ5 Induces the Myofibroblastic Differentiation of Dermal Fibroblasts

Asano, Y., Ihn, H., Yamane, K., Jinnin, M., & Tamaki, K. (2006) · The American Journal of Pathology · doi:10.2353/ajpath.2006.041306 · Cited by 175 · see citing works

Pirfenidone improves renal function and fibrosis in the post-obstructed kidney

Shimizu, T., Kuroda, T., Hata, S., Fukagawa, M., Margolin, S. B., & Kurokawa, K. (1998) · Kidney International · doi:10.1046/j.1523-1755.1998.00962.x · Cited by 161 · see citing works

Inhibition of pulmonary fibrosis in mice by CXCL10 requires glycosaminoglycan binding and syndecan-4

Jiang, D., Liang, J., Campanella, G. S. V., Guo, R., Yu, S., Xie, T., Liu, N., Jung, Y., Homer, R., Meltzer, E. B., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci38644 · Cited by 159 · see citing works

Locally applied GM-CSF induces the accumulation of α-smooth muscle act in containing myofibroblasts

Rubbia‐Brandt, L., Sappino, A., & Gabbiani, G. (1991) · Virchows Archiv B Cell Pathology Including Molecular Pathology · doi:10.1007/bf02899530 · Cited by 155 · see citing works

EW-7197 inhibits hepatic, renal, and pulmonary fibrosis by blocking TGF-β/Smad and ROS signaling

Park, S.-A., Kim, M.-J., Park, S.-Y., Kim, J.-S., Lee, S., Woo, H. A., Kim, D.-K., Nam, J., & Sheen, Y. Y. (2014) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-014-1798-6 · Cited by 154 · see citing works

Reversible differentiation of myofibroblasts by MyoD

Hecker, L., JAGIRDAR, R. M., Jin, T., & Thannickal, V. J. (2011) · Experimental Cell Research · doi:10.1016/j.yexcr.2011.03.016 · Cited by 153 · see citing works

The Fibroblast Integrin α11β1 Is Induced in a Mechanosensitive Manner Involving Activin A and Regulates Myofibroblast Differentiation

Carracedo, S., Lü, N., Popova, S. N., Jonsson, R., Eckes, B., & Gullberg, D. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.078766 · Cited by 145 · see citing works

Keloid and hypertrophic scar: Neurogenic inflammation hypotheses

Akaishi, S., Ogawa, R., & Hyakusoku, H. (2008) · Medical Hypotheses · doi:10.1016/j.mehy.2008.01.032 · Cited by 143 · see citing works

Connective tissue growth factor (CCN2, CTGF) and organ fibrosis: lessons from transgenic animals

Brigstock, D. R. (2009) · Journal of Cell Communication and Signaling · doi:10.1007/s12079-009-0071-5 · Cited by 134 · see citing works

Heparin induces alpha-smooth muscle actin expression in cultured fibroblasts and in granulation tissue myofibroblasts.

Desmoulière, A., Rubbia‐Brandt, L., Grau, G. E., & Gabbiani, G. (1992) · PubMed · Cited by 134 · see citing works

Relaxin Prevents Cardiac Fibroblast-Myofibroblast Transition via Notch-1-Mediated Inhibition of TGF-β/Smad3 Signaling

Sassoli, C., Chellini, F., Pini, A., Tani, A., Nistri, S., Nosi, D., Zecchi‐Orlandini, S., Bani, D., & Formigli, L. (2013) · PLoS ONE · doi:10.1371/journal.pone.0063896 · Cited by 129 · see citing works

CICATRIZATION OF WOUNDS

Carrel, A., & Hartmann, A. (1916) · The Journal of Experimental Medicine · doi:10.1084/jem.24.5.429 · Cited by 129 · see citing works

Effect of γ-Interferon on the Clinical and Biologic Evolution of Hypertrophic Scars and Dupuytrenʼs Disease

Pittet, B., Rubbia‐Brandt, L., Desmoulière, A., Sappino, A., Roggero, P., Grimaud, J.-A., Montandon, D., & Gabbiani, G. (1994) · Plastic & Reconstructive Surgery · doi:10.1097/00006534-199405000-00018 · Cited by 129 · see citing works

Regulation of myofibroblast activities: Calcium pulls some strings behind the scene

Castella, L. F., Gabbiani, G., McCulloch, C. A., & Hinz, B. (2010) · Experimental Cell Research · doi:10.1016/j.yexcr.2010.04.033 · Cited by 123 · see citing works

Myofibroblast communication is controlled by intercellular mechanical coupling

Castella, L. F., Schaub, S., Meister, J.-J., & Hinz, B. (2008) · Journal of Cell Science · doi:10.1242/jcs.024521 · Cited by 121 · see citing works

Perspective of Targeting Cancer-Associated Fibroblasts in Melanoma

Zhou, L., YANG, K. Y., Andl, T., Wickett, R. R., & Zhang, Y. (2015) · Journal of Cancer · doi:10.7150/jca.10865 · Cited by 118 · see citing works

Thy-1-Integrin αvβ5 Interactions Inhibit Lung Fibroblast Contraction-induced Latent Transforming Growth Factor-β1 Activation and Myofibroblast Differentiation

Zhou, Y., Hagood, J. S., Lu, B., Merryman, W. D., & Murphy-Ullrich, J. E. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.126227 · Cited by 118 · see citing works

Advantage of the Presence of Living Dermal Fibroblasts within in Vitro Reconstructed Skin for Grafting in Humans

Coulomb, B., Friteau, L., Baruch, J. P., Guilbaud, J., Chrétien-Marquet, B., Glicenstein, J., Lebreton, C., Bell, E., & Dubertret, L. (1998) · Plastic & Reconstructive Surgery · doi:10.1097/00006534-199806000-00018 · Cited by 108 · see citing works

Fibroblasts emerge via epithelial-mesenchymal transition in chronic kidney fibrosis

Zeisberg, M. (2008) · Frontiers in bioscience · doi:10.2741/3204 · Cited by 106 · see citing works

Delayed stress fiber formation mediates pulmonary myofibroblast differentiation in response to TGF-β

Sandbo, N. K., Lau, A., Kach, J., Ngam, C. R., Yau, D. M., & Dulin, N. O. (2011) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00166.2011 · Cited by 104 · see citing works

Influence of sensory neuropeptides on human cutaneous wound healing process

Chéret, J., Lebonvallet, N., Buhé, V., Carre, J. L., Misery, L., & Le Gall-Ianotto, C. (2014) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2014.02.001 · Cited by 103 · see citing works

