Major depressive disorder is characterized by greater reward network activation to monetary than pleasant image rewards
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Anhedonia, the loss of interest or pleasure in normally rewarding activities, is a hallmark feature of unipolar Major Depressive Disorder (MDD). A growing body of literature has identified frontostriatal dysfunction during reward anticipation and outcomes in MDD. However, no study to date has directly compared responses to different types of rewards such as pleasant images and monetary rewards in MDD. To investigate the neural responses to monetary and pleasant image rewards in MDD, a modified Monetary Incentive Delay task was used during functional magnetic resonance imaging to assess neural responses during anticipation and receipt of monetary and pleasant image rewards. Participants included nine adults with MDD and 13 affectively healthy controls. The MDD group showed lower activation than controls when anticipating monetary rewards in right orbitofrontal cortex and subcallosal cortex, and when anticipating pleasant image rewards in paracingulate and supplementary motor cortex. The MDD group had relatively greater activation in right putamen when anticipating monetary versus pleasant image rewards, relative to the control group. Results suggest reduced reward network activation in MDD when anticipating rewards, as well as relatively greater hypoactivation to pleasant image than monetary rewards.
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Reward-network function shows greater impairment in MDD while patients process pleasant images relative to monetary rewards.
“Finally, there is also evidence that reward-network function shows greater impairment in MDD while patients are processing pleasant images relative to monetary rewards [232].”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [232]
Reward-system dysfunction in a given disorder may be contingent on a particular class of stimuli (e.g., addiction cues in substance abuse, food images in eating disorders, sad pictures in unipolar depression).
“Additionally, there are a number of contexts in which reward-system dysfunction in a given disorder may be contingent on a particular class of stimuli (for example,, addiction cues in substance abuse [148], food images in eating disorders [326], and sad pictures in unipolar depression [232]).”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [232]
MDD patients generally exhibit reduced sensitivity to reward, reflected by reduced ventral CSTC loop activation in the orbitofrontal cortex, anterior cingulate and ventral striatum to reward and loss receipt/anticipation.
“MDD patients generally exhibit reduced sensitivity to reward; this cognitive blunting is reflected by reduced ventral CSTC loop activation in the orbitofrontal cortex, anterior cingulate and ventral striatum to reward and loss receipt/anticipation (Smoski et al., 2011; Chantiluke et al., 2012; Schiller et al., 2013; Admon et al., 2015; Manelis et al., 2016).”
From Cortico-striatal-thalamic loop circuits of the salience network: A central pathway in psychiatric disease and treatment (2016) · cites this paper as Smoski et al., 2011
Several fMRI studies using the monetary incentive delay task find ventral striatal activation changes without reaction-time changes, which suggests reaction time may be an insensitive reward-processing marker.
“It should be noted that in various studies utilizing fMRI and the monetary incentive delay task, changes in ventral striatal activation are often found in the absence of changes in reaction time (Jansma et al., 2013; Saji et al., 2013; Smoski et al., 2011), suggesting that reaction time may lack sensitivity as a marker for reward processing.”
From The effects of early life stress on reward processing (2018) · cites this paper as Smoski et al., 2011
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- Authors
- Smoski, M. J., Rittenberg, A., & Dichter, G. S.
- Affiliations
- Duke University (US)
- University of North Carolina at Chapel Hill (US)
- Corresponding author
- Smoski, Moria J.
- Venue
- Psychiatry Research: Neuroimaging
- Publisher
- Elsevier BV
- Published
- 2011-12
- Volume
- 194
- Issue
- 3
- Pages
- 263-270
- ISSN
- 0925-4927 (ISSN-L)
- PMC
- PMC3225489
- OpenAlex
- W2040046972
- Cited by
- 91
- References
- 33
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 3 · 2023: 7 · 2022: 3 · 2021: 6 · 2020: 9 · 2019: 6 · 2018: 7 · 2017: 5 · 2016: 9 · 2015: 7 · 2014: 6 · 2013: 10 · 2012: 2
- FWCI
- 3.08
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Psychiatry Research Neuroimaging (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
- UNC Libraries
- Funders
- NARSAD Young Investigator Program
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- major depressive disorder, anhedonia, reward anticipation, monetary rewards, reward network, orbitofrontal cortex, subcallosal cortex, paracingulate cortex, supplementary motor area, putamen, frontostriatal dysfunction, monetary incentive delay task
- MeSH terms
- Adolescent, Adult, Brain, Brain Mapping, Choice Behavior, Major Depressive Disorder, Emotions, Female, Games, Experimental, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged, Motivation, Nerve Net, Oxygen, Reaction Time, Reward, Multivariate Analysis, Young Adult
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