Effects of Soluble Corn Fiber Alone or in Synbiotic Combination with Lactobacillus rhamnosus GG and the Pilus-Deficient Derivative GG-PB12 on Fecal Microbiota, Metabolism, and Markers of Immune Function: A Randomized, Double-Blind, Placebo-Controlled, Crossover Study in Healthy Elderly (Saimes Study)

Costabile, Adele; Bergillos-Meca, Triana; Rasinkangas, Pia; Korpela, Katri; de Vos, Willem M.; Gibson, Glenn R.

doi:10.3389/fimmu.2017.01443

Cited by 94Probiotics and Fermented FoodsMicrobial Metabolites in Food BiotechnologyGut microbiota and health

Effects of Soluble Corn Fiber Alone or in Synbiotic Combination with Lactobacillus rhamnosus GG and the Pilus-Deficient Derivative GG-PB12 on Fecal Microbiota, Metabolism, and Markers of Immune Function: A Randomized, Double-Blind, Placebo-Controlled, Crossover Study in Healthy Elderly (Saimes Study)

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Costabile, Adele, Bergillos-Meca, Triana, Rasinkangas, Pia, Korpela, Katri, de Vos, Willem M., Gibson, Glenn R.·2017·Frontiers in Immunology

DOI 10.3389/fimmu.2017.01443PMC PMC5733116

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Abstract

The aging process leads to a potential decline in immune function and adversely affects the gut microbiota. Dietary intervention is one approach to affect gut microbiota composition and improved functioning of the immune system. We investigated the effects of a probiotic Lactobacillus rhamnosus GG and pilus-deficient L. rhamnosus GG-PB12 combined with PromitorTM Soluble Corn Fibre (SCF, a candidate prebiotic) on faecal microbiota, metabolism, immunity and blood lipids in healthy elderly persons. A prospective, double-blind, placebo controlled, randomized, single centered, cross-over study in 40 healthy elderly subjects (aged 60-80 y) was carried out. Volunteers were randomized to consume either probiotic and prebiotic as synbiotic, prebiotic or placebo (maltodextrin) during 3-weeks. Three-week wash-out periods separated all the treatments. We assessed effects upon blood lipids, glucose, cytokines, NK cell activity, phenotype and intestinal microbiota composition. SCF decreased IL-6, which was not observed with the synbiotics. Consumption of L. rhamnosus GG combined with SCF increased NK cell activity compared to baseline in females and the older group. In the faecal microbiota analyses, the strongest community shifts were due to L. rhamnosus GG combined with SCF and SCF treatments. L. rhamnosus GG combined with SCF and L. rhamnosus GG-PB12 combined with SCF significantly increased the genus Parabacteroides. L. rhamnosus GG combined with SCF and SCF increased concentrations of Ruminococcaceae Incertae sedis. Oscillospira and Desulfovibrio slightly decreased in the L. rhamnosus GG combined with SCF group, whereas Desulfovibrio decreased also in the L. rhamnosus GG-PB12 combined with SCF group. L. rhamnosus GG combined with SCF reduced total cholesterol and LDL-cholesterol in volunteers with initially elevated concentrations. CRP significantly decreased during L. rhamnosus GG-PB12 combined with SCF intervention compared to baseline. Piliated L. rhamnosus GG was more potent at inducing beneficial effects compared to L. rhamnosus GG-PB12 by modulating the microbiome, increasing NK cell activity compared to SCF alone in older volunteers and decrease of the pro-inflammatory cytokine IL-6. The trial was registered at clinical-trial.gov as NCT03168503.

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The structure of the intestinal microbial community is principally modulated by synbiotic intake.
“This is in line with the majority of the literature data [48,50], in which the structure of the intestinal microbial community is principally modulated by the synbiotic intake [22].”
From Effects of inulin-based prebiotics alone or in combination with probiotics on human gut microbiota and markers of immune system: a randomized, double-blind, placebo-controlled study in healthy subjects (2022) · cites this paper as [48]
The positive cumulative variation of Blautia, Faecalibacterium, and Ruminococcus demonstrates the efficacy of probiotic plus prebiotics intake against the normal decrease in the gut of elderly subjects.
“that demonstrate the efficacy of the probiotic plus the prebiotics intake against the normal decrease in the gut of elderly subjects [48].”
From Effects of inulin-based prebiotics alone or in combination with probiotics on human gut microbiota and markers of immune system: a randomized, double-blind, placebo-controlled study in healthy subjects (2022) · cites this paper as [48]

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Grundy, S. M., Cleeman, J. I., Merz, C. N. B., Brewer, H. B., Clark, L. T., Hunninghake, D. B., Pasternak, R. C., Smith, S. C., & Stone, N. J. (2004) · Circulation · doi:10.1161/01.cir.0000133317.49796.0e · Cited by 6,902 · see citing works
Complement factor H polymorphism in age-related macular degeneration
Klein, R. J., Zeiss, C., Chew, E. Y., Tsai, J.-Y., Sackler, R. S., Haynes, C., Henning, A. K., SanGiovanni, J. P., Mane, S. M., Mayne, S. T., et al. (2005) · Science · doi:10.1126/science.1109557 · Cited by 4,492 · see citing works
Determination of bacterial load by real-time PCR using a broad-range (universal) probe and primers set
Nadkarni, M. A., Martin, F. E., Jacques, N. A., & Hunter, N. (2002) · Microbiology · doi:10.1099/00221287-148-1-257 · Cited by 1,931 · see citing works
Quantifying effect of statins on low density lipoprotein cholesterol, ischaemic heart disease and stroke: systematic review and meta-analysis
Law, M. R., Wald, N. J., & Rudnicka, A. R. (2003) · BMJ · doi:10.1136/bmj.326.7404.1423 · Cited by 1,720 · see citing works
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Biagi, E., Nylund, L., Candela, M., Ostan, R., Bucci, L., Pini, E., Nikkïla, J., Monti, D., Satokari, R., Franceschi, C., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010667 · Cited by 1,483 · see citing works
Natural cytotoxic activity of peripheral-blood lymphocytes and cancer incidence: an 11-year follow-up study of a general population
Imai, K., Matsuyama, S., Miyaké, S., Suga, K., & Nakachi, K. (2000) · The Lancet · doi:10.1016/s0140-6736(00)03231-1 · Cited by 1,189 · see citing works
Towards the human intestinal microbiota phylogenetic core
Tap, J., Mondot, S., Levenez, F., Pelletier, E., Caron, C., Furet, J., Ugarte, E., Muñoz‐Tamayo, R., Paslier, D. L. E., Nalin, R., et al. (2009) · Environmental Microbiology · doi:10.1111/j.1462-2920.2009.01982.x · Cited by 927 · see citing works
The aging of the immune system
Weiskopf, D., Weinberger, B., & Grubeck-Loebenstein, B. (2009) · Transplant International · doi:10.1111/j.1432-2277.2009.00927.x · Cited by 908 · see citing works
Effectiveness of Influenza Vaccine in the Community-Dwelling Elderly
Nichol, K. L., Nordin, J. D., Nelson, D. B., Mullooly, J. P., & Hak, E. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa070844 · Cited by 647 · see citing works
Comparative analysis of fecal DNA extraction methods with phylogenetic microarray: Effective recovery of bacterial and archaeal DNA using mechanical cell lysis
Salonen, A., Nikkilä, J., Jalanka, J., Immonen, O., Rajilić-Stojanović, M. D., Kekkonen, R. A., Palva, A., & de Vos, W. M. (2010) · Journal of Microbiological Methods · doi:10.1016/j.mimet.2010.02.007 · Cited by 592 · see citing works
Issues in Outcomes Research: An Overview of Randomization Techniques for Clinical Trials
Kang, M., Ragan, B. G., & Park, J.-H. (2008) · Journal of Athletic Training · doi:10.4085/1062-6050-43.2.215 · Cited by 555 · cited 1× · see citing works
“An Excel-based covariate adaptive randomization program (16) to enter four intervention arms randomized the volunteers: L.”
