Cited by 248Neural and Behavioral Psychology StudiesNeurotransmitter Receptor Influence on BehaviorTreatment of Major Depression

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Neural representation of reward in recovered depressed patients

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McCabe, Ciara, Cowen, Philip J., Harmer, Catherine J.·2009·Psychopharmacology

DOI 10.1007/s00213-009-1573-9PMC PMC2718193

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Abstract

INTRODUCTION: Anhedonia, a loss of interest and pleasure in normally rewarding stimuli, is a key diagnostic criterion for major depression. It has been suggested that deficits in the processing of reward-relevant stimuli could represent an endophenotype for depression. We hypothesized that people at risk of depression by virtue of a personal history of the illness would show impaired neural responses to a primary rewarding stimulus. MATERIALS AND METHODS: Using functional magnetic resonance imaging, we measured the neural response to the sight and flavor of chocolate, and their combination, in 13 unmedicated recovered patients with a history of major depression and 14 healthy controls matched for age and gender. We also examined a control aversive condition consisting of the sight of moldy strawberries and a corresponding unpleasant taste. Participants simultaneously recorded subjective ratings of "pleasantness," "intensity," and "wanting." RESULTS AND DISCUSSION: Despite no differences between the groups in stimulus ratings, patients showed decreased neural responses to the pleasant stimulus in the ventral striatum and increases in the caudate nucleus to the aversive stimulus. Furthermore, patients had a diminished neural supralinearity response (the potentiation produced by simultaneous presentation of the sight and flavor of the stimuli) in the prefrontal cortex for both aversive and pleasant conditions. Patients recovered from depression appear to have deficits in the neural basis of reward and may also have impairments in the cross-modal integration of sensory stimuli. CONCLUSION: These findings support the view that abnormal neural responses to reward may be an endophenotype for depression and a potential target for intervention and prevention strategies.

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Authors: McCabe, C., Cowen, P. J., & Harmer, C. J.
Affiliations: Warneford Hospital (GB)
Corresponding author: McCabe, Ciara
ORCID: McCabe, Ciara
Cowen, Philip J.
Harmer, Catherine J.
Venue: Psychopharmacology
Publisher: Springer Science and Business Media LLC
Published: 2009-06-16
Volume: 205
Issue: 4
Pages: 667-677
ISSN: 0033-3158 (ISSN-L)
1432-2072
DOI: 10.1007/s00213-009-1573-9
PMC: PMC2718193
OpenAlex: W2106916957
Cited by: 248
References: 44
Citations by year: 2026: 3 · 2025: 5 · 2024: 7 · 2023: 10 · 2022: 8 · 2021: 13 · 2020: 10 · 2019: 15 · 2018: 16 · 2017: 15 · 2016: 21 · 2015: 36 · 2014: 23 · 2013: 23 · 2012: 13
FWCI: 6.96
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc
Locations: Psychopharmacology (publishedVersion, cc-by-nc)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Medical Research Council
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Keywords: anhedonia, major depressive disorder, endophenotypes, reward processing, recovered depression, ventral striatum, caudate nucleus, prefrontal cortex, cross-modal integration, sensory integration, aversive stimuli, chocolate
MeSH terms: Adult, Basal Ganglia, Caudate Nucleus, Depression, Female, Humans, Magnetic Resonance Imaging, Male, Reward, Case-Control Studies, Prefrontal Cortex

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Neural representation of reward in recovered depressed patients

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