Cited by 73Plant Micronutrient Interactions and EffectsPlant nutrient uptake and metabolismHeavy metals in environment

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Low-molecular-weight ligands in plants: role in metal homeostasis and hyperaccumulation

Seregin, I. V., Kozhevnikova, A. D.·2021·Photosynthesis Research

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Abstract

Mineral nutrition is one of the key factors determining plant productivity. In plants, metal homeostasis is achieved through the functioning of a complex system governing metal uptake, translocation, distribution, and sequestration, leading to the maintenance of a regulated delivery of micronutrients to metal-requiring processes as well as detoxification of excess or non-essential metals. Low-molecular-weight ligands, such as nicotianamine, histidine, phytochelatins, phytosiderophores, and organic acids, play an important role in metal transport and detoxification in plants. Nicotianamine and histidine are also involved in metal hyperaccumulation, which determines the ability of some plant species to accumulate a large amount of metals in their shoots. In this review we extensively summarize and discuss the current knowledge of the main pathways for the biosynthesis of these ligands, their involvement in metal uptake, radial and long-distance transport, as well as metal influx, isolation and sequestration in plant tissues and cell compartments. It is analyzed how diverse endogenous ligand levels in plants can determine their different tolerance to metal toxic effects. This review focuses on recent advances in understanding the physiological role of these compounds in metal homeostasis, which is an essential task of modern ionomics and plant physiology. It is of key importance in studying the influence of metal deficiency or excess on various physiological processes, which is a prerequisite to the improvement of micronutrient uptake efficiency and crop productivity and to the development of a variety of applications in phytoremediation, phytomining, biofortification, and nutritional crop safety.

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Items 201–400 of 481

Zinc tolerance and hyperaccumulation are genetically independent characters
Macnair, M. R., Bert, V., Huitson, S. B., Saumitou‐Laprade, P., & Petit, D. (1999) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.1999.0905 · Cited by 196
Phytochelatin synthase (PCS) protein is induced in Brassica juncea leaves after prolonged Cd exposure
Heiss, S. (2003) · Journal of Experimental Botany · doi:10.1093/jxb/erg205 · Cited by 195
A Putative Function for the Arabidopsis Fe–Phytosiderophore Transporter Homolog AtYSL2 in Fe and Zn Homeostasis
Schaaf, G., Schikora, A., Häberle, J., Vert, G., Ludewig, U., Briat, J., Curie, C., & von Wirén, N. (2005) · Plant and Cell Physiology · doi:10.1093/pcp/pci081 · Cited by 195
Distribution of Zn in functionally different leaf epidermal cells of the hyperaccumulator Thlaspi caerulescens
Frey, B., Keller, C., & Zierold, K. (2000) · Plant Cell & Environment · doi:10.1046/j.1365-3040.2000.00590.x · Cited by 193
Localization and chemical forms of cadmium in plant samples by combining analytical electron microscopy and X-ray spectromicroscopy
Isaure, M., Barbara Fayard, C., Géraldine Sarret, B., Sébastien Pairis, E., & Bourguignon, J. (2006) · Spectrochimica Acta Part B Atomic Spectroscopy · doi:10.1016/j.sab.2006.10.009 · Cited by 193
Transcriptional regulation of metal transport genes and mineral nutrition during acclimatization to cadmium and zinc in the Cd/Zn hyperaccumulator, Thlaspi caerulescens (Ganges population)
Küpper, H., & Kochian, L. V. (2010) · New Phytologist · doi:10.1111/j.1469-8137.2009.03051.x · Cited by 191
Distribution of cadmium in leaves of Thlaspi caerulescens
Cosio, C. (2005) · Journal of Experimental Botany · doi:10.1093/jxb/eri062 · Cited by 191
Cadmium hyperaccumulation leads to an increase of glutathione rather than phytochelatins in the cadmium hyperaccumulator Sedum alfredii
Sun, Q., Ye, Z. H., Wang, X. R., & Wong, M. H. (2007) · Journal of Plant Physiology · doi:10.1016/j.jplph.2006.10.001 · Cited by 187
Application of Quantitative Fluorescence and Absorption-Edge Computed Microtomography to Image Metal Compartmentalization in Alyssum murale
McNear, D. H., Peltier, E. F., Everhart, J. L., Chaney, R. L., Sutton, S. R., Newville, M. G., Rivers, M. L., & Sparks, D. L. (2005) · Environmental Science & Technology · doi:10.1021/es0492034 · Cited by 187
Increased Nicotianamine Biosynthesis Confers Enhanced Tolerance of High Levels of Metals, in Particular Nickel, to Plants
Kim, S., Takahashi, M., Higuchi, K., Tsunoda, K., Nakanishi, H., Yoshimura, E., Mori, S., & Nishizawa, N. K. (2005) · Plant and Cell Physiology · doi:10.1093/pcp/pci196 · Cited by 185
Constitutively High Expression of the Histidine Biosynthetic Pathway Contributes to Nickel Tolerance in Hyperaccumulator Plants
Ingle, R. A., Mugford, S. T., Rees, J. D., Campbell, M. M., & Smith, J. A. C. (2005) · The Plant Cell · doi:10.1105/tpc.104.030577 · Cited by 184
Identification of Zn–Nicotianamine and Fe–2′-Deoxymugineic Acid in the Phloem Sap from Rice Plants (Oryza sativa L.)