Method
Microbial pathways in colonic sulfur metabolism and links with health and disease
Carbonero, F., Benefiel, A. C., Alizadeh-Ghamsari, A. H., & Gaskins, H. R. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00448 · Cited by 544 · see citing works
Enhancement of immunity in the elderly by dietary supplementation with the probiotic Bifidobacterium lactis HN019
Gill, H. S., Rutherfurd, K. J., Cross, M. L., & Gopal, P. K. (2001) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/74.6.833 · Cited by 485 · cited 4× · see citing works
“Chiang BL, Sheih YH, Wang LH, Liao CK, Gill HS. Enhancing immunity by dietary consumption of a probiotic lactic acid bacterium (Bifidobacterium lactis HN019): optimization and definition of cellular immune responses.”
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Håkansson, Å., & Molin, G. (2011) · Nutrients · doi:10.3390/nu3060637 · Cited by 454 · see citing works
Microbial shifts in the aging mouse gut
Langille, M. G., Meehan, C. J., Koenig, J. E., Dhanani, A. S., Rose, R. A., Howlett, S. E., & Beiko, R. G. (2014) · Microbiome · doi:10.1186/s40168-014-0050-9 · Cited by 437 · see citing works
Value of immunological markers in predicting responsiveness to influenza vaccination in elderly individuals
Goronzy, J. J., Fulbright, J. W., Crowson, C. S., Poland, G. A., O'Fallon, W. M., & Weyand, C. M. (2001) · Journal of Virology · doi:10.1128/jvi.75.24.12182-12187.2001 · Cited by 402 · see citing works
Aging and innate immune cells
Plackett, T. P., Boehmer, E. D., Faunce, D. E., & Kovacs, E. J. (2004) · Journal of Leukocyte Biology · doi:10.1189/jlb.1103592 · Cited by 351 · see citing works
Dietary Probiotic Supplementation Enhances Natural Killer Cell Activity in the Elderly: An Investigation of Age-Related Immunological Changes
Gill, H. S., Rutherfurd, K. J., & Cross, M. L. (2001) · Journal of Clinical Immunology · doi:10.1023/a:1010979225018 · Cited by 304 · see citing works
Gut microbiota: Changes throughout the lifespan from infancy to elderly
O’Toole, P. W., & Claesson, M. J. (2009) · International Dairy Journal · doi:10.1016/j.idairyj.2009.11.010 · Cited by 279 · see citing works
Oral intake of Lactobacillus fermentum CECT5716 enhances the effects of influenza vaccination
Olivares, M. M., Díaz-Ropero, M. P., Sierra, S., Lara‐Villoslada, F., Fonollá, J., Navas, M., Rodríguez, J. M., & Xaus, J. (2007) · Nutrition · doi:10.1016/j.nut.2007.01.004 · Cited by 264 · see citing works
Effect of Lactobacillus gasseri PA 16/8, Bifidobacterium longum SP 07/3, B. bifidum MF 20/5 on common cold episodes: A double blind, randomized, controlled trial
de Vrese, M., Winkler, P., Rautenberg, P., Harder, T., Noah, C., Laue, C., Ott, S. J., Hampe, J., Schreiber, S., Heller, K. J., et al. (2005) · Clinical Nutrition · doi:10.1016/j.clnu.2005.02.006 · Cited by 252 · see citing works
Daily Probiotic’s (Lactobacillus casei Shirota) Reduction of Infection Incidence in Athletes
Gleeson, M., Bishop, N. C., Oliveira, M., & Tauler, P. (2011) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.21.1.55 · Cited by 239 · see citing works
Enhancing immunity by dietary consumption of a probiotic lactic acid bacterium (Bifidobacterium lactis HN019): optimization and definition of cellular immune responses
Chiang, B., Sheih, Y.-H., Wang, L. H., Liao, C., & Gill, H. S. (2000) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1601093 · Cited by 238 · see citing works
Systemic Immunity-Enhancing Effects in Healthy Subjects Following Dietary Consumption of the Lactic Acid BacteriumLactobacillus rhamnosusHN001
Sheih, Y.-H., Chiang, B., Wang, L.-H., Liao, C.-K., & Gill, H. S. (2001) · Journal of the American College of Nutrition · doi:10.1080/07315724.2001.10719027 · Cited by 237 · see citing works
Age-related changes in natural killer cell receptors from childhood through old age
Almeida-Oliveira, A., Smith-Carvalho, M., Pôrto, L. C., Cardoso-Oliveira, J., Ribeiro, A. D. S., Falcão, R. R., Abdelhay, E., Bouzas, L. F., Thuler, L. C. S., Ornellas, M. H., et al. (2011) · Human Immunology · doi:10.1016/j.humimm.2011.01.009 · Cited by 223 · see citing works
Association between natural killer cell activity and infection in immunologically normal elderly people
Ogata, K., An, E., Shioi, Y., Nakamura, K., Luo, S., Yokose, N., Minami, S., & Dan, K. (2001) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.2001.01571.x · Cited by 207 · see citing works
Probiotics, Immune Function, Infection and Inflammation: A Review of the Evidence from Studies Conducted in Humans
Lomax, A. E., & Calder, P. C. (2009) · Current Pharmaceutical Design · doi:10.2174/138161209788168155 · Cited by 203 · see citing works
Comparative effects of six probiotic strains on immune functionin vitro
Dong, H., Rowland, I. R., & Yaqoob, P. (2011) · British Journal Of Nutrition · doi:10.1017/s0007114511005824 · Cited by 196 · see citing works
Mechanisms of Microbial Hydrogen Disposal in the Human Colon and Implications for Health and Disease
Nakamura, N., Lin, H. C., McSweeney, C. S., Mackie, R. I., & Gaskins, H. R. (2010) · Annual Review of Food Science and Technology · doi:10.1146/annurev.food.102308.124101 · Cited by 194 · see citing works
Effects of a Fermented Milk Drink Containing Lactobacillus casei Strain Shirota on the Immune System in Healthy Human Subjects
Nagao, F., NAKAYAMA, M., Muto, T., & Okumura, K. (2000) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.64.2706 · Cited by 193 · see citing works
Meta-Analysis: Effects of Probiotic Supplementation on Lipid Profiles in Normal to Mildly Hypercholesterolemic Individuals
Shimizu, M., Hashiguchi, M., Shiga, T., Tamura, H.-O., & Mochizuki, M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0139795 · Cited by 182 · see citing works
The effects of probiotic and conventional yoghurt on lipid profile in women