Extracellular matrix players in metastatic niches

Óskarsson, T., & Massagué, J. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.469 · Cited by 100 · see citing works

Correlation between the distribution of smooth muscle or non muscle myosins and α‐smooth muscle actin in normal and pathological soft tissues

Benzonana, G., Skalli, O., & Gabbiani, G. (1988) · Cell Motility and the Cytoskeleton · doi:10.1002/cm.970110405 · Cited by 100 · see citing works

Sensory Peptides as Neuromodulators of Wound Healing in Aged Rats

Khalil, Z. G., & Helme, R. D. (1996) · The Journals of Gerontology Series A · doi:10.1093/gerona/51a.5.b354 · Cited by 99 · see citing works

Relaxin Regulates Myofibroblast Contractility and Protects against Lung Fibrosis

Huang, X., Gai, Y., Yang, N., Lu, B., Samuel, C. S., Thannickal, V. J., & Zhou, Y. (2011) · American Journal Of Pathology · doi:10.1016/j.ajpath.2011.08.018 · Cited by 94 · see citing works

miR-21 Induces Myofibroblast Differentiation and Promotes the Malignant Progression of Breast Phyllodes Tumors

Gong, C., Nie, Y., Qu, S., Liao, J.-Y., Cui, X., Yao, H., Zeng, Y., Su, F., Song, E., & Liu, Q. (2014) · Cancer Research · doi:10.1158/0008-5472.can-14-0125 · Cited by 93 · see citing works

Studies in Wound Healing

Watts, G. T., Grillo, H. C., & Gross, J. (1958) · Annals of Surgery · doi:10.1097/00000658-195808000-00002 · Cited by 91 · see citing works

The complex dialogue between (myo)fibroblasts and the extracellular matrix during skin repair processes and ageing

Vedrenne, N., Coulomb, B., Danigo, A., Bonté, F., & Desmoulière, A. (2012) · Pathologie Biologie · doi:10.1016/j.patbio.2011.10.002 · Cited by 89 · see citing works

Making sense of hypertrophic scar: a role for nerves

Scott, J. R., Muangman, P., & Gibran, N. S. (2007) · Wound Repair and Regeneration · doi:10.1111/j.1524-475x.2007.00222.x · Cited by 89 · see citing works

Myofibroblasts contribute to but are not necessary for wound contraction

Ibrahim, M. M., Chen, L., Bond, J. E., Medina, M. A., Ren, L., Kokosis, G., Selim, A. M., & Levinson, H. (2015) · Laboratory Investigation · doi:10.1038/labinvest.2015.116 · Cited by 88 · see citing works

Hypoxia Impairs Skin Myofibroblast Differentiation and Function

Modarressi, A., Pietramaggiori, G., Godbout, C., Vigato, E., Pittet, B., & Hinz, B. (2010) · Journal of Investigative Dermatology · doi:10.1038/jid.2010.224 · Cited by 87 · see citing works

Treatment of Peyronie's disease with PDE5 inhibitors: an antifibrotic strategy

González-Cadavid, N. F., & Rajfer, J. (2010) · Nature Reviews Urology · doi:10.1038/nrurol.2010.24 · Cited by 86 · see citing works

Inhibition of rat liver fibrogenesis through noradrenergic antagonism

Dubuisson, L., Desmoulière, A., Decourt, B., Evadé, L., Bedin, C., Boussarie, L., Barrier, L., Vidaud, M., & Rosenbaum, J. (2002) · Hepatology · doi:10.1053/jhep.2002.31166 · Cited by 85 · see citing works

Defining therapeutic targets for liver fibrosis: Exploiting the biology of inflammation and repair

Iredale, J. P. (2008) · Pharmacological Research · doi:10.1016/j.phrs.2008.06.011 · Cited by 80 · see citing works

Topical application of substance P promotes wound healing in streptozotocin-induced diabetic rats

Kant, V., Kumar, D., Kumar, D., Prasad, R., Gopal, A., Pathak, N. N., Kumar, P., & Tandan, S. K. (2015) · Cytokine · doi:10.1016/j.cyto.2014.12.015 · Cited by 79 · see citing works

The myofibroblast: a study of normal, reactive and neoplastic tissues, with an emphasis on ultrastructure.

Eyden, B. P. (2007) · PubMed · Cited by 77 · see citing works

Role of neurotrophins on dermal fibroblast survival and differentiation

Palazzo, E., Marconi, A., Truzzi, F., Dallaglio, K., Petrachi, T., Humbert, P. G., Schnebert, S., Perrier, É., Dumas, M., & Pincelli, C. (2011) · Journal of Cellular Physiology · doi:10.1002/jcp.22811 · Cited by 77 · see citing works

Neuropeptide-containing nerves in painful hypertrophic human scar tissue

CROWE, R., Parkhouse, N., McGrouther, D. A., & Burnstock, G. (1994) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1994.tb03376.x · Cited by 74 · see citing works

Nox-2 Is a Modulator of Fibrogenesis in Kidney Allografts

Djamali, A., Vidyasagar, A., Adulla, M., Hullett, D. A., & Reese, S. R. (2008) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2008.02463.x · Cited by 73 · see citing works

Physiological ER Stress Mediates the Differentiation of Fibroblasts

Matsuzaki, S., Hiratsuka, T., Taniguchi, M., Shingaki, K., Kubo, T., Kiya, K., 藤原敏宏, Kanazawa, S., Kanematsu, R., Maeda, T., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0123578 · Cited by 70 · see citing works

Collagen Formation and Wound Contraction during Repair of Small Excised Wounds in the Skin of Rats

Abercrombie, M., Flint, M. H., & James, D. W. (1954) · Development · doi:10.1242/dev.2.3.264 · Cited by 67 · see citing works

The α4β1 integrin and the EDA domain of fibronectin regulate a profibrotic phenotype in dermal fibroblasts

Shinde, A. V., Kelsh, R., Peters, J. H., Sekiguchi, K., Water, L. V. D., & McKeown‐Longo, P. J. (2014) · Matrix Biology · doi:10.1016/j.matbio.2014.11.004 · Cited by 65 · see citing works

The myofibroblast: a study of normal, reactive and neoplastic tissues, with an emphasis on ultrastructure. Part 1--normal and reactive cells.

