Cited by 214Prenatal Substance Exposure EffectsSmoking Behavior and CessationNicotinic Acetylcholine Receptors Study

Maternal tobacco smoking, nicotine replacement and neurobehavioural development

Pauly, James R, Slotkin, Theodore A·2008·Acta Paediatrica

Abstract

Abstract The adverse effects of prenatal cigarette smoke exposure on human reproductive outcomes are a major scientific and public health concern. In the United States, approximately 25% of women of childbearing age currently smoke cigarettes, and only a small percentage of these individuals quit after learning of their pregnancy. Women interested in smoking cessation during pregnancy have a number of options, including behavioural and pharmacological aids, but nicotine replacement therapy (NRT) is by far the most common approach. While NRT avoids exposure to the myriad compounds present in tobacco smoke, nicotine itself causes damage to the developing nervous system. The purpose of this article is to review the detrimental effects of developmental tobacco smoke exposure on short- and long-term outcomes with particular emphasis on neurobehavioural consequences. In conclusion based on the clear, adverse effects of nicotine on brain development observed in human and animal studies, we suggest that safer alternatives for smoking cessation in pregnancy are badly needed.

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Crossref · 10.1111/j.1651-2227.2008.00852.x

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74 of 74 references verified0 citation errors · 0 not checkable

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Authors
Pauly, J. R., & Slotkin, T. A.
Affiliations
  • University of Kentucky (US)
  • Duke Medical Center (US)
Corresponding author
Pauly, James R
Venue
Acta Paediatrica
Publisher
Wiley
Published
2008-09-02
Volume
97
Issue
10
Pages
1331-1337
ISSN
  • 0365-1436 (ISSN-L)
  • 0803-5253
  • 1651-2227
OpenAlex
W2131007207
Cited by
214
References
74
Citations by year
2026: 2 · 2025: 6 · 2024: 7 · 2023: 5 · 2022: 5 · 2021: 3 · 2020: 8 · 2019: 11 · 2018: 15 · 2017: 15 · 2016: 16 · 2015: 20 · 2014: 17 · 2013: 21 · 2012: 14
FWCI
2.22
Type
journal article
Language
en
Update notices
erratum (2008-12-09)
Open access
closed
Locations
  • Acta Paediatrica (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
  • Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
Keywords
maternal smoking, prenatal tobacco exposure, nicotine replacement therapy, smoking cessation during pregnancy, brain development, pregnancy outcomes
MeSH terms
Attention Deficit Disorder with Hyperactivity, Brain, Female, Ganglionic Stimulants, Humans, Infant, Newborn, Mothers, Nicotine, Pregnancy, Pregnancy Complications, Prenatal Exposure Delayed Effects, Risk Factors, Smoking, Sudden Infant Death, Time Factors, Smoking Cessation, Perinatal Care

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