A review of probiotic supplementation in healthy adults: helpful or hype?
Open accessAbstract
Probiotic supplements have a positive impact on several health outcomes. However, the majority of published studies have focused on populations with specific health pathologies. Therefore, this study reviewed the current literature on the health effects of probiotic consumption in "healthy adults." The findings from this review may help guide consumers, researchers, and manufacturers regarding probiotic supplementation. Relevant literature published between 1990 and August 2017 was reviewed. Studies were included if they were experimental trials, included healthy adults, used live bacteria, and had accessible full-text articles published in English. Included studies were classified according to common foci that emerged. Forty-five studies were included in this review. Five foci emerged: gut microbiota changes (n = 15); immune system response (n = 16); lipid profile and cardiovascular disease risk (n = 14); gastrointestinal discomfort (n = 11); and female reproductive health (n = 4). Results suggest that probiotic supplementation in healthy adults can lead to transient improvement in gut microbiota concentration of supplement-specific bacteria. Evidence also supports the role of probiotics in improving immune system responses, stool consistency, bowel movement, and vaginal lactobacilli concentration. There is insufficient evidence to support the role of probiotics to improve blood lipid profile. Probiotic consumption can improve in the immune, gastrointestinal, and female reproductive health systems in healthy adults. However, this review failed to support the ability of probiotics to cause persistent changes in gut microbiota, or improve lipid profile in healthy adults. The feasibility of probiotics consumption to provide benefits in healthy adults requires further investigation.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Evidence accumulated to-date on recovery of probiotics from feces indicates that most current probiotics do not colonize.
“Evidence accumulated to-date on recovery of probiotics from feces indicates that most current probiotics do not colonize.75,, 76”
From Emerging issues in probiotic safety: 2023 perspectives (2023) · cites this paper as [76]
Cites
Preferred reporting items for systematic reviews and meta-analyses: the PRISMA Statement.
(2009) · PubMed Central · Cited by 44,859 · see citing works
Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement
Moher, D., Liberati, A., Tetzlaff, J., Altman, D. G., & the PRISMA Group* (2009) · Annals of Internal Medicine · doi:10.7326/0003-4819-151-4-200908180-00135 · Cited by 37,554 · see citing works
Cochrane Handbook for Systematic Reviews of Interventions: Cochrane Book Series
(2008) · doi:10.1002/9780470712184 · Cited by 25,048 · see citing works
Dietary Modulation of the Human Colonic Microbiota: Introducing the Concept of Prebiotics
Gibson, G. R., & Roberfroid, M. B. (1995) · Journal of Nutrition · doi:10.1093/jn/125.6.1401 · Cited by 7,659 · see citing works
den Besten, G., van Eunen, K., Groen, A. K., Venema, K., Reijngoud, D.-J., & Bakker, B. M. (2013) · Journal of Lipid Research · doi:10.1194/jlr.r036012 · Cited by 5,048 · see citing works
Gut microbiota, metabolites and host immunity
Rooks, M. G., & Garrett, W. S. (2016) · Nature reviews. Immunology · doi:10.1038/nri.2016.42 · Cited by 3,409 · see citing works
Fiber and prebiotics: Mechanisms and health benefits
Slavin, J. (2013) · Nutrients · doi:10.3390/nu5041417 · Cited by 2,340 · see citing works
Akkermansia muciniphila gen. nov., sp. nov., a human intestinal mucin-degrading bacterium
Derrien, M., Vaughan, E. E., Plugge, C. M., & de Vos, W. M. (2004) · International Journal of Systematic and Evolutionary Microbiology · doi:10.1099/ijs.0.02873-0 · Cited by 2,094 · see citing works
