Anterior insular cortex plays a critical role in interoceptive attention
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Abstract
Accumulating evidence indicates that the anterior insular cortex (AIC) mediates interoceptive attention which refers to attention towards physiological signals arising from the body. However, the necessity of the AIC in this process has not been demonstrated. Using a novel task that directs attention toward breathing rhythm, we assessed the involvement of the AIC in interoceptive attention in healthy participants using functional magnetic resonance imaging and examined the necessity of the AIC in interoceptive attention in patients with AIC lesions. Results showed that interoceptive attention was associated with increased AIC activation, as well as enhanced coupling between the AIC and somatosensory areas along with reduced coupling between the AIC and visual sensory areas. In addition, AIC activation was predictive of individual differences in interoceptive accuracy. Importantly, AIC lesion patients showed disrupted interoceptive discrimination accuracy and sensitivity. These results provide compelling evidence that the AIC plays a critical role in interoceptive attention.
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The anterior insular cortex plays a crucial role in mediating interoceptive awareness.
“AIC, that plays a crucial role in mediating interoceptive awareness (Wang et al. 2019)”
From Neuroanatomical correlates of peripersonal space: bridging the gap between perception, action, emotion and social cognition (2024) · cites this paper as Wang et al. 2019
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Gender Brain Structural Differences and Interoception
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Self-citationMigraine as an allostatic reset triggered by unresolved interoceptive prediction errors
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“It is worthy to note that AIC, that plays a crucial role in mediating interoceptive awareness (Wang et al. 2019), is part of the ventral attention network (Vossel et al. 2014) and has been implied in PPS representation (Lloyd et al. 2006; de Borst and de Gelder 2022).”
BackgroundSupraspinal Mechanisms of Intestinal Hypersensitivity
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What Makes an Elite Shooter and Archer? The Critical Role of Interoceptive Attention
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Self-citationTemporal Dynamics of Functional Brain States Underlie Cognitive Performance
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Self-citationInsular cortex: A hub for saliency, cognitive control, and interoceptive awareness
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Cardiac and Gastric Interoceptive Awareness Have Distinct Neural Substrates
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- Authors
- Wang, X., Wu, Q., Egan, L., Gu, X., Liu, P., Gu, H., Yang, Y., Luo, J., Wu, Y., Gao, Z., & Fan, J.
- Affiliations
- Capital Medical University (CN)
- Peking University (CN)
- Queens College, CUNY (US)
- James J. Peters VA Medical Center (US)
- National Institute on Drug Abuse (US)
- Capital Normal University (CN)
- Corresponding author
- Fan, Jin
- ORCID
- Venue
- eLife
- Publisher
- eLife Sciences Publications, Ltd
- Published
- 2019-04-15
- Volume
- 8
- ISSN
- 2050-084X (ISSN-L)
- PMC
- PMC6488299
- OpenAlex
- W2899948248
- Cited by
- 204
- References
- 131
- Citations by year
- 2026: 31 · 2025: 37 · 2024: 31 · 2023: 40 · 2022: 28 · 2021: 17 · 2020: 18 · 2019: 2
- FWCI
- 12.95
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- eLife (publishedVersion, cc-by)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, public-domain)
- PubMed Central (publishedVersion, public-domain)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Greater South Information System
- Funders
- Beijing Municipal Administration of Hospitals (Youth Program QML20170503)
- National Natural Science Foundation of China (81600931, 31771205, 61690205, 81328008, 81729001)
- Capital Health Development Research Project of Beijing (2016-4-1074)
- Brain Research Project of Beijing (Z16110002616014)
- China Postdoctoral Science Foundation (2016M600835)
- National Institute on Drug Abuse (1R01DA043695, Intramul Research Program)
- The Mental Illness Research, Education, and Clinical Center, James J. Peter Veterans Affairs Medical Center (MIRECC VISN 2)
- National Basic Research Program of China (973-2015CB351800)
- National Institute of Mental Health (R01MH094305)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
- Life Sciences › Neuroscience › Cognitive Neuroscience › Tactile and Sensory Interactions
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Keywords
- anterior insula, interoceptive attention, interoception, respiratory rhythm, interoceptive accuracy, interoceptive sensitivity, somatosensory cortex, individual differences
- MeSH terms
- Attention, Brain Mapping, Cerebral Cortex, Humans, Magnetic Resonance Imaging, Healthy Volunteers, Interoception
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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