The hidden side of intentional action: the role of the anterior insular cortex
Abstract
Cognitive neuroscience research has begun to reveal the functional neuroanatomy of intentional action. This research has primarily pointed to the role of the medial frontal cortex for the voluntary control of behaviour. However, a closer inspection of the literature reveals that the anterior insular cortex (AIC) is also routinely activated in tasks that involve different aspects of intentional action. In the present article, we outline studies that have found AIC activation in various intentional action paradigms. Based on these findings, we discuss two hypotheses about the AIC's contribution to voluntary control. One hypothesis states that AIC is involved in forming intentions, by providing information about the internal states of the system. The alternative view suggests that AIC evaluates the outcomes of intentional action decisions that have been previously formed elsewhere. The limited evidence so far favours the evaluative hypothesis. AIC may provide interoceptive signals that play an essential role in evaluating the consequences of intentional action. AIC is therefore a key structure for the adaptive, affective training of the individual will, on which human society depends.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The relationship between anterior insular cortex anticipatory engagement and self-reported intensity suggests that the anterior insular cortex directly affects how an event is experienced, including subjective arousal and emotionality.
“The relationship between AIC anticipatory engagement and self-reported ratings of the intensity of the experience suggests that the AIC directly impacts the way in which an event is experienced, including the subjective arousal and emotionality evoked by the experience [42, 43].”
From The role of the anterior insula in adolescent decision making (2014) · cites this paper as [42]
Cites
How do you feel — now? The anterior insula and human awareness
(Bud) Craig, A. D. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2555 · Cited by 6,657 · cited 1× · see citing works
“How do these results from intentional action fit with the dominant view that the AIC plays a role in interoception (Critchley et al. 2004; Craig 2009)? We suggest that AIC may signal the affective consequences of decisions about intentional action.”
BackgroundHow do you feel? Interoception: The sense of the physiological condition of the body
Craig, A. D. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn894 · Cited by 6,006 · see citing works
Neural systems supporting interoceptive awareness
Critchley, H. D., Wiens, S., Rotshtein, P., Öhman, A., & Dolan, R. J. (2004) · Nature Neuroscience · doi:10.1038/nn1176 · Cited by 3,406 · cited 1× · see citing works
“How do these results from intentional action fit with the dominant view that the AIC plays a role in interoception (Critchley et al. 2004; Craig 2009)? We suggest that AIC may signal the affective consequences of decisions about intentional action.”
BackgroundInhibition and the right inferior frontal cortex
Aron, A. R., Robbins, T. W., & Poldrack, R. A. (2004) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2004.02.010 · Cited by 3,197 · see citing works
Interoception: the sense of the physiological condition of the body
(Bud) Craig, A. (2003) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(03)00090-4 · Cited by 2,556 · see citing works
LIBET, B., GLEASON, C. A., WRIGHT, E. W., & PEARL, D. K. (1983) · Brain · doi:10.1093/brain/106.3.623 · Cited by 2,498 · see citing works
Circuitry and functional aspects of the insular lobe in primates including humans
AUGUSTINE, J. (1996) · Brain Research Reviews · doi:10.1016/s0165-0173(96)00011-2 · Cited by 1,776 · see citing works
Unconscious determinants of free decisions in the human brain
Soon, C. S., Brass, M., Heinze, H.-J., & Haynes, J.-D. (2008) · Nature Neuroscience · doi:10.1038/nn.2112 · Cited by 1,741 · see citing works
Central cancellation of self-produced tickle sensation
Blakemore, S.-J., Wolpert, D. M., & Frith, C. D. (1998) · Nature Neuroscience · doi:10.1038/2870 · Cited by 1,467 · see citing works
Human volition: towards a neuroscience of will
Haggard, P. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2497 · Cited by 1,134 · see citing works
Self-citationSelf-initiated versus externally triggered movements
Jahanshahi, M., Jenkins, I. H., Brown, R. G., MARSDEN, C. D., Passingham, R. E., & Brooks, D. J. (1995) · Brain · doi:10.1093/brain/118.4.913 · Cited by 999 · see citing works
Time of Conscious Intention to Act in Relation to Onset of Cerebral Activity (Readiness-Potential)
Libet, B., Gleason, C. A., Wright, E. W., & Pearl, D. K. (1993) · Birkhäuser Boston eBooks · doi:10.1007/978-1-4612-0355-1_15 · Cited by 792 · see citing works
Functional organization of human supplementary motor cortex studied by electrical stimulation
Fried, I., Katz, A., McCarthy, G., Sass, K., Williamson, P., Spencer, S., & Spencer, D. (1991) · The Journal of Neuroscience · doi:10.1523/jneurosci.11-11-03656.1991 · Cited by 791 · see citing works
Self-initiated versus externally triggered movements
Jenkins, I. H., Jahanshahi, M., Jueptner, M., Passingham, R. E., & Brooks, D. J. (2000) · Brain · doi:10.1093/brain/123.6.1216 · Cited by 746 · see citing works
Movement intention after parietal cortex stimulation in humans
Desmurget, M., Reilly, K. T., Richard, N., Szathmari, A., Mottolese, C., & Sirigu, A. (2009) · Science · doi:10.1126/science.1169896 · Cited by 695 · see citing works
Conjoint activity of anterior insular and anterior cingulate cortex: awareness and response
Medford, N., & Critchley, H. D. (2010) · Brain Structure and Function · doi:10.1007/s00429-010-0265-x · Cited by 627 · see citing works
Forebrain emotional asymmetry: a neuroanatomical basis?
