Cited by 149Social and Intergroup PsychologyRacial and Ethnic Identity ResearchNeural and Behavioral Psychology Studies

The DOI matches its Crossref record; 30 of the 32 references it cites were found in a registry or an index; none of the 32 sources its claims cite is checked for support yet.

Propranolol reduces implicit negative racial bias

Open access

Abstract

Background: Implicit negative attitudes towards other races are important in certain kinds of prejudicial social behaviour. Emotional mechanisms are thought to be involved in mediating implicit “outgroup” bias but there is little evidence concerning the underlying neurobiology. The aim of the present study was to examine the role of noradrenergic mechanisms in the generation of implicit racial attitudes. Methods: Healthy volunteers ( n = 36) of white ethnic origin, received a single oral dose of the β-adrenoceptor antagonist, propranolol (40 mg), in a randomised, double-blind, parallel group, placebo-controlled, design. Participants completed an explicit measure of prejudice and the racial implicit association test (IAT), 1–2 h after propranolol administration. Results: Relative to placebo, propranolol significantly lowered heart rate and abolished implicit racial bias, without affecting the measure of explicit racial prejudice. Propranolol did not affect subjective mood. Conclusions: Our results indicate that β-adrenoceptors play a role in the expression of implicit racial attitudes suggesting that noradrenaline-related emotional mechanisms may mediate negative racial bias. Our findings may also have practical importance given that propranolol is a widely used drug. However, further studies will be needed to examine whether a similar effect can be demonstrated in the course of clinical treatment.

Overview

AI snapshot

Written from the paper’s full text.

TL;DR

In a double-blind, placebo-controlled study of 36 white healthy volunteers, a single 40 mg oral dose of propranolol reduced implicit racial bias on the IAT without changing explicit racial prejudice or subjective mood. The authors conclude that noradrenergic/β-adrenoceptor mechanisms may mediate implicit negative racial attitudes.

Key findings

  • Propranolol significantly lowered heart rate relative to placebo (main effect of treatment: F(4, 30)=6.56, p=0.02; time × treatment: F(4, 30)=4.62, p=0.00).
  • Propranolol abolished the implicit racial bias effect: the IAT effect was smaller in the propranolol group (M=0.26, SD=1.09) than placebo (M=1.02, SD=0.84; t(33)=2.3, p=0.03, d=0.8), with a significant congruency × treatment interaction (F(1, 33)=6.20, p=0.02).
  • Explicit racial prejudice did not differ between groups, and no significant differences were found for religious, sexual, or drug-addiction prejudice (all p>0.2).
  • Propranolol did not alter VAS ratings of tense, angry, happy, sad, tired, or alert (all p>0.2); 34% of propranolol participants had a “negative” IAT score versus 0% of placebo participants (χ²(1, n=37)=7.2, p=0.02).

Methods

  • Randomized, double-blind, parallel-group, placebo-controlled design; 36 healthy volunteers of white ethnic origin, mostly British students, received either propranolol 40 mg orally (n=18) or placebo (n=18).
  • Participants completed an explicit prejudice feeling thermometer at 70 min and a computerized racial picture version of the IAT at 120 min after drug administration; heart rate and subjective mood were monitored.
  • IAT data were analyzed using Greenwald et al. (2003) improved algorithm; ANOVA was used for IAT, heart rate, and VAS, with post hoc unpaired t-tests, and Mann–Whitney U-tests for explicit prejudice scores.

Limitations

  • The paper states that explicit and implicit prejudice measures were given in a fixed order with a time gap, which might have produced a confounding effect whereby prior explicit testing interacted with propranolol to affect the IAT.
  • The paper notes that further studies are needed to determine whether the effect persists with sustained propranolol treatment, whether it modulates implicit bias outside the laboratory, and whether the action is peripheral or central.
  • Evident from the text: the sample was small (n=36), all white and mostly from a British student population, and the study used only behavioral measures; the authors also note that the IAT effect in the propranolol group was not significant, and the chi-square test reports n=37 despite 36 participants.

Model-written summary. Check it against the paper before relying on it.

Integrity signals

Registry

Crossref · 10.1007/s00213-012-2657-5

Cites

30 of 30 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

22 Not checked yet · 12 Own result · 5 Own method · 3 Own interpretation · 1 No basis given

Verify all 32 references — free account

Show all 20 claims

  • The quote only partly states this claim. 1
  • It may state two separate claims as one. 10
  • Probably not a substantial claim. 18
23 of 23
  • The paper relies on this without support.

    Negative evaluations of minority groups are a central source of avoidance, discrimination, and conflict.

    “Negative evaluations of minority groups are a central source of avoidance, discrimination, and conflict — problems which are of particular importance in today’s increasingly cosmopolitan world.”
  • The paper relies on this without support.

    Implicit negative attitudes towards other races are important in certain kinds of prejudicial social behaviour.

