CoChat
Sign Up
Cited by 241Muscle metabolism and nutritionPancreatic function and diabetesDiet, Metabolism, and Disease

The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.

Effect of long-term dietary protein intake on glucose metabolism in humans

Open access
Linn, T., Santosa, B., Grönemeyer, D., Aygen, S., Scholz, N., Busch, M., Bretzel, R. G.·2000·Diabetologia
DOI 10.1007/s001250051521
Open this paper in CoChat — free accountOpen PDF

Abstract

Aims/hypothesis A meal rich in protein stimulates insulin secretion. Long-term effects of dietary protein on insulin release and glucose metabolism are, however, still not known. Our study focussed on the effect of different protein intake on pancreatic insulin secretion capacity, glycogen turnover and gluconeogenesis.Methods Subjects with constant (6 months) dietary protein of 1.87 +/- 0.26 g kg(-1) day(-1) (1.25-2.41) named high protein group and with 0.74 +/- 0.08 (0.57-0.80), normal protein group, were identified by a food questionnaire and were matched (n = 9) according to sex, age and calorie intake. They underwent an intravenous glucose tolerance test and a euglycaemic hyperinsulinaemic clamp with infusion of [6,6-2H2]-glucose combined with indirect calorimetry. To estimate net gluconeogenesis the usual diet was enriched by deuterated water or U-[13C6]-glucose and breath and plasma were sampled.Results Glucose-stimulated insulin secretion was increased in the high protein group (516 +/- 45 pmol/l vs 305 +/- 32, p = 0.012) due to reduced glucose threshold of the endocrine beta cells (4.2 +/- 0.5 mmol/l vs 4.9 +/- 0.3, p = 0.031). Endogeneous glucose output was increased by 12% (p = 0.009) at 40 pmol/l plasma insulin in the high protein group, but not at higher insulin concentration whereas overall glucose disposal was reduced. Fasting plasma glucagon was 34% increased in the high protein group (p = 0.038). Fractional gluconeogenesis was increased by 40% in subjects receiving a high protein diet as determined by both methods.Conclusion/interpretation High protein diet is accompanied by increased stimulation of glucagon and insulin within the endocrine pancreas, high glycogen turnover and stimulation of gluconeogenesis.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1007/s001250051521

Cites

5 of 5 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 5 references

Cited by

Sorted by citations

Related

See all

Metadata

Authors
Linn, T., Santosa, B., Grönemeyer, D., Aygen, S., Scholz, N., Busch, M., & Bretzel, R. G.
Affiliations
  • Witten/Herdecke University (DE)
  • Justus-Liebig-Universität Gießen (DE)
ORCID
Venue
Diabetologia
Publisher
Springer Science and Business Media LLC
Published
2000-10-02
Volume
43
Issue
10
Pages
1257-1265
ISSN
  • 0012-186X (ISSN-L)
  • 1432-0428
DOI
10.1007/s001250051521
OpenAlex
W2074497389
Semantic Scholar
7e12ba375f9c9537cea1dec3acda695fb924cfcc
Cited by
241
References
5
Citations by year
2026: 2 · 2025: 7 · 2024: 9 · 2023: 12 · 2022: 9 · 2021: 8 · 2020: 9 · 2019: 8 · 2018: 11 · 2017: 9 · 2016: 14 · 2015: 13 · 2014: 13 · 2013: 12 · 2012: 17
FWCI
1.42
Type
journal article
Language
en
Open access
Licence
www.springer.com/tdm (tdm)
Locations
  • Diabetologia (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
Keywords
dietary protein, high-protein diet, glucose metabolism, insulin secretion, glucose-stimulated insulin secretion, endogenous glucose production, gluconeogenesis, glycogen turnover, glucagon, glucose disposal, hyperinsulinemic-euglycemic clamp, heavy water, isotope tracers
MeSH terms
Insulin Secretion, Adult, Blood Glucose, Energy Intake, Calorimetry, Indirect, Deuterium, Dietary Proteins, Female, Glucagon, Gluconeogenesis, Glucose, Glucose Tolerance Test, Glycogen, Humans, Insulin, Liver, Male, Oxidation-Reduction, Pancreas, Surveys and Questionnaires, Glucose Clamp Technique

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review