Eyden, B. P. (2005) · PubMed · Cited by 63 · see citing works

Acetylcholine promotes the proliferation and collagen gene expression of myofibroblastic hepatic stellate cells

Oben, J. A., Yang, S., Lin, H., Ono, M., & Diehl, A. M. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)02773-0 · Cited by 61 · see citing works

Topically applied substance P enhanced healing of open excision wound in rats

Kant, V., Gopal, A., Kumar, D., Bag, S., Kurade, N. P., Kumar, A., Tandan, S. K., & Kumar, D. (2013) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2013.04.042 · Cited by 60 · see citing works

Force-induced Myofibroblast Differentiation through Collagen Receptors Is Dependent on Mammalian Diaphanous (mDia)

Chan, M. W. C., Chaudary, F., Lee, W., Copeland, J. W. R., & McCulloch, C. A. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.075218 · Cited by 60 · see citing works

BLOCKADE OF β1‐ AND β2‐ADRENOCEPTORS DELAYS WOUND CONTRACTION AND RE‐EPITHELIALIZATION IN RATS

Romana‐Souza, B., dos Santos, J. S., & Monte‐Alto‐Costa, A. (2006) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2006.04383.x · Cited by 59 · see citing works

Stromal Fibroblast in Age-Related Cancer: Role in Tumorigenesis and Potential as Novel Therapeutic Target

El‐Khattouti, A., Hassan, M., & Gómez, C. R. (2015) · Frontiers in Oncology · doi:10.3389/fonc.2015.00158 · Cited by 56 · see citing works

Changes in cutaneous innervation in patients with chronic pain after burns

Hamed, K., Giles, N. L., Anderson, J. R., Phillips, J. K., Dawson, L. F., Drummond, P. D., Wallace, H. J., Wood, F. M., Rea, S. M., & Fear, M. W. (2011) · Burns · doi:10.1016/j.burns.2010.11.010 · Cited by 56 · see citing works

Sympathetic denervation accelerates wound contraction but delays reepithelialization in rats

Romana‐Souza, B., Cardoso, J. F., Amadeu, T. P., Desmoulière, A., & Monte‐Alto‐Costa, A. (2005) · Wound Repair and Regeneration · doi:10.1111/j.1067-1927.2005.00070.x · Cited by 53 · see citing works

Transforming growth factor-β1differentially mediates fibronectin and inflammatory cytokine expression in kidney tubular cells

Qi, W., Chen, X., Holian, J., Mreich, E., Twigg, S., Gilbert, R. E., & Pollock, C. A. (2006) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00013.2006 · Cited by 48 · see citing works

Endothelin-1 Induces Bronchial Myofibroblast Differentiation

Sun, G. Y., Stacey, M. A., Bellini, A., Marini, M. A., & Mattoli, S. (1997) · Peptides · doi:10.1016/s0196-9781(97)00194-0 · Cited by 47 · see citing works

Human dermal and gingival fibroblasts in a three-dimensional culture: a comparative study on matrix remodeling

Chaussain, C., Septier, D., Bonnefoix, M., Lécolle, S., Lebreton, C., Coulomb, B., Pellat, B., & Godeau, G. (2002) · Clinical Oral Investigations · doi:10.1007/s00784-001-0143-2 · Cited by 46 · see citing works

Emerging cellular and molecular targets in fibrosis

Castelino, F. V., & Varga, J. (2014) · Current Opinion in Rheumatology · doi:10.1097/bor.0000000000000110 · Cited by 45 · see citing works

Brief Report: Fibrosis Caused by Loss of PTEN Expression in Mouse Fibroblasts Is Crucially Dependent on CCN2

Liu, S., Parapuram, S. K., & Leask, A. (2013) · Arthritis & Rheumatism · doi:10.1002/art.38121 · Cited by 44 · see citing works

Chronic inhibition of cyclic guanosine monophosphate-specific phosphodiesterase 5 prevented cardiac fibrosis through inhibition of transforming growth factor β-induced Smad signaling

Gong, W., Yan, M., Chen, J., Chaugai, S., Chen, C., & Wang, D. W. (2014) · Frontiers of Medicine · doi:10.1007/s11684-014-0378-3 · Cited by 42 · see citing works

Nerve fibres: a possible role in keloid pathogenesis

Hochman, B., Nahas, F. X., Sobral, C. S., Arias, V., Locali, R. F., Juliano, Y., & Ferreira, L. M. (2008) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2007.08401.x · Cited by 40 · see citing works

Blockade of PDGF receptor signaling reduces myofibroblast number and attenuates renal fibrosis

LeBleu, V. S., & Kalluri, R. K. (2011) · Kidney International · doi:10.1038/ki.2011.300 · Cited by 38 · see citing works

Relationships between nerves and myofibroblasts during cutaneous wound healing in the developing rat

Liu, M., Warn, J. D., Fan, Q., Smith, P. G., & Smith, R. L. (1999) · Cell and Tissue Research · doi:10.1007/s004410051369 · Cited by 38 · see citing works

Direct contact of fibroblasts with neuronal processes promotes differentiation to myofibroblasts and induces contraction of collagen matrix in vitro

Fujiwara, T., Kubo, T., Kanazawa, S., Shingaki, K., Taniguchi, M., Matsuzaki, S., Gurtner, G. C., Tohyama, M., & Hosokawa, K. (2013) · Wound Repair and Regeneration · doi:10.1111/wrr.12059 · Cited by 31 · see citing works

Proteomic Analysis of Differentially Expressed Proteins in Peripheral Cholangiocarcinoma

Darby, I. A., Vuillier-Devillers, K., Pinault, É., Sarrazy, V., Lepreux, S., Balabaud, C. P., Bioulac‐Sage, P., & Desmoulière, A. (2010) · Cancer Microenvironment · doi:10.1007/s12307-010-0047-2 · Cited by 27 · see citing works

Innovative approaches to the therapy of fibrosis

de Andrade, J. A., & Thannickal, V. J. (2009) · Current Opinion in Rheumatology · doi:10.1097/bor.0b013e328330da9b · Cited by 22 · see citing works

Effect of cholinergic denervation on hepatic fibrosis induced by carbon tetrachloride in rats

Lam, H.-B., Yeh, C., Cheng, K., Hsu, C., & Cheng, J. (2008) · Neuroscience Letters · doi:10.1016/j.neulet.2008.04.048 · Cited by 21 · see citing works

Cancer-associated fibroblasts in the single-cell era

Lavie, D., Ben‐Shmuel, A., Erez, N., & Scherz‐Shouval, R. (2022) · Nature Cancer · doi:10.1038/s43018-022-00411-z · Cited by 636 · see citing works

The role of α-smooth muscle actin in fibroblast-mediated matrix contraction and remodeling

Shinde, A. V., Humeres, C. D., & Frangogiannis, N. G. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2016.11.006 · Cited by 575 · see citing works

NOX4 inhibition potentiates immunotherapy by overcoming cancer-associated fibroblast-mediated CD8 T-cell exclusion from tumors