Nishiyama, R., Kato, M., Nagata, S., Yanagisawa, S., & Yoneyama, T. (2012) · Plant and Cell Physiology · doi:10.1093/pcp/pcr188 · Cited by 182
Functional analysis of the rice vacuolar zinc transporter OsMTP1
Menguer, P. K., Farthing, E. C., Peaston, K. A., Ricachenevsky, F. K., Fett, J. P., & Williams, L. E. (2013) · Journal of Experimental Botany · doi:10.1093/jxb/ert136 · Cited by 182
The role of C2H2 zinc finger proteins in plant responses to abiotic stresses
Wang, K., Ding, Y., Cai, C., et al. (2018) · Physiologia Plantarum · doi:10.1111/ppl.12728 · Cited by 182
Phytochelatin and cadmium accumulation in wheat
Stolt, J. P., Sneller, F. E. C., Bryngelsson, T., Lundborg, T., & Schat, H. (2002) · Environmental and Experimental Botany · doi:10.1016/s0098-8472(02)00045-x · Cited by 180
cDNA microarray analysis of gene expression during Fe‐deficiency stress in barley suggests that polar transport of vesicles is implicated in phytosiderophore secretion in Fe‐deficient barley roots
Negishi, T., Nakanishi, H., Yazaki, J., Kishimoto, N., Fujii, F., Shimbo, K., Yamamoto, K., Sakata, K., Sasaki, T., Kikuchi, S., et al. (2002) · The Plant Journal · doi:10.1046/j.1365-313x.2002.01270.x · Cited by 179
Cadmium-Induced Sulfate Uptake in Maize Roots
Nocito, F. F., Pirovano, L., COCUCCI, M., et al. (2002) · PLANT PHYSIOLOGY · doi:10.1104/pp.002659 · Cited by 177
Isolation and identification of a citrato-complex of nickel from nickel-accumulating plants
Lee, J., Reeves, R. D., Brooks, R. R., & Jaffré, T. (1977) · Phytochemistry · doi:10.1016/0031-9422(77)84010-7 · Cited by 176
Phytochelatins protect plant enzymes from heavy metal poisoning
Kneer, R., & Zenk, M. H. (1992) · Phytochemistry · doi:10.1016/0031-9422(92)83607-z · Cited by 174
Cadystin a and b, major unit peptides comprising cadmium binding peptides induced in a fission yeast ----- separation, revision of structures and synthesis
Kondo, N., Imai, K., Isobe, M., et al. (1984) · Tetrahedron Letters · doi:10.1016/s0040-4039(01)91190-6 · Cited by 173
Chloroplastic and mitochondrial metal homeostasis
Nouet, C., Motté, P., & Hanikenne, M. (2011) · Trends in Plant Science · doi:10.1016/j.tplants.2011.03.005 · Cited by 172
Cloning sulfur assimilation genes of Brassica juncea L.: cadmium differentially affects the expression of a putative low-affinity sulfate transporter and isoforms of ATP sulfurylase and APS reductase
Heiss, S., Schäfer, H., Haag-Kerwer, A., et al. (1999) · Plant Molecular Biology · doi:10.1023/a:1006169717355 · Cited by 171
Bio‐available zinc in rice seeds is increased by activation tagging of nicotianamine synthase
Lee, S., Persson, D. P., Hansen, T. H., et al. (2011) · Plant Biotechnology Journal · doi:10.1111/j.1467-7652.2011.00606.x · Cited by 165
Complexation and Toxicity of Copper in Higher Plants. I. Characterization of Copper Accumulation, Speciation, and Toxicity in Crassula helmsii as a New Copper Accumulator
Küpper, H., Götz, B., Mijovilovich, A., Küpper, F. C., & Meyer-Klaucke, W. (2009) · Plant Physiology · doi:10.1104/pp.109.139717 · Cited by 164
The relation between nickel and citric acid in some nickel-accumulating plants
Lee, J., Reeves, R. D., Brooks, R. R., & Jaffré, T. (1978) · Phytochemistry · doi:10.1016/s0031-9422(00)94274-2 · Cited by 163
Translocation of copper and other micronutrients in tomato plants (Lycopersicon esculentumMill.): nicotianamine-stimulated copper transport in the xylem
Pich, A., & Scholz, G. (1996) · Journal of Experimental Botany · doi:10.1093/jxb/47.1.41 · Cited by 162
Regulation of Glutathione Synthesis by Cadmium in Pisum sativum L.
Rüegsegger, A., Schmutz, D., & Brunold, C. (1990) · PLANT PHYSIOLOGY · doi:10.1104/pp.93.4.1579 · Cited by 161
Root-to-shoot long-distance circulation of nicotianamine and nicotianamine-nickel chelates in the metal hyperaccumulator Thlaspi caerulescens
Mari, S., Gendre, D., Pianelli, K., Ouerdane, L., Łobiński, R., Briat, J., Lebrun, M., & Czernic, P. (2006) · Journal of Experimental Botany · doi:10.1093/jxb/erl184 · Cited by 160
Mechanisms of metal hyperaccumulation in plants
Salt, D. E., & Kraemer, U. (2000) · MPG.PuRe (Max Planck Society) · Cited by 159
Homo‐phytochelatins are heavy metal‐binding peptides of homo‐glutathione containing Fabales
Grill, E., Gekeler, W., Winnacker, E. ‐., & Zenk, H. H. (1986) · FEBS Letters · doi:10.1016/0014-5793(86)80863-8 · Cited by 159
Changes in glutathione and phytochelatins in roots of maize seedlings exposed to cadmium
Tukendorf, A., & Rauser, W. E. (1990) · Plant Science · doi:10.1016/0168-9452(90)90129-c · Cited by 158
Simultaneous Hyperaccumulation of Nickel, Manganese, and Calcium in Alyssum Leaf Trichomes