Craig, A. D. (. (2005) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2005.10.005 · Cited by 626 · see citing works
The Rupture and Repair of Cooperation in Borderline Personality Disorder
King‐Casas, B., Sharp, C., Lomax-Bream, L., Lohrenz, T. M., Fonagy, P., & Montague, P. R. (2008) · Science · doi:10.1126/science.1156902 · Cited by 603 · see citing works
The neurophysiology of unmyelinated tactile afferents
Olausson, H., Wessberg, J., Morrison, I., McGlone, F., & Vallbo, Å. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2008.09.011 · Cited by 587 · see citing works
Cunnington, R., Windischberger, C., Deecke, L., & Moser, E. (2002) · NeuroImage · doi:10.1006/nimg.2001.0976 · Cited by 546 · see citing works
Lau, H. C., Rogers, R. D., Haggard, P., & Passingham, R. E. (2004) · Science · doi:10.1126/science.1090973 · Cited by 539 · see citing works
Self-citationSelective perturbation of visual input during prehension movements
Paulignan, Y., Jeannerod, M., MacKenzie, C. L., & Marteniuk, R. G. (1991) · Experimental Brain Research · doi:10.1007/bf00231858 · Cited by 522 · see citing works
Conscious perception of errors and its relation to the anterior insula
Ullsperger, M., Harsay, H. A., Wessel, J. R., & Ridderinkhof, K. R. (2010) · Brain Structure and Function · doi:10.1007/s00429-010-0261-1 · Cited by 463 · see citing works
Selective perturbation of visual input during prehension movements
Paulignan, Y., MacKenzie, C. L., Marteniuk, R. G., & Jeannerod, M. (1991) · Experimental Brain Research · doi:10.1007/bf00229827 · Cited by 450 · see citing works
Awareness of action: Inference and prediction
Moore, J. W., & Haggard, P. (2007) · Consciousness and Cognition · doi:10.1016/j.concog.2006.12.004 · Cited by 443 · see citing works
Self-citationGambling near-misses enhance motivation to gamble and recruit win-related brain circuitry
Clark, L., Lawrence, A. J., Astley-Jones, F., & Gray, N. (2009) · Neuron · doi:10.1016/j.neuron.2008.12.031 · Cited by 410 · see citing works
To Do or Not to Do: The Neural Signature of Self-Control
Braß, M., & Haggard, P. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.0924-07.2007 · Cited by 363 · see citing works
Self-citationAwareness of the Functioning of One's Own Limbs Mediated by the Insular Cortex?
Karnath, H., Baier, B., & Nägele, T. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.1590-05.2005 · Cited by 361 · see citing works
Ball, T., Schreiber, A., Feige, B., Wagner, M., Lücking, C. H., & Kristeva-Feige, R. (1999) · NeuroImage · doi:10.1006/nimg.1999.0507 · Cited by 351 · see citing works
Shared cortical anatomy for motor awareness and motor control
Berti, A., Bottini, G., Gandola, M., Pia, L., Smania, N., Stracciari, A., Castiglioni, I., Vallar, G., & Paulesu, E. (2005) · Science · doi:10.1126/science.1110625 · Cited by 351 · see citing works
Altered awareness of voluntary action after damage to the parietal cortex
Sirigu, A., Daprati, E., Ciancia, S., Giraux, P., Nighoghossian, N., Posada, A., & Haggard, P. (2004) · Nature Neuroscience · doi:10.1038/nn1160 · Cited by 329 · see citing works
Self-citationThe What, When, Whether Model of Intentional Action
Braß, M., & Haggard, P. (2008) · The Neuroscientist · doi:10.1177/1073858408317417 · Cited by 323 · see citing works
Self-citationVolition and Conflict in Human Medial Frontal Cortex
Nachev, P., Rees, G. E., Parton, A. D., Christopher Kennard, C., & Masud Husain, B. (2005) · Current Biology · doi:10.1016/j.cub.2005.01.006 · Cited by 319 · see citing works
Sterzer, P., Stadler, C., Poustka, F., & Kleinschmidt, A. K. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2007.04.043 · Cited by 299 · see citing works
Size matters: Increased grey matter in boys with conduct problems and callous–unemotional traits
De Brito, S. A., Mechelli, A., Wilke, M., Laurens, K. R., Jones, A. P., Barker, G. J., Hodgins, S., & Viding, E. (2009) · Brain · doi:10.1093/brain/awp011 · Cited by 292 · see citing works
de Oliveira‐Souza, R., Hare, R. D., Bramati, I. E., Garrido, G. J., Ignácio, F. A., Tovar-Moll, F. F., & Moll, J. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2007.12.054 · Cited by 269 · see citing works
Forstmann, B. U., Jahfari, S., Scholte, H. S., Wolfensteller, U., van den Wildenberg, W. P. M., & Ridderinkhof, K. R. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.1465-08.2008 · Cited by 254 · see citing works
What is reinforced by phasic dopamine signals?