    “Implicit negative attitudes towards other races are important in certain kinds of prejudicial social behaviour.”
  • The paper relies on this without support.

    There is extensive evidence that implicit bias remains a live and potent influence.

    “There is, however, extensive evidence that implicit bias — automatic negative attitudes associated with out-group members (Greenwald et al. 1998) — remains a live and a potent influence.”
3 of 3

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Statistics recomputed

Every reported test result, recomputed from its test statistic and degrees of freedom. A result shows as not adding up only once an independent check has confirmed it.

  • ConsistentF(4, 30) = 6.56reported p = .02 · recomputed p < .001

    “F(4, 30) = 6.56, p = .02”

    The paper states a correction for multiple tests

  • ConsistentF(4, 30) = 4.62reported p = 0 · recomputed p = .005

    “F(4, 30) = 4.62, p = .00”

  • Consistentt(33) = 2.51reported p = .02 · recomputed p = .017

    “t(33) = 2.51, p = .02”

  • Consistentt(34) = 2.4reported p = .02 · recomputed p = .022

    “t(34) = 2.4, p = .02”

  • ConsistentF(1, 33) = 13.6reported p = .001 · recomputed p < .001

    “F(1, 33) = 13.60, p = .001”

  • ConsistentF(1, 33) = 6.2reported p = .02 · recomputed p = .018

    “F(1, 33) = 6.20, p = .02”

  • ConsistentF(1, 33) = 0.26reported p = .61 · recomputed p = .614

    “F(1, 33) = 0.26, p = .61”

  • Consistentt(33) = -1.85reported p > .05 · recomputed p = .073

    “t(33) = −1.85, p > .05”

  • Consistentt(33) = 0.95reported p > .05 · recomputed p = .349

    “t(33) = 0.95, p > .05”

  • Consistentt(33) = 2.3reported p = .03 · recomputed p = .028

    “t(33) = 2.3, p = .03”

  • Consistentt(17) = 4.3reported p = .001 · recomputed p < .001

    “t(17) = 4.30, p = .001”

    The paper prints p at a floor (such as p < .001)

  • Consistentt(17) = 2.8reported p = .01 · recomputed p = .012

    “t(17) = 2.80, p = .01”

  • Consistentt(18) = -0.53reported p > .05 · recomputed p = .603

    “t(18) = −0.53, p > .05”

  • Consistentt(18) = 1.82reported p > .05 · recomputed p = .085

    “t(18)=1.82, p > .05”

14 of 14

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

Each contradiction between two passages listed here was confirmed by an independent check.

2 of 2

Citations

Cites

Show all 32 references

Research works printed but not linked: 3

  1. Converse JM, Presser S (1986) Survey questions, handcrafting the standardized questionnaire, series: quantitative applications in the social science 63. Thousand Oaks, California: SAGE Publications
  2. Eysenck HJ, Eysenck SBG (1964) Manual of the Eysenck personal inventory. Educational and Industrial Testing Service, San Diego
  3. Poehlman TA, Uhlmann E, Greenwald AG, Banaji MR (2004) Understanding and using the implicit association test: III. Meta-analysis of predictive validity. Eur J Soc Psychol 38:922–934

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Metadata

Authors
Terbeck, S., Kahane, G., McTavish, S., Savulescu, J., Cowen, P. J., & Hewstone, M.
Affiliations
  • University of Oxford (GB)
  • Warneford Hospital (GB)
Corresponding author
Terbeck, Sylvia
Venue
Psychopharmacology
Published
2012-02-28
Volume
222
Issue
3
Pages
419-424
ISSN
  • 0033-3158 (ISSN-L)
  • 1432-2072
OpenAlex
W2058912915
Cited by
149
References
32
Citations by year
2026: 5 · 2025: 11 · 2024: 14 · 2023: 20 · 2022: 3 · 2021: 13 · 2020: 5 · 2019: 8 · 2018: 11 · 2017: 13 · 2016: 12 · 2015: 7 · 2014: 10 · 2013: 9 · 2012: 8
FWCI
35.87
Type
journal article
Language
en
Open access
Locations
  • Psychopharmacology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • PEARL (University of Plymouth) (submittedVersion)
  • PEARL (University of Plymouth) (submittedVersion, other-oa)
Funders
  • Wellcome Trust (087208, WT087208MF, 086041, WT086041MA)
  • Arts and Humanities Research Council (AH/F019513/1)
Topics
  • Social Sciences › Sociology and Political Science › Social and Intergroup Psychology
  • Social Sciences › Sociology and Political Science › Racial and Ethnic Identity Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords
propranolol, implicit racial bias, racial prejudice, beta-blockers, norepinephrine, emotional mechanisms, Implicit Association Test, heart rate, out-group bias, explicit prejudice
MeSH terms
Adrenergic beta-Antagonists, Double-Blind Method, Female, Heart Rate, Humans, Male, Prejudice, Propranolol, Social Behavior, White People

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