DSM‐IV combined type ADHD shows familial association with sibling trait scores: A sampling strategy for QTL linkage
Open accessAbstract
Attention deficit hyperactivity disorder (ADHD) is a discrete clinical syndrome characterized by the triad of inattention, hyperactivity, and impulsivity in the context of marked impairments. Molecular genetic studies have been successful in identifying genetic variants associated with ADHD, particularly with DSM‐IV inattentive and combined subtypes. Quantitative trait locus (QTL) approaches to linkage and association mapping have yet to be widely used in ADHD research, although twin studies investigating individual differences suggest that genetic liability for ADHD is continuously distributed throughout the population, underscoring the applicability of quantitative dimensional approaches. To investigate the appropriateness of QTL approaches, we tested the familial association between 894 probands with a research diagnosis of DSM‐IV ADHD combined type and continuous trait measures among 1,135 of their siblings unselected for phenotype. The sibling recurrence rate for ADHD combined subtype was 12.7%, yielding a sibling recurrence risk ratio (λ sib) of 9.0. Estimated sibling correlations around 0.2–0.3 are similar to those estimated from the analysis of fraternal twins in population twin samples. We further show that there are no threshold effects on the sibling risk for ADHD among the ADHD probands; and that both affected and unaffected siblings contributed to the association with ADHD trait scores. In conclusion, these data confirm the main requirement for QTL mapping of ADHD by demonstrating that narrowly defined DSM‐IV combined type probands show familial association with dimensional ADHD symptom scores amongst their siblings. © 2008 Wiley‐Liss, Inc.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
All the situations in the PACS and TIP represent different levels of structure and expectations.
“All these situations represent different levels of structure and expectations.”
From Practitioner Review: Do performance-based measures and ratings of executive function assess the same construct? (2013) · cites this paper as Chen et al., 2008
Family-based studies consistently found higher rates of ADHD in parents and siblings of affected probands compared to biological relatives of unaffected controls.
“Family-based studies have consistently found higher rates of ADHD in parents and siblings of affected probands, compared to the biological relatives of unaffected controls (Chen et al., 2008).”
From A Review of Heterogeneity in Attention Deficit/Hyperactivity Disorder (ADHD) (2019) · cites this paper as Chen et al., 2008
ADHD symptoms are continuously distributed throughout the population and there is no natural boundary between affected and unaffected individuals.
“This is critical because the symptoms of ADHD are found to be continuously distributed throughout the population and there is no natural boundary between affected and unaffected individuals [193].”
From European consensus statement on diagnosis and treatment of adult ADHD: The European Network Adult ADHD (2010) · cites this paper as [193]
Cites
The Strengths and Difficulties Questionnaire: A research note
Goodman, R. (1997) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.1997.tb01545.x · Cited by 14,908 · see citing works
An Introduction to the Theory of Statistics
(1911) · Nature · doi:10.1038/087345a0 · Cited by 4,430 · see citing works
Wechsler Intelligence Scale for Children
Miles-Mason, E. (2018) · Sage eBooks · doi:10.4135/9781483392271.n537 · Cited by 4,133 · see citing works
Regression standard errors in clustered samples
Rogers, W. H. (1993) · Stata technical bulletin · Cited by 2,775 · see citing works
A Note on Robust Variance Estimation for Cluster‐Correlated Data
Williams, R. L. (2000) · Biometrics · doi:10.1111/j.0006-341x.2000.00645.x · Cited by 2,501 · see citing works
Molecular genetics of attention-deficit/hyperactivity disorder
Faraone, S. V., Perlis, R. H., Doyle, A. E., Smoller, J. W., Goralnick, J. J., Holmgren, M. A., & Sklar, P. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.11.024 · Cited by 2,357 · see citing works
Self-citationAn Introduction to the Theory of Statistics
Dempster, A. P., & Plackett, R. L. (1973) · International Statistical Review · doi:10.2307/1402858 · Cited by 1,468 · see citing works
The British Child and Adolescent Mental Health Survey 1999: The Prevalence of DSM-IV Disorders
FORD, T., GOODMAN, R., & MELTZER, H. (2003) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-200310000-00011 · Cited by 1,227 · cited 16× · see citing works
“First we replicated previous findings of increased recurrence risk of ADHD-CT in siblings of ADHD-CT probands.”
