The Separation of ADHD Inattention and Hyperactivity-Impulsivity Symptoms: Pathways from Genetic Effects to Cognitive Impairments and Symptoms
Open accessAbstract
Both shared and unique genetic risk factors underlie the two symptom domains of attention deficit hyperactivity disorder (ADHD): inattention and hyperactivity-impulsivity. The developmental course and relationship to co-occurring disorders differs across the two symptom domains, highlighting the importance of their partially distinct etiologies. Familial cognitive impairment factors have been identified in ADHD, but whether they show specificity in relation to the two ADHD symptom domains remains poorly understood. We aimed to investigate whether different cognitive impairments are genetically linked to the ADHD symptom domains of inattention versus hyperactivity-impulsivity. We conducted multivariate genetic model fitting analyses on ADHD symptom scores and cognitive data, from go/no-go and fast tasks, collected on a population twin sample of 1,312 children aged 7-10. Reaction time variability (RTV) showed substantial genetic overlap with inattention, as observed in an additive genetic correlation of 0.64, compared to an additive genetic correlation of 0.31 with hyperactivity-impulsivity. Commission errors (CE) showed low additive genetic correlations with both hyperactivity-impulsivity and inattention (genetic correlations of 0.17 and 0.11, respectively). The additive genetic correlation between RTV and CE was also low and non-significant at -0.10, consistent with the etiological separation between the two indices of cognitive impairments. Overall, two key cognitive impairments phenotypically associated with ADHD symptoms, captured by RTV and CE, showed different genetic relationships to the two ADHD symptom domains. The findings extend a previous model of two familial cognitive impairment factors in combined subtype ADHD by separating pathways underlying inattention and hyperactivity-impulsivity symptoms.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Most cases of ADHD arise from a 'pool' of genetic and environmental risk factors.
“These approaches have received clear support from aetiological studies indicating that most cases of ADHD arise from a 'pool' of genetic and environmental risk factors.”
From Attention-deficit/hyperactivity disorder (2015) · cites this paper as [33]
The Introduction and Discussion describe shared and distinct genetic influences on ADHD symptom domains. The Methods also consider environmental influences in the twin models, but the paper does not establish that most ADHD cases arise from a pool of genetic and environmental risk factors; its findings concern variation in symptoms and cognitive impairments, not the causes of most diagnosed cases. (LLM, conf=0.82)
Experimental — accuracy not yet measuredNeurocognitive, neuroimaging and genetic theories of ADHD have shifted from single-cause or single-pathway models to models that delineate causes that lead to ADHD through several molecular, neural and neurocognitive pathways.
“Neurocognitive, neuroimaging and genetic theories of ADHD have shifted from single-cause or singlepathway models to models that delineate causes that lead to ADHD through several molecular, neural and neurocognitive pathways 33,98-102 .”
From Attention-deficit/hyperactivity disorder (2015) · cites this paper as [33]
The Discussion (page unavailable) highlights shared and unique etiological pathways and different genetic relationships between cognitive impairments and the two ADHD symptom domains. This supports a multiple-pathway account, but the paper does not establish the claimed historical shift across neurocognitive, neuroimaging, and genetic theories or delineate molecular and neural pathways. (LLM, conf=0.85)
Experimental — accuracy not yet measuredFamily and twin studies have demonstrated that genetic influences are shared between ADHD and a wide range of other neurodevelopmental and psychopathological traits and disorders, including conduct disorder and problems, cognitive performance, autism spectrum disorders and mood disorders.
“Family and twin studies have also demonstrated that genetic influences are shared between ADHD and a wide range of other neurodevelopmental and psycho pathological traits and disorders, including conduct disorder and problems 32 , cognitive performance 33 , autism s pectrum disorders 34 and mood disorders 35,36 .”
From Attention-deficit/hyperactivity disorder (2015) · cites this paper as [33]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision (DSM-IV-TR)
American Psychiatric Association (2000) · doi:10.1176/appi.books.9780890423349 · Cited by 11,069 · see citing works
Genetics of Food Intake Self-Regulation in Childhood: Literature Review and Research Opportunities
Faith, M. S., Carnell, S., & Kral, T. V. E. (2013) · Human Heredity · doi:10.1159/000353879 · Cited by 7,628 · see citing works
Wechsler Intelligence Scale for Children
Miles-Mason, E. (2018) · Sage eBooks · doi:10.4135/9781483392271.n537 · Cited by 4,133 · see citing works
Methodology for Genetic Studies of Twins and Families
Neale, M. C., & Cardon, L. R. (1992) · doi:10.1007/978-94-015-8018-2 · Cited by 4,005 · see citing works
Conners, C. K., Sitarenios, G., Parker, J. D. A., & Epstein, J. N. (1998) · Journal of Abnormal Child Psychology · doi:10.1023/a:1022602400621 · Cited by 1,772 · see citing works
Biederman, J. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.5.816 · Cited by 1,498 · cited 5× · see citing works
“Furthermore, hyperactivityimpulsivity decreases relative to inattention throughout development in both clinical (Biederman et al. 2000; Todd et al. 2008) and population (Larsson et al.”
InfluentialAnalytic approaches to twin data using structural equation models
Rijsdijk, F. V. (2002) · Briefings in Bioinformatics · doi:10.1093/bib/3.2.119 · Cited by 761 · cited 3× · see citing works
“The extent to which MZ twins are not 100 % concordant for a trait reflects E (Rijsdijk and Sham 2002).”
InfluentialConners, C. K., Sitarenios, G., Parker, J. D. A., & Epstein, J. N. (1998) · Journal of Abnormal Child Psychology · doi:10.1023/a:1022606501530 · Cited by 678 · see citing works
Leth-Steensen, C., King Elbaz, Z., & Douglas, V. I. (2000) · Acta Psychologica · doi:10.1016/s0001-6918(00)00019-6 · Cited by 580 · cited 2× · see citing works
“The baseline condition, with a fore period of 8 s and consisting of 72 trials, followed a standard warned four-choice RT task (Leth-Steensen et al. 2000).”
Assessment of Children: WISC-IV and WPPSI-III Supplement
Sattler, J. M. (2004) · Cited by 466 · see citing works
Halperin, J. M., & Schulz, K. P. (2006) · Psychological Bulletin · doi:10.1037/0033-2909.132.4.560 · Cited by 446 · cited 3× · see citing works
“The two cognitive impairments in ADHD may also interplay throughout development, leading to different outcomes for ADHD as individuals pass from childhood into adulthood (Halperin and Schulz 2006; Halperin et al. 2008).”
BackgroundMethodSymptom profiles in children with ADHD: effects of comorbidity and gender.
Newcorn, J. H., Halperin, J., Jensen, P. S., Abikoff, H., Arnold, L. E., Cantwell, D., Conners, C., Elliott, G., Epstein, J. N., Greenhill, L. L., et al. (2001) · Journal of the American Academy of Child and Adolescent Psychiatry · doi:10.1097/00004583-200102000-00008 · Cited by 442 · cited 2× · see citing works
“For example, reading difficulties are linked predominantly to inattention (Paloyelis et al. 2010; Willcutt et al. 2007), and oppositional behaviours to hyperactivity-impulsivity (Newcorn et al. 2001; Wood et al. 2009).”