Sadrzadeh-Yeganeh, H., Elmadfa, I., Djazayery, A., Jalali, M., Heshmat, R., & Chamary, M. (2010) · British Journal Of Nutrition · doi:10.1017/s0007114509993801 · Cited by 179 · see citing works
Distinct Bifidobacterium strains drive different immune responses in vitro
López, P., Gueimonde, M., Margollés, A., & Suárez, A. (2010) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2009.12.023 · Cited by 174 · see citing works
Xylo-oligosaccharides alone or in synbiotic combination with Bifidobacterium animalis subsp. lactis induce bifidogenesis and modulate markers of immune function in healthy adults: a double-blind, placebo-controlled, randomised, factorial cross-over study
Childs, C. E., Röytiö, H., Alhoniemi, E. J., Fekete, A. A., Forssten, S. D., Hudjec, N., Lim, Y. N., Steger, C. J., Yaqoob, P., Tuohy, K. M., et al. (2014) · British Journal Of Nutrition · doi:10.1017/s0007114513004261 · Cited by 169 · see citing works
Self-citation
The relationship between reduction in low-density lipoprotein cholesterol by statins and reduction in risk of cardiovascular outcomes: An updated meta-analysis
Delahoy, P. J., Magliano, D. J., Webb, K., Grobler, M. P., & Liew, D. (2009) · Clinical Therapeutics · doi:10.1016/j.clinthera.2009.02.017 · Cited by 167 · see citing works
Effects of a Fermented Milk Drink Containing Lactobacillus casei Strain Shirota on the Human NK-Cell Activity1,
Takeda, K., & Okumura, K. (2007) · Journal of Nutrition · doi:10.1093/jn/137.3.791s · Cited by 161 · see citing works
Resistant dextrin, as a prebiotic, improves insulin resistance and inflammation in women with type 2 diabetes: a randomised controlled clinical trial
Aliasgharzadeh, A., Dehghan, P., Gargari, B. P., & Jafarabadi, M. A. (2015) · British Journal Of Nutrition · doi:10.1017/s0007114514003675 · Cited by 150 · see citing works
Effects of a nutritional supplement on the immune response and cytokine production in free‐living Chilean elderly
Bunout, D. C., Barrera, G. F., Hirsch, S., Gattas, V., de la Maza, M., Haschke, F., Steenhout, P. G., Klassen, P., Hager, C., Avendano, M., et al. (2004) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607104028005348 · Cited by 143 · see citing works
Immunomodulatory effects of a probiotic drink containing Lactobacillus casei Shirota in healthy older volunteers
Dong, H., Rowland, I., Thomas, L. V., & Yaqoob, P. (2013) · European Journal of Nutrition · doi:10.1007/s00394-012-0487-1 · Cited by 127 · see citing works
Consumption of prebiotic inulin enriched with oligofructose in combination with the probiotics Lactobacillus rhamnosus and Bifidobacterium lactis has minor effects on selected immune parameters in polypectomised and colon cancer patients
Roller, M., Clune, Y., Collins, K., Rechkemmer, G., & Watzl, B. (2007) · British Journal of Nutrition · doi:10.1017/s0007114507450292 · Cited by 125 · see citing works
The Effect of the Undigested Fraction of Maize Products on the Activity and Composition of the Microbiota Determined in a Dynamicin VitroModel of the Human Proximal Large Intestine
Maathuis, A. J. H., Hoffman, A., Evans, A., Sanders, L., & Venema, K. (2009) · Journal of the American College of Nutrition · doi:10.1080/07315724.2009.10719798 · Cited by 121 · see citing works
Natural killer cells in healthy aging
Solana, R., Alonso, M. C., & Peña, J. (1999) · Experimental Gerontology · doi:10.1016/s0531-5565(99)00008-x · Cited by 116 · see citing works
The active human gut microbiota differs from the total microbiota
Peris-Bondia, F., Latorre, A., Artacho, A., Moya, A., & D'Auria, G. (2011) · PLoS ONE · doi:10.1371/journal.pone.0022448 · Cited by 113 · see citing works
Aging and serum MCP-1 are associated with gut microbiome composition in a murine model
Conley, M. N., Wong, C. P., Duyck, K. M., Hord, N. G., Ho, E., & Sharpton, T. J. (2016) · PeerJ · doi:10.7717/peerj.1854 · Cited by 108 · see citing works
Digestive physiological outcomes related to polydextrose and soluble maize fibre consumption by healthy adult men
Boler, B. M. V., Serao, M. C. R., Bauer, L. L., Staeger, M. A., Boileau, T. W.-M., Swanson, K. S., & Fahey, G. C., Jr. (2011) · British Journal Of Nutrition · doi:10.1017/s0007114511002388 · Cited by 100 · see citing works
Cholesterol-Lowering Interventions and Stroke
Caterina, R. D., Scarano, M., Marfisi, R., Lucisano, G., Palma, F., Tatasciore, A., & Marchioli, R. (2010) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2009.07.062 · Cited by 95 · see citing works
Immune-stimulating effects of lactic acid bacteria in vivo and in vitro
Elmadfa, I., Klein, P., & Meyer, A. L. (2010) · Proceedings of the Nutrition Society · doi:10.1017/s0029665110001710 · Cited by 89 · see citing works
Evaluation of the Effect of Four Fibers on Laxation, Gastrointestinal Tolerance and Serum Markers in Healthy Humans
Stewart, M., Nikhanj, S. D., Timm, D. A., Thomas, W. T. B., & Slavin, J. L. (2010) · Annals of Nutrition and Metabolism · doi:10.1159/000275962 · Cited by 88 · see citing works
Modulation of natural killer cell activity by supplementation of fermented milk containing Lactobacillus casei in habitual smokers
Morimoto, K., Takeshita, T., Nanno, M., Tokudome, S., & Nakayama, K. (2004) · Preventive Medicine · doi:10.1016/j.ypmed.2004.07.019 · Cited by 85 · see citing works
Maintenance of a healthy trajectory of the intestinal microbiome during aging: A dietary approach
Candela, M., Biagi, E., Brigidi, P., O’Toole, P. W., & de Vos, W. M. (2013) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2013.12.004 · Cited by 85 · see citing works
Immunomodulation by food: promising concept for mitigating allergic disease?
Wichers, H. J. (2009) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-009-2838-1 · Cited by 79 · see citing works
Effects of corticosteroids on natural killer cell activity in systemic lupus erythematosus.