ResultInfluentialConners' rating scales-revised : technical manual
Conners, C. K. (1997) · Medical Entomology and Zoology · Cited by 1,014 · see citing works
LEVY, F., HAY, D. A., McSTEPHEN, M., WOOD, C., & WALDMAN, I. (1997) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199706000-00009 · Cited by 956 · see citing works
Multiple regression analysis of twin data
DeFries, J. C., & Fulker, D. W. (1985) · Behavior Genetics · doi:10.1007/bf01066239 · Cited by 660 · see citing works
Corners' Rating Scales-Revised
Kollins, S. H., Epstein, J. N., & Conners, C. K. (2014) · Routledge eBooks · doi:10.4324/9781410610621-8 · Cited by 628 · see citing works
Li, D.-W., Sham, P., Owen, M., & He, L. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl152 · Cited by 611 · see citing works
Self-citationBrookes, K., Xu, X., Chen, W., Zhou, K., Neale, B., Lowe, N., Aneey, R., Franke, B., Gill, M., Ebstein, R., et al. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001869 · Cited by 533 · see citing works
Self-citationEaves, L. J., Silberg, J. L., Meyer, J. M., Maes, H. H., Simonoff, E., Pickles, A., Rutter, M., Reynolds, C. A., Heath, A. C., Truett, K. R., et al. (1997) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.1997.tb01614.x · Cited by 489 · see citing works
Hyperactivity and conduct problems as risk factors for adolescent development.
Taylor, E., Chadwick, O., Heptinstall, E., & Danckaerts, M. (1996) · Journal of the American Academy of Child and Adolescent Psychiatry · doi:10.1097/00004583-199609000-00019 · Cited by 484 · see citing works
Self-citationThe DSM-IV Rates of Child and Adolescent Disordersin Puerto Rico
CANINO, G. J., Shrout, P. E., Rubio‐Stipec, M., Bird, H., Bravo, M., Ramírez, R., Chavez, L. M., Alegria, M. M., Bauermeister, J. J., Hohmann, A. A., et al. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.1.85 · Cited by 453 · see citing works
Willcutt, E. G., Pennington, B. F., Boada, R., Ogline, J. S., Tunick, R. A., Chhabildas, N. A., & Olson, R. K. (2001) · Journal of Abnormal Psychology · doi:10.1037//0021-843x.110.1.157 · Cited by 451 · see citing works
Willcutt, E. G., Pennington, B. F., Boada, R., Ogline, J. S., Tunick, R. A., Chhabildas, N. A., & Olson, R. K. (2001) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.110.1.157 · Cited by 451 · see citing works
Wechsler Intelligence Scale for Children
(2012) · SpringerReference · doi:10.1007/springerreference_184296 · Cited by 419 · see citing works
Molecular Genetics of Attention Deficit Hyperactivity Disorder
Faraone, S. V., & Mick, E. (2010) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2009.12.004 · Cited by 411 · cited 3× · see citing works
“Molecular genetic studies using candidate gene association approaches have yielded positive findings with dopamine and related monoamine neurotransmitter genes, in particular with genetic variants of the dopamine transporter, dopamine D4 and D5 receptor genes [reviewed in Asherson and The Image Consortium, 2004; Farao…”
BackgroundResultSelf-citationGenetic basis of attention deficit and hyperactivity
Thapar, A., Holmes, J., Poulton, K., & Harrington, R. (1999) · The British Journal of Psychiatry · doi:10.1192/bjp.174.2.105 · Cited by 399 · see citing works
Maternal Smoking During Pregnancy and Attention Deficit Hyperactivity Disorder Symptoms in Offspring
Thapar, A., Fowler, T., Rice, F. J., Scourfield, J., van den Bree, M. B. M., Thomas, H. V., Harold, G. T., & Hay, D. F. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.11.1985 · Cited by 389 · see citing works
Goodman, R., & Stevenson, J. (1989) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.1989.tb00782.x · Cited by 363 · see citing works
A Twin Study of Competence and Problem Behavior in Childhood and Early Adolescence
EDELBROCK, C. S., Rende, R., Plomin, R. J., & Thompson, L. A. (1995) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.1995.tb01328.x · Cited by 323 · see citing works
Self-citationA genomewide scan for loci involved in attention-deficit/hyperactivity disorder.
