The Autism Diagnostic Observation Schedule, Module 4: Revised Algorithm and Standardized Severity Scores
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The recently published Autism Diagnostic Observation Schedule, 2nd edition (ADOS-2) includes revised diagnostic algorithms and standardized severity scores for modules used to assess younger children. A revised algorithm and severity scores are not yet available for Module 4, used with verbally fluent adults. The current study revises the Module 4 algorithm and calibrates raw overall and domain totals to provide metrics of autism spectrum disorder (ASD) symptom severity. Sensitivity and specificity of the revised Module 4 algorithm exceeded 80 % in the overall sample. Module 4 calibrated severity scores provide quantitative estimates of ASD symptom severity that are relatively independent of participant characteristics. These efforts increase comparability of ADOS scores across modules and should facilitate efforts to examine symptom trajectories from toddler to adulthood.
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Participants had previous diagnoses of ASD supported by the Autism Diagnostic Interview-Revised (ADI-R) and the Autism Diagnostic Observation Schedule, Second Edition revised module 4 (ADOS-2), as well as previous IQ assessments based on the Wechsler Adult Intelligence Scale, Fourth Edition (WAIS-IV) indicating the absence of ID (Total IQ above 80).
“They had previous diagnoses of ASD supported by the Autism Diagnostic Interview-Revised (ADI-R; Rutter et al., 2003) and the Autism Diagnostic Observation Schedule, Second Edition revised module 4 (ADOS-2; Hus & Lord, 2014; Lord et al., 2012), as well as previous IQ assessments based on the Wechsler Adult Intelligence Scale, Fourth Edition (WAIS-IV; Wechsler, 2011) indicating the absence of ID (T”
From Feasibility, Acceptability and Preliminary Efficacy of Dialectical Behavior Therapy for Autistic Adults without Intellectual Disability: A Mixed Methods Study (2022) · cites this paper as Hus & Lord, 2014
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- Authors
- Hus, V., & Lord, C.
- Affiliations
- University of Michigan (US)
- ORCID
- Lord, Catherine
- Venue
- Journal of Autism and Developmental Disorders
- Published
- 2014-03-04
- Volume
- 44
- Issue
- 8
- Pages
- 1996-2012
- ISSN
- 0162-3257 (ISSN-L)
- 1573-3432
- PMC
- PMC4104252
- OpenAlex
- W2049567796
- Cited by
- 547
- References
- 52
- Citations by year
- 2026: 33 · 2025: 43 · 2024: 53 · 2023: 43 · 2022: 68 · 2021: 69 · 2020: 52 · 2019: 49 · 2018: 42 · 2017: 46 · 2016: 21 · 2015: 25 · 2014: 3
- FWCI
- 17.66
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Journal of Autism and Developmental Disorders (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Rutgers University Community Repository (Rutgers University) (submittedVersion)
- Funders
- Foundation for the National Institutes of Health
- Autism Speaks (AS7032)
- Simons Foundation
- Simons Foundation Autism Research Initiative
- National Institute of Mental Health (R01MH081873)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Health Sciences › Medicine › Psychiatry and Mental health › Child Nutrition and Feeding Issues
- Social Sciences › Psychology › Developmental and Educational Psychology › Behavioral and Psychological Studies
- Keywords
- Autism Diagnostic Observation Schedule, autism spectrum disorder, diagnostic algorithm, severity scoring, symptom severity, sensitivity and specificity, score calibration, symptom trajectories
- MeSH terms
- Adolescent, Adult, Calibration, Child, Child Development Disorders, Pervasive, Child, Preschool, Female, Humans, Longitudinal Studies, Male, Middle Aged, Psychiatric Status Rating Scales, Psychological Tests, Reference Standards, Sensitivity and Specificity, Young Adult
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