BackgroundTrouton, A., Spinath, F. M., & Plomin, R. (2002) · Twin Research · doi:10.1375/136905202320906255 · Cited by 410 · see citing works
The Cholesky approach: A cautionary note
Loehlin, J. C. (1996) · Behavior Genetics · doi:10.1007/bf02361160 · Cited by 351 · cited 1× · see citing works
“A triangular decomposition was run and converted to the mathematical equivalent correlated factor solution (Loehlin 1996), in which the order of traits is arbitrary.”
MethodOliver, B. R., & Plomin, R. (2007) · Twin Research and Human Genetics · doi:10.1375/twin.10.1.96 · Cited by 350 · cited 1× · see citing works
“The TEDS families are representative of the UK population with respect to parental occupation, education and ethnicity (Oliver and Plomin 2007).”
Johnson, K. A., Kelly, S. P., Bellgrove, M. A., Barry, E., Cox, M., Gill, M., & Robertson, I. H. (2007) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2006.03.034 · Cited by 262 · cited 1× · see citing works
“Drawing on the arousal-attention (Johnson et al. 2007; O’Connell et al. 2008) and developmental (Halperin and Schulz 2006; Halperin et al. 2008) models of ADHD, we proposed that the first factor (RT) may represent bottom-up arousal dysregulation and the second factor (errors) top-down control of…”
MethodHalperin, J. M., Trampush, J. W., Miller, C. J., Marks, D. J., & Newcorn, J. H. (2008) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2008.01926.x · Cited by 252 · cited 5× · see citing works
“2008) and developmental (Halperin and Schulz 2006; Halperin et al. 2008) models of ADHD, we proposed that the first factor (RT) may represent bottom-up arousal dysregulation and the second factor (errors) top-down control of sustained attention and inhibition (Kuntsi et al.”
BackgroundMethodInfluentialWillcutt, E. G., Pennington, B. F., Olson, R. K., & DeFries, J. C. (2007) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30310 · Cited by 205 · cited 2× · see citing works
“For example, reading difficulties are linked predominantly to inattention (Paloyelis et al. 2010; Willcutt et al. 2007), and oppositional behaviours to hyperactivity-impulsivity (Newcorn et al. 2001; Wood et al. 2009).”
BackgroundGenetic Contributions to the Development of ADHD Subtypes From Childhood to Adolescence
Larsson, H., Lichtenstein, P., & Larsson, J. (2006) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/01.chi.0000222787.57100.d8 · Cited by 200 · cited 3× · see citing works
“Furthermore, hyperactivityimpulsivity decreases relative to inattention throughout development in both clinical (Biederman et al. 2000; Todd et al. 2008) and population (Larsson et al. 2006) samples.”
Reaction time performance in ADHD: improvement under fast-incentive condition and familial effects
ANDREOU, P., NEALE, B. M., CHEN, W., CHRISTIANSEN, H., GABRIELS, I., HEISE, A., MEIDAD, S., MULLER, U. C., UEBEL, H., BANASCHEWSKI, T., et al. (2007) · Psychological Medicine · doi:10.1017/s0033291707000815 · Cited by 182 · cited 5× · see citing works
“sensitive improvement in RTV (for example under rewarded conditions (Andreou et al. 2007; Kuntsi et al. 2009; Uebel et al. 2010)), measure largely the same etiological process as RTVunder baseline condition (Kuntsi et al.”
InfluentialSelf-citationChen, W., Zhou, K., Sham, P., Franke, B., Kuntsi, J., Campbell, D., Fleischman, K., Knight, J., Andreou, P., Arnold, R., et al. (2008) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30672 · Cited by 173 · cited 1× · see citing works
“The similarity between the findings presented here and the previous study using clinical cases of ADHD provides further evidence that ADHD reflects the extreme and impairing tail of quantitative traits for inattention and hyperactivity-impulsivity (Chen et al. 2008).”
ResultSelf-citationTodd, R. D., Rasmussen, E. R., Neuman, R. J., Reich, W., Hudziak, J. J., Bucholz, K. K., Madden, P. A. F., & Heath, A. C. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.11.1891 · Cited by 164 · cited 1× · see citing works
“Empirical approaches to ADHD subtypes indicate that many inattentive subtype cases reflect sub-threshold combined type ADHD and should not be treated as a separate category (Todd et al. 2001).”
BackgroundKuntsi, J., Wood, A. C., Johnson, K. A., Andreou, P., Arias-Vasquez, A., Buitelaar, J. K., Rommelse, N. N. J., Sergeant, J. A., Sonuga-Barke, E. J., Uebel, H., et al. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.139 · Cited by 162 · cited 20× · see citing works
“Secondly, we examine whether the etiological separation between impaired RT performance and CE (Kuntsi et al. 2010) is confirmed in a population twin sample.”
InfluentialSelf-citationUebel, H., Albrecht, B., Asherson, P., Börger, N. A., Butler, L., Chen, W., Christiansen, H., Heise, A., Kuntsi, J., Schäfer, U., et al. (2010) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2009.02139.x · Cited by 161 · cited 4× · see citing works
“2010a) were similar to those observed in a large clinical sample of ADHD combined subtype cases (Andreou et al. 2007; Kuntsi et al. 2010; Uebel et al. 2010; Wood et al. 2010b).”
InfluentialSelf-citationMultivariate Genetic Analysis of Sex Limitation and G × E Interaction
Neale, M. C., Røysamb, E., & Jacobson, K. C. (2006) · Twin Research and Human Genetics · doi:10.1375/183242706778024937 · Cited by 142 · cited 3× · see citing works
“Data for the 24 singleton twins were also used in the structural equation modeling (Neale et al. 2006a).”
BackgroundMethodToplak, M. E., Pitch, A., Flora, D. B., Iwenofu, L., Ghelani, K., Jain, U., & Tannock, R. (2009) · Research on Child and Adolescent Psychopathology · doi:10.1007/s10802-009-9336-y · Cited by 133 · cited 2× · see citing works
“…found that a general combined factor with separable inattention and hyperactivity-impulsivity dimensions best explained the symptom data (Toplak et al. 2009); a pattern of findings that is reflected in the shared and unique genetic effects that influence inattention and…”
McLoughlin, G., Ronald, A., Kuntsi, J., Asherson, P. J., & Plomin, R. J. (2007) · Research on Child and Adolescent Psychopathology · doi:10.1007/s10802-007-9149-9 · Cited by 130 · cited 2× · see citing works
“…analyses on ADHD symptom scores indicate that 55–80 % of the genetic influences on inattention also influence hyperactive-impulsivity, with the remaining genetic influences reflecting those that are unique to each symptom domain (Greven et al. 2011; McLoughlin et al. 2007, 2011;Wood et al. 2009).”