Fisher, S. E., Francks, C., McCracken, J. T., McGough, J. J., Marlow, A., MacPhie, I. L., Newbury, D., Crawford, L., Palmer, C. G. S., Woodward, J., et al. (2002) · American Journal of Human Genetics · doi:10.1086/340112 · Cited by 318 · see citing works
Brookes, K., Mill, J., Guindalini, C., Curran, S., Xu, X.-H., Knight, J., Chen, C.-K., Huang, Y.-S., Sethna, V., Taylor, E., et al. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.1.74 · Cited by 315 · see citing works
Self-citationChen, W. J., Faraone, S. V., Biederman, J., & Tsuang, M. T. (1994) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.62.5.1017 · Cited by 314 · see citing works
Self-citationMultiple Regression Analysis of Twin Data: Etiology of Deviant Scores versus Individual Differences
DeFries, J. C., & Fulker, D. W. (1988) · Acta geneticae medicae et gemellologiae · doi:10.1017/s0001566000003810 · Cited by 304 · see citing works
Conduct Disorder and Hyperactivity: I
Taylor, E., Everitt, B. J., Ruttermd, M. L., Thorley, G., Schachar, R. J., & Wieselberg, M. (1986) · The British Journal of Psychiatry · doi:10.1192/bjp.149.6.760 · Cited by 294 · see citing works
Self-citationFarrington, D. P., Loeber, R., & van Kammen, W. B. (1990) · Cited by 292 · see citing works
Biederman, J., Faraone, S. V., Doyle, A. E., Lehman, B. K., Kraus, I., Perrin, J. M., & Tsuang, M. T. (1993) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.1993.tb01785.x · Cited by 263 · see citing works
Self-citationBakker, S. C., Meulen, E. M. V. D., Buitelaar, J. K., Sandkuijl, L. A., Pauls, D. L., Monsuur, A. J., Slot, R. V. ‘., Minderaa, R. B., Gunning, W. B., Pearson, P. L., et al. (2003) · The American Journal of Human Genetics · doi:10.1086/375143 · Cited by 257 · see citing works
Self-citationSHERMAN, D. K., IACONO, W. G., & McGUE, M. K. (1997) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199706000-00010 · Cited by 250 · see citing works
Genetic influence on language delay in two-year-old children
Dale, P. S., Simonoff, E. A., Bishop, D., Eley, T. C., Oliver, B. R., Price, T. S., Purcell, S., Stevenson, J., & Plomin, R. J. (1998) · Nature Neuroscience · doi:10.1038/1142 · Cited by 244 · see citing works
Self-citationCornish, K. M., Manly, T., Savage, R., Swanson, J., Morisano, D., Butler, N., Grant, C., Cross, G., Bentley, L., & Hollis, C. P. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001641 · Cited by 220 · see citing works
Ogdie, M. N., Macphie, I. L., Minassian, S. L., Yang, M., Fisher, S. E., Francks, C., Cantor, R. M., McCracken, J. T., McGough, J. J., Nelson, S. F., et al. (2003) · The American Journal of Human Genetics · doi:10.1086/375139 · Cited by 220 · see citing works
Arcos‐Burgos, M., Castellanos, F. X., Pineda, D. A., Lopera, F. J., Palacio, J. D., Palacio, L. G., Rapoport, J. L., Berg, K. A., Wilson, J., & Muenke, M. (2004) · The American Journal of Human Genetics · doi:10.1086/426154 · Cited by 211 · see citing works
Taylor, E. A., Schachar, R. J., Thorley, G., Wieselberg, H. M., Everitt, B. J., & Rutter, M. L. (1987) · Psychological Medicine · doi:10.1017/s0033291700013039 · Cited by 210 · see citing works
Self-citationFergusson, D. M., & Horwood, L. J. (1995) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199504000-00015 · Cited by 201 · see citing works
Gjone, H., Stevenson, J., & Sundet, J. M. (1996) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199605000-00013 · Cited by 200 · see citing works
Lowe, N., Kirley, A., Hawi, Z., Sham, P., Wickham, H., Kratochvil, C., Smith, S. D., Lee, S. Y., Levy, F., Kent, L., et al. (2004) · American Journal of Human Genetics · doi:10.1086/381561 · Cited by 196 · see citing works