Ford, K., Hanley, C. J., Mellone, M., Szyndralewiez, C., Heitz, F., Wiesel, P., Wood, O., Machado, M., Lopez, M.-A., Ganesan, A.-P., et al. (2020) · Cancer Research · doi:10.1158/0008-5472.can-19-3158 · Cited by 411 · see citing works

Epithelial-Mesenchymal Transition (EMT): The Type-2 EMT in Wound Healing, Tissue Regeneration and Organ Fibrosis

Marconi, G. D., Fonticoli, L., Rajan, T. S., Pierdomenico, S. D., Trubiani, O., Pizzicannella, J., & Diomede, F. (2021) · Cells · doi:10.3390/cells10071587 · Cited by 423 · see citing works

Skeletal muscle fibrosis: an overview

Mahdy, M. A. A. (2018) · Cell and Tissue Research · doi:10.1007/s00441-018-2955-2 · Cited by 320 · see citing works

Resolution of organ fibrosis

Jun, J.-I., & Lau, L. F. (2018) · Journal of Clinical Investigation · doi:10.1172/jci93563 · Cited by 348 · see citing works

Mechanical and Physical Regulation of Fibroblast–Myofibroblast Transition: From Cellular Mechanoresponse to Tissue Pathology

D’Urso, M., & Kurniawan, N. A. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.609653 · Cited by 281 · see citing works

Muscle injuries and strategies for improving their repair

Laumonier, T., & Ménétrey, J. (2016) · Journal of Experimental Orthopaedics · doi:10.1186/s40634-016-0051-7 · Cited by 276 · see citing works

Upper and lower airway remodelling mechanisms in asthma, allergic rhinitis and chronic rhinosinusitis: The one airway concept revisited

Samitas, Κ., Carter, A., Kariyawasam, H. H., & Xanthou, G. (2017) · Allergy · doi:10.1111/all.13373 · Cited by 271 · see citing works

The IL-4/IL-13 axis in skin fibrosis and scarring: mechanistic concepts and therapeutic targets

Nguyen, J. K., Austin, E., Huang, A., Mamalis, A., & Jagdeo, J. R. (2019) · Archives of Dermatological Research · doi:10.1007/s00403-019-01972-3 · Cited by 234 · see citing works

Dynamics of cellular states of fibro-adipogenic progenitors during myogenesis and muscular dystrophy

Malecová, B., Gatto, S., Etxaniz, U., Passafaro, M., Cortez, A., Nicoletti, C., Giordani, L., Torcinaro, A., Bardi, M. D., Bicciato, S., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-06068-6 · Cited by 221 · see citing works

Origin and Consequences of Necroinflammation

Sarhan, M., Land, W. G., Tonnus, W., Hugo, C., & Linkermann, A. (2018) · Physiological Reviews · doi:10.1152/physrev.00041.2016 · Cited by 210 · see citing works

Skin Changes During Ageing

Bonté, F., Girard, D., Archambault, J.-C., & Desmoulière, A. (2019) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-981-13-3681-2_10 · Cited by 215 · see citing works

Current and upcoming therapies to modulate skin scarring and fibrosis.

Coentro, J. Q., Pugliese, E., Hanley, G., Raghunath, M., & Zeugolis, D. (2019) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2018.08.009 · Cited by 184 · see citing works

Drug targeting to myofibroblasts: Implications for fibrosis and cancer

Yazdani, S., Bansal, R., & Prakash, J. (2017) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2017.07.010 · Cited by 186 · see citing works

Mechanical stretch promotes hypertrophic scar formation through mechanically activated cation channel Piezo1

He, J., Fang, B., Shan, S., Xie, Y., Wang, C., Zhang, Y., Zhang, X., & Li, Q. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-03481-6 · Cited by 172 · see citing works

Fibroblast-to-myofibroblast transition in bronchial asthma

Michalik, M., Wójcik‐Pszczoła, K., Paw, M., Wnuk, D., Koczurkiewicz, P., Sanak, M., Pękala, E., & Madeja, Z. (2018) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-018-2899-4 · Cited by 160 · see citing works

Subretinal fibrosis in neovascular age-related macular degeneration: current concepts, therapeutic avenues, and future perspectives

Tenbrock, L., Wolf, J., Boneva, S., Schlecht, A., Agostini, H. T., Wieghofer, P., Schlunck, G., & Lange, C. (2021) · Cell and Tissue Research · doi:10.1007/s00441-021-03514-8 · Cited by 155 · see citing works

Human Mesenchymal Stromal Cell-Derived Exosomes Promote In Vitro Wound Healing by Modulating the Biological Properties of Skin Keratinocytes and Fibroblasts and Stimulating Angiogenesis

Tutuianu, R., Rosca, A., Iacomi, D., Simionescu, M., & Titorencu, I. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22126239 · Cited by 108 · see citing works

Hyaluronic Acid and Skin: Its Role in Aging and Wound-Healing Processes

Chylińska, N., & Maciejczyk, M. (2025) · Gels · doi:10.3390/gels11040281 · Cited by 136 · see citing works

3D in vitro M2 macrophage model to mimic modulation of tissue repair

Sapudom, J., Karaman, S., Mohamed, W. K. E. A., Garcia‐Sabaté, A., Quartey, B. C., & Teo, J. C. M. (2021) · npj Regenerative Medicine · doi:10.1038/s41536-021-00193-5 · Cited by 114 · see citing works

Role of the Hippo Pathway in Fibrosis and Cancer

Kim, C.-L., Choi, S.-H., & Mo, J. (2019) · Cells · doi:10.3390/cells8050468 · Cited by 113 · see citing works

Stimulation of Transforming Growth Factor-β1-Induced Endothelial-To-Mesenchymal Transition and Tissue Fibrosis by Endothelin-1 (ET-1): A Novel Profibrotic Effect of ET-1

Wermuth, P. J., Li, Z., Mendoza, F. A., & Jiménez, S. A. (2016) · PLoS ONE · doi:10.1371/journal.pone.0161988 · Cited by 110 · see citing works

Stromal microenvironment in type VII collagen-deficient skin: The ground for squamous cell carcinoma development

Guerra, L., Odorisio, T., Zambruno, G., & Castiglia, D. (2017) · Matrix Biology · doi:10.1016/j.matbio.2017.01.002 · Cited by 106 · see citing works

Advances in 3D skin bioprinting for wound healing and disease modeling

Zhang, M., Zhang, C., Li, Z., Fu, X., & Huang, S. (2022) · Regenerative Biomaterials · doi:10.1093/rb/rbac105 · Cited by 111 · see citing works