Self-citationKUNTSI, J., ROGERS, H., SWINARD, G., BÖRGER, N., MEERE, J. V. D., RIJSDIJK, F., & ASHERSON, P. (2006) · Psychological Medicine · doi:10.1017/s0033291706008580 · Cited by 126 · cited 3× · see citing works
“To limit the total number of variables, to create psychometrically robust variables (Kuntsi et al. 2006) and to enable a comparison to our previous findings using the same tasks in a clinically diagnosed sample (Kuntsi et al. 2010), summed scores were obtained across two tasks or conditions as…”
Self-citationSelf-Alert Training: Volitional modulation of autonomic arousal improves sustained attention
O’Connell, R. G., Bellgrove, M. A., Dockree, P. M., Lau, A., Fitzgerald, M., & Robertson, I. H. (2008) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2007.12.018 · Cited by 124 · see citing works
Increase in Power through Multivariate Analyses
Schmitz, S., Cherny, S. S., & Fulker, D. W. (1998) · Behavior Genetics · doi:10.1023/a:1021669602220 · Cited by 120 · cited 1× · see citing works
“As multivariate models have increased power over univariate models (Schmitz et al. 1998), we do not present parameter estimates from univariate models.”
MethodKuntsi, J., Andreou, P., Ma, J., Börger, N. A., & van der Meere, J. J. (2005) · BMC Psychiatry · doi:10.1186/1471-244x-5-40 · Cited by 105 · cited 2× · see citing works
“The go/no-go task (Borger and van der Meere 2000; Kuntsi et al. 2005; van der Meere et al. 1995) On each trial, one of two possible stimuli appeared for 300 ms in the middle of the computer screen.”
Self-citationTODD, R. D., HUANG, H., TODOROV, A. A., NEUMAN, R. J., REIERSEN, A. M., HENDERSON, C. A., & REICH, W. C. (2008) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/chi.0b013e31815a6aca · Cited by 96 · cited 4× · see citing works
“Furthermore, hyperactivityimpulsivity decreases relative to inattention throughout development in both clinical (Biederman et al. 2000; Todd et al. 2008) and population (Larsson et al. 2006) samples.”
InfluentialGreven, C. U., Rijsdijk, F. V., & Plomin, R. J. (2010) · Research on Child and Adolescent Psychopathology · doi:10.1007/s10802-010-9451-9 · Cited by 94 · cited 4× · see citing works
“This degree of separation is notable, given the strong genetic correlation between inattention and hyperactivity symptoms, as reported previously (Greven et al. 2011; McLoughlin et al. 2007, 2011; Paloyelis et al. 2010; Wood et al. 2009) and further confirmed here (ra=0.”
InfluentialWood, A. C., Asherson, P., van der Meere, J., & Kuntsi, J. (2009) · Psychological Medicine · doi:10.1017/s003329170999119x · Cited by 88 · cited 4× · see citing works
“Our findings also confirm the previous observation (Wood et al. 2010a) that MRT indexes largely the same genetic liability as RTV, observed in the high additive genetic correlation of 0.87.”
InfluentialSelf-citationPaloyelis, Y., Rijsdijk, F. V., Wood, A. C., Asherson, P. J., & Kuntsi, J. (2010) · Research on Child and Adolescent Psychopathology · doi:10.1007/s10802-010-9429-7 · Cited by 88 · cited 2× · see citing works
“For example, reading difficulties are linked predominantly to inattention (Paloyelis et al. 2010; Willcutt et al. 2007), and oppositional behaviours to hyperactivity-impulsivity (Newcorn et al. 2001; Wood et al. 2009).”
Self-citationKUNTSI, J., WOOD, A. C., VAN DER MEERE, J., & ASHERSON, P. (2009) · Journal of the International Neuropsychological Society · doi:10.1017/s135561770909081x · Cited by 80 · cited 5× · see citing works
“…we previously found that associations between ADHD symptoms and the cognitive impairments of slow and variable RTs and commission errors (CE) (Kuntsi et al. 2009; Wood et al. 2010a) were similar to those observed in a large clinical sample of ADHD combined subtype cases (Andreou et al. 2007;…”
InfluentialSelf-citationWood, A. C., Rijsdijk, F. V., Johnson, K. A., Andreou, P., Albrecht, B., Vásquez, A. A., Buitelaar, J. K., McLoughlin, G., Rommelse, N. N. J., Sergeant, J. A., et al. (2010) · Psychological Medicine · doi:10.1017/s003329171000108x · Cited by 72 · cited 4× · see citing works
“Our findings also confirm the previous observation (Wood et al. 2010a) that MRT indexes largely the same genetic liability as RTV, observed in the high additive genetic correlation of 0.87.”
InfluentialSelf-citationvan der Meere, J., Stemerdink, N., & Gunning, B. (1995) · Perceptual and Motor Skills · doi:10.2466/pms.1995.81.1.259 · Cited by 71 · cited 1× · see citing works
“The go/no-go task (Borger and van der Meere 2000; Kuntsi et al. 2005; van der Meere et al. 1995) On each trial, one of two possible stimuli appeared for 300 ms in the middle of the computer screen.”
Adams, Z. W., Derefinko, K. J., Milich, R. S., & Fillmore, M. T. (2008) · Developmental Disabilities Research Reviews · doi:10.1002/ddrr.37 · Cited by 69 · cited 1× · see citing works
“A more strictly defined pure inattentive subtype was, however, linked to early attentional problems and inconsistent performance, whereas inhibition difficulties were observed across ADHD subgroups (Adams et al. 2008; Carr et al. 2010).”
BackgroundCognitive Control and Attentional Selection in Adolescents with ADHD Versus ADD
Carr, L., Henderson, J., & Nigg, J. T. (2010) · Journal of Clinical Child & Adolescent Psychology · doi:10.1080/15374416.2010.517168 · Cited by 61 · cited 2× · see citing works
“A more strictly defined pure inattentive subtype was, however, linked to early attentional problems and inconsistent performance, whereas inhibition difficulties were observed across ADHD subgroups (Adams et al. 2008; Carr et al. 2010).”
BackgroundVisual Behaviour of ADHD Children During an Attention Test: An Almost Forgotten Variable
Börger, N. A., & van der Meere, J. (2000) · Journal of Child Psychology and Psychiatry · doi:10.1111/1469-7610.00637 · Cited by 44 · see citing works
Journal of Child Psychology and Psychiatry
Flouri, E., Tzavidis, N., & Kallis, C. (2010) · Journal of Child Psychology and Psychiatry · doi:10.1111/(issn)1469-7610 · Cited by 41 · see citing works
Wood, A. C., Rijsdijk, F. V., Asherson, P. J., & Kuntsi, J. (2009) · Behavior Genetics · doi:10.1007/s10519-009-9290-z · Cited by 36 · cited 5× · see citing works
“Previous twin analyses on ADHD symptom scores indicate that 55–80 % of the genetic influences on inattention also influence hyperactive-impulsivity, with the remaining genetic influences reflecting those that are unique to each symptom domain (Greven et al. 2011; McLoughlin et al. 2007, 2011;Wood et al. 2009).”
InfluentialSelf-citationGenetic analysis of reaction time variability: room for improvement?