Oshimi, K., Gonda, N., Sumiya, M., & Kano, S. (1980) · PubMed Central · Cited by 59 · see citing works
Probiotic supplementation to enhance natural immunity in the elderly: effects of a newly characterized immunostimulatory strain Lactobacillus rhamnosus HN001 (DR20™) on leucocyte phagocytosis
Gill, H. S., & Rutherfurd, K. J. (2001) · Nutrition Research · doi:10.1016/s0271-5317(00)00294-3 · Cited by 57 · see citing works
Effect of polydextrose and soluble maize fibre on energy metabolism, metabolic profile and appetite control in overweight men and women
Konings, E., Schoffelen, P. F. M., Stegen, J. H. C. H., & Blaak, E. E. (2013) · British Journal Of Nutrition · doi:10.1017/s0007114513002183 · Cited by 56 · see citing works
Prebiotic Potential of a Maize-Based Soluble Fibre and Impact of Dose on the Human Gut Microbiota
Costabile, A., Deaville, E. R., Morales, A. M., & Gibson, G. R. (2016) · PLoS ONE · doi:10.1371/journal.pone.0144457 · Cited by 47 · see citing works
Self-citation
Effects of prebiotic supplementation on the expression of proteins regulating iron absorption in anaemic growing rats
Marciano, R., Santamarina, A. B., de Santana, A. A., Silva, M. D. L. C., Amâncio, O. M. S., do Nascimento, C. M. D. P. O., Oyama, L. M., & de Morais, M. B. (2015) · British Journal Of Nutrition · doi:10.1017/s0007114514004334 · Cited by 41 · see citing works
Prebiotic inulin supplementation modulates the immune response and restores gut morphology in Giardia duodenalis-infected malnourished mice
Shukla, G., Bhatia, R., & Sharma, A. (2016) · Parasitology Research · doi:10.1007/s00436-016-5196-x · Cited by 41 · see citing works
Pregabalin versus gabapentin in partial epilepsy: a meta-analysis of dose-response relationships
Delahoy, P. J., Thompson, S., & Marschner, I. C. (2010) · BMC Neurology · doi:10.1186/1471-2377-10-104 · Cited by 36 · see citing works
The effects of fermented milks with simple and complex probiotic mixtures on the intestinal microbiota and immune response of healthy adults and children
Zanini, K., Marzotto, M., Castellazzi, A. M., Borsari, A., Dellaglio, F., & Torriani, S. (2007) · International Dairy Journal · doi:10.1016/j.idairyj.2007.01.017 · Cited by 28 · see citing works
Microbial–Host Interactions: Selecting the Right Probiotics and Prebiotics for Infants
Salminen, S., Collado, M. C., Isolauri, E., & Gueimonde, M. (2009) · Nestlé Nutrition Institute Workshop series · doi:10.1159/000235792 · Cited by 27 · see citing works
Daily ingestion of a nutritional probiotic supplement enhances innate immune function in healthy adults
Berman, S. H., Eichelsdoerfer, P. E., Yim, D., Elmer, G. W., & Wenner, C. A. (2006) · Nutrition Research · doi:10.1016/j.nutres.2006.08.002 · Cited by 26 · see citing works
Genomic Characterization of Non-Mucus-Adherent Derivatives of Lactobacillus rhamnosus GG Reveals Genes Affecting Pilus Biogenesis
Rasinkangas, P., Reunanen, J., Douillard, F. P., Ritari, J., Uotinen, V., Palva, A., & de Vos, W. M. (2014) · Applied and Environmental Microbiology · doi:10.1128/aem.02006-14 · Cited by 19 · see citing works
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Ghosh, T. S., Shanahan, F., & O’Toole, P. W. (2022) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-022-00605-x · Cited by 817 · see citing works
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Myhrstad, M. C. W., Tunsjø, H. S., Charnock, C., & Telle‐Hansen, V. H. (2020) · Nutrients · doi:10.3390/nu12030859 · Cited by 280 · see citing works
Age-dependent changes in GI physiology and microbiota: time to reconsider?
An, R., Wilms, E., Masclee, A. A. M., Smidt, H., Zoetendal, E. G., & Jonkers, D. (2018) · Gut · doi:10.1136/gutjnl-2017-315542 · Cited by 209 · see citing works
Critical role of the gut microbiota in immune responses and cancer immunotherapy
Li, Z., Xiong, W., Zhu, L. W., Wang, J., Zeng, Z., Kołat, D., Li, X., Zhou, D., Xu, X., & Zhao, L.-Y. (2024) · Journal of Hematology & Oncology · doi:10.1186/s13045-024-01541-w · Cited by 188 · see citing works
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Poggi, A. D., Benelli, R., Venè, R., Costa, D., Ferrari, N., Tosetti, F., & Zocchi, M. R. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00961 · Cited by 156 · see citing works
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Pujari, R., & Banerjee, G. (2020) · Immunology and Cell Biology · doi:10.1111/imcb.12409 · Cited by 145 · see citing works
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Kazemi, A., Soltani, S., Ghorabi, S., Keshtkar, A., Daneshzad, E., Nasri, F., & Mazloomi, S. M. (2020) · Clinical Nutrition · doi:10.1016/j.clnu.2019.04.004 · Cited by 131 · see citing works
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Coman, V., & Vodnar, D. C. (2020) · Experimental Gerontology · doi:10.1016/j.exger.2020.111095 · Cited by 124 · see citing works
Feruloylated oligosaccharides and ferulic acid alter gut microbiome to alleviate diabetic syndrome
Song, Y., Wu, M.-S., Tao, G., Lu, M., Lin, J., & Huang, J. (2020) · Food Research International · doi:10.1016/j.foodres.2020.109410 · Cited by 114 · see citing works
Probiotic Bifidobacterium longum BB68S Improves Cognitive Functions in Healthy Older Adults: A Randomized, Double-Blind, Placebo-Controlled Trial
Shi, S., Zhang, Q., Sang, Y., Ge, S., Wang, Q., Wang, R., & He, J. (2022) · Nutrients · doi:10.3390/nu15010051 · Cited by 101 · see citing works
Members of the Lactobacillus Genus Complex (LGC) as Opportunistic Pathogens: A Review
Rossi, F., Amadoro, C., & Colavita, G. (2019) · Microorganisms · doi:10.3390/microorganisms7050126 · Cited by 97 · see citing works
Effect of synbiotic supplementation on immune parameters and gut microbiota in healthy adults: a double-blind randomized controlled trial
Li, X., Hu, S., Yin, J., Peng, X., King, L., Li, L., Xu, Z., Zhou, L., Peng, Z., Ze, X., et al. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2247025 · Cited by 94 · see citing works
Precision nutrition and the microbiome part II: potential opportunities and pathways to commercialisation
Mills, S., Lane, J. A., Smith, G. J., Grimaldi, K. A., Ross, R. P., & Stanton, C. (2019) · Nutrients · doi:10.3390/nu11071468 · Cited by 88 · see citing works
Niche availability and competitive loss by facilitation control proliferation of bacterial strains intended for soil microbiome interventions
Čaušević, S., Dubey, M., Morales, M., Salazar, G., Sentchilo, V., Carraro, N., Ruscheweyh, H., Sunagawa, S., & van der Meer, J. R. (2024) · Nature Communications · doi:10.1038/s41467-024-46933-1 · Cited by 87 · see citing works
The intestinal microbiome and its relevance for functionality in older persons
Ticinesi, A., Tana, C., & Nouvenne, A. (2019) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000521 · Cited by 80 · see citing works
The gut microbiota and aging: interactions, implications, and interventions
Gyriki, D., Nikolaidis, C. G., Bezirtzoglou, E., Voidarou, C. C., Stavropoulou, E., & Tsigalou, C. (2025) · Frontiers in Aging · doi:10.3389/fragi.2025.1452917 · Cited by 75 · see citing works