Silica particles disorganize the polarization of pulmonary macrophages in mice

Zhao, Y., Hao, C., Bao, L., Wang, D., Li, Y., Qu, Y., Ding, M., Zhao, A., & Yao, W. (2020) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2020.110364 · Cited by 102 · see citing works

Identifying collagen VI as a target of fibrotic diseases regulated by CREBBP/EP300

Williams, L. M., McCann, F. E., Cabrita, M., Layton, T., Cribbs, A. P., Knezevic, B., Fang, H., Knight, J. C., Zhang, M., Fischer, R., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2004281117 · Cited by 86 · see citing works

Dermal αSMA+ myofibroblasts orchestrate skin wound repair via β1 integrin and independent of type I collagen production

McAndrews, K. M., Miyake, T., Ehsanipour, E. A., Kelly, P. J., Becker, L. M., McGrail, D. J., Sugimoto, H., LeBleu, V. S., Ge, Y., & Kalluri, R. (2022) · The EMBO Journal · doi:10.15252/embj.2021109470 · Cited by 88 · see citing works

New developments on skin fibrosis - Essential signals emanating from the extracellular matrix for the control of myofibroblasts

Schulz, J.-N., Plomann, M., Sengle, G., Gullberg, D., Krieg, T. M., & Eckes, B. (2018) · Matrix Biology · doi:10.1016/j.matbio.2018.01.025 · Cited by 86 · see citing works

Advances in biomaterials for skeletal muscle engineering and obstacles still to overcome

Smoak, M. M., & Mikos, A. G. (2020) · Materials Today Bio · doi:10.1016/j.mtbio.2020.100069 · Cited by 81 · see citing works

Mechanisms and Future of Non-Small Cell Lung Cancer Metastasis

Zhu, T., Bao, X., Chen, M., Lin, R., Zhuyan, J., Zhen, T., Xing, K., Zhou, W. J., & Zhu, S. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.585284 · Cited by 80 · see citing works

Targeted apoptosis of myofibroblasts by elesclomol inhibits hypertrophic scar formation

Feng, Y., Wu, J., Sun, Z., Liu, S., Zou, M., Yuan, Z., Yu, S., Lv, G., & Yuan, F. (2020) · EBioMedicine · doi:10.1016/j.ebiom.2020.102715 · Cited by 79 · see citing works

The Mighty Fibroblast and Its Utility in Scleroderma Research

Garrett, S. M., Frost, D. B., & Feghali‐Bostwick, C. A. (2017) · Journal of Scleroderma and Related Disorders · doi:10.5301/jsrd.5000240 · Cited by 78 · see citing works

Nerve growth factor and burn wound healing: Update of molecular interactions with skin cells.

Baassiri, M. G. E., Dosh, L., Haidar, H., Gerges, A., Baassiri, S., Leone, A., Rappa, F., & Jurjus, A. (2022) · Burns · doi:10.1016/j.burns.2022.11.001 · Cited by 69 · see citing works

Collagen Fibril Density Modulates Macrophage Activation and Cellular Functions during Tissue Repair

Sapudom, J., Mohamed, W. K. E. A., Garcia‐Sabaté, A., Alatoom, A., Karaman, S., Mahtani, N., & Teo, J. C. M. (2020) · Bioengineering · doi:10.3390/bioengineering7020033 · Cited by 72 · see citing works

Biotechnological Management of Skin Burn Injuries: Challenges and Perspectives in Wound Healing and Sensory Recovery

Girard, D., Laverdet, B., Buhé, V., Trouillas, M., Ghazi, K., Alexaline, M. M., Egles, C., Misery, L., Coulomb, B., Lataillade, J., et al. (2016) · Tissue Engineering Part B Reviews · doi:10.1089/ten.teb.2016.0195 · Cited by 70 · see citing works

Interferon-γ enhances the antifibrotic effects of pirfenidone by attenuating IPF lung fibroblast activation and differentiation

Vu, T. N., Chen, X., Foda, H. D., Smaldone, G. C., & Hasaneen, N. A. (2019) · Respiratory Research · doi:10.1186/s12931-019-1171-2 · Cited by 71 · see citing works

3D-Printed Gelatin Methacrylate Scaffolds with Controlled Architecture and Stiffness Modulate the Fibroblast Phenotype towards Dermal Regeneration

Ibañez, R. I. R., do Amaral, R. J. F. C., Reis, R. L., Marques, A. P., Murphy, C. M., & O’Brien, F. J. (2021) · Polymers · doi:10.3390/polym13152510 · Cited by 69 · see citing works

Fibroblast fate regulation by time dependent TGF-β1 and IL-10 stimulation in biomimetic 3D matrices

Sapudom, J., Wu, X., Chkolnikov, M., Ansorge, M., Anderegg, U., & Pompe, W. (2017) · Biomaterials Science · doi:10.1039/c7bm00286f · Cited by 69 · see citing works

Targeting nuclear receptors in cancer-associated fibroblasts as concurrent therapy to inhibit development of chemoresistant tumors

Chan, J. S. K., Sng, M. K., Teo, Z. Q., Chong, H. C., Twang, J. S., & Tan, N. S. (2017) · Oncogene · doi:10.1038/onc.2017.319 · Cited by 67 · see citing works

Role of NGF and its receptors in wound healing (Review)

Liu, Z., Wu, H., & Huang, S. (2021) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2021.10031 · Cited by 65 · see citing works

Enhanced asthma-related fibroblast to myofibroblast transition is the result of profibrotic TGF-β/Smad2/3 pathway intensification and antifibrotic TGF-β/Smad1/5/(8)9 pathway impairment

Wnuk, D., Paw, M., Ryczek, K., Bochenek, G., Sładek, K., Madeja, Z., & Michalik, M. (2020) · Scientific Reports · doi:10.1038/s41598-020-73473-7 · Cited by 64 · see citing works

Stem cells, niches and scaffolds: Applications to burns and wound care

Watt, S. M., & Pleat, J. (2017) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2017.10.012 · Cited by 62 · see citing works

Treatment of pulmonary fibrosis with siRNA against a collagen-specific chaperone HSP47 in vitamin A-coupled liposomes

Otsuka, M., Shiratori, M., Chiba, H., Kuronuma, K., Sato, Y., Niitsu, Y., & Takahashi, H. (2017) · Experimental Lung Research · doi:10.1080/01902148.2017.1354946 · Cited by 61 · see citing works

Melatonin ameliorates renal fibroblast‐myofibroblast transdifferentiation and renal fibrosis through miR‐21‐5p regulation

Li, N., Wang, Z., Gao, F., Lei, Y., & Li, Z. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.15221 · Cited by 59 · see citing works