Self-citationFaraone, S. V., Biederman, J., & Monuteaux, M. C. (2000) · Genetic Epidemiology · doi:10.1002/(sici)1098-2272(200001)18:1 · Cited by 195 · see citing works
Self-citationEvidence for a genetic etiology in hyperactivity in children
Stevenson, J. (1992) · Behavior Genetics · doi:10.1007/bf01066665 · Cited by 187 · see citing works
Attention deficit disorder in reading-disabled twins: Evidence for a genetic etiology
Gillis, J. J., Gilger, J. W., Pennington, B. F., & DeFries, J. C. (1992) · Research on Child and Adolescent Psychopathology · doi:10.1007/bf00916694 · Cited by 175 · see citing works
NADDER, T. S., RUTTER, M., SILBERG, J. L., MAES, H. H., & EAVES, L. J. (2002) · Psychological Medicine · doi:10.1017/s0033291701004792 · Cited by 172 · see citing works
Todd, R. D., Rasmussen, E. R., Neuman, R. J., Reich, W., Hudziak, J. J., Bucholz, K. K., Madden, P. A. F., & Heath, A. C. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.11.1891 · Cited by 164 · see citing works
A genome-wide scan for attention-deficit/hyperactivity disorder in 155 German sib-pairs
Hebebrand, J., Dempfle, A., Saar, K., Thiele, H., Herpertz-Dahlmann, B., Linder, M., Kiefl, H., Remschmidt, H., Hemminger, U., Warnke, A., et al. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001761 · Cited by 159 · see citing works
Simonoff, E. A., Pickles, A. R., Amaia Hervas, G., Silberg, J. L., Rutter, M. L., & Eaves, L. J. (1998) · Psychological Medicine · doi:10.1017/s0033291798006886 · Cited by 154 · see citing works
Sherman, D. K., McGue, M. K., & Iacono, W. G. (1997) · American Journal of Psychiatry · doi:10.1176/ajp.154.4.532 · Cited by 153 · see citing works
Thapar, A., Amaia Hervas, G., & McGuffin, P. (1995) · Behavior Genetics · doi:10.1007/bf02327577 · Cited by 151 · see citing works
Self-citationDoes the Definition of ADHD Affect Heritability?
Thapar, A., Harrington, R., Ross, K., & McGuffin, P. (2000) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-200012000-00015 · Cited by 150 · see citing works
Self-citationPsychological Mechanisms in Hyperactivity: II The Role of Genetic Factors
Kuntsi, J., & Stevenson, J. (2001) · Journal of Child Psychology and Psychiatry · doi:10.1111/1469-7610.00712 · Cited by 146 · see citing works
Self-citationHudziak, J. J., van Beijsterveldt, C. E. M., Bartels, M., Rietveld, M. J. H., Rettew, D. C., Derks, E. M., & Boomsma, D. I. (2003) · Behavior Genetics · doi:10.1023/a:1025782918793 · Cited by 144 · see citing works
Eaves, L. C., Wingert, H., & Ho, H. H. (2006) · Autism · doi:10.1177/1362361306063288 · Cited by 141 · see citing works
Coolidge, F. L., Thede, L. L., & Young, S. E. (2000) · Developmental Neuropsychology · doi:10.1207/s15326942dn1703_1 · Cited by 137 · see citing works
Rietveld, M. J. H., Hudziak, J. J., Bartels, M., van Beijsterveldt, C. E. M., & Boomsma, D. I. (2002) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.10024 · Cited by 136 · see citing works
Observer effects and heritability of childhood attention-deficit hyperactivity disorder symptoms
Martin, N. C., Scourfield, J., & McGuffin, P. (2002) · The British Journal of Psychiatry · doi:10.1192/bjp.180.3.260 · Cited by 136 · see citing works
Self-citationOgdie, M. N., Fisher, S. E., Yang, M., Ishii, J., Francks, C., Loo, S. K., Cantor, R. M., McCracken, J. T., McGough, J. J., Smalley, S. L., et al. (2004) · The American Journal of Human Genetics · doi:10.1086/424387 · Cited by 133 · see citing works
Asherson, P., Brookes, K., Franke, B., Chen, W., Gill, M., Ebstein, R. P., Buitelaar, J., Banaschewski, T., Sonuga-Barke, E., Eisenberg, J., et al. (2007) · American Journal of Psychiatry · doi:10.1176/appi.ajp.164.4.674 · Cited by 128 · see citing works