The potential role of adherence factors in probiotic function in the gastrointestinal tract of adults and pediatrics: a narrative review of experimental and human studies
Gorreja, F., & Walker, W. A. (2022) · Gut Microbes · doi:10.1080/19490976.2022.2149214 · Cited by 74 · see citing works
Gut microbiota and aging-A focus on centenarians
Cӑtoi, A. F., Corina, A., Katsiki, N., Vodnar, D. C., Andreicuț, A. D., Stoian, A. P., Rizzo, M., & Pérez-Martínez, P. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2020.165765 · Cited by 70 · see citing works
Achieving healthy aging through gut microbiota-directed dietary intervention: Focusing on microbial biomarkers and host mechanisms
Xiao, Y., Feng, Y., Zhao, J., Chen, W., & Lu, W. (2024) · Journal of Advanced Research · doi:10.1016/j.jare.2024.03.005 · Cited by 75 · see citing works
Feruloylated oligosaccharides modulate the gut microbiota in vitro via the combined actions of oligosaccharides and ferulic acid
Gong, L., Wang, H., Wang, T., Liu, Y., Wang, J., & Sun, B. (2019) · Journal of Functional Foods · doi:10.1016/j.jff.2019.103453 · Cited by 67 · see citing works
Short-term probiotic supplementation enhances cellular immune function in healthy elderly: systematic review and meta-analysis of controlled studies
Miller, L. E., Lehtoranta, L., & Lehtinen, M. J. (2019) · Nutrition Research · doi:10.1016/j.nutres.2018.12.011 · Cited by 60 · see citing works
Effect of ingesting yogurt fermented with Lactobacillus delbrueckii ssp. bulgaricus OLL1073R-1 on influenza virus-bound salivary IgA in elderly residents of nursing homes: a randomized controlled trial
Yamamoto, Y., Saruta, J., Takahashi, T., To, M., Shimizu, T., Hayashi, T., Morozumi, T., Kubota, N., Kamata, Y., Makino, S., et al. (2019) · Acta Odontologica Scandinavica · doi:10.1080/00016357.2019.1609697 · Cited by 57 · see citing works
The Effect of Probiotics on Health Outcomes in the Elderly: A Systematic Review of Randomized, Placebo-Controlled Studies
Hutchinson, A. N., Bergh, C., Krüger, K., Sűsserová, M., Allen, J., Améen, S., & Tingö, L. (2021) · Microorganisms · doi:10.3390/microorganisms9061344 · Cited by 54 · see citing works
Gut microbiota in hepatocellular carcinoma immunotherapy: immune microenvironment remodeling and gut microbiota modification
Huang, M., Ji, Q., Huang, H., Wang, X., & Wang, L. (2025) · Gut Microbes · doi:10.1080/19490976.2025.2486519 · Cited by 53 · see citing works
Effects of probiotic supplementation on natural killer cell function in healthy elderly individuals: a meta-analysis of randomized controlled trials
Gui, Q., Wang, A., Zhao, X., Huang, S., Tan, Z., Xiao, C., & Yang, Y. (2020) · European Journal of Clinical Nutrition · doi:10.1038/s41430-020-0670-z · Cited by 49 · see citing works
Gut microbiome and aging nexus and underlying mechanism
Shi, X., Ma, T., Sakandar, H. A., Menghe, B., & Sun, Z. (2022) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-022-12089-5 · Cited by 48 · see citing works
Effects of inulin-based prebiotics alone or in combination with probiotics on human gut microbiota and markers of immune system: a randomized, double-blind, placebo-controlled study in healthy subjects
De Giani, A., Sandionigi, A., Zampolli, J., Michelotti, A., Tursi, F., Labra, M., & Di Gennaro, P. (2022) · Microorganisms · doi:10.3390/microorganisms10061256 · Cited by 46 · see citing works
From microbiome composition to functional engineering, one step at a time
Burz, S. D., Čaušević, S., Co, A. D., Dmitrijeva, M., Engel, P., Garrido‐Sanz, D., Greub, G., Hapfelmeier, S., Hardt, W., Vassily Hatzimanikatis, A., et al. (2023) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00063-23 · Cited by 42 · see citing works
Therapeutic Potential of Various Plant-Based Fibers to Improve Energy Homeostasis via the Gut Microbiota
Martinez, T. M., Meyer, R. K., & Duca, F. A. (2021) · Nutrients · doi:10.3390/nu13103470 · Cited by 41 · see citing works
Effects of different microbial pretreatments on the anaerobic digestion of giant grass under anaerobic and microaerobic conditions
Wang, L., Liu, C., Wei, B., Song, C., Cai, F., Liu, G., & Chen, C. (2021) · Bioresource Technology · doi:10.1016/j.biortech.2021.125456 · Cited by 37 · see citing works
The Effects of Prebiotics, Synbiotics, and Short-Chain Fatty Acids on Respiratory Tract Infections and Immune Function: A Systematic Review and Meta-Analysis
Williams, L. M., Stoodley, I. L., Berthon, B. S., & Wood, L. G. (2021) · Advances in Nutrition · doi:10.1093/advances/nmab114 · Cited by 34 · see citing works
The role of gut microbiota in human metabolism and inflammatory diseases: a focus on elderly individuals
Khaledi, M., Poureslamfar, B., Alsaab, H. O., Tafaghodi, S., Hjazi, A. M., Singh, R., Alawadi, A. H., Alsaalamy, A. H., Qasim, Q. A., & Sameni, F. (2024) · Annals of Microbiology · doi:10.1186/s13213-023-01744-5 · Cited by 46 · see citing works
Improvement of sleep by resistant dextrin prebiotic in type 2 diabetic women coincides with attenuation of metabolic endotoxemia: involvement of gut–brain axis
Saleh‐Ghadimi, S., Dehghan, P., Sarmadi, B., & Maleki, P. (2022) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.11876 · Cited by 34 · see citing works
Potential Modulation of Inflammation by Probiotic and Omega-3 Supplementation in Elderly with Chronic Low-Grade Inflammation—A Randomized, Placebo-Controlled Trial
Tingö, L., Hutchinson, A. N., Bergh, C., Stiefvatter, L., Schweinlin, A., Jensen, M. G., Krüger, K., Bischoff, S. C., & Brummer, R. J. (2022) · Nutrients · doi:10.3390/nu14193998 · Cited by 30 · see citing works
Emerging cellular senescence-centric understanding of immunological aging and its potential modulation through dietary bioactive components
Sharma, R., Diwan, B., Sharma, A., & Witkowski, J. M. (2022) · Biogerontology · doi:10.1007/s10522-022-09995-6 · Cited by 29 · see citing works
Nutraceuticals-Based Immunotherapeutic Concepts and Opportunities for the Mitigation of Cellular Senescence and Aging: A Narrative Review
Sharma, R., & Padwad, Y. S. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101141 · Cited by 27 · see citing works
Whole genome and acid stress comparative transcriptome analysis of Lactiplantibacillus plantarum ZDY2013
Peng, L., Zhao, K., Chen, S., Ren, Z., Wei, H., & Wan, C. (2021) · Archives of Microbiology · doi:10.1007/s00203-021-02240-7 · Cited by 27 · see citing works
Current trends in non-dairy based synbiotics
Mishra, A., Chakravarty, I., & Mandavgane, S. A. (2021) · Critical Reviews in Biotechnology · doi:10.1080/07388551.2021.1898329 · Cited by 27 · see citing works
Anthocyanin-Colored Microencapsulation Effects on Survival Rate of Lactobacillus rhamnosus GG, Color Stability, and Sensory Parameters in Strawberry Nectar Model
Morsy, M. K., Morsy, O. M., Abdelmonem, M. A., & Elsabagh, R. (2022) · Food and Bioprocess Technology · doi:10.1007/s11947-022-02758-8 · Cited by 26 · see citing works
Effects of probiotic Lactobacillus paracasei TD3 on moderation of cholesterol biosynthesis pathway in rats.