Broadhurst, C. L., Chaney, R. L., Angle, J. S., Maugel, T. K., Erbe, E. F., & Murphy, C. A. (2004) · Environmental Science & Technology · doi:10.1021/es0493796 · Cited by 157
Synthesis of Phytochelatins and Homo-Phytochelatins in Pisum sativum L
Klapheck, S., Schlunz, S., & Bergmann, L. (1995) · PLANT PHYSIOLOGY · doi:10.1104/pp.107.2.515 · Cited by 157
The tonoplast copper transporter COPT5 acts as an exporter and is required for interorgan allocation of copper in Arabidopsis thaliana
Klaumann, S., Nickolaus, S. D., Fürst, S. H., Starck, S., Schneider, S., Neuhaus, H. E., & Trentmann, O. (2011) · New Phytologist · doi:10.1111/j.1469-8137.2011.03798.x · Cited by 155
Identification and localisation of the rice nicotianamine aminotransferase gene OsNAAT1 expression suggests the site of phytosiderophore synthesis in rice
Inoue, H., Takahashi, M., Kobayashi, T., et al. (2007) · Plant Molecular Biology · doi:10.1007/s11103-007-9262-8 · Cited by 155
cDNA cloning and expression analysis of genes encoding GSH synthesis in roots of the heavy-metal accumulator Brassica juncea L.: evidence for Cd-induction of a putative mitochondrial γ-glutamylcysteine synthetase isoform
Schäfer, H., Haag-Kerwer, A., & Rausch, T. (1998) · Plant Molecular Biology · doi:10.1023/a:1005929022061 · Cited by 154
Fortified Foods and Phytoremediation. Two Sides of the Same Coin
Guerinot, M. L., & Salt, D. E. (2001) · PLANT PHYSIOLOGY · doi:10.1104/pp.125.1.164 · Cited by 154
Characterization of phytochelatin synthase from tomato
Chen, J., Zhou, J., & Goldsbrough, P. B. (1997) · Physiologia Plantarum · doi:10.1111/j.1399-3054.1997.tb01833.x · Cited by 152
Histidine biosynthesis in plants
Stepansky, A., & Leustek, T. (2006) · Amino Acids · doi:10.1007/s00726-005-0247-0 · Cited by 152
The Arabidopsis YELLOW STRIPE LIKE4 and 6 Transporters Control Iron Release from the Chloroplast
Divol, F., Couch, D., Conéjéro, G., Roschzttardtz, H., Mari, S., & Curie, C. (2013) · The Plant Cell · doi:10.1105/tpc.112.107672 · Cited by 152
Metal species involved in long distance metal transport in plants
Álvarez‐Fernández, A., Díaz-Benito, P., AbadÃa, A., LÃ³pez-MillÃ¡n, A.-F., & Abadı́a, J. (2014) · Frontiers in Plant Science · doi:10.3389/fpls.2014.00105 · Cited by 152
Speciation of Nickel in a Hyperaccumulating Plant by High-Performance Liquid Chromatography−Inductively Coupled Plasma Mass Spectrometry and Electrospray MS/MS Assisted by Cloning Using Yeast Complementation
Vacchina, V., Mari, S., Czernic, P., Marqués, L. P., Pianelli, K., Schaumlöffel, D., Lebrun, M., & Łobiński, R. (2003) · Analytical Chemistry · doi:10.1021/ac020704m · Cited by 150
Cadmium tolerance and phytochelatin content of Arabidopsis seedlings over-expressing the phytochelatin synthase gene AtPCS1
Brunetti, P., Zanella, L., Proia, A., Paolis, A. D., Falasca, G., Altamura, M. M., di Toppi, L. S., Costantino, P., & Cardarelli, M. (2011) · Journal of Experimental Botany · doi:10.1093/jxb/err228 · Cited by 150
Arabidopsis thaliana gamma-glutamylcysteine synthetase is structurally unrelated to mammalian, yeast, and Escherichia coli homologs.
May, M. J., & Leaver, C. J. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.21.10059 · Cited by 149
Chelation by histidine inhibits the vacuolar sequestration of nickel in roots of the hyperaccumulator Thlaspi caerulescens
Richau, K. H., Kozhevnikova, A. D., Seregin, I. V., Vooijs, R., Koevoets, P. L. M., Smith, J. A. C., Ivanov, V. B., & Schat, H. (2009) · New Phytologist · doi:10.1111/j.1469-8137.2009.02826.x · Cited by 147
Self-citation
Cost-Minimization of Amino Acid Usage
Seligmann, H. (2003) · Journal of Molecular Evolution · doi:10.1007/s00239-002-2388-z · Cited by 147
Formation of metal‐nicotianamine complexes as affected by pH, ligand exchange with citrate and metal exchange. A study by electrospray ionization time‐of‐flight mass spectrometry
Rellán‐Álvarez, R., Abadı́a, J., & Álvarez‐Fernández, A. (2008) · Rapid Communications in Mass Spectrometry · doi:10.1002/rcm.3523 · Cited by 146
The metal hyperaccumulators from New Caledonia can broaden our understanding of nickel accumulation in plants
Jaffré, T., Pillon, Y., Thomine, S., & Merlot, S. (2013) · Frontiers in Plant Science · doi:10.3389/fpls.2013.00279 · Cited by 146
An Improved Grafting Technique for Mature Arabidopsis Plants Demonstrates Long-Distance Shoot-to-Root Transport of Phytochelatins in Arabidopsis
Chen, A. P., Komives, E. A., & Schroeder, J. I. (2006) · PLANT PHYSIOLOGY · doi:10.1104/pp.105.072637 · Cited by 146
Molecular Dissection of the Role of Histidine in Nickel Hyperaccumulation in Thlaspi goesingense(Halacsy)