GLP-1 receptor agonist ameliorates experimental lung fibrosis

Fandiño, J., Toba, L., González-Matías, L. C., Diz-Chaves, Y., & Mallo, F. (2020) · Scientific Reports · doi:10.1038/s41598-020-74912-1 · Cited by 59 · see citing works

Parthenolide attenuated bleomycin-induced pulmonary fibrosis via the NF-κB/Snail signaling pathway

Li, X., Xiao, T., Yang, J., Qin, Y., Gao, J., Liu, H., & Zhou, H. (2018) · Respiratory Research · doi:10.1186/s12931-018-0806-z · Cited by 58 · see citing works

Adipose-Derived Mesenchymal Stromal Cells in Regenerative Medicine: State of Play, Current Clinical Trials, and Future Prospects

Laloze, J., Fiévet, L., & Desmoulière, A. (2020) · Advances in Wound Care · doi:10.1089/wound.2020.1175 · Cited by 58 · see citing works

Overactivated sonic hedgehog signaling aggravates intrauterine adhesion via inhibiting autophagy in endometrial stromal cells

Cheng, W., Pan, Y., Zhang, Y., Dai, Y., Jiang, L., Shi, L., Yang, W., Xu, S., Zhang, Y., Xu, W., et al. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-02956-2 · Cited by 57 · see citing works

Phagocytosis mediated by scavenger receptor class BI promotes macrophage transition during skeletal muscle regeneration

Zhang, J., Qu, C., Li, T., Cui, W., Wang, X.-N. H., & Du, J. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.008795 · Cited by 48 · see citing works

More than a syllable in fib-ROS-is: The role of ROS on the fibrotic extracellular matrix and on cellular contacts

Grosche, J., Meißner, J., & Eble, J. A. (2018) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2018.03.005 · Cited by 53 · see citing works

Coordinate activities of BRD4 and CDK9 in the transcriptional elongation complex are required for TGFβ-induced Nox4 expression and myofibroblast transdifferentiation

Ijaz, T., Jamaluddin, M., Zhao, Y., Zhang, Y., Jay, J. W., Finnerty, C. C., Herndon, D. N., Tilton, R. G., & Brasier, A. R. (2017) · Cell Death and Disease · doi:10.1038/cddis.2016.434 · Cited by 54 · see citing works

The role of metabolic reprogramming and de novo amino acid synthesis in collagen protein production by myofibroblasts: implications for organ fibrosis and cancer

Hamanaka, R. B., & Mutlu, G. M. (2021) · Amino Acids · doi:10.1007/s00726-021-02996-8 · Cited by 52 · see citing works

Transforming Growth Factor-Beta1 and Human Gingival Fibroblast-to-Myofibroblast Differentiation: Molecular and Morphological Modifications

Marconi, G. D., Fonticoli, L., Rajan, T. S., Lanuti, P., Rocca, Y. D., Pierdomenico, S. D., Trubiani, O., Pizzicannella, J., & Diomede, F. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.676512 · Cited by 53 · see citing works

Translocation of TRPV4-PI3Kγ complexes to the plasma membrane drives myofibroblast transdifferentiation

Grove, L. M., Mohan, M. L., Abraham, S., Scheraga, R. G., Southern, B. D., Crish, J. F., Prasad, S. V. N., & Olman, M. A. (2019) · Science Signaling · doi:10.1126/scisignal.aau1533 · Cited by 52 · see citing works

The current landscape of antifibrotic therapy across different organs: A systematic approach

Fuster‐Martínez, I., & Calatayud, S. (2024) · Pharmacological Research · doi:10.1016/j.phrs.2024.107245 · Cited by 52 · see citing works

Anti-Tumour Necrosis Factor Therapy for Dupuytren's Disease: A Randomised Dose Response Proof of Concept Phase 2a Clinical Trial

Nanchahal, J., Ball, C., Davidson, D., Williams, L. M., Sones, W. R., McCann, F. E., Cabrita, M., Swettenham, J. B., Cahoon, N. J., Copsey, B. J., et al. (2018) · EBioMedicine · doi:10.1016/j.ebiom.2018.06.022 · Cited by 52 · see citing works

A centralized communication network: Recent insights into the role of the cancer associated fibroblast in the development of drug resistance in tumors

Leask, A. (2019) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2019.10.016 · Cited by 52 · see citing works

Activated Human Lung Fibroblasts Produce Extracellular Vesicles with Antifibrotic Prostaglandins

Lacy, S., Woeller, C. F., Thatcher, T., Pollock, S. J., Small, E., Sime, P., & Phipps, R. (2019) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2017-0248oc · Cited by 47 · see citing works

Dermal fibroblast-to-myofibroblast transition sustained by αvß3 integrin-ILK-Snail1/Slug signaling is a common feature for hypermobile Ehlers-Danlos syndrome and hypermobility spectrum disorders

Zoppi, N., Chiarelli, N., Binetti, S., Ritelli, M., & Colombi, M. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2018.01.005 · Cited by 49 · see citing works

CD39+ Fibroblasts Enhance Myofibroblast Activation by Promoting IL-11 Secretion in Hypertrophic Scars

Huang, X., Gu, S., Liu, C., Zhang, L., Zhang, Z., Zhao, Y., Khoong, Y., Li, H., Gao, Y., Liu, Y., et al. (2021) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2021.07.181 · Cited by 48 · see citing works

Tackling muscle fibrosis: From molecular mechanisms to next generation engineered models to predict drug delivery

Bersini, S., Gilardi, M., Mora, M., Krol, S., Arrigoni, C., Candrian, C., Zanotti, S., & Moretti, M. (2018) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2018.02.009 · Cited by 50 · see citing works

Rapamycin Protects Against Peritendinous Fibrosis Through Activation of Autophagy

Zheng, W., Qian, Y., Chen, S., Ruan, H., & Fan, C. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00402 · Cited by 48 · see citing works

Epigallocatechin gallate-loaded pH-responsive dressing with effective antioxidant, antibacterial and anti-biofilm properties for wound healing

Tan, S., Han, J., Yuan, X., Song, Z., Gao, L., Gao, J., & Wang, L. (2023) · Materials & Design · doi:10.1016/j.matdes.2023.111701 · Cited by 47 · see citing works

Tissue fibroblasts are versatile immune regulators: An evaluation of their impact on the aging process

Salminen, A., Kaarniranta, K., & Kauppinen, A. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102296 · Cited by 49 · see citing works

Generation and analysis of spheroids from human primary skin myofibroblasts: an experimental system to study myofibroblasts deactivation