Redgrave, P., GURNEY, K. N., & Reynolds, J. N. J. (2007) · Brain Research Reviews · doi:10.1016/j.brainresrev.2007.10.007 · Cited by 254 · see citing works
Right insula for our sense of limb ownership and self-awareness of actions
Karnath, H.-O., & Baier, B. (2010) · Brain Structure and Function · doi:10.1007/s00429-010-0250-4 · Cited by 223 · see citing works
Willed action and attention to the selection of action
Lau, H. C., Rogers, R. D., Ramnani, N., & Passingham, R. E. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2003.10.034 · Cited by 220 · see citing works
Two Modes of Sensorimotor Integration in Intention-Based and Stimulus-Based Actions
Herwig, A., Prinz, W., & Waszak, F. (2007) · Quarterly Journal of Experimental Psychology · doi:10.1080/17470210601119134 · Cited by 192 · cited 1× · see citing works
“Moreover, intentional actions are thought to depend more strongly on effect learning than externallytriggered actions (Herwig et al. 2007).”
BackgroundKnowing When to Stop: The Brain Mechanisms of Chasing Losses
Campbell-Meiklejohn, D. K., Woolrich, M. W., Passingham, R. E., & Rogers, R. D. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.05.014 · Cited by 179 · see citing works
Brain anatomy of persistent violent offenders: More rather than less
Tiihonen, J., Rossi, R., Laakso, M. P., Hodgins, S., Testa, C., Pérez, J., Repo‐Tiihonen, E., Vaurio, O., Soininen, H. S., Aronen, H. J., et al. (2008) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2007.08.012 · Cited by 177 · see citing works
Manipulating the Experienced Onset of Intention after Action Execution
Lau, H. C., Rogers, R. D., & Passingham, R. E. (2007) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.2007.19.1.81 · Cited by 165 · see citing works
Decision-related loss: Regret and disappointment
Chua, H. F., Gonzalez, R., Taylor, S. F., Welsh, R. C., & Liberzon, I. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.06.006 · Cited by 147 · see citing works
The role of the preSMA and the rostral cingulate zone in internally selected actions
Mueller, V. A., Brass, M., Waszak, F., & Prinz, W. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2007.06.018 · Cited by 135 · see citing works
Intentional inhibition: How the “veto‐area” exerts control
Kühn, S., Haggard, P., & Braß, M. (2008) · Human Brain Mapping · doi:10.1002/hbm.20711 · Cited by 127 · see citing works
Self-citationDissociating response selection and conflict in the medial frontal surface
Lau, H., Rogers, R. D., & Passingham, R. E. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2005.07.050 · Cited by 125 · see citing works
Ramautar, J. R., Slagter, H. A., Kok, A., & Ridderinkhof, K. R. (2006) · Brain Research · doi:10.1016/j.brainres.2006.02.091 · Cited by 120 · see citing works
Ach, N. (1905) · Vandenhoeck & Ruprecht eBooks · Cited by 111 · see citing works
Self-observation reinstates motor awareness in anosognosia for hemiplegia
Fotopoulou, A., Rudd, A. G., Holmes, P. S., & Kopelman, M. D. (2009) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2009.01.018 · Cited by 111 · see citing works
The role of the ventrolateral frontal cortex in inhibitory oculomotor control
Hodgson, T. L., Chamberlain, M. S., Parris, B. A., James, M. A., Gutowski, N. J., Masud Husain, B., & Christopher Kennard, C. (2007) · Brain · doi:10.1093/brain/awm064 · Cited by 101 · see citing works
Dissociating what and when of intentional actions
Krieghoff, V. (2009) · Frontiers in Human Neuroscience · doi:10.3389/neuro.09.003.2009 · Cited by 79 · see citing works
Implementation of visuospatial cues in response selection
van Eimeren, T., Wolbers, T., Münchau, A. M., Büchel, C., Weiller, C., & Siebner, H. R. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2005.07.014 · Cited by 63 · see citing works
When doing nothing is an option: The neural correlates of deciding whether to act or not
Kühn, S., & Braß, M. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.03.020 · Cited by 43 · see citing works
Wiese, H., Stude, P., Nebel, K., Forsting, M., & de Greiff, A. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2005.06.044 · Cited by 23 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
An Interoceptive Predictive Coding Model of Conscious Presence
Seth, A. K., Suzuki, K., & Critchley, H. D. (2012) · Frontiers in Psychology · doi:10.3389/fpsyg.2011.00395 · Cited by 950 · see citing works