Dehkohneh, A., Jafari, P., & Fahimi, H. (2019) · PubMed Central · doi:10.22038/ijbms.2019.33933.8073 · Cited by 25 · see citing works
Targeting immunosenescence for improved tumor immunotherapy
Liu, Z., Zuo, L., Zhou, Z., Liu, S., Ba, Y., Zuo, A., Ren, Y., Zhang, C., Chen, Y., Ma, H., et al. (2024) · MedComm · doi:10.1002/mco2.777 · Cited by 24 · see citing works
Gut microbiota in coronary artery disease: a friend or foe?
Zhang, B., Wang, X., Ran, X., & Li, C. (2020) · Bioscience Reports · doi:10.1042/bsr20200454 · Cited by 24 · see citing works
Looking inside Mexican Traditional Food as Sources of Synbiotics for Developing Novel Functional Products
Torres-Maravilla, E., Méndez-Trujillo, V., Hernández-Delgado, N. C., Bermúdez‐Humarán, L. G., & Reyes-Pavón, D. (2022) · Fermentation · doi:10.3390/fermentation8030123 · Cited by 26 · see citing works
The effect of oral synbiotics on the gut microbiota and inflammatory biomarkers in healthy adults: a systematic review and meta-analysis
Cosier, D., Lambert, K., Neale, E. P., Probst, Y., & Charlton, K. E. (2024) · Nutrition Reviews · doi:10.1093/nutrit/nuae002 · Cited by 22 · see citing works
Galacto-Oligosaccharides and the Elderly Gut: Implications for Immune Restoration and Health
Hu, Y., Aljumaah, M. R., & Azcárate-Peril, M. A. (2024) · Advances in Nutrition · doi:10.1016/j.advnut.2024.100263 · Cited by 23 · see citing works
Prebiotic to Improve Calcium Absorption in Postmenopausal Women After Gastric Bypass: A Randomized Controlled Trial
Wu, K. C., Cao, S., Weaver, C. M., King, N. J., Patel, S., Kingman, H., Sellmeyer, D. E., McCauley, K. E., Li, D., Lynch, S. V., et al. (2021) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgab883 · Cited by 19 · see citing works
Age-Dependent Prebiotic Effects of Soluble Corn Fiber in M-SHIME® Gut Microbial Ecosystems
Calatayud, M., Laurie, I., Rotsaert, C., Marzorati, M., Risso, D. S., & Karnik, K. (2023) · Plant Foods for Human Nutrition · doi:10.1007/s11130-023-01043-z · Cited by 19 · see citing works
Valorization of Cereal Byproducts with Supercritical Technology: The Case of Corn
Santana, Á. L., & Meireles, M. A. A. (2023) · Processes · doi:10.3390/pr11010289 · Cited by 17 · see citing works
Enhancing therapeutic effects of murine cancer vaccine by reshaping gut microbiota with Lactobacillus rhamnosus GG and jujube powder
Jing, N., Wang, L., Zhuang, H., Jiang, G., & Liu, Z. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1195075 · Cited by 17 · see citing works
Short-Term Intake of Theobroma grandiflorum Juice Fermented with Lacticaseibacillus rhamnosus ATCC 9595 Amended the Outcome of Endotoxemia Induced by Lipopolysaccharide
Zagmignan, A., Mendes, Y. C., Mesquita, G. P., dos Santos, G. D. C., Silva, L. D. S., Sales, A. C. D. S., Branco, S. J. D. S. C., Carvalho, A. R., Bazán, J. M. N., Alves, E. R., et al. (2023) · Nutrients · doi:10.3390/nu15041059 · Cited by 16 · see citing works
Helichrysum italicum (Roth) G. Don and Helichrysum arenarium (L.) Moench Infusion Consumption Affects the Inflammatory Status and the Composition of Human Gut Microbiota in Patients with Traits of Metabolic Syndrome: A Randomized Comparative Study
Petelin, A., Novak, K. Š., Hladnik, M., Bandelj, D., Arbeiter, A. B., Kramberger, K., Kenig, S., & Pražnikar, Z. J. (2022) · Foods · doi:10.3390/foods11203277 · Cited by 16 · see citing works
Alginate and Probiotics Synergistically Reversed Dextran Sulfate Sodium Salt (DSS)-Induced Gut Barrier Damage
Zhao, C., Hu, Q., Wu, X., Chen, G., Wu, H., & Ren, J. (2019) · Macromolecular Research · doi:10.1007/s13233-019-7122-4 · Cited by 15 · see citing works
Effects of microbiota-driven therapy on inflammatory responses in elderly individuals: A systematic review and meta-analysis
Qu, H., Zhang, Y., Chai, H., Gao, Z.-Y., & Shi, D. (2019) · PLoS ONE · doi:10.1371/journal.pone.0211233 · Cited by 14 · see citing works
Targeting the gut to prevent and counteract metabolic disorders and pathologies during aging
Milenković, D., Capel, F., Combaret, L., Comte, B., Dardevet, D. P., Evrard, B., Guillet, C., Monfoulet, L., Pinel, A., Polakof, S., et al. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2089870 · Cited by 14 · see citing works
Gut microbiota disturbances in hospitalized older adults with malnutrition and clinical outcomes
Fernández, S. S. M., Garcez, F. B., de Alencar, J. C. G., Bastos, A. A., Morley, J. E., Cederholm, T., Aprahamian, I., de Souza, H. P., Avelino‐Silva, T. J., Bindels, L. B., et al. (2024) · Nutrition · doi:10.1016/j.nut.2024.112369 · Cited by 12 · see citing works
The effects of synbiotics surpass prebiotics in improving inflammatory biomarkers in children and adults: A systematic review, meta-analysis, and meta-evidence of data from 5207 participants in 90 randomized controlled trials
Zhang, Y., Hong, J., Zhang, Y., Gao, Y., & Liang, L. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.107832 · Cited by 14 · see citing works
EFFECTS OF SYNBIOTIC SUPPLEMENTATION ON GUT FUNCTIONING AND SYSTEMIC INFLAMMATION OF COMMUNITY-DWELLING ELDERS - SECONDARY ANALYSES FROM A RANDOMIZED CLINICAL TRIAL
Neto, J. V., Chella, T. P., Rudnik, D. P., & Ribeiro, S. M. L. (2020) · Arquivos de Gastroenterologia · doi:10.1590/s0004-2803.202000000-06 · Cited by 11 · see citing works
Growth conditions and survival kinetics during storage of Lactobacillus rhamnosus GG for the design of a sustainable probiotic whey‐based beverage containing Costa Rican guava fruit pulp
Montero‐Zamora, J., Cortés‐Muñoz, M., Esquivel, P., Mora-Villalobos, J.-A., & Velázquez, C. (2020) · Journal of Food Science · doi:10.1111/1750-3841.15430 · Cited by 11 · see citing works
From Dysbiosis to Diagnosis: The Role of Gut Microbiota in Breast Cancer Etiology and Management
Mishra, P., Mishra, S. P., Pattnaik, A., Singh, S., Shakri, A. R., Badhai, J., Ganguly, S., Guria, A., & Cheekatla, S. S. (2025) · Applied Microbiology · doi:10.3390/applmicrobiol5040134 · Cited by 10 · see citing works
Gut Microbiota and Its Metabolites: The Emerging Bridge Between Coronary Artery Disease and Anxiety and Depression?