The Firmicutes/Bacteroidetes ratio of the human microbiota changes with age
Mariat, D., Firmesse, O., Levenez, F., Guimarăes, V., Sokol, H., Doré, J., Corthier, G., & Furet, J.-P. (2009) · BMC Microbiology · doi:10.1186/1471-2180-9-123 · Cited by 1,755 · see citing works
Control of pathogens and pathobionts by the gut microbiota
Kamada, N., Chen, G. Y., Inohara, N., & Núñez, G. (2013) · Nature Immunology · doi:10.1038/ni.2608 · Cited by 1,625 · see citing works
Principles and clinical implications of the brain-gut-enteric microbiota axis
Rhee, S. H., Pothoulakis, C., & Mayer, E. A. (2009) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2009.35 · Cited by 1,342 · see citing works
The Prolongation of Life: Optimistic Studies
Metchnikoff, É. (2003) · Cited by 883 · see citing works
LeBlanc, J. G., Chain, F., Martín, R., Bermúdez‐Humarán, L. G., Courau, S., & Langella, P. (2017) · Microbial Cell Factories · doi:10.1186/s12934-017-0691-z · Cited by 881 · see citing works
Causes, consequences, and reversal of immune system aging
Montecino-Rodriguez, E., Berent-Maoz, B., & Dorshkind, K. (2013) · Journal of Clinical Investigation · doi:10.1172/jci64096 · Cited by 793 · see citing works
Kailasapathy, K., & Chin, J. (2000) · Immunology and Cell Biology · doi:10.1046/j.1440-1711.2000.00886.x · Cited by 780 · see citing works
Ford, A. C., Quigley, E. M. M., Lacy, B. E., Lembo, A. J., Saito, Y. A., Schiller, L. R., Soffer, E. E., Spiegel, B. M. R., & Moayyedi, P. (2014) · American Journal of Gastroenterology · doi:10.1038/ajg.2014.202 · Cited by 747 · see citing works
The Mucin Degrader Akkermansia muciniphila Is an Abundant Resident of the Human Intestinal Tract
Derrien, M., Collado, M. C., Amor, K. B., Salminen, S., & de Vos, W. M. (2007) · Applied and Environmental Microbiology · doi:10.1128/aem.01226-07 · Cited by 659 · see citing works
Luczynski, P., McVey Neufeld, K.-A., Oriach, C. S., Clarke, G., Dinan, T. G., & Cryan, J. F. (2016) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyw020 · Cited by 632 · see citing works
Kristensen, N. B., Bryrup, T., Allin, K. H., Nielsen, T., Hansen, T. H., & Pedersen, O. (2016) · Genome Medicine · doi:10.1186/s13073-016-0300-5 · Cited by 561 · see citing works
Probiotics: determinants of survival and growth in the gut
Bezkorovainy, A. (2001) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/73.2.399s · Cited by 533 · see citing works
Khalesi, S., Sun, J., Buys, N., & Jayasinghe, R. (2014) · Hypertension · doi:10.1161/hypertensionaha.114.03469 · Cited by 516 · see citing works
Self-citationReid, G., Charbonneau, D., Erb, J., Kochanowski, B., Beuerman, D., Poehner, R., & Bruce, A. W. (2003) · FEMS Immunology & Medical Microbiology · doi:10.1016/s0928-8244(02)00465-0 · Cited by 514 · see citing works
Huang, R., Wang, K., & Hu, J. (2016) · Nutrients · doi:10.3390/nu8080483 · Cited by 505 · see citing works
Influence of high-fat diet on gut microbiota
Murphy, E. A., Velázquez, K. T., & Herbert, K. (2015) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000209 · Cited by 495 · see citing works
Gill, H. S., Rutherfurd, K. J., Cross, M. L., & Gopal, P. K. (2001) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/74.6.833 · Cited by 485 · see citing works
Woodmansey, E. J., McMurdo, M. E. T., Macfarlane, G. T., & Macfarlane, S. (2004) · Applied and Environmental Microbiology · doi:10.1128/aem.70.10.6113-6122.2004 · Cited by 418 · see citing works
The role of lactobacilli and probiotics in maintaining vaginal health
Borges, S., Silva, J., & Teixeira, P. (2014) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-013-3064-9 · Cited by 397 · see citing works
Johnston, B. C., Ma, S. S. Y., Goldenberg, J. Z., Thorlund, K., Vandvik, P. O., Loeb, M., & Guyatt, G. H. (2012) · Annals of Internal Medicine · doi:10.7326/0003-4819-157-12-201212180-00563 · Cited by 367 · see citing works