Kuntsi, J., Wood, A. C., Banaschewski, T., Gill, M., Miranda, A., Oades, R. D., Roeyers, H., Rothenberger, A., Steinhausen, H., van der Meere, J. J., et al. (2012) · Psychological Medicine · doi:10.1017/s0033291712002061 · Cited by 28 · cited 2× · see citing works
“…improvement in RTV (for example under rewarded conditions (Andreou et al. 2007; Kuntsi et al. 2009; Uebel et al. 2010)), measure largely the same etiological process as RTVunder baseline condition (Kuntsi et al. 2013), supporting theories emphasizing the malleability of the observed high RTV.”
Self-citationMcLoughlin, G., Rijsdijk, F. V., Asherson, P. J., & Kuntsi, J. (2011) · Behavior Genetics · doi:10.1007/s10519-011-9473-2 · Cited by 25 · cited 2× · see citing works
“…analyses on ADHD symptom scores indicate that 55–80 % of the genetic influences on inattention also influence hyperactive-impulsivity, with the remaining genetic influences reflecting those that are unique to each symptom domain (Greven et al. 2011; McLoughlin et al. 2007, 2011;Wood et al. 2009).”
Self-citationVisual Behaviour of ADHD Children During an Attention Test: An Almost Forgotten Variable
Börger, N. A., & van der Meere, J. (2000) · Journal of Child Psychology and Psychiatry · doi:10.1017/s0021963000005655 · Cited by 20 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- American Psychiatric Association (APA) Diagnostic and statistical manual of mental disorders, 4 edition, text revision 2000 APA Washington 4th ed.
Cited by
Sorted by citations
ADHD Working Group of the Psychiatric Genomics Consortium (PGC), Demontis, D., Early Lifecourse & Genetic Epidemiology (EAGLE) Consortium, 23andMe Research Team, Walters, R. K., Martin, J., Mattheisen, M., Als, T. D., Agerbo, E., Baldursson, G., et al. (2019) · Nature Genetics · doi:10.1038/s41588-018-0269-7 · Cited by 2,203 · see citing works
Self-citationAttention-deficit/hyperactivity disorder
Faraone, S. V., Asherson, P., Banaschewski, T., Biederman, J., Buitelaar, J. K., Ramos-Quiroga, J. A., Rohde, L. A., Sonuga-Barke, E. J. S., Tannock, R., & Franke, B. (2015) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2015.20 · Cited by 1,479 · see citing works
Self-citationAdult attention-deficit hyperactivity disorder: key conceptual issues
Asherson, P., Buitelaar, J., Faraone, S. V., & Rohde, L. A. (2016) · The Lancet Psychiatry · doi:10.1016/s2215-0366(16)30032-3 · Cited by 347 · see citing works
Self-citationLinking RDoC and HiTOP: A new interface for advancing psychiatric nosology and neuroscience
Michelini, G., Palumbo, I. M., DeYoung, C. G., Latzman, R. D., & Kotov, R. (2021) · Clinical Psychology Review · doi:10.1016/j.cpr.2021.102025 · Cited by 285 · see citing works
Mind wandering perspective on attention-deficit/hyperactivity disorder
Bozhilova, N. S., Michelini, G., Kuntsi, J., & Asherson, P. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.07.010 · Cited by 182 · see citing works
“processes are both associated with ADHD in children, but are genetically largely uncorrelated, reflecting distinct aetiological pathways (Kuntsi et al., 2014; Kuntsi et al., 2010).”
Self-citationCarlsson, T., Molander, F., Taylor, M., Jonsson, U., & Bölte, S. (2020) · Development and Psychopathology · doi:10.1017/s0954579420000620 · Cited by 155 · see citing works
“…in ASD are genetically dissociable (Happé & Ronald, 2008), and that hyperactivity/impulsiveness and inattentiveness in ADHD have distinguishable underlying pathways (Castellanos, Sonuga-Barke, Milham, & Tannock, 2006; Kuntsi et al., 2014; Luo, Weibman, Halperin, & Li, 2019; Sonuga-Barke, 2005).”
BackgroundCognitive and neurophysiological markers of ADHD persistence and remission
Cheung, C. H. M., Rijsdijk, F., McLoughlin, G., Brandeis, D., Banaschewski, T., Asherson, P., & Kuntsi, J. (2016) · British Journal of Psychiatry · doi:10.1192/bjp.bp.114.145185 · Cited by 146 · see citing works
“…ADHD, who during childhood assessments demonstrated impairment in cognitive measures of RTV, Go/No-Go (GNG) task commission error (CE) and omission error (OE), 6,8,16,17 IQ 10 and digit spans, 18 and had a higher mean and variability of objectively measured actigraph movement intensity and count.”
InfluentialSelf-citationExecutive Functioning and Emotion Regulation in Children with and without ADHD
Groves, N. B., Wells, E. L., Soto, E. F., Marsh, C. L., Jaisle, E. M., Harvey, T. K., & Kofler, M. J. (2022) · Research on Child and Adolescent Psychopathology · doi:10.1007/s10802-021-00883-0 · Cited by 110 · see citing works
“We examined inattention and hyperactivity/impulsivity separately based on evidence that these symptom clusters differentially impact other ADHDrelated impairments (Kuntsi et al., 2014), but we did not have specific hypotheses for these symptom clusters due to mixed findings in extant literature.”
BackgroundAsk, H., Gustavson, K., Ystrøm, E., Havdahl, A., Tesli, M., Askeland, R. B., & Reichborn‐Kjennerud, T. (2018) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/jamapediatrics.2018.1315 · Cited by 99 · see citing works
Computer-based Cognitive Training for ADHD
Sonuga-Barke, E., Brandeis, D., Holtmann, M., & Cortese, S. (2014) · Child and Adolescent Psychiatric Clinics of North America · doi:10.1016/j.chc.2014.05.009 · Cited by 92 · see citing works
Grissom, N. M., Herdt, C. T., Desilets, J., Lidsky-Everson, J., & Reyes, T. M. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.313 · Cited by 91 · see citing works
Alemany, S., Ribasés, M., Vilor-Tejedor, N., Bustamante, M., Sánchez-Mora, C., Bosch, R., Richarte, V., Cormand, B., Casas, M., Ramos-Quiroga, J., et al. (2015) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32341 · Cited by 89 · see citing works
“…indicating that reaction time variability was genetically correlated with both inattention and hyperactivity ADHD symptoms in a twin sample from the general population whereas commission errors presented lower and non-significant genetic correlations with these symptoms [Kuntsi et al., 2014].”
BackgroundResultGene-Environment Interactions in ADHD: The Roles of SES and Chaos
Gould, K. L., Coventry, W. L., Olson, R. K., & Byrne, B. (2017) · Research on Child and Adolescent Psychopathology · doi:10.1007/s10802-017-0268-7 · Cited by 88 · see citing works
“Such findings align with earlier research supporting distinct etiological pathways for inattention and hyperactivity-impulsivity, and emphasise the importance of considering them separately in GxE analyses (Kuntsi et al. 2014; Nikolas and Burt 2010).”