Persans, M. W., Yan, X., Patnoe, J.-M. M. L., Krämer, U., & Salt, D. E. (1999) · PLANT PHYSIOLOGY · doi:10.1104/pp.121.4.1117 · Cited by 146
Metal ligands in micronutrient acquisition and homeostasis
Clemens, S. (2019) · Plant Cell & Environment · doi:10.1111/pce.13627 · Cited by 146
Efficient xylem transport and phloem remobilization of Z n in the hyperaccumulator plant species S edum alfredii
Lu, L., Tian, S., Zhang, J., Yang, X., Labavitch, J. M., Webb, S. M., Latimer, M. J., & Brown, P. H. (2013) · New Phytologist · doi:10.1111/nph.12168 · Cited by 145
Zinc compartmentation in root, transport into xylem, and absorption into leaf cells in the hyperaccumulating species of Sedum alfredii Hance
Yang, X., Li, T., Yang, J., He, Z. L., Lu, L., & Meng, F. (2005) · Planta · doi:10.1007/s00425-005-0194-8 · Cited by 143
Function of phytochelatin synthase in catabolism of glutathione‐conjugates
Blum, R., Beck, A., Korte, A., Stengel, A., Letzel, T., Lendzian, K. J., & Grill, E. (2007) · The Plant Journal · doi:10.1111/j.1365-313x.2006.02993.x · Cited by 143
The nicotianamine molecule is made-to-measure for complexation of metal micronutrients in plants
Stephan, U. W., Schmidke, I., Stephan, V., & Scholz, G. (1996) · BioMetals · doi:10.1007/bf00188095 · Cited by 141
Zinc and cadmium hyperaccumulation act as deterrents towards specialist herbivores and impede the performance of a generalist herbivore
Kazemi‐Dinan, A., Thomaschky, S., Stein, R. J., Krämer, U., & Müller, C. (2014) · New Phytologist · doi:10.1111/nph.12663 · Cited by 134
Hydroxymethyl-Phytochelatins [([gamma]-Glutamylcysteine)n-Serine] Are Metal-Induced Peptides of the Poaceae
Klapheck, S., Fliegner, W., & Zimmer, I. (1994) · PLANT PHYSIOLOGY · doi:10.1104/pp.104.4.1325 · Cited by 133
Phytochelatin Synthase, a Dipeptidyltransferase That Undergoes Multisite Acylation with γ-Glutamylcysteine during Catalysis
Vatamaniuk, O. K., Mari, S., Lang, A., Chalasani, S. H., Demkiv, L. O., & Rea, P. A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m313142200 · Cited by 133
Ectopic expression of nicotianamine synthase genes results in improved iron accumulation and increased nickel tolerance in transgenic tobacco
Douchkov, D., Gryczka, C., Stephan, U. W., Hell, R., & Bäumlein, H. (2004) · Plant Cell & Environment · doi:10.1111/j.1365-3040.2005.01273.x · Cited by 133
Overexpression of phytochelatin synthase in tobacco: distinctive effects of AtPCS1 and CePCS genes on plant response to cadmium
Wojas, S., Clemens, S., Hennig, J., Skłodowska, A., Kopera, E., Schat, H., Bal, W., & Antosiewicz, D. M. (2008) · Journal of Experimental Botany · doi:10.1093/jxb/ern092 · Cited by 133
Molecular Biology of Metal Homeostasis and Detoxification
Tamás, M. J., & Martinoia, E. (2006) · Topics in current genetics · doi:10.1007/b98249 · Cited by 133
Evidence for posttranscriptional activation of γ-glutamylcysteine synthetase during plant stress responses
May, M. J., Vernoux, T., Sánchez‐Fernández, R., MONTAGU, M. V., & Inzé, D. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.20.12049 · Cited by 129
Expression and functional analysis of metal transporter genes in two contrasting ecotypes of the hyperaccumulator Thlaspi caerulescens
Plaza, S., Tearall, K. L., Zhao, F. J., Büchner, P., McGrath, S. P., & Hawkesford, M. J. (2007) · Journal of Experimental Botany · doi:10.1093/jxb/erm025 · Cited by 129
Nicotianamine is a major player in plant Zn homeostasis
Clemens, S., Deinlein, U., Ahmadi, H., Höreth, S., & Uraguchi, S. (2013) · BioMetals · doi:10.1007/s10534-013-9643-1 · Cited by 128
Tandem Quadruplication of HMA4 in the Zinc (Zn) and Cadmium (Cd) Hyperaccumulator Noccaea caerulescens
Lochlainn, S. Ó., Bowen, H. C., Fray, R. G., Hammond, J. P., King, G. J. W., White, P. J., Graham, N. S., & Broadley, M. R. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017814 · Cited by 128
Isolation, characterization and cDNA cloning of nicotianamine synthase from barley
Herbik, A., Koch, G., Mock, H., Dushkov, D., Czihal, A., Thielmann, J., Stephan, U. W., & Bäumlein, H. (1999) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.1999.00717.x · Cited by 126
Nicotianamine Over-accumulation Confers Resistance to Nickel in Arabidopsis thaliana
Pianelli, K., Mari, S., Marqués, L. P., Lebrun, M., & Czernic, P. (2005) · Transgenic Research · doi:10.1007/s11248-005-7159-3 · Cited by 125
Intron Retention in the 5′UTR of the Novel ZIF2 Transporter Enhances Translation to Promote Zinc Tolerance in Arabidopsis
Rémy, E., Cabrito, T. R., Batista, R. A., Hussein, M. A., Teixeira, M. C., Athanasiadis, A., Sá‐Correia, I., & Duque, P. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004375 · Cited by 125
Cd speciation and localization in the hyperaccumulator Arabidopsis halleri