Self-citationAttention?Deficit Hyperactivity Disorder in the post?genomic era
Asherson, P. J. (2004) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-004-1006-6 · Cited by 124 · see citing works
Self-citationWillcutt, E. G., Pennington, B. F., & DeFries, J. C. (2000) · Research on Child and Adolescent Psychopathology · doi:10.1023/a:1005170730653 · Cited by 122 · see citing works
Conduct Disorder and Hyperactivity: II
Taylor, E. A., Everitt, B. J., Rutter, M. L., Thorley, G., Schachar, R. J., & Wieselberg, H. M. (1986) · The British Journal of Psychiatry · doi:10.1192/bjp.149.6.768 · Cited by 115 · see citing works
Self-citationRasmussen, E., Neuman, R. J., Heath, A. C., Lévy, F., Hay, D. A., & Todd, R. D. (2004) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2004.00248.x · Cited by 114 · see citing works
Mill, J., Xu, X.-H., Ronald, A., Curran, S., Price, T., Knight, J., Craig, I., Sham, P., Plomin, R., & Asherson, P. (2005) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30107 · Cited by 109 · see citing works
Self-citationGenetic Effects on ADHD Symptomatology in 7- to 13-Year-Old Twins: Results from a Telephone Survey
Nadder, T. S., Silberg, J. L., Eaves, L. J., MAES, H. H. M., & Meyer, J. M. (1998) · Behavior Genetics · doi:10.1023/a:1021686906396 · Cited by 104 · see citing works
The serotonin transporter gene as a QTL for ADHD
Curran, S., Purcell, S., Craig, I., Asherson, P., & Sham, P. (2005) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30118 · Cited by 91 · see citing works
Self-citationRefining the attention deficit hyperactivity disorder phenotype for molecular genetic studies
Thapar, A., Langley, K., O’Donovan, M. C., & Owen, M. J. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001831 · Cited by 82 · see citing works
Boyle, M. H. (1997) · Archives of General Psychiatry · doi:10.1001/archpsyc.1997.01830210029003 · Cited by 82 · see citing works
HYPERACTIVITY IN PRESCHOOL CHILDREN IS HIGHLY HERITABLE
Price, T. S., Simonoff, E. A., Waldman, I. D., Asherson, P. J., & Plomin, R. J. (2001) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-200112000-00002 · Cited by 73 · see citing works
Self-citationRothenberger, A., & Woerner, W. (2004) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-004-2001-7 · Cited by 64 · see citing works
Self-citationOgdie, M. N., Bakker, S., Fisher, S., Francks, C., Yang, M. H., Cantor, R., Loo, S., van der Meulen, E. M., Pearson, P. L., Buitelaar, J., et al. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001760 · Cited by 57 · see citing works
Self-citationA Model-Fitting Implementation of the DeFries-Fulker Model for Selected Twin Data
Purcell, S., & Sham, P. C. (2003) · Behavior Genetics · doi:10.1023/a:1023494408079 · Cited by 49 · see citing works
Self-citationTHE RELATIONSHIP BETWEEN ATTENTION PROBLEMS IN CHILDHOOD AND ANTISOCIAL BEHAVIOR EIGHT YEARS LATER
Wallander, J. L. (1988) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.1988.tb00688.x · Cited by 32 · see citing works
Prevalence of psychiatric disorder: with and without psychosocial impairment
McArdle, P., Prosser, J., & Kolvin, I. (2004) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-004-0367-1 · Cited by 30 · see citing works
Behavioral Ratings of Children Diagnosed for Attention Deficit Disorder
EDELBROCK, C. S. (1986) · Psychiatric Annals · doi:10.3928/0048-5713-19860101-08 · Cited by 12 · see citing works
Resilience and Self-Control Impairment
Chen, W., & Taylor, E. (2012) · Springer eBooks · doi:10.1007/978-1-4614-3661-4_13 · Cited by 11 · see citing works
Self-citationIsolation of the genetic factors underlying speech and language disorders.