ResultBuon, M., Seara‐Cardoso, A., & Viding, E. M. (2016) · Psychonomic Bulletin & Review · doi:10.3758/s13423-016-1042-5 · Cited by 79 · see citing works
“Children with ADHD present symptoms of inattention, hyperactivity, and/or impulsivity (Kuntsi et al., 2014).”
BackgroundGarrido, L. E., Barrada, J. R., Aguasvivas, J., Martínez‐Molina, A., Arias, V. B., Golino, H. F., Legaz, E., Ferrís, G., & Rojo‐Moreno, L. (2018) · Assessment · doi:10.1177/1073191118780461 · Cited by 67 · see citing works
“The contemporary literature regards hyperactivity and attention deficit as two related but separate constructs (Kuntsi et al., 2014; Willcutt et al., 2012).”
BackgroundMaternal fever during pregnancy and offspring attention deficit hyperactivity disorder
Gustavson, K., Ask, H., Ystrøm, E., Stoltenberg, C., Lipkin, W. I., Surén, P., Håberg, S. E., Magnus, P. M., Knudsen, G. P., Eilertsen, E. M., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-45920-7 · Cited by 61 · see citing works
Skirrow, C., McLoughlin, G., Banaschewski, T., Brandeis, D., Kuntsi, J., & Asherson, P. J. (2014) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2014.09.015 · Cited by 50 · see citing works
Self-citationTye, C., Johnson, K. A., Kelly, S. P., Asherson, P. J., Kuntsi, J., Ashwood, K. L., Azadi, B., Bolton, P., & McLoughlin, G. (2016) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.12608 · Cited by 49 · see citing works
“(Kuntsi et al., 2014), although significant associations between CV and hyperactive/impulsive symptoms were also demonstrated.”
BackgroundSelf-citationGmehlin, D., Fuermaier, A. B. M., Walther, S., Tucha, L., Koerts, J., Lange, K. W., Tucha, O. M., Weisbrod, M., & Aschenbrenner, S. (2016) · Archives of Clinical Neuropsychology · doi:10.1093/arclin/acw016 · Cited by 46 · see citing works
“…multicenter-multivariate familial analysis on a large sample of children with ADHD and control siblings: Kuntsi and colleagues suggested two key cognitive impairments phenotypically associated with ADHD symptoms, which can be captured by IIV of RT and commission errors (Kuntsi et al., 2010, 2014).”
BackgroundMoore, D. A., Russell, A. E., Matthews, J., Ford, T. J., Rogers, M., Ukoumunne, O. C., Kneale, D., Coon, J. T., Sutcliffe, K., Nunns, M., et al. (2018) · Review of Education · doi:10.1002/rev3.3149 · Cited by 54 · see citing works
Association Between Auditory and Visual Continuous Performance Tests in Students With ADHD
Schmidt, S. L., Simões, E. N., & Carvalho, A. L. N. (2016) · Journal of Attention Disorders · doi:10.1177/1087054716679263 · Cited by 45 · see citing works
Pinto, R., Rijsdijk, F. V., Ronald, A., Asherson, P. J., & Kuntsi, J. (2015) · Research on Child and Adolescent Psychopathology · doi:10.1007/s10802-015-0037-4 · Cited by 42 · see citing works
“Selection of Cognitive Variables for Analyses To limit the total number of variables and to enable a comparison to our previous analyses (Kuntsi et al. 2010, 2014) summed scores were obtained across two tasks or conditions as follows: unstandardized RTV across fast task baseline condition and go/…”
BackgroundMethodResultInfluentialSelf-citationSudre, G. P., Frederick, J., Sharp, W. S., Ishii‐Takahashi, A., Mangalmurti, A., Choudhury, S., & Shaw, P. (2019) · Molecular Psychiatry · doi:10.1038/s41380-019-0350-3 · Cited by 42 · see citing works
Cognitive mechanisms underlying depressive disorders in ADHD: A systematic review
Mayer, J. S., Bernhard, A., Fann, N., Boxhoorn, S., Hartman, C. A., Reif, A., & Freitag, C. M. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.12.018 · Cited by 39 · see citing works
Nigg, J. T. (2016) · Wiley eBooks · doi:10.1002/9781119125556.devpsy314 · Cited by 40 · see citing works
Insights into attention-deficit/hyperactivity disorder from recent genetic studies
Brikell, I., Burton, C. L., Mota, N. R., & Martin, J. (2021) · Psychological Medicine · doi:10.1017/s0033291721000982 · Cited by 36 · see citing works
Shared Cognitive Impairments and Aetiology in ADHD Symptoms and Reading Difficulties
Cheung, C. H. M., Fazier-Wood, A. C., Asherson, P. J., Rijsdijk, F. V., & Kuntsi, J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0098590 · Cited by 34 · see citing works
“To obtain a composite score for ADHD symptoms, ADHD inattention and hyperactivity-impulsivity symptoms were obtained using the summed parent and teacher ratings on the 9-item inattentive DISM-IV subscales and the 9-item hyperactivity-impulsivity DSM-IV subscales, respectively, consistent with our previous studies that…”
MethodSelf-citationMichelini, G., Kitsune, V., Vainieri, I., Hosang, G., Brandeis, D., Asherson, P., & Kuntsi, J. (2018) · Brain Topography · doi:10.1007/s10548-018-0625-z · Cited by 26 · see citing works
“These overlapping symptoms may reflect, at the cognitive level, the common fluctuations in attentional performance and increased RTV displayed by individuals with ADHD and BD (Albaugh et al. 2017; Kuntsi et al. 2014).”
BackgroundSelf-citationLin, Y., & Gau, S. S. (2018) · Psychological Medicine · doi:10.1017/s0033291718001599 · Cited by 33 · see citing works
“The longitudinal familial genetic studies would be more informative to identify endophenotypes in the pathway from genes to ADHD phenotypes (Gau and Shang, 2010; Kuntsi et al., 2014).”
BackgroundCustodio, R. J. P., Botanas, C. J., de la Peña, J. B., Peña, I. J. D., Kim, M., Sayson, L. V., Abiero, A., Ryoo, Z. Y., Kim, B.-N., Kim, H. J., et al. (2018) · Neuroscience · doi:10.1016/j.neuroscience.2018.08.008 · Cited by 29 · see citing works
Adamo, N., Hodsoll, J., Asherson, P., Buitelaar, J. K., & Kuntsi, J. (2019) · Journal of Abnormal Child Psychology · doi:10.1007/s10802-018-0457-z · Cited by 28 · see citing works
“With our current and previous (Kuntsi et al. 2013b) results pointing to stronger associations of the RTV improvements with inattentive than hyperactive- impulsive traits, our findings further motivate future exploration of the neural correlates of RTV fluctuations in both ADHD subdomains.”