Huguet, S., Bert, V., Laboudigue, A., Barthès, V., Isaure, M.-P., Llorens, I., Schat, H., & Sarret, G. (2012) · Environmental and Experimental Botany · doi:10.1016/j.envexpbot.2012.03.011 · Cited by 124
The five AhMTP1 zinc transporters undergo different evolutionary fates towards adaptive evolution to zinc tolerance in Arabidopsis halleri
Shahzad, Z., Gosti, F., Frérot, H., Lacombe, E., Roosens, N., Saumitou-Laprade, P., & Berthomieu, P. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1000911 · Cited by 124
Arabidopsis thaliana Yellow Stripe1-Like4 and Yellow Stripe1-Like6 localize to internal cellular membranes and are involved in metal ion homeostasis
Conte, S. S., Chu, H. H., Chan-Rodríguez, D., et al. (2013) · Frontiers in Plant Science · doi:10.3389/fpls.2013.00283 · Cited by 124
Comparison of essential and non‐essential element distribution in leaves of the Cd/Zn hyperaccumulator Thlaspi praecox as revealed by micro‐PIXE
Vogel‐Mikuš, K., Simčič, J., Pelicon, P., Budnar, M., Kump, P., Nečemer, M., Mesjasz‐Przybyłowicz, J., Przybyłowicz, W. J., & Regvar, M. (2008) · Plant Cell & Environment · doi:10.1111/j.1365-3040.2008.01858.x · Cited by 122
Variation in HMA4 gene copy number and expression among Noccaea caerulescens populations presenting different levels of Cd tolerance and accumulation
Craciun, A. R., Meyer, C.-L., Chen, J., Roosens, N. H. C., Groodt, R. D., Hilson, P., & Verbruggen, N. (2012) · Journal of Experimental Botany · doi:10.1093/jxb/ers104 · Cited by 122
Gene Expression Differences betweenNoccaea caerulescensEcotypes Help to Identify Candidate Genes for Metal Phytoremediation
Halimaa, P., Lin, Y., Ahonen, V. H., Blande, D., Clemens, S., Gyenesei, A., Häikiö, E., Kärenlampi, S. O., Laiho, A., Aarts, M. G. M., et al. (2014) · Environmental Science & Technology · doi:10.1021/es4042995 · Cited by 121
Molecular Characterization of the Homo-phytochelatin Synthase of Soybean Glycine max
Oven, M., Page, J. E., Zenk, M. H., & Kutchan, T. M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m108254200 · Cited by 119
The metal transporter PgIREG1 from the hyperaccumulator Psychotria gabriellae is a candidate gene for nickel tolerance and accumulation
Merlot, S., Hannibal, L., Martins, S., Martinelli, L., Amir, H., Lebrun, M., & Thomine, S. (2014) · Journal of Experimental Botany · doi:10.1093/jxb/eru025 · Cited by 119
Transcript levels of AtMRPs after cadmium treatment: induction of AtMRP3
Bovet, L., Eggmann, T., Meylan-Bettex, M., POLIER, J., Kammer, P. M., Marín, E., Feller, U., & Martinoia, E. (2003) · Plant Cell & Environment · doi:10.1046/j.1365-3040.2003.00968.x · Cited by 118
Root and shoot transcriptome analysis of two ecotypes of N occaea caerulescens uncovers the role of N c N ramp1 in C d hyperaccumulation
Milner, M. J., Mitani‐Ueno, N., Yamaji, N., Yokosho, K., Craft, E. J., Fei, Z., Ebbs, S. D., Zambrano, M. C., Feng, J. X., & Kochian, L. V. (2014) · The Plant Journal · doi:10.1111/tpj.12480 · Cited by 117
Seed and vascular expression of a high-affinity transporter for cationic amino acids in Arabidopsis.
Frommer, W. B., Hummel, S., Unseld, M., et al. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.26.12036 · Cited by 117
Iron-dependent changes of heavy metals, nicotianamine, and citrate in different plant organs and in the xylem exudate of two tomato genotypes. Nicotianamine as possible copper translocator
Pich, A., Scholz, G., & Stephan, U. W. (1995) · Springer eBooks · doi:10.1007/978-94-011-0503-3_8 · Cited by 117
Relationship between cadmium, glutathione and cadmium-binding peptides (phytochelatins) in leaves of intact tobacco seedlings
Vögeli‐Lange, R., & Wagner, G. J. (1996) · Plant Science · doi:10.1016/0168-9452(95)04299-7 · Cited by 117
Increased Activity of [gamma]-Glutamylcysteine Synthetase in Tomato Cells Selected for Cadmium Tolerance
Chen, J., & Goldsbrough, P. B. (1994) · PLANT PHYSIOLOGY · doi:10.1104/pp.106.1.233 · Cited by 117
Poly(γ-glutamylcysteinyl)glycine Synthesis in Datura innoxia and Binding with Cadmium
Delhaize, E., Jackson, P. J., Lujan, L. D., & Robinson, N. J. (1989) · PLANT PHYSIOLOGY · doi:10.1104/pp.89.2.700 · Cited by 116
Natural Variation at the FRD3 MATE Transporter Locus Reveals Cross-Talk between Fe Homeostasis and Zn Tolerance in Arabidopsis thaliana
Pineau, C. P., Loubet, S., Lefoulon, C., Chalies, C., Fizames, C., Lacombe, B., Ferrand, M., Loudet, O., Berthomieu, P., & Richard, O. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1003120 · Cited by 116
Possible involvement of plant ABC transporters in cadmium detoxification: a cDNA sub-microarray approach