“The AIC is proposed to be specifically involved in updating previously existing prediction models in reward learning contexts (Palaniyappan and Liddle, 2011), and AIC activity elicited during intentional action is suggested to provide interoceptive signals essential for evaluating the affective consequences of motor i…”
BackgroundA multisensory investigation of the functional significance of the “pain matrix”
Mouraux, A., Diukova, A., Lee, M., Wise, R. G., & Iannetti, G. D. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.09.084 · Cited by 556 · see citing works
Suzuki, K., Garfinkel, S. N., Critchley, H. D., & Seth, A. K. (2013) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2013.08.014 · Cited by 476 · see citing works
Role of the anterior insula in task-level control and focal attention
Nelson, S. M., Dosenbach, N. U. F., Cohen, A. L., Wheeler, M. E., Schlaggar, B. L., & Petersen, S. E. (2010) · Brain Structure and Function · doi:10.1007/s00429-010-0260-2 · Cited by 435 · see citing works
Contributions of the insula to cognition and emotion
Gasquoine, P. G. (2014) · Neuropsychology Review · doi:10.1007/s11065-014-9246-9 · Cited by 400 · see citing works
The Organization of the Primate Insular Cortex
Evrard, H. (2019) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2019.00043 · Cited by 233 · see citing works
Holsen, L. M., Lawson, E. A., Blum, J. I., Ko, E., Makris, N., Fazeli, P. K., Klibanski, A., & Goldstein, J. M. (2012) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.110156 · Cited by 183 · see citing works
The “What” and “When” of Self-Initiated Movements
Hoffstaedter, F., Grefkes, C., Zilles, K., & Eickhoff, S. B. (2013) · Cerebral Cortex · doi:10.1093/cercor/bhr391 · Cited by 166 · see citing works
Brain systems underlying the affective and social monitoring of actions: An integrative review
Koban, L., & Pourtois, G. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.02.014 · Cited by 159 · see citing works
The macaque lateral grasping network: A neural substrate for generating purposeful hand actions
Borra, E., Gerbella, M., Rozzi, S., & Luppino, G. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.01.017 · Cited by 143 · see citing works
The Insula: A Brain Stimulation Target for the Treatment of Addiction
Ibrahim, C., Rubin-Kahana, D. S., Pushparaj, A., Musiol, M., Blumberger, D. M., Daskalakis, Z. J., Zangen, A., & Le Foll, B. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00720 · Cited by 133 · see citing works
Droutman, V., Bechara, A., & Read, S. J. (2015) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2015.00309 · Cited by 131 · see citing works
Melloni, M., Sedeño, L., Couto, B., Reynoso, M., Gelormini, C., Favaloro, R., Canales-Johnson, A., Sigman, M., Manes, F., & Ibanez, A. (2013) · Behavioral and Brain Functions · doi:10.1186/1744-9081-9-47 · Cited by 127 · see citing works
Couto, B., Sedeño, L., Sposato, L. A., Sigman, M., Riccio, P. M., Salles, A., López, V., Schröeder, J., Manes, F. F., & Ibáñez, A. M. (2012) · Cortex · doi:10.1016/j.cortex.2012.08.006 · Cited by 116 · see citing works
The role of the anterior insula in adolescent decision making
Smith, A. R., Steinberg, L., & Chein, J. (2014) · Developmental Neuroscience · doi:10.1159/000358918 · Cited by 110 · see citing works
Imaging volition: what the brain can tell us about the will
Braß, M., Lynn, M. T., Demanet, J., & Rigoni, D. (2013) · Experimental Brain Research · doi:10.1007/s00221-013-3472-x · Cited by 99 · see citing works
Statistical learning attenuates visual activity only for attended stimuli
Richter, D., & de Lange, F. P. (2019) · eLife · doi:10.7554/elife.47869 · Cited by 102 · see citing works
Anterior insular cortex is a bottleneck of cognitive control
Wu, T., Wang, X., Wu, Q., Spagna, A., Yang, J., Yuan, C., Wu, Y., Gao, Z., Hof, P. R., & Fan, J. (2019) · NeuroImage · doi:10.1016/j.neuroimage.2019.02.042 · Cited by 96 · see citing works
Neural Correlates of Impulsivity in Healthy Males and Females with Family Histories of Alcoholism
DeVito, E. E., Meda, S. A., Jiantonio‐Kelly, R. E., Potenza, M. N., Krystal, J. H., & Pearlson, G. D. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.92 · Cited by 77 · see citing works
Effects of social context and predictive relevance on action outcome monitoring
Koban, L., Pourtois, G., Bediou, B., & Vuilleumier, P. O. (2012) · Cognitive Affective & Behavioral Neuroscience · doi:10.3758/s13415-012-0091-0 · Cited by 75 · see citing works
Integration of Error Agency and Representation of Others' Pain in the Anterior Insula