MethodResultSelf-citationKonok, V., Binet, M.-A., Korom, Á., Pogány, Á., Miklósi, Á., & Fitzpatrick, C. (2024) · Frontiers in Child and Adolescent Psychiatry · doi:10.3389/frcha.2024.1276154 · Cited by 27 · see citing works
A novel approach to intra-individual performance variability in ADHD
Bluschke, A., Zink, N., Mückschel, M., Roessner, V., & Beste, C. (2020) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-020-01555-y · Cited by 26 · see citing works
James, S.-N., Cheung, C. H. M., Rijsdijk, F., Asherson, P., & Kuntsi, J. (2016) · Biological Psychiatry: Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2016.06.003 · Cited by 44 · see citing works
“In twin analyses the genetic association of RTV was observed particularly strongly with inattention symptoms (28).”
BackgroundSelf-citationZucchelli, M. M., & Ugazio, G. (2019) · Frontiers in Psychology · doi:10.3389/fpsyg.2019.01427 · Cited by 24 · see citing works
Context Regulation of Mind Wandering in ADHD
Bozhilova, N. S., Michelini, G., Jones, C., Kuntsi, J., Rubia, K., & Asherson, P. J. (2020) · Journal of Attention Disorders · doi:10.1177/1087054720956714 · Cited by 25 · see citing works
Self-citationWood, A. C., Carnell, S., Peña, O. D. R., Hughes, S. O., O’Connor, T. M., Asherson, P. J., & Kuntsi, J. (2014) · Obesity · doi:10.1002/oby.20862 · Cited by 24 · see citing works
Self-citationSharp, W. S., Mangalmurti, A., Hall, C., Choudhury, S., & Shaw, P. (2019) · Social Science & Medicine · doi:10.1016/j.socscimed.2019.02.054 · Cited by 25 · see citing works
“Thirdly, inattention and hyperactivity-impulsivity are considered separately in view of their partly distinct genetic etiologies, cognitive substrates, comorbidities and dissociable developmental trajectories (Kuntsi et al., 2014; Larsson et al., 2011; Weiler et al., 2000; Willcutt et al., 2007; Wood et al., 2009).”
BackgroundThissen, A. J. A. M., Bralten, J., Rommelse, N., Arias-Vásquez, A., Greven, C., Heslenfeld, D., Luman, M., Oosterlaan, J., Hoekstra, P., Hartman, C., et al. (2015) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32290 · Cited by 29 · see citing works
“, 2012]) and their unaffected siblings [Kuntsi et al., 2013; Rommelse et al., 2008a; Rommelse, 2008; Rommelse et al., 2008c], and based on previously reported associations with our genes of interest ([DRD4]: Altink et al.”
BackgroundVolitional eye movement control and ADHD traits: a twin study
Sanchez, M. S., Falck‐Ytter, T., Kennedy, D. P., Bölte, S., Lichtenstein, P., D'Onofrio, B. M., & Pettersson, E. (2020) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.13210 · Cited by 23 · see citing works
“statistical power to detect unique genetic contributions after controlling for all covariates (Kuntsi et al., 2014).”
BackgroundThissen, A. J. A. M., Luman, M., Hartman, C., Hoekstra, P., van Lieshout, M., Franke, B., Oosterlaan, J., Rommelse, N. N. J., & Buitelaar, J. K. (2014) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2014.05.015 · Cited by 22 · see citing works
Pinto, R., Asherson, P., Ilott, N., Cheung, C. H. M., & Kuntsi, J. (2016) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32463 · Cited by 19 · see citing works
“Another overlapping set of associations was observed for rs7984966 in HTR2A with RTV, RD and inattention, implicating it as a potential candidate marker, in line with our previous quantitative genetic finding that the association of RTV and RD with ADHD largely reflects genetic influences shared with inattention that…”
BackgroundMethodResultInfluentialSelf-citationSabhlok, A., Malanchini, M., Engelhardt, L. E., Madole, J. W., Tucker–Drob, E. M., & Harden, K. P. (2021) · Developmental Science · doi:10.1111/desc.13168 · Cited by 18 · see citing works
Lee, D., Knight, E. Q., Song, H., Lee, S., Pae, C., Yoo, S., & Park, H. (2021) · PLoS ONE · doi:10.1371/journal.pone.0260295 · Cited by 19 · see citing works
Qin, L., Liu, H., Zhang, H., Fu, Y., & Li, D. (2018) · BMC Psychiatry · doi:10.1186/s12888-018-1970-x · Cited by 17 · see citing works
“ADHD is a multifactorial disorder, and genetic factors might be associated with the risk of ADHD [17, 18].”
BackgroundKrieger, V., & Amador-Campos, J. A. (2021) · Child Neuropsychology · doi:10.1080/09297049.2021.1917530 · Cited by 16 · see citing works
Manor, I., Rubin, J., Daniely, Y., & Adler, L. (2014) · Postgraduate medicine · doi:10.3810/pgm.2014.09.2795 · Cited by 16 · see citing works
Liu, C., Li, Y., Viding, E., Asherson, P., & Pingault, J.-B. (2018) · European Child and Adolescent Psychiatry · doi:10.1007/s00787-018-1200-6 · Cited by 17 · see citing works
Self-citationMiranda, P., Cox, C. D., Alexander, M., Danev, S., & Lakey, J. R. T. (2020) · Medical Devices Evidence and Research · doi:10.2147/mder.s241205 · Cited by 17 · see citing works
Wu, Z.-M., Wang, P., Liu, J., Liu, L., Cao, X., Sun, L., Yang, L., Cao, Q., Wang, Y., & Yang, B. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1099882 · Cited by 14 · see citing works
Alger, J. R., O’Neill, J., O’Connor, M. J., Kalender, G., Ly, R., Ng, A., Dillon, A., Narr, K. L., Loo, S. K., & Levitt, J. G. (2021) · Neurotoxicity Research · doi:10.1007/s12640-021-00342-0 · Cited by 15 · see citing works
Luo, Y., Adamek, J. H., Crocetti, D., Mostofsky, S. H., & Ewen, J. B. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.893239 · Cited by 13 · see citing works
ADHD subtypes: Do they hold beyond core symptoms? A multilevel testing of an additive model
Rostami, M., Khosrowabadi, R., Albrecht, B., Pouretemad, H., & Rothenberger, A. (2020) · Applied Neuropsychology Child · doi:10.1080/21622965.2020.1806067 · Cited by 12 · see citing works
Xu, Y., Lin, S., Tao, J., Liu, X., Zhou, R., Chen, S., Vyas, P. K., Yang, C., Chen, B., Qian, A., et al. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.1003542 · Cited by 11 · see citing works
Effect of methylphenidate on the onset of puberty and reproductive organ development in rats
Khoubbieh, F., Erdogan, C. S., Önel, T., Yıldırım, E., Sümer, E., Yaba, A., & Yılmaz, B. (2023) · Physiology & Behavior · doi:10.1016/j.physbeh.2023.114204 · Cited by 11 · see citing works
Remote Administration of ADHD-Sensitive Cognitive Tasks: A Pilot Study
Sun, S.-X., Denyer, H., Sankesara, H., Deng, Q., Ranjan, Y., Conde, P., Rashid, Z., Bendayan, R., Asherson, P., Bilbow, A., et al. (2023) · Journal of Attention Disorders · doi:10.1177/10870547231172763 · Cited by 8 · see citing works
“Our previous research indicates very high phenotypic and genetic/familial correlations (.8–.9) between RTV and MRT, suggesting they capture largely the same process on both the Fast task and the GNG task (Kuntsi et al., 2010, 2014).”
