Reward system activation in schizophrenic patients switched from typical neuroleptics to olanzapine

Schlagenhauf, Florian; Juckel, Georg; Koslowski, Michael; Kahnt, Thorsten; Knutson, Brian; Dembler, Theresa; Kienast, Thorsten; Gallinat, Jürgen; Wrase, Jana; Heinz, Andreas

doi:10.1007/s00213-007-1016-4

Cited by 204Schizophrenia research and treatmentNeurotransmitter Receptor Influence on BehaviorNeural and Behavioral Psychology Studies

Reward system activation in schizophrenic patients switched from typical neuroleptics to olanzapine

Schlagenhauf, Florian, Juckel, Georg, Koslowski, Michael, Kahnt, Thorsten, Knutson, Brian, Dembler, Theresa, Kienast, Thorsten, Gallinat, Jürgen +2 more·2008·Psychopharmacology

DOI 10.1007/s00213-007-1016-4

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Abstract

Rationale High blockade of dopamine D2 receptors in the ventral striatum including the nucleus accumbens may interfere with reward anticipation and cause secondary negative symptoms such as apathy or anhedonia. This may not be the case with newer neuroleptics such as olanzapine, which show less dopamine D2 receptor blockade and a faster off-rate from the receptor.Objectives We used functional magnetic resonance imaging to assess the blood oxygenation level dependent response in the ventral striatum of schizophrenics medicated with typical neuroleptics (T1) and after switching them to olanzapine (T2) and of healthy control subjects at corresponding time points during reward anticipation.Materials and methods Ten schizophrenics, while medicated with typical neuroleptics (T1) and after having been switched to olanzapine (T2), and ten matched healthy volunteers participated in a monetary incentive delay task, in which visual cues predicted that a rapid response to a subsequent target stimulus would either result in monetary gain or have no consequence.Results During reward anticipation, healthy volunteers showed significantly higher ventral striatal activation compared to schizophrenic patients treated with typical neuroleptics but not olanzapine, which was reflected in a significant interaction between group and session. In patients treated with typical neuroleptics, but not with olanzapine, decreased left ventral striatal activation was correlated with negative symptoms.Conclusions Failure to activate the ventral striatum during reward anticipation was pharmacologically state-dependent and observed only in patients treated with typical neuroleptics but not with olanzapine, which may indicate that this drug did not induce secondary negative symptoms via interference with reward anticipation.

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Striatal responses during monetary anticipation in schizophrenia are partially normalized by olanzapine but not by other antipsychotics.
“A handful of studies also suggest that striatal responses during monetary anticipation in schizophrenia are partially normalized by the antipsychotic, olanzapine [279,417,423] but not by other antipsychotics [418]”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [423]

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ORIGINAL INVESTIGATION Reward system activation in schizophrenic patients switched from typical neuroleptics to olanzapine
Schlagenhauf, F., Juckel, G., Koslowski, M., Kahnt, T., Knutson, B. D., Dembler, T., Kienast, T., Gallinat, J., Wrase, J., & Heinz, A. (2007)
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Psychopharmacology DOI 10.1007/s00213-007-1016-4 ORIGINAL INVESTIGATION Reward system activation in schizophrenic patients switched from typical neuroleptics to olanzapine
Schlagenhauf, F., Juckel, G., Koslowski, M., Kahnt, T., Knutson, B. D., Dembler, T., Kienast, T., Gallinat, J., Wrase, J., Heinz, A., et al. (2007)
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Dysfunction of ventral striatal reward prediction in schizophrenic patients treated with typical, not atypical, neuroleptics
Juckel, G., Schlagenhauf, F., Koslowski, M., Filonov, D., Wüstenberg, T., Villringer, A., Knutson, B., Kienast, T., Gallinat, J., Wrase, J., et al. (2006) · Psychopharmacology · doi:10.1007/s00213-006-0405-4 · Cited by 323 · see citing works
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Human reward system activation is modulated by a single dose of olanzapine in healthy subjects in an event-related, double-blind, placebo-controlled fMRI study
Abler, B., Erk, S., & Walter, H. (2007) · Psychopharmacology · doi:10.1007/s00213-006-0690-y · Cited by 118 · see citing works
Inhibition of the reward system by antipsychotic treatment
Juckel, G. (2016) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2016.18.1/gjuckel · Cited by 25 · see citing works
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Authors: Schlagenhauf, F., Juckel, G., Koslowski, M., Kahnt, T., Knutson, B., Dembler, T., Kienast, T., Gallinat, J., Wrase, J., & Heinz, A.
Affiliations: Stiftung Charité (DE)
Charité – Universitätsmedizin Berlin (DE)
Stanford University (US)
Corresponding author: Heinz, Andreas
ORCID: Schlagenhauf, Florian
Juckel, Georg
Koslowski, Michael
Kahnt, Thorsten
Knutson, Brian
Gallinat, Jürgen
Heinz, Andreas
Venue: Psychopharmacology
Publisher: Springer Science and Business Media LLC
Published: 2007-12-21
Volume: 196
Issue: 4
Pages: 673-684
ISSN: 0033-3158 (ISSN-L)
1432-2072
DOI: 10.1007/s00213-007-1016-4
OpenAlex: W2153437292
Cited by: 204
References: 48
Citations by year: 2026: 2 · 2025: 2 · 2024: 1 · 2023: 7 · 2022: 4 · 2021: 6 · 2020: 4 · 2019: 10 · 2018: 12 · 2017: 14 · 2016: 20 · 2015: 22 · 2014: 19 · 2013: 18 · 2012: 17
FWCI: 6.46
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Psychopharmacology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords: schizophrenia, olanzapine, typical antipsychotics, reward anticipation, ventral striatum, nucleus accumbens, dopamine D2 receptor blockade, negative symptoms, anhedonia, apathy, monetary incentive delay task, antipsychotic switching, functional MRI
MeSH terms: Olanzapine, Adult, Analysis of Variance, Benzodiazepines, Female, Flupenthixol, Fluphenazine, Haloperidol, Humans, Magnetic Resonance Imaging, Male, Motivation, Nucleus Accumbens, Oxygen, Psychomotor Performance, Reaction Time, Reward, Schizophrenia, Schizophrenic Psychology, Antipsychotic Agents, Neostriatum, Receptors, Dopamine D2, Dopamine D2 Receptor Antagonists

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Reward system activation in schizophrenic patients switched from typical neuroleptics to olanzapine

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