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Cited by 25Cardiovascular and exercise physiologyPhysical Activity and HealthCardiovascular Health and Disease Prevention

The benefits of regular aerobic exercise training on cerebrovascular function and cognition in older adults

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Bliss, Edward S., Biki, Samia M., Wong, Rachel H. X., Howe, Peter R. C., Mills, Dean E.·2023·European Journal of Applied Physiology
DOI 10.1007/s00421-023-05154-yPMC PMC9938957
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Abstract

We compared the differences in cerebrovascular and cognitive function between 13 aerobic exercise trained, older adults and 13 age-, height- and sex-matched sedentary, untrained controls. We determined whether other measures accounted for differences in cerebrovascular and cognitive function between these groups and examined the associations between these functions. Participants undertook anthropometric, mood, cardiovascular, exercise performance, strength, cerebrovascular, and cognitive measurements, and a blood collection. Transcranial Doppler ultrasonography determined cerebrovascular responsiveness (CVR) to hypercapnia and cognitive stimuli. The trained group had a higher CVR to hypercapnia (80.3 ± 7.2 vs 35.1 ± 6.7%, P < 0.001), CVR to cognitive stimuli (30.1 ± 2.9 vs 17.8 ± 1.4%, P = 0.001) and total composite cognitive score (117 ± 2 vs 98 ± 4, P < 0.001) than the controls. These parameters no longer remained statistically different between the groups following adjustments for covariates. There were positive correlations between the total composite cognitive score and CVR to hypercapnia ( r = 0.474, P = 0.014) and CVR to cognitive stimuli ( r = 0.685, P < 0.001). We observed a relationship between cerebrovascular and cognitive function in older adults and an interaction between regular lifelong aerobic exercise training and cardiometabolic factors that may directly influence these functions.

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Cited by

Sorted by citations

Authors
Bliss, E. S., Biki, S. M., Wong, R. H. X., Howe, P. R. C., & Mills, D. E.
Affiliations
University of Southern Queensland (AU)
Corresponding author
Bliss, Edward S.
ORCID
Venue
European Journal of Applied Physiology
Publisher
Springer Science and Business Media LLC
Published
2023-02-19
Volume
123
Issue
6
Pages
1323-1342
ISSN
  • 0020-9376 (ISSN-L)
  • 1439-6319
  • 1439-6327
DOI
10.1007/s00421-023-05154-y
PMC
PMC9938957
OpenAlex
W4321454675
Cited by
25
References
11
Citations by year
2026: 4 · 2025: 10 · 2024: 8 · 2023: 3
FWCI
7.64
Type
journal article
Language
en
Open access
Licence
Locations
  • European Journal of Applied Physiology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • NOVA (University of Newcastle Australia) (submittedVersion)
Funders
University of Southern Queensland
Topics
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
  • Health Sciences › Medicine › Physiology › Physical Activity and Health
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
Keywords
aerobic exercise training, older adults, cerebrovascular function, cognitive function, hypercapnia, transcranial Doppler, sedentary lifestyle, cardiometabolic risk factors, lifelong physical exercise
MeSH terms
Aged, Cerebrovascular Circulation, Cognition, Humans, Hypercapnia, Exercise

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