Koban, L., Corradi‐Dell’Acqua, C., & Vuilleumier, P. O. (2012) · Journal of Cognitive Neuroscience · doi:10.1162/jocn_a_00324 · Cited by 73 · see citing works
Papeo, L., Negri, G. A. L., Zadini, A., & Rumiati, R. I. (2010) · Cognitive Neuropsychology · doi:10.1080/02643294.2011.570326 · Cited by 72 · see citing works
Once an island, now the focus of attention
Craig, A. D. (2010) · Brain Structure and Function · doi:10.1007/s00429-010-0270-0 · Cited by 71 · see citing works
Nociceptive Local Field Potentials Recorded from the Human Insula Are Not Specific for Nociception
Liberati, G., Klöcker, A., Safronova, M. M., Santos, S. F., Vaz, J.-G. R., Raftopoulos, C., & Mouraux, A. (2016) · PLoS Biology · doi:10.1371/journal.pbio.1002345 · Cited by 68 · see citing works
Bardi, L., Desmet, C., Nijhof, A. D., Wiersema, J. R., & Braß, M. (2016) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsw143 · Cited by 68 · see citing works
Immordino-Yang, M. H., Yang, X.-F., & Damasio, H. (2014) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2014.00728 · Cited by 67 · see citing works
The Interaction between Interoceptive and Action States within a Framework of Predictive Coding
Marshall, A. C., Gentsch, A., & Schütz‐Bosbach, S. (2018) · Frontiers in Psychology · doi:10.3389/fpsyg.2018.00180 · Cited by 64 · see citing works
Performance on the Frontal Assessment Battery is sensitive to frontal lobe damage in stroke patients
Kopp, B., Rösser, N., Tabeling, S., Stürenburg, H. J., de Haan, B., Karnath, H., & Wessel, K. (2013) · BMC Neurology · doi:10.1186/1471-2377-13-179 · Cited by 64 · see citing works
Tinaz, S., Para, K., Vives‐Rodriguez, A., Martinez‐Kaigi, V., Nalamada, K., Sezgi̇n, M., Scheinost, D., Hampson, M., Louis, E. D., & Constable, R. T. (2018) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2018.00496 · Cited by 62 · see citing works
Ge, S., Liu, H., Lin, P., Gao, J., Xiao, C., & Li, Z. (2018) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2018.00283 · Cited by 64 · see citing works
Rae, C. L., Ahmad, A., Larsson, D. E. O., Silva, M., van Praag, C. G., Garfinkel, S. N., & Critchley, H. (2020) · Scientific Reports · doi:10.1038/s41598-020-60405-8 · Cited by 61 · see citing works
Cona, G., Bisiacchi, P. S., Sartori, G., & Scarpazza, C. (2016) · Scientific Reports · doi:10.1038/srep25983 · Cited by 61 · see citing works
Gamma-Band Oscillations Preferential for Nociception can be Recorded in the Human Insula
Liberati, G., Klöcker, A., Algoet, M., Mulders, D., Safronova, M. M., Santos, S. F., Vaz, J.-G. R., Raftopoulos, C., & Mouraux, A. (2017) · Cerebral Cortex · doi:10.1093/cercor/bhx237 · Cited by 56 · see citing works
The neural mechanisms underlying internally and externally guided task selection
Orr, J. M., & Banich, M. T. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2013.08.047 · Cited by 51 · see citing works
Anorexia nervosa – A noradrenergic dysregulation hypothesis
Nunn, K., Frampton, I. J., & Lask, B. D. (2012) · Medical Hypotheses · doi:10.1016/j.mehy.2012.01.033 · Cited by 51 · see citing works
How distinct functional insular subdivisions mediate interacting neurocognitive systems
Zhao, H., Turel, O., Bechara, A., & He, Q. (2022) · Cerebral Cortex · doi:10.1093/cercor/bhac169 · Cited by 51 · see citing works
An intrinsic connectivity network approach to insula-derived dysfunctions among cocaine users
Wisner, K., Patzelt, E. H., Lim, K. O., & MacDonald, A. W. (2013) · The American Journal of Drug and Alcohol Abuse · doi:10.3109/00952990.2013.848211 · Cited by 48 · see citing works
Gerbella, M., Borra, E., Rozzi, S., & Luppino, G. (2014) · Brain Structure and Function · doi:10.1007/s00429-014-0892-8 · Cited by 46 · see citing works
Functional lateralization of the anterior insula during feedback processing
Späti, J., Chumbley, J. R., Brakowski, J., Doerig, N., Holtforth, M. G., Seifritz, E., & Spinelli, S. (2014) · Human Brain Mapping · doi:10.1002/hbm.22484 · Cited by 42 · see citing works
Same Same but Different. Different Trigeminal Chemoreceptors Share the Same Central Pathway
Kollndorfer, K., Kowalczyk, K., Frasnelli, J., Hoche, E., Unger, E., Mueller, C. A., Krajnik, J., Trattnig, S., & Schöpf, V. (2015) · PLoS ONE · doi:10.1371/journal.pone.0121091 · Cited by 41 · see citing works
Supramodal Mechanisms of the Cognitive Control Network in Uncertainty Processing
Wu, T., Spagna, A., Chen, C., Schulz, K. P., Hof, P. R., & Fan, J. (2020) · Cerebral Cortex · doi:10.1093/cercor/bhaa189 · Cited by 37 · see citing works
Libet's Legacy: A Primer to the Neuroscience of Volition.