Self-citationVainieri, I., Martin, J., Rommel, A., Asherson, P. J., Banaschewski, T., Buitelaar, J. K., Cormand, B., Crosbie, J., Faraone, S. V., Franke, B., et al. (2021) · Psychological Medicine · doi:10.1017/s0033291720005218 · Cited by 11 · see citing works
“The findings from the sibling and twin studies (Kuntsi et al., 2010, 2014) suggested a potential separation, at the genetic level, between attention regulation and response inhibition processes in their association with ADHD.”
BackgroundResultInfluentialSelf-citationArnett, A. B., McGrath, L., Flaherty, B. P., Pennington, B., & Willcutt, E. (2022) · Journal of Attention Disorders · doi:10.1177/10870547221075842 · Cited by 11 · see citing works
“A prior study by Kuntsi and colleagues (Kuntsi et al., 2014) measured shared and independent genetic influences on ADHD symptom domains, reaction time, VRT, and commission errors among school-age twins.”
BackgroundGing-Jehli, N. R., Cavanagh, J. F., Ahn, M., Segar, D. J., Asaad, W. F., & Frank, M. J. (2025) · PLoS Biology · doi:10.1371/journal.pbio.3002978 · Cited by 12 · see citing works
The aetiological association between the dynamics of cortisol productivity and ADHD
Pinto, R., Rijsdijk, F. V., Ouellet‐Morin, I., Asherson, P. J., McLoughlin, G., & Kuntsi, J. (2016) · Journal of Neural Transmission · doi:10.1007/s00702-016-1534-5 · Cited by 10 · see citing works
“Moreover, a series of analyses have highlighted the comparability of our quantitative genetic findings across both diagnostic and dimensional approaches to the ADHD phenotype (Cheung et al. 2012, 2014; Kuntsi et al. 2010, 2014; Paloyelis et al. 2010; Wood et al. 2010a, 2011).”
BackgroundSelf-citationVoronin, I., Ouellet-Morin, I., Petitclerc, A., Morneau-Vaillancourt, G., Brendgen, M., Dione, G., Vitaro, F., & Boivin, M. (2024) · JCPP Advances · doi:10.1002/jcv2.12222 · Cited by 6 · see citing works
“…substantial genetic specificity that links inattention to cognitive deficit, learning disability and educational outcomes (DuPaul & Volpe, 2009; Greven, Harlaar, et al., 2011; Kuntsi et al., 2014), and hyperactivity to oppositional and substance use problems (Quinn et al., 2016; Wood et al., 2009).”
BackgroundAttention Deficit Hyperactivity Disorder: Insight from Quantitative Genetic Research
Wood, A. C., Rommel, A., & Kuntsi, J. (2014) · Springer eBooks · doi:10.1007/978-1-4614-9509-3_1 · Cited by 8 · see citing works
Self-citationSanchez, M. S., Bussu, G., Portugal, A. M., Ronald, A., & Falck‐Ytter, T. (2024) · Child Development · doi:10.1111/cdev.14185 · Cited by 7 · see citing works
Current Perspectives on Attention-deficit Hyperactivity Disorder
Shafiullah, S., & Dhaneshwar, S. S. (2023) · Current Molecular Medicine · doi:10.2174/1566524023666230522145950 · Cited by 8 · see citing works
Catelan, R. F., Zsila, Á., Pietkiewicz, I. J., & Nardi, A. E. (2023) · Psychiatria i Psychologia Kliniczna · doi:10.15557/pipk.2023.0018 · Cited by 7 · see citing works
The Age of Onset of Attention-Deficit Hyperactivity Disorder
Coghill, D., Asherson, P. J., Faraone, S. V., & Rohde, L. A. (2018) · Springer eBooks · doi:10.1007/978-3-319-72619-9_12 · Cited by 7 · see citing works
Self-citationDevelopment of graphomotor fluency in adults with ADHD: Evidence of attenuated procedural learning.
Duda, T. A., Casey, J., & McNevin, N. (2015) · Human Movement Science · doi:10.1016/j.humov.2015.08.006 · Cited by 7 · see citing works
“…in nature, with research implicating interactions between genetic and environmental factors and their neurological corollaries as primary causal agents (Cortese, 2012; Koziol, Budding, & Chidekel, 2013; Kuntsi et al., 2014; McLoughlin, Palmer, Rijsdijk, & Makeig, 2014; Merwood et al., 2014).”
BackgroundKoltermann, G., Becker, N., Paiva, G. M., Gomides, M. R. D. A., Haase, V. G., & de Salles, J. F. (2020) · Developmental Neuropsychology · doi:10.1080/87565641.2020.1828424 · Cited by 5 · see citing works
Tansey, R., Graff, K., Rohr, C. S., Dimond, D., Ip, A., Dewey, D., & Bray, S. (2022) · Cerebral Cortex Communications · doi:10.1093/texcom/tgac011 · Cited by 6 · see citing works
“Studies suggest that in the general population, inattention and hyperactivity have differential associations with cognitive measures (Kuntsi et al. 2014), symptom trajectories (Larsson et al.”
BackgroundSchermer, J. A., & Vernon, P. A. (2015) · Journal of Intelligence · doi:10.3390/jintelligence3040160 · Cited by 5 · see citing works
“Typically studies examining the relationship between reaction time and intelligence are conducted with adult participants (see [1]), although some have examined adolescents [2,3] and others have looked at young twins with clinical issues such as attention deficit hyperactivity disorder [4].”
Anning, K. L., Langley, K., Hobson, C. W., de Sonneville, L. M. J., & van Goozen, S. H. M. (2023) · Child Neuropsychology · doi:10.1080/09297049.2023.2190964 · Cited by 5 · see citing works
“Anxiety may inhibit impulsive responding by increasing behavioral control and monitoring, resulting in fewer commission errors (Kuntsi et al., 2014; Newcorn et al., 2001; White et al., 2011; Yurtbaşı et al., 2018).”
BackgroundMethodTamm, L., Dudley, J. A., Karalunas, S. L., Simon, J. O., Maloney, T. C., Atluri, G., & Epstein, J. N. (2025) · NeuroImage: Reports · doi:10.1016/j.ynirp.2025.100263 · Cited by 4 · see citing works
“Additionally, RTV is highly heritable (Kuntsi et al., 2014).”