Chen, H., Zhang, L., Li, Y., Meng, X., Chi, Y., & Liu, M. (2024) · Aging and Disease · doi:10.14336/ad.2024.0538 · Cited by 11 · see citing works
Understanding Aging through the Lense of Gut Microbiome
Ira, R., Adwani, J., Krishnan, A. O., Subramanian, G., Yadav, S., Shukla, S., Rao, S., & Prakash, T. (2024) · Exploratory Research and Hypothesis in Medicine · doi:10.14218/erhm.2024.00008 · Cited by 9 · see citing works
Immunosenescence and Inflamm-Aging: Clinical Interventions and the Potential for Reversal of Aging
Kumar, S. J., Shukla, S., Kumar, S., & Mishra, P. (2024) · Cureus · doi:10.7759/cureus.53297 · Cited by 11 · see citing works
An update on the role of gut microbiota in chronic inflammatory diseases, and potential therapeutic targets
Laing, B. B., Barnett, M. P. G., Marlow, G., Nasef, N. A., & Ferguson, L. R. (2018) · Expert Review of Gastroenterology & Hepatology · doi:10.1080/17474124.2018.1505497 · Cited by 10 · see citing works
Understanding the role of the human gut microbiome in overweight and obesity
McBurney, M. I., & Cho, C. E. (2024) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.15215 · Cited by 11 · see citing works
Gut microbiome responses to dietary intake of grain-based fibers with the potential to modulate markers of metabolic disease: a systematic literature review
Williams, G. M., Tapsell, L. C., O'Brien, C. L., Tosh, S. M., Barrett, E. M., & Beck, E. J. (2020) · Nutrition Reviews · doi:10.1093/nutrit/nuaa128 · Cited by 9 · see citing works
Probiotic lactic acid bacteria in biotechnology and the food industry: A review
Avci, D., Gillarová, S., Henke, S., Bubník, Z., & Sluková, M. (2025) · Czech Journal of Food Sciences · doi:10.17221/17/2025-cjfs · Cited by 8 · see citing works
Regulation of SARS-CoV-2 infection by diet-modulated gut microbiota
Tieu, V., Tibi, S., & Ling, J. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2023.1167827 · Cited by 8 · see citing works
Effects of non-pharmacological interventions on gut microbiota and intestinal permeability in older adults: A systematic review
Hisham, H. I. H., Lim, S. M., Neoh, C. F., Majeed, A. B. A., Shahar, S., & Ramasamy, K. (2024) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2024.105640 · Cited by 8 · see citing works
Influence of Lactobacillus rhamnosus Supplementation on the Glycaemic Index, Lipid Profile, and Microbiome of Healthy Elderly Subjects: A Preliminary Randomized Clinical Trial
Chaiyasut, C., Sivamaruthi, B. S., Thangaleela, S., Sisubalan, N., Bharathi, M., Khongtan, S., Kesika, P., Sirilun, S., Choeisoongnern, T., Peerajan, S., et al. (2024) · Foods · doi:10.3390/foods13091293 · Cited by 7 · see citing works
Type 2–resistant starch and Lactiplantibacillus plantarum NCIMB 8826 result in additive and interactive effects in diet-induced obese mice
Barouei, J., Martinic, A., Bendiks, Z., Mishchuk, D. O., Heeney, D. D., Slupsky, C. M., & Marco, M. L. (2023) · Nutrition Research · doi:10.1016/j.nutres.2023.07.003 · Cited by 6 · see citing works
A Review: Cereals on Modulating the Microbiota/Metabolome for Metabolic Health
Kulathunga, J., & Şimşek, Ş. (2022) · Current Nutrition Reports · doi:10.1007/s13668-022-00424-1 · Cited by 6 · see citing works
Moderate intakes of soluble corn fibre or inulin do not cause gastrointestinal discomfort and are well tolerated in healthy children
Risso, D. S., Kaczmarczyk, M. M., Laurie, I., Mah, E., Blonquist, T. M., Derrig, L. H., & Karnik, K. (2022) · International Journal of Food Sciences and Nutrition · doi:10.1080/09637486.2022.2133098 · Cited by 6 · see citing works
Local and systemic features of ILC immunometabolism
Surace, L., & Santo, J. P. D. (2022) · Current Opinion in Hematology · doi:10.1097/moh.0000000000000722 · Cited by 6 · see citing works
White and Red Sorghum as Primary Carbohydrate Sources in Extruded Diets of Felines
von Schaumburg, P., He, F., Rodriguez‐Zas, S. L., Southey, B. R., Parsons, C. M. M., & de Godoy, M. R. C. (2021) · Frontiers in Veterinary Science · doi:10.3389/fvets.2021.668255 · Cited by 5 · see citing works
Gut microbial community and host intestinal gene expression with combined fish oil and soluble corn fiber compared with corn oil and maltodextrin: A randomized crossover trial in healthy older individuals
Moosavi, D., Mullens, D. A., Davidson, L. A., Fan, Y.-Y., Goldsby, J. S., Ivanov, I. V., Levy, L., Kahsai, O. J., Curtis, K. R., Raftery, D., et al. (2025) · American Journal of Clinical Nutrition · doi:10.1016/j.ajcnut.2025.04.031 · Cited by 5 · see citing works
Advances in the Functional Activity, Mechanisms, and Bioavailability of Corn Bioactive Compounds
Wu, J., Zhao, J., Guo, A., Meng, S., Cai, D., Zheng, M., Liu, H., Wen, C., & Liu, J. (2025) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.70363 · Cited by 4 · see citing works
Isomaltooligosaccharide, galactomannan, and Lacticaseibacillus rhanmosus synergistically regulate intestinal immunity through the “gut-metabolism-immune axis”
Chen, C., Zhang, Q., Li, S., Su, Y., Zhang, Y. S., Jiang, Y., Guo, L., & Yang, X. (2026) · Food Research International · doi:10.1016/j.foodres.2026.118478 · Cited by 3 · see citing works
Lacticaseibacillus rhamnosus LM1019 Enhances Natural Killer Cell Activity in Defined Adult Subsets: A Double-Blind, Placebo-Controlled Trial