Granato, G., Ruocco, M. R., Iaccarino, A., Masone, S., Calı̀, G., Avagliano, A., Russo, V., Bellevicine, C., Spigna, G. D., Fiume, G., et al. (2017) · Cell Death Discovery · doi:10.1038/cddiscovery.2017.38 · Cited by 45 · see citing works

Fibroblasts Promote Inflammation and Pain via IL-1α Induction of the Monocyte Chemoattractant Chemokine (C-C Motif) Ligand 2

Paish, H. L., Kalson, N. S., Smith, G. R., Pons, A. D. C., Baldock, T., Smith, N., Swist-Szulik, K., Weir, D. J., Bardgett, M., Deehan, D. J., et al. (2017) · American Journal Of Pathology · doi:10.1016/j.ajpath.2017.11.007 · Cited by 45 · see citing works

Matrix Remodeling and Hyaluronan Production by Myofibroblasts and Cancer-Associated Fibroblasts in 3D Collagen Matrices

Sapudom, J., Müller, C. D., Nguyen, K.-T., Martin, S., Anderegg, U., & Pompe, W. (2020) · Gels · doi:10.3390/gels6040033 · Cited by 46 · see citing works

An Emerging Frontier in Intercellular Communication: Extracellular Vesicles in Regeneration

Avalos, P. N., & Forsthoefel, D. J. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.849905 · Cited by 49 · see citing works

A Skin Stress Shielding Platform Based on Body Temperature‐Induced Shrinking of Hydrogel for Promoting Scar‐Less Wound Healing

Chen, Q., Li, S., Li, K., Zhao, W., & Zhao, C. (2024) · Advanced Science · doi:10.1002/advs.202306018 · Cited by 42 · see citing works

Stroma in normal and cancer wound healing

Huet, E., Jaroz, C., Nguyen, H. Q., Belkacemi, Y., de la Taille, A., Stavrinides, V., & Whitaker, H. (2019) · The FEBS Journal · doi:10.1111/febs.14842 · Cited by 42 · see citing works

The Ameliorative Effects of Arctiin and Arctigenin on the Oxidative Injury of Lung Induced by Silica via TLR‐4/NLRP3/TGF‐β Signaling Pathway

Liu, X., Wang, J., Dou, P., Zhang, X., Ran, X., Liu, L., & Dou, D. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/5598980 · Cited by 43 · see citing works

Unraveling the molecular architecture of autoimmune thyroid diseases at spatial resolution

Martínez‐Hernández, R., de la Blanca, N. S., Sacristan-Gomez, P., Serrano-Somavilla, A., de Nova, J. L. M., Sánchez‐Cabo, F., Heyn, H., Sampedro-Nuñez, M. A., & Marazuela, M. (2024) · Nature Communications · doi:10.1038/s41467-024-50192-5 · Cited by 45 · see citing works

Identification of Novel Fibrosis Modifiers by In Vivo siRNA Silencing

Vollmann, E. H., Cao, L., Amatucci, A., Reynolds, T. L., Hamann, S., Dalkilic-Liddle, I., Cameron, T. O., Hoßbach, M., Kauffman, K. J., Mir, F. F., et al. (2017) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2017.04.014 · Cited by 41 · see citing works

The Role of Airway Myofibroblasts in Asthma

Jendzjowsky, N. G., & Kelly, M. M. (2019) · CHEST Journal · doi:10.1016/j.chest.2019.08.1917 · Cited by 41 · see citing works

The role of eIF4F-driven mRNA translation in regulating the tumour microenvironment

Bartish, M., Abraham, M. J., Gonçalves, C., Larsson, O. S., Rolny, C., & Rincon, S. V. D. (2023) · Nature reviews. Cancer · doi:10.1038/s41568-023-00567-5 · Cited by 39 · see citing works

An update on myofibromas and myofibromatosis affecting the oral regions with report of 24 new cases

Smith, M. H., Reith, J. D., Cohen, D. M., Islam, N., Sibille, K. T., & Bhattacharyya, I. (2017) · Oral Surgery Oral Medicine Oral Pathology and Oral Radiology · doi:10.1016/j.oooo.2017.03.051 · Cited by 40 · see citing works

Metformin prevents peritendinous fibrosis by inhibiting transforming growth factor-β signaling

Zheng, W., Song, J., Zhang, Y., Chen, S., Ruan, H., & Fan, C. (2017) · Oncotarget · doi:10.18632/oncotarget.21695 · Cited by 40 · see citing works

Contraction of fibrin‐derived matrices and its implications for in vitro human skin bioengineering

Montero, A., Acosta, S., Hernández, R., Elvira, C., Jorcano, J. L., & Velasco, D. (2020) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.37033 · Cited by 40 · see citing works

Cancer-Associated Fibroblast Heterogeneity and Its Influence on the Extracellular Matrix and the Tumor Microenvironment

Knipper, K., Lyu, S. I., Quaas, A., Bruns, C. J., & Schmidt, T. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241713482 · Cited by 39 · see citing works

Baicalein represses TGF-β1-induced fibroblast differentiation through the inhibition of miR-21

Cui, X., Sun, X., Lu, F., & Jiang, X. (2018) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2018.09.007 · Cited by 38 · see citing works

Photobiomodulation of red and green lights in the repair process of third-degree skin burns

Simões, T. M. S., Neto, J. D. A. F., de Oliveira, T. K. B., Nonaka, C. F. W., & Catão, M. H. C. D. V. (2019) · Lasers in Medical Science · doi:10.1007/s10103-019-02776-7 · Cited by 40 · see citing works

Targeting persistently activated inflammatory microenvironment to promote chronic wound healing

Dai, Y., & Chen, Y. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1708358 · Cited by 38 · see citing works

Macrophage Infiltration Is a Causative Factor for Ligamentum Flavum Hypertrophy through the Activation of Collagen Production in Fibroblasts

Saito, T., Hara, M., Kumamaru, H., Kobayakawa, K., Yokota, K., Kijima, K., Yoshizaki, S., Harimaya, K., Matsumoto, Y., Kawaguchi, K., et al. (2017) · American Journal Of Pathology · doi:10.1016/j.ajpath.2017.08.020 · Cited by 37 · see citing works

Nuclear hyaluronidase 2 drives alternative splicing of CD44 pre-mRNA to determine profibrotic or antifibrotic cell phenotype

Midgley, A. C., Oltean, S., Hascall, V., Woods, E. L., Steadman, R., Phillips, A. O., & Meran, S. (2017) · Science Signaling · doi:10.1126/scisignal.aao1822 · Cited by 37 · see citing works

Cardiac reprogramming factor Gata4 reduces postinfarct cardiac fibrosis through direct repression of the profibrotic mediator snail