Fisher, S. E. (2003) · American Psychological Association eBooks · doi:10.1037/10480-012 · Cited by 8 · see citing works
Recent developments in quantitative trait loci analysis.
Sham, P. C. (2003) · American Psychological Association eBooks · doi:10.1037/10480-003 · Cited by 7 · see citing works
Self-citationResilience and Self-Control Impairment
Chen, W., & Taylor, E. (2007) · Springer eBooks · doi:10.1007/0-306-48572-9_16 · Cited by 6 · see citing works
Self-citationMASON, O. T. (1886) · Science · doi:10.1126/science.ns-8.183.115 · Cited by 4 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Toplak, M. E., West, R. F., & Stanovich, K. E. (2013) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.12001 · Cited by 1,381 · see citing works
Genetics of attention deficit hyperactivity disorder
Faraone, S. V., & Larsson, H. (2019) · Molecular Psychiatry · doi:10.1038/s41380-018-0070-0 · Cited by 1,338 · see citing works
Self-citationKooij, S. J., Bejerot, S., Blackwell, A., Caci, H., Casas-Brugué, M., Carpentier, P. J., Edvinsson, D., Fayyad, J., Foeken, K., Fitzgerald, M., et al. (2010) · BMC Psychiatry · doi:10.1186/1471-244x-10-67 · Cited by 928 · see citing works
“This is critical because the symptoms of ADHD are found to be continuously distributed throughout the population and there is no nat-ural boundary between affected and unaffected individuals [193].”
Self-citationA Review of Heterogeneity in Attention Deficit/Hyperactivity Disorder (ADHD)
Luo, Y., Weibman, D., Halperin, J. M., & Li, X. (2019) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2019.00042 · Cited by 394 · see citing works
Larsson, H., Chang, Z., D'Onofrio, B. M., & Lichtenstein, P. (2014) · Psychological Medicine · doi:10.1017/s0033291713002493 · Cited by 364 · see citing works
Adult attention-deficit hyperactivity disorder: key conceptual issues
Asherson, P., Buitelaar, J., Faraone, S. V., & Rohde, L. A. (2016) · The Lancet Psychiatry · doi:10.1016/s2215-0366(16)30032-3 · Cited by 347 · see citing works
Self-citationBolea-Alamañac, B., Nutt, D. J., Adamou, M., Asherson, P., Bazire, S., Coghill, D., Heal, D., Müller, U., Nash, J., Santosh, P., et al. (2014) · Journal of Psychopharmacology · doi:10.1177/0269881113519509 · Cited by 287 · see citing works
Self-citationUnder Diagnosis of Adult ADHD: Cultural Influences and Societal Burden
Asherson, P., Akehurst, R., Kooij, J. J. S., Huss, M., Beusterien, K., Sasané, R., Gholizadeh, S., & Hodgkins, P. (2012) · Journal of Attention Disorders · doi:10.1177/1087054711435360 · Cited by 189 · see citing works
Self-citationPaloyelis, Y., Asherson, P., Mehta, M. A., Faraone, S. V., & Kuntsi, J. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.124 · Cited by 180 · see citing works
Self-citationKuntsi, J., Wood, A. C., Johnson, K. A., Andreou, P., Arias-Vasquez, A., Buitelaar, J. K., Rommelse, N. N. J., Sergeant, J. A., Sonuga-Barke, E. J., Uebel, H., et al. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.139 · Cited by 162 · see citing works
Self-citationMowlem, F. D., Skirrow, C., Reid, P., Maltezos, S., Nijjar, S. K., Merwood, A., Barker, E., Cooper, R., Kuntsi, J., & Asherson, P. (2019) · Journal of Attention Disorders · doi:10.1177/1087054716651927 · Cited by 156 · see citing works
Self-citationCognitive and neurophysiological markers of ADHD persistence and remission
Cheung, C. H. M., Rijsdijk, F., McLoughlin, G., Brandeis, D., Banaschewski, T., Asherson, P., & Kuntsi, J. (2016) · British Journal of Psychiatry · doi:10.1192/bjp.bp.114.145185 · Cited by 146 · see citing works
Self-citationNeuropsychological correlates of emotional lability in children with ADHD
Banaschewski, T., Jennen‐Steinmetz, C., Brandeis, D., Buitelaar, J. K., Kuntsi, J., Poustka, L., Sergeant, J. A., Sonuga‐Barke, E. J., Frazier‐Wood, A. C., Albrecht, B., et al. (2012) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2012.02596.x · Cited by 122 · see citing works
Self-citationKuntsi, J., Pinto, R., Price, T. S., van der Meere, J. J., Frazier-Wood, A. C., & Asherson, P. (2014) · Journal of Abnormal Child Psychology · doi:10.1007/s10802-013-9771-7 · Cited by 106 · see citing works
“The similarity between the findings presented here and the previous study using clinical cases of ADHD provides further evidence that ADHD reflects the extreme and impairing tail of quantitative traits for inattention and hyperactivity-impulsivity (Chen et al. 2008).”