Chen, X., Wang, S., Yang, X., Yu, C., Ni, F., Yang, J., Tian, Y., Ye, J., Liu, H., Chen, X., et al. (2026) · Psychology Research and Behavior Management · doi:10.2147/prbm.s550150 · Cited by 4 · see citing works
Bidirectional associations between video game playing and ADHD symptoms among school-aged children
Tiraboschi, G. A., Fitzpatrick, C., Kim, H. S. A., Superbia-Guimarães, L., Kosak, L.-A., & Garon‐Carrier, G. (2025) · Computers in Human Behavior Reports · doi:10.1016/j.chbr.2025.100740 · Cited by 4 · see citing works
Behavior, neuropsychology and fMRI
Bennett, M. R., Hatton, S. N., Hermens, D. F., & Lagopoulos, J. (2016) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2016.07.001 · Cited by 4 · see citing works
Dolan, C. V., de Zeeuw, E. D., Zayats, T., van Beijsterveldt, C. E. M., & Boomsma, D. (2020) · Behavior Genetics · doi:10.1007/s10519-020-10002-2 · Cited by 2 · see citing works
Micalizzi, L., Brick, L., Marraccini, M. E., Benca-Bachman, C., Palmer, R., & Knopik, V. (2020) · Development and Psychopathology · doi:10.1017/s0954579419001573 · Cited by 3 · see citing works
“This finding is not consistent with a study of young twins that determined that the association among inattention and two aspects of neurocognitive functioning (reaction time variability and commission errors) was, in part, attributable to common additive genetic effects (Kuntsi et al., 2014).”
BackgroundResultClinical practice guidelines on cognitive impairment and ADHD-Assessment and Management
Malhotra, S., Kishore, M. T., & Sousa, A. D. (2025) · Indian Journal of Psychiatry · doi:10.4103/indianjpsychiatry.indianjpsychiatry_720_24 · Cited by 3 · see citing works
Genetic variance in conscientiousness relates to youth psychopathology beyond executive functions.
Shields, A. N., Malanchini, M., Vinnik, L., Tucker–Drob, E. M., Harden, K. P., & Tackett, J. L. (2022) · Journal of Psychopathology and Clinical Science · doi:10.1037/abn0000781 · Cited by 3 · see citing works
Bijnens, A., & Pistono, A. (2025) · Speech Communication · doi:10.1016/j.specom.2025.103244 · Cited by 3 · see citing works
Genetic factors and the brain in ADHD
Bralten, J. (2015) · Radboud Repository (Radboud University) · Cited by 3 · see citing works
Knyspel, J., Morneau‐Vaillancourt, G., & Eley, T. C. (2024) · Behavior Genetics · doi:10.1007/s10519-024-10204-y · Cited by 2 · see citing works
Adult ADHD: Future Directions for Practice and Research
Pallanti, S., & Salerno, L. (2020) · Springer eBooks · doi:10.1007/978-3-030-39051-8_20 · Cited by 2 · see citing works
Developmental perspectives on ADHD, treatment implications, and achieving good outcomes
Coghill, D., & Seth, S. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-819749-3.00009-9 · Cited by 1 · see citing works
Pollock, B. E. (2014) · Cited by 1 · see citing works
Attention-deficit/hyperactivity disorder
Klein, M. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-85654-6.00029-0 · Cited by 1 · see citing works
Gennatas, E. D., Wren-Jarvis, J., Powers, R., Lazerwitz, M. C., Bourla, I., Cai, L. T., Choi, H. L., Chu, R., Trimarchi, K. J., Garcia, R. D., et al. (2024) · Imaging Neuroscience · doi:10.1162/imag_a_00076 · Cited by 1 · see citing works
“…with ADHD show gray matter (GM) and white matter (WM) differences from typically developing children ( Hoogman et al., 2019); however, findings are largely divergent ( Pereira-Sanchez & Castellanos, 2021), in major part due to clinical heterogeneity of the ADHD phenotype ( Kuntsi et al., 2014).”
BackgroundAin, Y., Rai, S., Galbraith, A., Buerkner, J., Andrews‐Hanna, J. R., Callahan, B. L., & Kam, J. W. Y. (2025) · Journal of Attention Disorders · doi:10.1177/10870547251394173 · Cited by 1 · see citing works
“…between the genetic determinants and functional outcomes associated with both inattention and hyperactivity-impulsivity symptom dimensions of ADHD (Kuntsi et al., 2014), and researchers have highlighted the need for more studies contrasting the developmental, etiological, and psychological…”
Rodriguez, P. D., & Stauffacher, J. E. (2022) · Midwest Social Sciences Journal · doi:10.22543/2766-0796.1061 · Cited by 1 · see citing works
“Given the lack of consensus on diagnosing subtypes for ADHD (Kuntsi et al. 2014; Lee et al. 2016), the differential behavioral results in ADHD literature, and the need for further investigation of neural correlates underlying the disorder (Silk et al. 2016), it is crucial that the neural basis of…”
BackgroundGreen, B. C. (2018) · Minerva Access (University of Melbourne) · Cited by 1 · see citing works
Meeuwsen, M. (2015) · ORCA Online Research @Cardiff (Cardiff University)
Asherson, P. J., Buitelaar, J. K., Faraone, S. V., Jebsen, K. G., & Rohde, L. A. (2016)
Self-citationMarley, C. (2019) · The University of Queensland · doi:10.14264/uql.2019.176
Maheswary, K. U., & Priya, S. M. (2020) · Springer eBooks · doi:10.1007/978-3-030-41862-5_173
Maema, E. K. (2021) · Unisa Institutional Repository (University of South Africa)
(2019) · Emerald Group Publishing Limited eBooks · doi:10.1108/978-1-83867-895-120191002
(2022) · Midwest Social Sciences Journal · doi:10.22543/2766-0796.1103
Kawichai, T., Plaimas, K., & Suratanee, A. (2019) · doi:10.58837/chula.the.2020.1358
- Authors
- Kuntsi, J., Pinto, R., Price, T. S., van der Meere, J. J., Frazier-Wood, A. C., & Asherson, P.
- Affiliations
- King's College London (GB)
- Corresponding author
- Kuntsi, Jonna
- Venue
- Journal of Abnormal Child Psychology
- Published
- 2013-07-10
- Volume
- 42
- Issue
- 1
- Pages
- 127-136
- ISSN
- 0091-0627 (ISSN-L)
- 1573-2835
- PMC
- PMC4520068
- OpenAlex
- W2012675790
- Cited by
- 106
- References
- 46
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 9 · 2023: 6 · 2022: 8 · 2021: 10 · 2020: 13 · 2019: 8 · 2018: 13 · 2017: 1 · 2016: 11 · 2015: 9 · 2014: 9
- FWCI
- 6.84
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Research on Child and Adolescent Psychopathology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Research Portal (King's College London) (submittedVersion, other-oa)
- Research Portal (King's College London) (submittedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion, other-oa)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
- Funders
- Wellcome Trust (GR070345MF, 070345)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- attention deficit hyperactivity disorder, inattention, hyperactivity/impulsivity, genetic correlation, reaction time variability, commission errors, cognitive impairment, twin studies, children, go/no-go task
- MeSH terms
- Attention, Attention Deficit Disorder with Hyperactivity, Child, Cognition Disorders, Female, Humans, Impulsive Behavior, Male, Psychiatric Status Rating Scales, Reaction Time, Risk Factors, Twins, Comorbidity, Multivariate Analysis, Genetic Predisposition to Disease
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