Dominik, T., Mele, A., Schurger, A., & Maoz, U. (2023) · Neuroscience and Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105503 · Cited by 27 · see citing works
Cuomo, G., Maglianella, V., Ghooshchy, S. G., Zoccolotti, P., Martelli, M., Paolucci, S., Morone, G., & Iosa, M. (2021) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2022.2018301 · Cited by 37 · see citing works
Gray matter volumetric study of major depression and suicidal behavior
Rizk, M. M., Rubin-Falcone, H., Lin, X., Keilp, J. G., Miller, J. M., Milak, M. S., Sublette, M. E., Oquendo, M. A., Ogden, R. T., Abdelfadeel, N. A., et al. (2019) · Psychiatry Research: Neuroimaging · doi:10.1016/j.pscychresns.2018.11.007 · Cited by 35 · see citing works
Amplified engagement of prefrontal cortex during control of voluntary action in Tourette syndrome
Rae, C. L., Parkinson, J., Betka, S., Praag, C. D. G., Bouyagoub, S., Polyanska, L., Larsson, D. E. O., Harrison, N. A., Garfinkel, S. N., & Critchley, H. (2020) · Brain Communications · doi:10.1093/braincomms/fcaa199 · Cited by 35 · see citing works
Spatial neglect and perseveration in visuomotor exploration.
Ronchi, R., Algeri, L., Chiapella, L., Spada, M. S., & Vallar, G. (2012) · Neuropsychology · doi:10.1037/a0029216 · Cited by 30 · see citing works
Role of the right anterior insular cortex in joint attention-related identification with a partner
Koike, T., Tanabe, H. C., Adachi-Abe, S., Okazaki, S., Nakagawa, E., Sasaki, A. T., Shimada, K., Sugawara, S. K., Takahashi, H. K., Yoshihara, K., et al. (2019) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsz087 · Cited by 27 · see citing works
Si, R., Rowe, J. B., & Zhang, J. (2021) · NeuroImage · doi:10.1016/j.neuroimage.2021.118468 · Cited by 26 · see citing works
Tan, Y., Yan, R., Gao, Y., Zhang, M., & Northoff, G. (2022) · NeuroImage · doi:10.1016/j.neuroimage.2022.119500 · Cited by 34 · see citing works
Separating neural activity associated with emotion and implied motion: An fMRI study.
Kolesar, T. A., Kornelsen, J., & Smith, S. D. (2016) · Emotion · doi:10.1037/emo0000209 · Cited by 25 · see citing works
van Elk, M., Viswanathan, S., van Schie, H. T., Harold Bekkering, A., & Grafton, S. T. (2012) · Experimental Brain Research · doi:10.1007/s00221-012-3016-9 · Cited by 24 · see citing works
Cracco, E., Desmet, C., & Braß, M. (2015) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsv120 · Cited by 23 · see citing works
Single subject analyses reveal consistent recruitment of frontal operculum in performance monitoring
Amiez, C., Wutte, M., Faillenot, I., Petrides, M., Burle, B., & Procyk, E. (2016) · NeuroImage · doi:10.1016/j.neuroimage.2016.03.003 · Cited by 24 · see citing works
Distinct electrophysiological potentials for intention in action and prior intention for action.