Effect of Lactobacillus plantarum 299v on cardiovascular disease risk factors in smokers
Naruszewicz, M., Johansson, M.-L., Zapolska‐Downar, D., & Bukowska, H. (2002) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/76.6.1249 · Cited by 365 · see citing works
Ageing of the human metaorganism: the microbial counterpart
Biagi, E., Candela, M., Fairweather‐Tait, S. J., Franceschi, C., & Brigidi, P. (2011) · AGE · doi:10.1007/s11357-011-9217-5 · Cited by 365 · see citing works
Probiotics for Prevention and Treatment of Diarrhea
Guandalini, S. (2011) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0b013e3182257e98 · Cited by 351 · see citing works
Vulevic, J., Juric, A., Tzortzis, G., & Gibson, G. R. (2013) · The Journal of Nutrition · doi:10.3945/jn.112.166132 · Cited by 349 · see citing works
Sources, isolation, characterisation and evaluation of probiotics
Fontana, L., Bermudez-Brito, M., Plaza-Diaz, J., Muñoz-Quezada, S., & Gil, A. (2013) · British Journal of Nutrition · doi:10.1017/s0007114512004011 · Cited by 348 · see citing works
Probiotic<i>Lactobacillus</i>dose required to restore and maintain a normal vaginal flora
Reid, G., Beuerman, D., Heinemann, C., & Bruce, A. W. (2001) · FEMS Immunology & Medical Microbiology · doi:10.1111/j.1574-695x.2001.tb00531.x · Cited by 328 · see citing works
Rajkumar, H., Mahmood, N., Kumar, M., Varikuti, S. R., Challa, H. R., & Myakala, S. P. (2014) · Mediators of Inflammation · doi:10.1155/2014/348959 · Cited by 301 · see citing works
Guillemard, E., Tondu, F., Lacoin, F., & Schrezenmeir, J. (2009) · British Journal Of Nutrition · doi:10.1017/s0007114509991395 · Cited by 257 · see citing works
de Vrese, M., Winkler, P., Rautenberg, P., Harder, T., Noah, C., Laue, C., Ott, S. J., Hampe, J., Schreiber, S., Heller, K. J., et al. (2005) · Clinical Nutrition · doi:10.1016/j.clnu.2005.02.006 · Cited by 252 · see citing works
Guo, Z., Liu, X. M., Zhang, Q. X., Shen, Z., Tian, F., Zhang, H., Sun, Z., Zhang, H. P., & Chen, W. (2011) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2011.04.008 · Cited by 249 · see citing works
From yaks to yogurt: the history, development, and current use of probiotics
McFarland, L. V. (2015) · Clinical Infectious Diseases · doi:10.1093/cid/civ054 · Cited by 248 · see citing works
A dynamic model that simulates the human upper gastrointestinal tract for the study of probiotics
Mainville, I., Arcand, Y., & Farnworth, E. R. (2004) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2004.08.020 · Cited by 247 · see citing works
Takada, M., Nishida, K., Kataoka‐Kato, A., Gondo, Y., Ishikawa, H., Suda, K., Kawai, M., Hoshi, R., Watanabe, O., Igarashi, T., et al. (2016) · Neurogastroenterology & Motility · doi:10.1111/nmo.12804 · Cited by 243 · see citing works
Makino, S., Ikegami, S., Akinori, K., Horiuchi, H., Sasaki, H., & Orii, N. M. (2010) · British Journal Of Nutrition · doi:10.1017/s000711451000173x · Cited by 233 · see citing works
Ferrario, C., Taverniti, V., Milani, C., Fiore, W., Laureati, M., De Noni, I., Stuknyte, M., Chouaia, B., Riso, P., & Guglielmetti, S. (2014) · The Journal of Nutrition · doi:10.3945/jn.114.197723 · Cited by 228 · see citing works
Probiotics for Prevention and Treatment of Diarrhea
Guarino, A., Guandalini, S., & Vecchio, A. L. (2015) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0000000000000349 · Cited by 217 · see citing works
Probiotic approach to prevent antibiotic resistance
Ouwehand, A. C., Forssten, S., Hibberd, A. A., Lyra, A., & Stahl, B. (2016) · Annals of Medicine · doi:10.3109/07853890.2016.1161232 · Cited by 216 · see citing works
Concepts and Controversies in Evaluating Vitamin K Status in Population-Based Studies
Shea, M. K., & Booth, S. L. (2016) · Nutrients · doi:10.3390/nu8010008 · Cited by 197 · see citing works
Hypocholesterolaemic effect of a new fermented milk product in healthy middle-aged men.