ResultSelf-citationStergiakouli, E., Martin, J., Hamshere, M. L., Langley, K., Evans, D. M., St Pourcain, B., Timpson, N. J., Owen, M. J., O'Donovan, M., Thapar, A., et al. (2015) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2015.01.010 · Cited by 94 · see citing works
Striatal sensitivity during reward processing in attention-deficit/hyperactivity disorder
Paloyelis, Y., Mehta, M. A., Faraone, S. V., Asherson, P., & Kuntsi, J. (2012) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2012.05.006 · Cited by 94 · see citing works
Self-citationAre ADHD Symptoms Associated With Delay Aversion or Choice Impulsivity? A General Population Study
Paloyelis, Y., Asherson, P., & Kuntsi, J. (2009) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/chi.0b013e3181ab8c97 · Cited by 82 · see citing works
Self-citationKUNTSI, J., WOOD, A. C., VAN DER MEERE, J., & ASHERSON, P. (2009) · Journal of the International Neuropsychological Society · doi:10.1017/s135561770909081x · Cited by 80 · see citing works
Self-citationFliers, E. A., Vasquez, A. A., Poelmans, G., Rommelse, N., Altink, M., Buschgens, C., Asherson, P., Banaschewski, T., Ebstein, R., Gill, M., et al. (2012) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2011.560279 · Cited by 46 · see citing works
Self-citationHoogman, M., Rijpkema, M., Janss, L., Brunner, H., Fernandez, G., Buitelaar, J., Franke, B., & Arias-Vásquez, A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0031273 · Cited by 46 · see citing works
Self-citationQuantitative and Molecular Genetics of ADHD
Asherson, P., & Gurling, H. (2011) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2011_155 · Cited by 43 · see citing works
Self-citationMichelini, G., Cheung, C. H. M., Kitsune, V., Brandeis, D., Banaschewski, T., McLoughlin, G., Asherson, P., Rijsdijk, F., & Kuntsi, J. (2021) · Journal of Attention Disorders · doi:10.1177/1087054718771191 · Cited by 27 · see citing works
Self-citationPinto, R., Asherson, P., Ilott, N., Cheung, C. H. M., & Kuntsi, J. (2016) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32463 · Cited by 19 · see citing works
Self-citationMurphy, D., Glaser, K., Hayward, H., Eklund, H., Cadman, T., Findon, J., Woodhouse, E., Ashwood, K., Beecham, J., Bolton, P., et al. (2018) · Programme Grants for Applied Research · doi:10.3310/pgfar06020 · Cited by 18 · see citing works
“Parent Account of Childhood Symptoms Parent Account of Childhood Symptoms (PACS) is a semistructured, standardised, investigator-based interview developed as an instrument to provide an objective measure of children’s behaviour.(87) A trained interviewer administered PACS with parents, who were asked for detailed desc…”
BackgroundSelf-citationPalacio-Ortiz, J. D., Palacios-Cruz, L., Martínez-Zamora, M., Valencia-Echeverry, J., Macias-Duran, J., & López-Jaramillo, C. A. (2024) · Psychiatry Research · doi:10.1016/j.psychres.2024.115997 · Cited by 2 · see citing works
- Authors
- Chen, W., Zhou, K., Sham, P., Franke, B., Kuntsi, J., Campbell, D., Fleischman, K., Knight, J., Andreou, P., Arnold, R., Altink, M., Boer, F., Boholst, M. J., Buschgens, C., Butler, L., Christiansen, H., Fliers, E., Howe‐Forbes, R., Gabriëls, I., Heise, A., Korn‐Lubetzki, I., Marco, R., Medad, S., Minderaa, R., Müller, U. C., Mulligan, A., Psychogiou, L., Rommelse, N., Sethna, V., Uebel, H., McGuffin, P., Plomin, R., Banaschewski, T., Buitelaar, J., Ebstein, R., Eisenberg, J., Gill, M., Manor, I., Miranda, A., Mulas, F., Oades, R. D., Roeyers, H., Rothenberger, A., Sergeant, J., Sonuga‐Barke, E., Steinhausen, H., Taylor, E., Thompson, M., Faraone, S. V., & Asherson, P.