Vinding, M., Jensen, M., & Overgaard, M. (2014) · Cortex; a journal devoted to the study of the nervous system and behavior · doi:10.1016/j.cortex.2013.09.001 · Cited by 24 · see citing works
Flook, E. A., Luchsinger, J. R., Silveri, M. M., Winder, D. G., Benningfield, M. M., & Blackford, J. U. (2020) · Addiction Biology · doi:10.1111/adb.12861 · Cited by 22 · see citing works
Swallowing Intentional Off-State in Aging and Alzheimer's Disease: Preliminary Study
Humbert, I. A., McLaren, D. G., Malandraki, G. A., Johnson, S. C., & Robbins, J. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-110380 · Cited by 21 · see citing works
EEG signature of breaks in embodiment in VR
Porssut, T., Iwane, F., Chavarriaga, R., Blanke, O., Millán, J. D. R., Boulic, R., & Herbelin, B. (2023) · PLoS ONE · doi:10.1371/journal.pone.0282967 · Cited by 20 · see citing works
Voluntary inhibition of pain avoidance behavior: an fMRI study
Lynn, M. T., Demanet, J., Krebs, R. M., Dessel, P. V., & Braß, M. (2014) · Brain Structure and Function · doi:10.1007/s00429-014-0972-9 · Cited by 20 · see citing works
Weaker Functional Connectivity Strength in Patients with Type 2 Diabetes Mellitus
Liu, L., Li, W., Zhang, Y., Qin, W., Lu, S., & Zhang, Q. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00390 · Cited by 19 · see citing works
Influences of unconscious priming on voluntary actions: Role of the rostral cingulate zone
Teuchies, M., Demanet, J., Sidarus, N., Haggard, P., Stevens, M., & Braß, M. (2016) · NeuroImage · doi:10.1016/j.neuroimage.2016.04.036 · Cited by 16 · see citing works
Self-citationIntention Concepts and Brain-Machine Interfacing
Thinnes-Elker, F., Iljina, O., Apostolides, J. K., Kraemer, F., Schulze‐Bonhage, A., Aertsen, A., & Tonio Ball, A. (2012) · Frontiers in Psychology · doi:10.3389/fpsyg.2012.00455 · Cited by 17 · see citing works
Bello, M. D., Giudetti, F., Palani, S., Petrocchi, N., McIntosh, R. C., & Ottaviani, C. (2022) · International Journal of Clinical and Health Psychology · doi:10.1016/j.ijchp.2022.100362 · Cited by 16 · see citing works
Anterior insula activity and the effect of agency on the Stimulus‐Preceding Negativity
Hackley, S. A., Hirao, T., Onoda, K., Ogawa, K., & Masaki, H. (2020) · Psychophysiology · doi:10.1111/psyp.13519 · Cited by 14 · see citing works
Task-based functional connectivity identifies two segregated networks underlying intentional action
Doganci, N., Iannotti, G. R., & Ptak, R. (2023) · NeuroImage · doi:10.1016/j.neuroimage.2023.119866 · Cited by 14 · see citing works
Sakata, H., Itoh, K., Suzuki, Y., Nakamura, K., Watanabe, M., Igarashi, H., & Nakada, T. (2017) · eNeuro · doi:10.1523/eneuro.0183-17.2017 · Cited by 16 · see citing works
Blank, H., Alink, A., & Büchel, C. (2023) · Communications Biology · doi:10.1038/s42003-023-04508-8 · Cited by 12 · see citing works
Effects of intentionality and subliminal information in free-choices to inhibit
Dall’Acqua, T., Begliomini, C., Motta, R., D, D. M. M., & Castiello, U. (2017) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2017.11.035 · Cited by 13 · see citing works
Functional brain networks associated with the urge for action: Implications for pathological urge
Zouki, J., Eapen, V., Efron, D., Maxwell, A., & Silk, T. J. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105779 · Cited by 10 · see citing works
Heartfelt choices: The influence of cardiac phase on free‐choice actions
Mussini, E., Perrucci, M. G., Costantini, M., & Ferri, F. (2024) · Psychophysiology · doi:10.1111/psyp.14682 · Cited by 13 · see citing works
Sutherland, M. T., & Fishbein, D. H. (2017) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2017.00245 · Cited by 10 · see citing works
Insular Cortex Activity as the Neural Base of Intrinsic Motivation
Lee, W. (2016) · Advances in motivation and achievement · doi:10.1108/s0749-742320160000019016 · Cited by 9 · see citing works
Mussini, E., Bianco, V., Pitzalis, S., & Russo, F. D. (2022) · Biological Psychology · doi:10.1016/j.biopsycho.2022.108360 · Cited by 6 · see citing works
Tinaz, S., Elfil, M., Kamel, S., Aravala, S., Louis, E., & Sinha, R. (2020) · Clinical Parkinsonism & Related Disorders · doi:10.1016/j.prdoa.2020.100051 · Cited by 9 · see citing works
Parvizi-Wayne, D., & Severs, L. (2024) · Cognitive Affective & Behavioral Neuroscience · doi:10.3758/s13415-024-01189-6 · Cited by 8 · see citing works
Diao, L., Li, W., Fan, L., Valesi, R., & Ma, Q. (2021) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2021.01.020 · Cited by 7 · see citing works
Left neglect dyslexia: Perseveration and reading error types