Agerbæk, M., Gerdes, L. U., & Richelsen, B. (1995) · PubMed · Cited by 196 · see citing works
Lahti, L., Salonen, A., Kekkonen, R. A., Salojärvi, J., Jalanka, J., Palva, A., Orešič, M., & de Vos, W. M. (2013) · PeerJ · doi:10.7717/peerj.32 · Cited by 196 · see citing works
Gut Microbiota and Brain Function: An Evolving Field in Neuroscience: Table 1.
Foster, J. A., Lyte, M., Meyer, E., & Cryan, J. F. (2015) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyv114 · Cited by 188 · see citing works
Where are all the new antibiotics? The new antibiotic paradox
Conly, J. M., & Johnston, B. (2005) · Canadian Journal of Infectious Diseases and Medical Microbiology · doi:10.1155/2005/892058 · Cited by 187 · see citing works
Sun, J., & Buys, N. J. (2015) · Annals of Medicine · doi:10.3109/07853890.2015.1071872 · Cited by 186 · see citing works
Shimizu, M., Hashiguchi, M., Shiga, T., Tamura, H.-O., & Mochizuki, M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0139795 · Cited by 182 · see citing works
The effects of probiotic and conventional yoghurt on lipid profile in women
Sadrzadeh-Yeganeh, H., Elmadfa, I., Djazayery, A., Jalali, M., Heshmat, R., & Chamary, M. (2010) · British Journal Of Nutrition · doi:10.1017/s0007114509993801 · Cited by 179 · see citing works
Wu, Y., Zhang, Q., Ren, Y., & Ruan, Z. (2017) · PLoS ONE · doi:10.1371/journal.pone.0178868 · Cited by 179 · see citing works
Walton, G., van den Heuvel, E. G. H. M., Kosters, M. H. W., Rastall, R. A., Tuohy, K. M., & Gibson, G. R. (2011) · British Journal Of Nutrition · doi:10.1017/s0007114511004697 · Cited by 173 · see citing works
Kekkonen, R. A., Vasankari, T. J., Vuorimaa, T., Haahtela, T., Julkunen, I., & Korpela, R. (2007) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.17.4.352 · Cited by 170 · see citing works
Novel probiotics and prebiotics: road to the market
Kumar, H., Salminen, S., Verhagen, H., Rowland, I. R., Heimbach, J., Bañares, S., Young, T., Nomoto, K., & Lalonde, M. (2014) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2014.11.021 · Cited by 165 · see citing works
West, N. P., Horn, P. L., Pyne, D. B., Gebski, V. J., Lahtinen, S. J., Fricker, P. A., & Cripps, A. W. (2014) · Clinical Nutrition · doi:10.1016/j.clnu.2013.10.002 · Cited by 159 · see citing works
Curto, A. L., Pitino, I., Mandalari, G., Dainty, J. R., Faulks, R. M., & Wickham, M. S. J. (2011) · Food Microbiology · doi:10.1016/j.fm.2011.06.007 · Cited by 144 · see citing works
Effect of Probiotics on Blood Lipid Concentrations: A Meta-Analysis of Randomized Controlled Trials
Cho, Y. A., & Kim, J. (2015) · Medicine · doi:10.1097/md.0000000000001714 · Cited by 143 · see citing works