- Affiliations
- University of Hong Kong (HK)
- Radboud University Nijmegen (NL)
- De Bascule (NL)
- Trinity College Dublin (IE)
- Ghent University (BE)
- University of Göttingen (DE)
- Shaare Zedek Medical Center (IL)
- Universitat de València (ES)
- Geha Mental Health Center (IL)
- University Medical Center Groningen (NL)
- University of Zurich (CH)
- University of Southampton (GB)
- Vrije Universiteit Amsterdam (NL)
- Central Institute of Mental Health (DE)
- Herzog Hospital (IL)
- Hospital Universitari i Politècnic La Fe (ES)
- SUNY Upstate Medical University (US)
- Corresponding author
- Asherson, Philip
- ORCID
- Chen, Wai
- Sham, Pak
- Franke, Barbara
- Kuntsi, Jonna
- Campbell, Desmond
- Knight, Jo
- Boer, Frits
- Christiansen, Hanna
- Korn‐Lubetzki, Isabelle
- Mulligan, Aisling
- Psychogiou, Lamprini
- Rommelse, Nanda
- Sethna, Vaheshta
- Plomin, Robert
- Banaschewski, Tobias
- Buitelaar, Jan
- Ebstein, Richard
- Gill, Michael
- Manor, Iris
- Miranda, Ana
- Roeyers, Herbert
- Rothenberger, Aribert
- Sergeant, Joseph
- Steinhausen, Hans‐Christoph
- Taylor, Eric
- Thompson, Margaret
- Faraone, Stephen V.
- Asherson, Philip
- Venue
- American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
- Publisher
- Wiley
- Published
- 2008-01-11
- Volume
- 147B
- Issue
- 8
- Pages
- 1450-1460
- ISSN
- 1552-4841 (ISSN-L)
- 1552-485X
- OpenAlex
- W2099924108
- Cited by
- 173
- References
- 81
- Citations by year
- 2026: 6 · 2025: 7 · 2024: 9 · 2023: 5 · 2022: 5 · 2021: 4 · 2020: 7 · 2019: 8 · 2018: 11 · 2017: 9 · 2016: 18 · 2015: 12 · 2014: 8 · 2013: 10 · 2012: 13
- FWCI
- 9.58
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- American Journal of Medical Genetics Part B Neuropsychiatric Genetics (publishedVersion)
- PubMed (publishedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion)
- VU Research Portal (publishedVersion, other-oa)
- ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (acceptedVersion)
- DuEPublico (University of Duisburg-Essen) (submittedVersion)
- UWA Profiles and Research Repository (UWA) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion)
- Digital Academic REpository of VU University Amsterdam (Vrije Universiteit Amsterdam) (submittedVersion)
- Lancaster EPrints (Lancaster University) (submittedVersion)
- ePrints Soton (University of Southampton) (submittedVersion)
- The HKU Scholars Hub (University of Hong Kong) (submittedVersion)
- Research Portal (King's College London) (submittedVersion)
- GRO (submittedVersion)
- Pure Amsterdam UMC (submittedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Funders
- National Institute of Mental Health (R01MH062873)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Mapping and Diversity in Plants and Animals
- Keywords
- attention deficit hyperactivity disorder, combined type ADHD, sibling recurrence risk, familial association, quantitative trait loci, inattention, hyperactivity, impulsivity, genetic susceptibility, threshold effects
- MeSH terms
- Attention Deficit Disorder with Hyperactivity, Family, Female, Humans, Interviews as Topic, Genetic Linkage, Male, Regression Analysis, Sibling Relations, Twins, Dizygotic, Genetic Predisposition to Disease, Diagnostic and Statistical Manual of Mental Disorders, Quantitative Trait Loci
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
