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Cited by 29Tryptophan and brain disordersAdipokines, Inflammation, and Metabolic DiseasesStress Responses and Cortisol

Elevated hs-CRP level is associated with depression in younger adults: Results from the Korean National Health and Nutrition Examination Survey (KNHANES 2016)

Jung, Young-Eun, Kang, Kwi Young·2019·Psychoneuroendocrinology
DOI 10.1016/j.psyneuen.2019.104397
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Abstract

Introduction Reports on the association between the level of circulating high-sensitivity C-reactive protein (hs-CRP) and depression have been inconsistent. The aim of this study was to examine the association between hs-CRP and depression in a large sample.Methods This study used data obtained from a representative Korean sample of 5447 people who participated in the first (2016) year of the seventh Korean National Health and Nutrition Examination Survey (KNHNES VII-1). Depression was identified using a cutoff of 5 on the Patient Health Questionnaire-9 (PHQ-9), and high hs-CPR level was defined as ≥ 3.0 mg/L.Findings Participants with a high CRP levels had a significantly higher rate of depression than did those with a low hs-CRP levels (25.1% vs. 19.8%, p = 0.007). Serum hs-CRP was independently associated with the PHQ-9 total score after adjusting for potentially confounding factors (B = 0.014; 95% CI = 0.008-0.020). After controlling for body mass index (BMI), smoking, alcohol use problems, hypertension, diabetes, dyslipidemia, chronic illness related hs-CRP, and metabolic syndrome. Furthermore, elevated hs-CRP level was significantly associated with an increased risk of depression (adjusted OR = 1.44; 95% CI = 1.01-2.07) in younger adults, but no significant association was observed among older adults.Conclusion These findings suggest a significant correlation between high hs-CRP levels and depression in younger adults. Further studies are necessary to investigate the age-specific association and the biological mechanism involved.

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  • This association appeared to be more prominent in younger adults than in older patients.

    “Furthermore, the authors found that this association appeared to be more prominent in younger adults than in older patients [61].”

    From C-Reactive protein as a biomarker for major depressive disorder? (2022) · cites this paper as [61]

  • hs-CRP levels were independently associated with PHQ-9 scores, even after adjustment of confounders.

    “In addition, hs-CRP levels were independently associated with PHQ-9 scores, even after adjustment of confounders.”

    From C-Reactive protein as a biomarker for major depressive disorder? (2022) · cites this paper as [61]

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Authors
Jung, Y.-E., & Kang, K. Y.
Affiliations
  • Jeju National University (KR)
  • The Catholic University of Korea Incheon St. Mary's Hospital (KR)
Corresponding author
Kang, Kwi Young
ORCID
Venue
Psychoneuroendocrinology
Publisher
Elsevier BV
Published
2019-11
Volume
109
Pages
104397
ISSN
0306-4530 (ISSN-L)
DOI
10.1016/j.psyneuen.2019.104397
OpenAlex
W2965689518
Cited by
29
References
70
Citations by year
2026: 3 · 2025: 5 · 2024: 7 · 2023: 3 · 2022: 4 · 2021: 1 · 2020: 6
FWCI
0.90
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Psychoneuroendocrinology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords
high-sensitivity C-reactive protein, depression, inflammation, young adults, age-specific associations, PHQ-9, metabolic syndrome, Korean adults
MeSH terms
Adult, Aged, C-Reactive Protein, Depression, Depressive Disorder, Female, Humans, Hypertension, Male, Middle Aged, Nutrition Surveys, Risk Factors, Body Mass Index, Metabolic Syndrome, Dyslipidemias, Young Adult, Republic of Korea

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