Klein, A., Friedrich, U., Vogelsang, H., & Jahreis, G. (2007) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1602761 · Cited by 136 · see citing works
Hulston, C. J., Churnside, A. A., & Venables, M. (2015) · British Journal Of Nutrition · doi:10.1017/s0007114514004097 · Cited by 133 · see citing works
Berggren, A., Ahrén, I. L., Larsson, N., & Önning, G. (2010) · European Journal of Nutrition · doi:10.1007/s00394-010-0127-6 · Cited by 132 · see citing works
Drying process strongly affects probiotics viability and functionalities
Iaconelli, C., Lemetais, G., Kechaou, N., Chain, F., Bermúdez‐Humarán, L. G., Langella, P., Gervais, P., & Beney, L. (2015) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2015.08.022 · Cited by 129 · see citing works
Dong, H., Rowland, I., Thomas, L. V., & Yaqoob, P. (2013) · European Journal of Nutrition · doi:10.1007/s00394-012-0487-1 · Cited by 127 · see citing works
Nikbakht, E., Khalesi, S., Singh, I., Williams, L. T., West, N. P., & Colson, N. (2018) · European Journal of Nutrition · doi:10.1007/s00394-016-1300-3 · Cited by 126 · see citing works
Self-citationMcKean, J., Naug, H., Nikbakht, E., Amiet, B., & Colson, N. (2017) · The Journal of Alternative and Complementary Medicine · doi:10.1089/acm.2016.0023 · Cited by 125 · see citing works
Sun, J., & Buys, N. J. (2016) · British Journal of Nutrition · doi:10.1017/s0007114516000076 · Cited by 122 · see citing works
Zhang, Q., Wu, Y., & Fei, X. (2016) · International Journal of Food Sciences and Nutrition · doi:10.1080/09637486.2016.1181156 · Cited by 122 · see citing works
Effect of probiotics on biomarkers of cardiovascular disease: implications for heart-healthy diets
DiRienzo, D. B. (2013) · Nutrition Reviews · doi:10.1111/nure.12084 · Cited by 119 · see citing works
Rizkalla, S. W., Luo, J., Kabir, M., Chevalier, A., Pacher, N., & Slama, G. (2000) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/72.6.1474 · Cited by 115 · see citing works
de Roos, N., Schouten, G. K., & Katan, M. (1999) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1600722 · Cited by 112 · see citing works
Recent Trends and Applications of Encapsulating Materials for Probiotic Stability
Riaz, Q. U. A., & Masud, T. (2012) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2010.524953 · Cited by 110 · see citing works
Puyenbroeck, K. V., Hens, N., Coenen, S., Michiels, B., Beunckens, C., Molenberghs, G., Royen, P. V., & Verhoeven, V. (2012) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.111.026831 · Cited by 109 · see citing works
Probiotic viability–does it matter?
