Maternal tobacco smoking, nicotine replacement and neurobehavioural development
Abstract
Abstract The adverse effects of prenatal cigarette smoke exposure on human reproductive outcomes are a major scientific and public health concern. In the United States, approximately 25% of women of childbearing age currently smoke cigarettes, and only a small percentage of these individuals quit after learning of their pregnancy. Women interested in smoking cessation during pregnancy have a number of options, including behavioural and pharmacological aids, but nicotine replacement therapy (NRT) is by far the most common approach. While NRT avoids exposure to the myriad compounds present in tobacco smoke, nicotine itself causes damage to the developing nervous system. The purpose of this article is to review the detrimental effects of developmental tobacco smoke exposure on short- and long-term outcomes with particular emphasis on neurobehavioural consequences. In conclusion based on the clear, adverse effects of nicotine on brain development observed in human and animal studies, we suggest that safer alternatives for smoking cessation in pregnancy are badly needed.
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Prenatal nicotine exposure in rats at plasma levels comparable to human active smokers causes apoptosis, fewer neuronal cells, truncated axonogenesis, and deficient synaptogenesis.
“In developing rats exposed prenatally to nicotine at plasma levels comparable to those in human active smokers, standard biomarkers of cell injury indicate apoptosis, reductions in the numbers of neuronal cells, truncation of axonogenesis, and deficient synaptogenesis.”
From Developmental toxicity of nicotine: A transdisciplinary synthesis and implications for emerging tobacco products (2017) · cites this paper as [56]
Animal models show that prenatal nicotine exposure reproduces the brain and behavior effects seen with maternal smoking in pregnancy.
“Animal models of prenatal nicotine exposure have successfully recapitulated the neurodevelopmental and behavioral phenotypes associated with maternal cigarette smoking during pregnancy,(55-57, 64, 306)”
From Developmental toxicity of nicotine: A transdisciplinary synthesis and implications for emerging tobacco products (2017) · cites this paper as [56]
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- Authors
- Pauly, J. R., & Slotkin, T. A.
- Affiliations
- University of Kentucky (US)
- Duke Medical Center (US)
- Corresponding author
- Pauly, James R
- ORCID
- Slotkin, Theodore A
- Venue
- Acta Paediatrica
- Publisher
- Wiley
- Published
- 2008-09-02
- Volume
- 97
- Issue
- 10
- Pages
- 1331-1337
- ISSN
- 0365-1436 (ISSN-L)
- 0803-5253
- 1651-2227
- OpenAlex
- W2131007207
- Cited by
- 214
- References
- 74
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 7 · 2023: 5 · 2022: 5 · 2021: 3 · 2020: 8 · 2019: 11 · 2018: 15 · 2017: 15 · 2016: 16 · 2015: 20 · 2014: 17 · 2013: 21 · 2012: 14
- FWCI
- 2.22
- Type
- journal article
- Language
- en
- Update notices
- erratum (2008-12-09)
- Open access
- closed
- Locations
- Acta Paediatrica (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Keywords
- maternal smoking, prenatal tobacco exposure, nicotine replacement therapy, smoking cessation during pregnancy, brain development, pregnancy outcomes
- MeSH terms
- Attention Deficit Disorder with Hyperactivity, Brain, Female, Ganglionic Stimulants, Humans, Infant, Newborn, Mothers, Nicotine, Pregnancy, Pregnancy Complications, Prenatal Exposure Delayed Effects, Risk Factors, Smoking, Sudden Infant Death, Time Factors, Smoking Cessation, Perinatal Care
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