Cited by 127Probiotics and Fermented FoodsMicrobial Metabolites in Food BiotechnologyInfant Nutrition and Health

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Immunomodulatory effects of a probiotic drink containing Lactobacillus casei Shirota in healthy older volunteers

Dong, Honglin, Rowland, Ian, Thomas, Linda V., Yaqoob, Parveen·2013·European Journal of Nutrition

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Abstract

Purpose There is growing evidence that probiotics confer health benefits to the host by modulating immune function, especially in older people, where immunosenescence is a feature even of healthy ageing. The aim of this study was to investigate the effect of a probiotic drink containing Lactobacillus casei Shirota (LcS) on immune function in a healthy non-immunocompromised older population.Methods Thirty healthy old volunteers were recruited into a randomized placebo-controlled, single-blind crossover study. The volunteers were supplemented with the probiotic drink containing 1.3 × 10(10) CFU LcS or skimmed milk per day for 4 weeks, followed by 4 weeks of washout and were crossed over to the other treatment. Peripheral blood and saliva samples were collected at baseline and end of each treatment.Results Probiotic consumption was associated with a significant increase in natural killer (NK) cell activity relative to baseline and a significant decrease in the mean fluorescence intensity of CD25 expression in the resting T cells compared with placebo. Additionally, there was a trend towards an increased ratio of IL-10 to IL-12 relative to baseline after LcS intake.Conclusions Consumption of a probiotic drink containing LcS improved NK cell activity and tended to produce a more anti-inflammatory cytokine profile in an older population.

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Authors: Dong, H., Rowland, I., Thomas, L. V., & Yaqoob, P.
Affiliations: University of Reading (GB)
Corresponding author: Yaqoob, Parveen
ORCID: Dong, Honglin
Rowland, Ian
Thomas, Linda V.
Yaqoob, Parveen
Venue: European Journal of Nutrition
Publisher: Springer Science and Business Media LLC
Published: 2013-01-10
Volume: 52
Issue: 8
Pages: 1853-1863
ISSN: 1436-6207 (ISSN-L)
1436-6215
DOI: 10.1007/s00394-012-0487-1
OpenAlex: W2057844433
Cited by: 127
References: 50
Citations by year: 2026: 2 · 2025: 9 · 2024: 10 · 2023: 4 · 2022: 6 · 2021: 16 · 2020: 11 · 2019: 18 · 2018: 6 · 2017: 12 · 2016: 13 · 2015: 10 · 2014: 3 · 2013: 7
FWCI: 16.37
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: European Journal of Nutrition (publishedVersion)
PubMed (publishedVersion)
Funders: University of Reading
Topics: Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
Keywords: probiotics, Lactobacillus casei Shirota, immunomodulation, older adults, immunosenescence, NK cell cytotoxicity, anti-inflammatory cytokines, probiotic beverages, healthy aging
MeSH terms: Aged, Beverages, Blood Glucose, Female, Humans, Immunity, Innate, Killer Cells, Natural, Lacticaseibacillus casei, Leukocyte Count, Leukocytes, Mononuclear, Lipids, Male, Middle Aged, Phagocytes, Phenotype, T-Lymphocytes, Biomarkers, Single-Blind Method, Cytokines, Interleukin-10, Cross-Over Studies, Interleukin-12, Probiotics, Cell Proliferation, Interleukin-2 Receptor alpha Subunit, Healthy Volunteers

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Immunomodulatory effects of a probiotic drink containing Lactobacillus casei Shirota in healthy older volunteers

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