Cited by 248Neural and Behavioral Psychology StudiesNeurotransmitter Receptor Influence on BehaviorTreatment of Major Depression

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Neural representation of reward in recovered depressed patients

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McCabe, Ciara, Cowen, Philip J., Harmer, Catherine J.·2009·Psychopharmacology

DOI 10.1007/s00213-009-1573-9PMC PMC2718193

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Abstract

INTRODUCTION: Anhedonia, a loss of interest and pleasure in normally rewarding stimuli, is a key diagnostic criterion for major depression. It has been suggested that deficits in the processing of reward-relevant stimuli could represent an endophenotype for depression. We hypothesized that people at risk of depression by virtue of a personal history of the illness would show impaired neural responses to a primary rewarding stimulus. MATERIALS AND METHODS: Using functional magnetic resonance imaging, we measured the neural response to the sight and flavor of chocolate, and their combination, in 13 unmedicated recovered patients with a history of major depression and 14 healthy controls matched for age and gender. We also examined a control aversive condition consisting of the sight of moldy strawberries and a corresponding unpleasant taste. Participants simultaneously recorded subjective ratings of "pleasantness," "intensity," and "wanting." RESULTS AND DISCUSSION: Despite no differences between the groups in stimulus ratings, patients showed decreased neural responses to the pleasant stimulus in the ventral striatum and increases in the caudate nucleus to the aversive stimulus. Furthermore, patients had a diminished neural supralinearity response (the potentiation produced by simultaneous presentation of the sight and flavor of the stimuli) in the prefrontal cortex for both aversive and pleasant conditions. Patients recovered from depression appear to have deficits in the neural basis of reward and may also have impairments in the cross-modal integration of sensory stimuli. CONCLUSION: These findings support the view that abnormal neural responses to reward may be an endophenotype for depression and a potential target for intervention and prevention strategies.

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An inventory for measuring depression
BECK, A. T. (1961) · Archives of General Psychiatry · doi:10.1001/archpsyc.1961.01710120031004 · Cited by 38,032
A rating scale for depression
Hamilton, M. (1960) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.23.1.56 · Cited by 32,817
An automated method for neuroanatomic and cytoarchitectonic atlas-based interrogation of fMRI data sets
Maldjian, J. A., Laurienti, P. J., Kraft, R., & Burdette, J. H. (2003) · NeuroImage · doi:10.1016/s1053-8119(03)00169-1 · Cited by 5,066
Automatic 3D intersubject registration of MR volumetric data in standardized Talairach space
Collins, D. L., Neelin, P., Peters, T. M., & Evans, A. C. (1994) · Journal of Computer Assisted Tomography · doi:10.1097/00004728-199403000-00005 · Cited by 3,431 · cited 2×
“Preprocessing of the data used SPM5 realignment, reslicing with sinc interpolation, normalization to the Montreal Neurological Institute (MNI) coordinate system and spatial smoothing with a 6-mm full width at half maximum isotropic Gaussian kernel and global scaling (Collins et al. 1994).”
Method
Intensely pleasurable responses to music correlate with activity in brain regions implicated in reward and emotion
Blood, A. J., & Zatorre, R. J. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.191355898 · Cited by 2,814
Emotion and motivation: the role of the amygdala, ventral striatum, and prefrontal cortex
Cardinal, R. N., Parkinson, J. A., Hall, J., & Everitt, B. J. (2002) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(02)00007-6 · Cited by 2,129
The mesolimbic dopamine reward circuit in depression
Nestler, E. J., & Carlezon, W. A. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.09.018 · Cited by 2,059
Abstract reward and punishment representations in the human orbitofrontal cortex
O'Doherty, J., Kringelbach, M. L., Rolls, E. T., Hornak, J., & Andrews, C. (2001) · Nature Neuroscience · doi:10.1038/82959 · Cited by 2,003
The functional neuroanatomy of the human orbitofrontal cortex: Evidence from neuroimaging and neuropsychology
KRINGELBACH, M. (2004) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2004.03.006 · Cited by 1,977
Assessing the significance of focal activations using their spatial extent
Friston, K. J., Worsley, K. J., Frackowiak, R. S. J., Mazziotta, J. C., & Evans, A. C. (1994) · Human Brain Mapping · doi:10.1002/hbm.460010306 · Cited by 1,907

Show all 44 references

Research works printed but not linked: 1

Spitzer RL, Williams JB, Gibbon M, First MB (2004) Structured clinical interview for the DSM-IV (SCID-I/P). American Psychiatric Press, Arlington, VA

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Authors: McCabe, C., Cowen, P. J., & Harmer, C. J.
Affiliations: Warneford Hospital (GB)
Corresponding author: McCabe, Ciara
ORCID: McCabe, Ciara
Cowen, Philip J.
Harmer, Catherine J.
Venue: Psychopharmacology
Publisher: Springer Science and Business Media LLC
Published: 2009-06-16
Volume: 205
Issue: 4
Pages: 667-677
ISSN: 0033-3158 (ISSN-L)
1432-2072
DOI: 10.1007/s00213-009-1573-9
PMC: PMC2718193
OpenAlex: W2106916957
Cited by: 248
References: 44
Citations by year: 2026: 3 · 2025: 5 · 2024: 7 · 2023: 10 · 2022: 8 · 2021: 13 · 2020: 10 · 2019: 15 · 2018: 16 · 2017: 15 · 2016: 21 · 2015: 36 · 2014: 23 · 2013: 23 · 2012: 13
FWCI: 6.96
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc
Locations: Psychopharmacology (publishedVersion, cc-by-nc)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Medical Research Council
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Keywords: anhedonia, major depressive disorder, endophenotypes, reward processing, recovered depression, ventral striatum, caudate nucleus, prefrontal cortex, cross-modal integration, sensory integration, aversive stimuli, chocolate
MeSH terms: Adult, Basal Ganglia, Caudate Nucleus, Depression, Female, Humans, Magnetic Resonance Imaging, Male, Reward, Case-Control Studies, Prefrontal Cortex

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Neural representation of reward in recovered depressed patients

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