Lahtinen, S. J. (2012) · Microbial Ecology in Health & Disease · doi:10.3402/mehd.v23i0.18567 · Cited by 107 · see citing works
Higashikawa, F., Noda, M., Awaya, T., Nomura, K., Oku, H., & Sugiyama, M. (2009) · Nutrition · doi:10.1016/j.nut.2009.05.008 · Cited by 104 · see citing works
Jespersen, L., Tarnow, I., Eskesen, D. C., Melsæther, C., Michelsen, B., Bügel, S., Dragsted, L. O., Rijkers, G. T., & Calder, P. C. (2015) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.114.103531 · Cited by 103 · see citing works
Bacillus coagulans GBI-30, 6086 Modulates Faecalibacterium prausnitzii in Older Men and Women
Nyangale, E. P., Farmer, S., Cash, H. A., Keller, D., Chernoff, D., & Gibson, G. R. (2015) · Journal of Nutrition · doi:10.3945/jn.114.199802 · Cited by 89 · see citing works
Recine, N., Palma, E., Domenici, L., Giorgini, M., Imperiale, L., Sassu, C., Musella, A., Marchetti, C., Muzii, L., & Benedetti Panici, P. (2016) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-015-3810-2 · Cited by 88 · see citing works
Osterberg, K. L., Boutagy, N. E., McMillan, R. P., Stevens, J. R., Frisard, M. I., Kavanaugh, J. W., Davy, B. M., Davy, K. P., & Hulver, M. W. (2015) · Obesity · doi:10.1002/oby.21230 · Cited by 86 · see citing works
A probiotics-containing biscuit modulates the intestinal microbiota in the elderly
Rampelli, S., Candela, M., Severgnini, M., Biagi, E., Turroni, S., Roselli, M., Carnevali, P., Donini, L. M., & Brigidi, P. (2012) · The journal of nutrition health & aging · doi:10.1007/s12603-012-0372-x · Cited by 85 · see citing works
Parra, M. D., de Morentin, B. E. M., Cobo, J., Mateos, A., & Martínez, J. A. (2004) · Journal of Physiology and Biochemistry · doi:10.1007/bf03168444 · Cited by 82 · see citing works
Probiotic capsules do not lower plasma lipids in young women and men
Greany, K. A., Bonorden, M. J. L., Hamilton‐Reeves, J. M., McMullen, M. H., Wangen, K. E., Phipps, W. R., Feirtag, J. M., Thomas, W. T. B., & Kurzer, M. S. (2007) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1602719 · Cited by 77 · see citing works
Kang, E. J., Kim, S. Y., Hwang, I.-H., & Ji, Y. (2013) · Korean Journal of Family Medicine · doi:10.4082/kjfm.2013.34.1.2 · Cited by 77 · see citing works
The Use of Probiotics in Healthy Volunteers With Evacuation Disorders and Hard Stools
Piano, M. D., Carmagnola, S., Anderloni, A. A., Andorno, S., Ballare, M., Balzarini, M., Montino, F., Orsello, M., Pagliarulo, M., Sartori, M., et al. (2010) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0b013e3181ee31c3 · Cited by 71 · see citing works
Baron, M. (2009) · Postgraduate Medicine · doi:10.3810/pgm.2009.03.1971 · Cited by 66 · see citing works
Hanifi, A., Culpepper, T., Mai, V., Anand, A., Ford, A., Ukhanova, M., Christman, M. C., Tompkins, T. A., & Dahl, W. J. (2014) · Beneficial Microbes · doi:10.3920/bm2014.0031 · Cited by 65 · see citing works
Plaza‐Díaz, J., Fernández-Caballero, J. Á., Chueca, N., García, F., Gómez‐Llorente, C., Sáez‐Lara, M. J., Fontana, L., & Gil, Á. (2015) · Nutrients · doi:10.3390/nu7063999 · Cited by 58 · see citing works
Alberti, D. D., Russo, R., Terruzzi, F., Nobile, V., & Ouwehand, A. C. (2015) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-015-3711-4 · Cited by 57 · see citing works
Verdenelli, M. C., Cecchini, C., Coman, M. M., Silvi, S., Orpianesi, C., Coata, G., Cresci, A., & Renzo, G. C. D. (2016) · Current Microbiology · doi:10.1007/s00284-016-1085-x · Cited by 48 · see citing works