Park, J., You, Y., Kim, S. H., Ku, H.-J., Han, H.-J., Kim, C.-H., Kim, T., Sohn, M., Kim, I., & Baeg, C. (2025) · Life · doi:10.3390/life15071002 · Cited by 2 · see citing works
Microbiome changes in aging
Reveles, K. R., Young, E. H., Zeidan, A. R., & Dong, Q. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-815962-0.00017-2 · Cited by 2 · see citing works
Modulating the human intestinal microbiome in healthy adults and elderly through dietary supplements
An, R. (2020) · doi:10.18174/531631 · Cited by 2 · see citing works
Longitudinal associations of sarcopenia and biological age acceleration with rate of cognitive decline
Hou, Y., Long, R., Sun, Q., Zhang, Y., & Wang, K. (2026) · BMC Public Health · doi:10.1186/s12889-026-26389-2 · Cited by 1 · see citing works
Perspectives on structurally complex dietary fibers as alternatives to traditional prebiotics in the modulation of the gut microbiome
Xavier-Santos, D., Abboud, K. Y., Bedani, R., Berilli, P., Santana, M. F. S. E., Machado, A. M. R., Bader‐Mittermaier, S., Eisner, P., & Sant’Ana, A. S. (2026) · Journal of Functional Foods · doi:10.1016/j.jff.2026.107380 · Cited by 1 · see citing works
Biosurfactants production by LAB and emerging applications
Kachrimanidou, V., Alexandri, M., Alimpoumpa, D., Lappa, I. K., Papadaki, A., & Kopsahelis, N. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-91930-2.00001-8 · Cited by 1 · see citing works
Clinical Trials Corner
(2019) · Nutrition and Healthy Aging · doi:10.3233/nha-189000 · Cited by 1 · see citing works
The Effects of Dietary Prebiotics and Chronic Circadian Disruption on Sleep, Cognition, and Adrenal Sensitivity
Gaffney, M. (2018) · CU Scholar (University of Colorado Boulder)
Gut microbiota and probiotics as palliative care which supports physical activity in geriatric health
Müller, V. T., de Brito, M. A., Malina, A., de Azevedo, Â. C. B., Brito, C. J., & Miarka, B. (2020) · Brazilian Journal of Health Review · doi:10.34119/bjhrv3n1-080
Can probiotics and prebiotics contribute to healthy ageing?
Rowland, I. R. (2022) · Nutrition and Healthy Aging · doi:10.3233/nha-210140
Synbiotics: Promising Approach for the Therapeutic Management of Cancer
Chan, Y., Tan, J. Z. X., Lim, X. W., Chellappan, D. K., & Dua, K. (2023) · Springer eBooks · doi:10.1007/978-981-19-7550-9_3
Associations of solute carrier family 23 member 1 (SLC23A1) rs6596473 genetic variant with serum vitamin C status and gut microbial profiles in healthy adults: A cross-sectional study
Sim, M., Hwang, G., Shin, D.-M., & Jeong, Y. (2026) · Clinical Nutrition · doi:10.1016/j.clnu.2026.106669
Development of a synbiotic potential score as a quantitative approach for selecting putative synergistic strain-prebiotic candidates
Wasiewska, L. A., Kareem, L., Linares, A. G., Gunnigle, E., Risso, D., Laurie, I., van Sinderen, D., Clarke, G. A., & Schellekens, H. (2026) · Journal of Applied Microbiology · doi:10.1093/jambio/lxag124
The Effects of Gut Microbiome (Microbiota) Changes in Aging on Fragility (Frailty Syndrome), Neurocognitive, and Immune Processes
Başaran, A. (2026) · Uluslararası Sağlık Bilimlerinde Disiplinler Arası Etkileşim Dergisi · doi:10.65349/mfaj7484
Gut microbiota: current insights into its role in the development of certain chronic noncommunicable diseases
Сергеевна, А. А., Nv, A., Klassova, A. T., & Khripunova, A. (2026) · Vrach · doi:10.29296/25877305-2026-07-03
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Ouweh, A. C., Tiihonen, K., Saarinen, M., Putaala, H., & Rautonen, N. (2016)
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Björklund, M., Ouwehand, A. C., Forssten, S. D., Nikkilä, J., Tiihonen, K., Rautonen, N., & Lahtinen, S. J. (2012) · AGE · doi:10.1007/s11357-011-9294-5 · Cited by 67 · see citing works
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Likotrafiti, E., Tuohy, K. M., Gibson, G. R., & Rastall, R. A. (2014) · Anaerobe · doi:10.1016/j.anaerobe.2014.03.009 · Cited by 64 · see citing works
Self-citation

Authors: Costabile, A., Bergillos-Meca, T., Rasinkangas, P., Korpela, K., de Vos, W. M., & Gibson, G. R.
Affiliations: University of Reading (GB)
University of Roehampton (GB)
University of Helsinki (FI)
Corresponding author: Costabile, Adele
ORCID: Costabile, Adele
Rasinkangas, Pia
Korpela, Katri
Gibson, Glenn R.
Venue: Frontiers in Immunology
Publisher: Frontiers Media SA
Published: 2017-12-12
Volume: 8
Pages: 1443-1443
ISSN: 1664-3224 (ISSN-L)
DOI: 10.3389/fimmu.2017.01443
PMC: PMC5733116
OpenAlex: W2781690695
Cited by: 94
References: 63
Citations by year: 2026: 9 · 2025: 8 · 2024: 14 · 2023: 10 · 2022: 16 · 2021: 9 · 2020: 13 · 2019: 10 · 2018: 5
FWCI: 8.62
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (unspecified)
Locations: Frontiers in Immunology (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
CentAUR (University of Reading) (acceptedVersion)
Socio-Environmental Systems Modeling (acceptedVersion, cc-by)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Työväentutkimus Vuosikirja (submittedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion, cc-by)
Topics: Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Keywords: synbiotics, Lactobacillus rhamnosus GG, prebiotics, probiotics, gut microbiota, aging, older adults, immune function, NK cell cytotoxicity, cytokines, interleukin-6, serum lipids, cholesterol, C-reactive protein, Parabacteroides

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