Bovet, L., Feller, U., & Martinoia, E. (2004) · Environment International · doi:10.1016/j.envint.2004.10.011 · Cited by 115
Cadmium stress induces production of thiol compounds and transcripts for enzymes involved in sulfur assimilation pathways in Arabidopsis
Harada, E., Yamaguchi, Y., Koizumi, N., et al. (2002) · Journal of Plant Physiology · doi:10.1078/0176-1617-00733 · Cited by 115
Zinc hyperaccumulation in Thlaspi caerulescens. II. Influence on organic acids
Tolrà, R. P., Poschenrieder, C., & Barceló, J. (1996) · Journal of Plant Nutrition · doi:10.1080/01904169609365220 · Cited by 115
The intracellular Arabidopsis COPT5 transport protein is required for photosynthetic electron transport under severe copper deficiency
Garcia‐Molina, A., Andrés‐Colás, N., Perea‐García, A., del Valle-Tascón, S., Peñarrubia, L., & Puig, S. (2010) · The Plant Journal · doi:10.1111/j.1365-313x.2010.04472.x · Cited by 114
Inventory of metal complexes circulating in plant fluids: a reliable method based on HPLC coupled with dual elemental and high‐resolution molecular mass spectrometric detection
Flis, P., Ouerdane, L., Grillet, L., et al. (2016) · New Phytologist · doi:10.1111/nph.13964 · Cited by 114
Organic Acids Accumulation and Antioxidant Enzyme Activities in Thlaspi caerulescens under Zn and Cd Stress
Wójcik, M., Skórzyńska-Polit, E., & Tukiendorf, A. (2006) · Plant Growth Regulation · doi:10.1007/s10725-005-5816-4 · Cited by 112
Sub‐cellular localization of Ni in the hyperaccumulator, Hybanthus floribundus (Lindley) F. Muell
Bidwell, S. D., Crawford, S., Woodrow, I. E., Sommer‐Knudsen, J., & Marshall, A. T. (2004) · Plant Cell & Environment · doi:10.1111/j.0016-8025.2003.01170.x · Cited by 112
Toxicity of Copper, Cobalt, and Nickel Salts Is Dependent on Histidine Metabolism in the YeastSaccharomyces cerevisiae
Pearce, D. A., & Sherman, F. (1999) · Journal of Bacteriology · doi:10.1128/jb.181.16.4774-4779.1999 · Cited by 112
Phytochelatins as biomarkers for heavy metal stress in maize (Zea mays L.) and wheat (Triticum aestivum L.): combined effects of copper and cadmium
Keltjens, W. G., & Beusichem, M. L. V. (1998) · Plant and Soil · doi:10.1023/a:1004373700581 · Cited by 112
Zn and Fe biofortification: The right chemical environment for human bioavailability
Clemens, S. (2014) · Plant Science · doi:10.1016/j.plantsci.2014.05.014 · Cited by 111
Nicotianamine ‐ a common constituent of strategies I and II of iron acquisition by plants: A review
Scholz, G., Becker, R., Pich, A., & Stephan, U. W. (1992) · Journal of Plant Nutrition · doi:10.1080/01904169209364428 · Cited by 111
Three families of thiol peptides are induced by cadmium in maize
Meuwly, P., Thibault, P., Schwan, A. L., et al. (1995) · The Plant Journal · doi:10.1046/j.1365-313x.1995.7030391.x · Cited by 111
Identification of the form of Cd in the leaves of a superior Cd-accumulating ecotype of Thlaspi caerulescens using 113Cd-NMR
Ueno, D., Feng, J. X., Iwashita, T., Zhao, F. J., & McGrath, S. P. (2005) · Planta · doi:10.1007/s00425-005-1491-y · Cited by 110
Variability of zinc tolerance among and within populations of the pseudometallophyte species Arabidopsis halleri and possible role of directional selection
Meyer, C., Kostecka, A. A., Saumitou‐Laprade, P., Créach, A., Castric, V., Pauwels, M., & Frérot, H. (2010) · New Phytologist · doi:10.1111/j.1469-8137.2009.03062.x · Cited by 110
Maize Yellow Stripe1, an iron-phytosiderophore uptake transporter, is a member of the oligopeptide transporter (OPT) family
Yen, M. R., Tseng, Y.-H., & Saier, M. H. (2001) · Microbiology · doi:10.1099/00221287-147-11-2881 · Cited by 110
Contrasting cadmium resistance strategies in two metallicolous populations of Arabidopsis halleri
Corso, M., Schvartzman, M. S., Guzzo, F., Souard, F., Malkowski, E., Hanikenne, M., & Verbruggen, N. (2018) · New Phytologist · doi:10.1111/nph.14948 · Cited by 110
Iron-dependent changes of heavy metals, nicotianamine, and citrate in different plant organs and in the xylem exudate of two tomato genotypes. Nicotianamine as possible copper translocator
Pich, A., Scholz, G., & Stephan, U. W. (1994) · Plant and Soil · doi:10.1007/bf00008061 · Cited by 109
Does Speciation between Arabidopsis halleri and Arabidopsis lyrata Coincide with Major Changes in a Molecular Target of Adaptation?
Roux, C., Castric, V., Pauwels, M., Wright, S., Saumitou‐Laprade, P., & Vekemans, X. (2011) · PLoS ONE · doi:10.1371/journal.pone.0026872 · Cited by 107
Multi-tasking phytochelatin synthases
Clemens, S., & Peršoh, D. (2009) · Plant Science · doi:10.1016/j.plantsci.2009.06.008 · Cited by 106
A broad-scale analysis of population differentiation for Zn tolerance in an emerging model species for tolerance study: Arabidopsis halleri (Brassicaceae)