Sakai, T., Makino, H., Ishikawa, E., Oishi, K., & Kushiro, A. (2011) · International Journal of Food Sciences and Nutrition · doi:10.3109/09637486.2010.542408 · Cited by 44 · see citing works
Survival of Lactobacillus casei strain Shirota in the intestines of healthy Chinese adults
Wang, R., Chen, S., Jin, J., Ren, F., Li, Y., Qiao, Z., Wang, Y., & Zhao, L. (2015) · Microbiology and Immunology · doi:10.1111/1348-0421.12249 · Cited by 42 · see citing works
Immune Response of Healthy Adults to the Ingested Probiotic Lactobacillus casei Shirota
Harbige, L. S., Pinto, E. F. M., Allgrove, J. E., & Thomas, L. V. (2016) · Scandinavian Journal of Immunology · doi:10.1111/sji.12495 · Cited by 42 · see citing works
Delivery of Probiotic Microorganisms into Gastrointestinal Tract by Food Products
Mohammad, A., Mohammadi, R., & Sohrabvandi, S. (2012) · InTech eBooks · doi:10.5772/47946 · Cited by 37 · see citing works
Nasrabadi, E. N., Jamaluddin, R., Mutalib, M. S. A., Khaza’ai, H., Khalesi, S., & Sabran, M. R. (2013) · Journal of Applied Microbiology · doi:10.1111/jam.12148 · Cited by 36 · see citing works
Self-citationWind, R. D., Tolboom, H., Klare, I., Huys, G. R. B., & Knol, J. (2010) · British Journal Of Nutrition · doi:10.1017/s0007114510002746 · Cited by 31 · see citing works
Cox, A. J., West, N. P., Horn, P. L., Lehtinen, M. J., Koerbin, G., Pyne, D. B., Lahtinen, S. J., Fricker, P. A., & Cripps, A. W. (2014) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2014.137 · Cited by 30 · see citing works
Fuller, R. (1994) · Springer series in applied biology · doi:10.1007/978-1-4471-3443-5_4 · Cited by 29 · see citing works
Brown, A. C., Shovic, A. C., Ibrahim, S. A., et al. (2005) · PubMed · Cited by 27 · see citing works
Novel encapsulation improves recovery of probiotic strains in fecal samples of human volunteers
Mai, V., Waugh, S. G., Byrd, D. A., Simpson, D. J., & Ukhanova, M. (2016) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-016-7915-8 · Cited by 27 · see citing works
Irwin, C. G., Khalesi, S., Cox, A. J., Grant, G. D., Davey, A. K., Bulmer, A. C., & Desbrow, B. (2017) · European Journal of Nutrition · doi:10.1007/s00394-017-1437-8 · Cited by 26 · see citing works
Self-citationBjerg, A. T., Sørensen, M. B., Krych, Ł., Hansen, L. H., Astrup, A. V., Kristensen, M., & Nielsen, D. S. (2014) · Beneficial Microbes · doi:10.3920/bm2014.0033 · Cited by 17 · see citing works
Wassenaar, T. M., Beimfohr, C., Geske, T., & Zimmermann, K. (2014) · Beneficial Microbes · doi:10.3920/bm2013.0087 · Cited by 16 · see citing works
Merenstein, D. J., D'Amico, F. J., Palese, C., Hahn, A., Sparenborg, J., Tan, T., Scott, H., Polzin, K. M., Kolberg, L. W., & Roberts, R. (2013) · British Journal Of Nutrition · doi:10.1017/s0007114513002237 · Cited by 12 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
The pros, cons, and many unknowns of probiotics
Suez, J., Zmora, N., Segal, E., & Elinav, E. (2019) · Nature Medicine · doi:10.1038/s41591-019-0439-x · Cited by 1,398 · see citing works
Emerging issues in probiotic safety: 2023 perspectives
Merenstein, D., Pot, B., Leyer, G., Ouwehand, A. C., Preidis, G. A., Elkins, C. A., Hill, C., Lewis, Z. T., Shane, A. L., Zmora, N., et al. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2185034 · Cited by 481 · see citing works