Mathison, M. N., Singh, V., Sanagasetti, D., Yang, L., Pinnamaneni, J. P., Yang, J., & Rosengart, T. K. (2017) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2017.06.035 · Cited by 36 · see citing works

Irradiated Human Umbilical Vein Endothelial Cells Undergo Endothelial-Mesenchymal Transition via the Snail/miR-199a-5p Axis to Promote the Differentiation of Fibroblasts into Myofibroblasts

Yi, M., Liu, B., Tang, Y., Li, F., Qin, W., & Yuan, X. (2018) · BioMed Research International · doi:10.1155/2018/4135806 · Cited by 36 · see citing works

Caffeine inhibits hypoxia-induced renal fibroblast activation by antioxidant mechanism

Nilnumkhum, A., Kanlaya, R., Yoodee, S., & Thongboonkerd, V. (2019) · Cell Adhesion & Migration · doi:10.1080/19336918.2019.1638691 · Cited by 36 · see citing works

Peptide DR8 suppresses epithelial-to-mesenchymal transition via the TGF-β/MAPK signaling pathway in renal fibrosis

Deng, B., Yang, W., Wang, D., Cheng, L., Bu, L., Rao, J., Zhang, J., Xie, J., & Zhang, B. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118465 · Cited by 36 · see citing works

Mesenchymal cells in the Lung: Evolving concepts and their role in fibrosis

Ligresti, G., Raslan, A., Hong, J., Caporarello, N., Confalonieri, M., & Huang, S. K. (2023) · Gene · doi:10.1016/j.gene.2022.147142 · Cited by 34 · see citing works

The Application of Nanoparticles Targeting Cancer-Associated Fibroblasts

Huang, Q., Ge, Y., He, Y. T., Wu, J., Tong, Y., Shang, H., Liu, X., Ba, X., Xia, D., Peng, E., et al. (2024) · International Journal of Nanomedicine · doi:10.2147/ijn.s447350 · Cited by 35 · see citing works

VEGF Receptor-2 Activation Mediated by VEGF-E Limits Scar Tissue Formation Following Cutaneous Injury

Wise, L. M., Stuart, G. S., Real, N. C., Fleming, S. B., & Mercer, A. A. (2017) · Advances in Wound Care · doi:10.1089/wound.2016.0721 · Cited by 35 · see citing works

Fibrogenic fibroblast-selective near-infrared phototherapy to control scarring

Chen, Z., Wang, Z., Jin, T., Shen, G., Wang, Y., Tan, X., Gan, Y., Yang, F., Liu, Y., Huang, C., et al. (2019) · Theranostics · doi:10.7150/thno.36375 · Cited by 35 · see citing works

Sinomenine attenuates pulmonary fibrosis by downregulating TGF-β1/Smad3, PI3K/Akt and NF-κB signaling pathways

Yao, F., Xu, M., Dong, L., Shen, X., Shen, Y., Jiang, Y., Zhu, T., Zhang, C., & Yu, G. (2024) · BMC Pulmonary Medicine · doi:10.1186/s12890-024-03050-5 · Cited by 34 · see citing works

Recent developments in the pathobiology of lung myofibroblasts

Jiang, D., Dey, T., & Liu, G. (2020) · Expert Review of Respiratory Medicine · doi:10.1080/17476348.2021.1829972 · Cited by 34 · see citing works

Scar Formation: Cellular Mechanisms

Darby, I. A., & Desmoulière, A. (2020) · Springer eBooks · doi:10.1007/978-3-030-44766-3_3 · Cited by 35 · see citing works

Mitochondrial Dysfunction and Alterations in Mitochondrial Permeability Transition Pore (mPTP) Contribute to Apoptosis Resistance in Idiopathic Pulmonary Fibrosis Fibroblasts

Luis‐García, E. R., Becerril, C., Salgado-Aguayo, A. R., Aparicio‐Trejo, O. E., Romero, Y., Flores‐Soto, E., Mendoza-Milla, C., Montaño, M., de Sánchez, V. C., Pedraza‐Chaverrí, J., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22157870 · Cited by 34 · see citing works

Single-nucleus chromatin accessibility identifies a critical role for TWIST1 in idiopathic pulmonary fibrosis myofibroblast activity

Valenzi, E., Bahudhanapati, H., Tan, J., Tabib, T., Sullivan, D. I., Nouraie, M. S., Sembrat, J., Fan, L., Chen, K., Liu, S., et al. (2023) · European Respiratory Journal · doi:10.1183/13993003.00474-2022 · Cited by 34 · see citing works

Keloid fibroblasts have elevated and dysfunctional mechanotransduction signaling that is independent of TGF-β

Deng, Z., Subilia, M., Chin, I. L., Hortin, N., Stevenson, A. W., Wood, F. M., Prêle, C. M., Choi, Y. S., & Fear, M. W. (2021) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2021.09.002 · Cited by 33 · see citing works

Crosstalk between oxidative stress, mitochondrial dysfunction, chromosome instability, and the activation of the cGAS-STING/IFN pathway in systemic sclerosis

Waseem, M., Imtiaz, A., Alexander, A., Graham, L. V. D., & Contreras-Galindo, R. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102812 · Cited by 33 · see citing works

Myofibroblasts in Epithelial Mesenchymal Transition and its Clinical Significance

Singh, D., Tegginamani, A. S., Singh, M. K., Samadi, F. M., Sharma, P. S., & Diwedi, A. (2014) · Indian Journal of Mednodent and Allied Sciences · doi:10.5958/j.2347-6206.2.1.010

Fibroblast Differentiation in Wound Healing and Fibrosis

Darby, I. A., & Hewitson, T. D. (2007) · International review of cytology · doi:10.1016/s0074-7696(07)57004-x · Cited by 605 · see citing works

The myofibroblast, multiple origins for major roles in normal and pathological tissue repair

Micallef, L., Védrenne, N., Billet, F., Coulomb, B., Darby, I. A., & Desmoulière, A. (2012) · Fibrogenesis & Tissue Repair · doi:10.1186/1755-1536-5-s1-s5 · Cited by 238 · see citing works

The myofibroblast in connective tissue repair and regeneration

Hinz, B. (2010) · Elsevier eBooks · doi:10.1533/9781845697792.39 · Cited by 20 · see citing works

Myofibroblasts: Function, Formation, and Scope of Molecular Therapies for Skin Fibrosis

Tai, Y., Woods, E. L., Dally, J., Kong, D., Steadman, R., Moseley, R., & Midgley, A. C. (2021) · Biomolecules · doi:10.3390/biom11081095 · Cited by 244 · see citing works