Pauwels, M., Frérot, H., Bonnin, I., & Saumitou-laprade, P. (2006) · Journal of Evolutionary Biology · doi:10.1111/j.1420-9101.2006.01178.x · Cited by 104
Arabidopsis thaliana expresses a second functional phytochelatin synthase
Cazalé, A., & Clemens, S. (2001) · FEBS Letters · doi:10.1016/s0014-5793(01)02976-3 · Cited by 104
A new amino acid, nicotianamine, from tobacco leaves
Noma, M., Noguchi, M., & Tamaki, E. (1971) · Tetrahedron Letters · doi:10.1016/s0040-4039(01)96769-3 · Cited by 104
Retention of Cadmium in Roots of Maize Seedlings (Role of Complexation by Phytochelatins and Related Thiol Peptides)
Rauser, W. E., & Meuwly, P. (1995) · PLANT PHYSIOLOGY · doi:10.1104/pp.109.1.195 · Cited by 102
Micro X-ray fluorescence imaging and micro X-ray absorption spectroscopy of cadmium hyper-accumulating plant, Arabidopsis halleri ssp. gemmifera, using high-energy synchrotron radiation
Fukuda, N., Hokura, A., 北島, 信., Terada, Y., Saito, H., Abe, T., & Nakai, I. (2008) · Journal of Analytical Atomic Spectrometry · doi:10.1039/b803602k · Cited by 102
A nickel-accumulating plant from Western Australia
Severne, B. C., & Brooks, R. R. (1972) · Planta · doi:10.1007/bf00394610 · Cited by 101
The Phytosiderophore Efflux Transporter TOM2 Is Involved in Metal Transport in Rice
Nozoye, T., Nagasaka, S., Kobayashi, T., Sato, Y., Uozumi, N., Nakanishi, H., & Nishizawa, N. K. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.635193 · Cited by 101
A novel plasma membrane-based NRAMP transporter contributes to Cd and Zn hyperaccumulation in Sedum alfredii Hance
Zhang, J., Zhang, M., Song, H., Zhao, J., Shabala, S. N., Tian, S., & Yang, X. (2020) · Environmental and Experimental Botany · doi:10.1016/j.envexpbot.2020.104121 · Cited by 99
Speciation analysis of nickel in the latex of a hyperaccumulating tree Sebertia acuminata by HPLC and CZE with ICP MS and electrospray MS-MS detection
Schaumlöffel, D., Ouerdane, L., Bouyssière, B., & Łobiński, R. (2003) · Journal of Analytical Atomic Spectrometry · doi:10.1039/b209819a · Cited by 98
Comparative studies of nickel, cobalt, and copper uptake by some nickel hyperaccumulators of the genus Alyssum
Homer, F. A., Morrison, R. S., Brooks, R. R., et al. (1991) · Plant and Soil · doi:10.1007/bf00012246 · Cited by 98
Localization of Nickel in Epidermal Subsidiary Cells of Leaves of Thlaspi montanum var. Siskiyouense (Brassicaceae) Using Energy-Dispersive X-Ray Microanalysis
Heath, S. M., Southworth, D., & D’Allura, J. A. (1997) · International Journal of Plant Sciences · doi:10.1086/297429 · Cited by 98
Nickel biopathways in tropical nickel hyperaccumulating trees from Sabah (Malaysia)
van der Ent, A., Callahan, D. L., Noller, B. N., Mesjasz‐Przybyłowicz, J., Przybyłowicz, W. J., Barnabas, A. D., & Harris, H. H. (2017) · Scientific Reports · doi:10.1038/srep41861 · Cited by 97
Iron-Nicotianamine Transporters Are Required for Proper Long Distance Iron Signaling
Kumar, R. K., Chu, H.-H., Abundis, C., Vasques, K. A., Chan-Rodríguez, D., Chia, J., Huang, R., Vatamaniuk, O. K., & Walker, E. L. (2017) · PLANT PHYSIOLOGY · doi:10.1104/pp.17.00821 · Cited by 97
The Role of Root Exudates in Nickel Hyperaccumulation and Tolerance in Accumulator and Nonaccumulator Species of Thlaspi
Salt, D. E., Kato, N., Krämer, U., Smith, R. D., & Raskin, I. (2020) · CRC Press eBooks · doi:10.1201/9780367803148-10 · Cited by 96
Evidence of various mechanisms of Cd sequestration in the hyperaccumulator Arabidopsis halleri, the non-accumulator Arabidopsis lyrata, and their progenies by combined synchrotron-based techniques
Isaure, M.-P., Huguet, S., Meyer, C.-L., Castillo-Michel, H., Testemale, D., Vantelon, D., Saumitou-Laprade, P., Verbruggen, N., & Sarret, G. (2015) · Journal of Experimental Botany · doi:10.1093/jxb/erv131 · Cited by 96
Molecular physiology of zinc transport in the Zn hyperaccumulator Thlaspi caerulescens
Lasat, M. M., Pence, N. S., Garvin, D. F., et al. (2000) · Journal of Experimental Botany · doi:10.1093/jxb/51.342.71 · Cited by 96
Role of Phytochelatins in Heavy Metal Stress and Detoxification Mechanisms in Plants
Gupta, D. K., Vandenhove, H., & Inouhe, M. (2013) · Springer eBooks · doi:10.1007/978-3-642-38469-1_4 · Cited by 95
Spatial distribution of cadmium in leaves of metal hyperaccumulating Thlaspi praecox using micro‐PIXE
Vogel‐Mikuš, K., Regvar, M., Mesjasz‐Przybyłowicz, J., Przybyłowicz, W. J., Simčič, J., Pelicon, P., & Budnar, M. (2008) · New Phytologist · doi:10.1111/j.1469-8137.2008.02519.x · Cited by 94
An update on the ABCC transporter family in plants: many genes, many proteins, but how many functions?