Detection of Vaginal Lactobacilli as Probiotic Candidates
Pino, A., Bartolo, E., Caggia, C., Cianci, A., & Randazzo, C. L. (2019) · Scientific Reports · doi:10.1038/s41598-019-40304-3 · Cited by 131 · see citing works
Probiotic safety—No guarantees
Cohen, P. A. (2018) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2018.5403 · Cited by 113 · see citing works
Diet-induced gut dysbiosis and inflammation: Key drivers of obesity-driven NASH
Kang, G. G., Trevaskis, N. L., Murphy, A. J., & Febbraio, M. A. (2023) · iScience · doi:10.1016/j.isci.2022.105905 · Cited by 94 · see citing works
Agolino, G., Pino, A., Vaccalluzzo, A., Cristofolini, M., Solieri, L., Caggia, C., & Randazzo, C. L. (2024) · Journal of Functional Foods · doi:10.1016/j.jff.2024.106357 · Cited by 87 · see citing works
Huang, W.-C., Pan, C.-H., Wei, C.-C., & Huang, H.-Y. (2020) · Nutrients · doi:10.3390/nu12082315 · Cited by 87 · see citing works
Ghavami, A., Khorvash, F., Heidari, Z., Khalesi, S., & Askari, G. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105668 · Cited by 62 · see citing works
Self-citationRole of the tumor microenvironment in cancer hallmarks and targeted therapy (Review)
Naser, R., Fakhoury, I., El‑Fouani, A., Abi‑Habib, R., & El‑Sibai, M. (2022) · International Journal of Oncology · doi:10.3892/ijo.2022.5471 · Cited by 61 · see citing works
Shinde, T., Hansbro, P. M., Sohal, S. S., Dingle, P., Eri, R., & Stanley, R. (2020) · Microorganisms · doi:10.3390/microorganisms8060921 · Cited by 61 · see citing works
Beldarrain-Iznaga, T., Villalobos-Carvajal, R., Sevillano-Armesto, E., & Leiva-Vega, J. (2021) · Food Research International · doi:10.1016/j.foodres.2021.110136 · Cited by 46 · see citing works
Mohr, A. E., Basile, A. J., Crawford, M. S., Sweazea, K. L., & Carpenter, K. C. (2020) · Journal of the Academy of Nutrition and Dietetics · doi:10.1016/j.jand.2019.08.018 · Cited by 37 · see citing works
- Authors
- Khalesi, S., Bellissimo, N., Vandelanotte, C., Williams, S., Stanley, D., & Irwin, C.
- Affiliations
- Central Queensland University (AU)
- Toronto Metropolitan University (CA)
- Griffith University (AU)
- Corresponding author
- Khalesi, Saman
- ORCID
- Venue
- European Journal of Clinical Nutrition
- Published
- 2018-03-26
- Volume
- 73
- Issue
- 1
- Pages
- 24-37
- ISSN
- 0954-3007 (ISSN-L)
- 1476-5640
- OpenAlex
- W2791205868
- Cited by
- 242
- References
- 104
- Citations by year
- 2026: 14 · 2025: 21 · 2024: 23 · 2023: 34 · 2022: 39 · 2021: 39 · 2020: 38 · 2019: 25 · 2018: 8 · 2017: 1
- FWCI
- 2.78
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.cqu.edu.au
- Licence
- other-oa
- www.springer.com/tdm (tdm)
- Locations
- European Journal of Clinical Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Acquire (CQUniversity) (submittedVersion, other-oa)
- Figshare (submittedVersion, cc-by)
- Griffith Research Online (submittedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
- Keywords
- probiotics, probiotic supplementation, healthy adults, gut microbiota, immune response, lipid profile, cardiovascular risk, gastrointestinal discomfort, stool consistency, vaginal lactobacilli, women's reproductive health
- MeSH terms
- Gastrointestinal Microbiome, Adult, Female, Genitalia, Female, Humans, Immune System, Male, Dietary Supplements, Probiotics, Gastrointestinal Tract, Healthy Volunteers
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