Ronchi, R., Algeri, L., Chiapella, L., Gallucci, M., Spada, M. S., & Vallar, G. (2016) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2016.07.023 · Cited by 7 · see citing works
fMRI evidence of movement familiarization effects on recognition memory in professional dancers
Wang, Y., Zhao, Q., Ji, Q., Jin, X., Zhou, C., & Lu, Y.-J. (2023) · Cerebral Cortex · doi:10.1093/cercor/bhad490 · Cited by 6 · see citing works
Pfurtscheller, G., Andrade, A., Koschutnig, K., Brunner, C., & Lopes, F. H. D. S. (2014) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2014.00093 · Cited by 6 · see citing works
Clouette, J., Potvin‐Desrochers, A., Seo, F., Churchward‐Venne, T. A., & Paquette, C. (2024) · Neuroscience · doi:10.1016/j.neuroscience.2024.01.005 · Cited by 4 · see citing works
Durlak, W., Herman‐Sucharska, I., Urbanik, A., Klimek, M., Karcz, P., Dutkowska, G., Nitecka, M., & Kwinta, P. (2016) · PLoS ONE · doi:10.1371/journal.pone.0156064 · Cited by 4 · see citing works
Effector-independent Representations Guide Sequential Target Selection Biases in Action
O’Bryan, S. R., Moher, J., McCarthy, J. D., & Song, J. (2024) · Journal of Cognitive Neuroscience · doi:10.1162/jocn_a_02102 · Cited by 3 · see citing works
Parkinson, J., & Haggard, P. (2013) · Consciousness and Cognition · doi:10.1016/j.concog.2013.08.009 · Cited by 2 · see citing works
Self-citationInitial learning in the brain: From rules to action
Fregni, S., Wolfensteller, U., & Ruge, H. (2024) · Imaging Neuroscience · doi:10.1162/imag_a_00274 · Cited by 2 · see citing works
Kavroulakis, E., van Kemenade, B. M., Arikan, B. E., Kircher, T., & Straube, B. (2021) · bioRxiv · doi:10.1101/2021.06.19.449116 · Cited by 1 · see citing works
Amplified engagement of prefrontal cortex during control of voluntary action in Tourette syndromePreprint
Rae, C. L. (2020) · doi:10.31234/osf.io/hsgc8 · Cited by 2 · see citing works
Sharing errors with human and non-human agents
Musco, M. A., Sacheli, L. M., Leggio, D., Basso, G., & Paulesu, E. (2025) · Cerebral Cortex · doi:10.1093/cercor/bhaf315 · Cited by 1 · see citing works
Interactions of conscious and unconscious processes in decision making
Teuchies, M. (2017) · Ghent University Academic Bibliography (Ghent University) · Cited by 1 · see citing works
EEG signature of breaks in embodiment in VRPreprint
Porssut, T., Iwane, F., Chavarriaga, R., Blanke, O., Millán, J. D. R., Boulic, R., & Herbelin, B. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.08.10.502929 · Cited by 1 · see citing works
Parvizi-Wayne, D., & Severs, L. (2024) · doi:10.31234/osf.io/65en8 · Cited by 1 · see citing works
Disconnection, network dysfunction and cognitive impairment after traumatic brain injury
Bonnelle, V. (2012) · Spiral (Imperial College London) · doi:10.25560/9782
Was wirkt, um Wohlbefinden zu erreichen?
Markowitsch, H. J., & Schreier, M. M. (2019) · Springer eBooks · doi:10.1007/978-3-662-58265-7_3
Appetite Regulation and Motivation to Eat in Eating Disorders
Murray, S. M., Kirchberg, M. C., & Kaye, W. H. (2025) · doi:10.1093/9780197675212.003.0007
Hackman, N., Neukam, P. T., Beltran, J., Li, M., Chowdhury, A., Treadway, M. T., Murrough, J. W., & Morris, L. S. (2026) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2026.07.013
- Authors
- Brass, M., & Haggard, P.
- Affiliations
- Ghent University (BE)
- University College London (GB)
- Corresponding author
- Brass, Marcel
- Haggard, Patrick
- Venue
- Brain Structure and Function
- Published
- 2010-05-29
- Volume
- 214
- Issue
- 5-6
- Pages
- 603-610
- ISSN
- 1863-2653 (ISSN-L)
- 1863-2661
- OpenAlex
- W2131765048
- Cited by
- 96
- References
- 56
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 7 · 2023: 5 · 2022: 5 · 2021: 4 · 2020: 7 · 2019: 6 · 2018: 4 · 2017: 7 · 2016: 9 · 2015: 3 · 2014: 8 · 2013: 10 · 2012: 11
- FWCI
- 0.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Brain Structure and Function (publishedVersion)
- PubMed (publishedVersion)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- Funders
- Biotechnology and Biological Sciences Research Council
- Economic and Social Research Council (RES-000-23-1571)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Free Will and Agency
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
- Keywords
- anterior insula, intentional action, intention formation, interoception, outcome measurement, medial frontal cortex
- MeSH terms
- Animals, Cerebral Cortex, Humans, Models, Neurological, Movement, Psychomotor Performance, Volition, Executive Function
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