Wanke, D., & Kolukisaoglu, H. Ü. (2010) · Plant Biology · doi:10.1111/j.1438-8677.2010.00380.x · Cited by 92
Root-Secreted Nicotianamine from Arabidopsis halleri Facilitates Zinc Hypertolerance by Regulating Zinc Bioavailability
Tsednee, M., Yang, S.-C., Lee, D., & Yeh, K. (2014) · PLANT PHYSIOLOGY · doi:10.1104/pp.114.241224 · Cited by 92
Organic Ligand and pH Effects on Isotopically Exchangeable Cadmium in Polluted Soils
Collins, R. N., Merrington, G., McLaughlin, M. J., et al. (2003) · Soil Science Society of America Journal · doi:10.2136/sssaj2003.1120 · Cited by 91
Cytosolic metal handling in plants: determinants for zinc specificity in metal transporters and metallothioneins
Blindauer, C. A., & Schmid, R. (2010) · Metallomics · doi:10.1039/c004880a · Cited by 91
CeHMT-1, a Putative Phytochelatin Transporter, Is Required for Cadmium Tolerance in Caenorhabditis elegans
Vatamaniuk, O. K., Bucher, E. A., Sundaram, M. V., & Rea, P. A. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m503362200 · Cited by 90
Purine Biosynthetic Genes Are Required for Cadmium Tolerance in Schizosaccharomyces pombe
Speiser, D. M., Ortiz, D. F., Kreppel, L. K., Scheel, G., McDonald, G., & Ow, D. W. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.12.5301 · Cited by 89
Cadmium detoxification in roots of Pisum sativum seedlings: relationship between toxicity levels, thiol pool alterations and growth
Lima, A., Pereira, S. I. A., Figueira, E. M. D. A. P., Caldeira, G., & Caldeira, H. D. Q. D. M. (2004) · Environmental and Experimental Botany · doi:10.1016/j.envexpbot.2004.10.008 · Cited by 89
Phloem translocation of Fe, Cu, Mn, and Zn in Ricinus seedlings in relation to the concentrations of nicotianamine, an endogenous chelator of divalent metal ions, in different seedling parts
Stephan, U. W., Schmidke, I., & Pich, A. (1995) · Springer eBooks · doi:10.1007/978-94-011-0503-3_7 · Cited by 89
Mechanisms of Plant Resistance to Metal and Metalloid Ions and Potential Biotechnological Applications
Meharg, A. A. (2005) · Plant and Soil · doi:10.1007/s11104-004-0262-z · Cited by 89
Copper uptake and translocation in chicory (Cichorium intybus L. cv Grasslands Puna) and tomato (Lycopersicon esculentum Mill. cv Rondy) plants grown in NFT system. II. The role of nicotianamine and histidine in xylem sap copper transport
Liao, M. T., Hedley, M. J., Woolley, D. J., Brooks, R. R., & Nichols, M. A. (2000) · Plant and Soil · doi:10.1023/a:1004843505053 · Cited by 88
Cadmium-Sulfide Crystallites in Cd-(γEC)nG Peptide Complexes from Tomato
Reese, R. N., White, C. A., & Winge, D. R. (1992) · PLANT PHYSIOLOGY · doi:10.1104/pp.98.1.225 · Cited by 88
Different effects of calcium and lanthanum on the expression of phytochelatin synthase gene and cadmium absorption in Lactuca sativa
He, Z., Li, J., Zhang, H., & Ma, M. (2004) · Plant Science · doi:10.1016/j.plantsci.2004.07.001 · Cited by 88
Stem and leaf sequestration of zinc at the cellular level in the hyperaccumulator Sedum alfredii
Tian, S., Lu, L., Yang, X., Labavitch, J. M., Huang, Y., & Brown, P. H. (2009) · New Phytologist · doi:10.1111/j.1469-8137.2008.02740.x · Cited by 88
Evolution of proteomes: fundamental signatures and global trends in amino acid compositions
Tekaia, F., & Yeramian, E. (2006) · BMC Genomics · doi:10.1186/1471-2164-7-307 · Cited by 87
Nature of nickel complexes in Psychotria douarrei and other nickel-accumulating plants
Kersten, W. J., Brooks, R. R., Reeves, R. D., & Jaffré, A. (1980) · Phytochemistry · doi:10.1016/0031-9422(80)83013-5 · Cited by 87
Phytochelatin synthesis plays a similar role in shoots of the cadmium hyperaccumulator Sedum alfredii as in non‐resistant plants
Zhang, Z., Chen, B.-X., & Qiu, B. (2010) · Plant Cell & Environment · doi:10.1111/j.1365-3040.2010.02144.x · Cited by 86
Poly(γ‐glutamylcysteinyl)glycines or phytochelatins and their role in cadmium tolerance of Silene vulgaris
Verkleij, J. A. C., Koevoets, P. L. M., Riet, J. V. '., Bank, R. A., NIJDAM, Y., & Ernst, W. H. O. (1990) · Plant Cell & Environment · doi:10.1111/j.1365-3040.1990.tb01981.x · Cited by 86
Speciation of non-covalent nickel species in plant tissue extracts by electrospray Q-TOFMS/MS after their isolation by 2D size exclusion-hydrophilic interaction LC (SEC-HILIC) monitored by ICP-MS
Ouerdane, L., Mari, S., Czernic, P., Lebrun, M., & Łobiński, R. (2006) · Journal of Analytical Atomic Spectrometry · doi:10.1039/b602689c · Cited by 86
Dynamic imaging of cytosolic zinc in A rabidopsis roots combining FRET sensors and RootChip technology
Lanquar, V., Großmann, G., Vinkenborg, J. L., Merkx, M., Thomine, S., & Frommer, W. B. (2013) · New Phytologist · doi:10.1111/nph.12652 · Cited by 86
Evolution of metal hyperaccumulation and phytoremediation hype
Ernst, W. H. O. (2000) · New Phytologist · doi:10.1046/j.1469-8137.2000.00669.x · Cited by 85
Genetic architecture of zinc hyperaccumulation in Arabidopsis halleri: the essential role of QTL × environment interactions
Frérot, H., Faucon, M., Willems, G., Godé, C., Courseaux, A., Darracq, A., Verbruggen, N., & Saumitou‐Laprade, P. (2010) · New Phytologist · doi:10.1111/j.1469-8137.2010.03295.x · Cited by 85
Relationships of nicotianamine and other amino acids with nickel, zinc and iron in Thlaspi hyperaccumulators
Callahan, D. L., Kolev, S. D., O’Hair, R. A. J., Salt, D. E., & Baker, A. J. M. (2007) · New Phytologist · doi:10.1111/j.1469-8137.2007.02216.x · Cited by 85
Purification and characterization of nicotianamine synthase from Fe-deficient barley roots
Higuchi, K., Kanazawa, K., Nishizawa, N., et al. (1994) · Plant and Soil · doi:10.1007/bf00008059 · Cited by 85
Complexation of cadmium in seeds and vegetative tissues of the cadmium hyperaccumulator Thlaspi praecox as studied by X-ray absorption spectroscopy
Vogel‐Mikuš, K., Arčon, I., & Kodre, A. (2010) · Plant and Soil · doi:10.1007/s11104-009-0264-y · Cited by 84
Identification of three relationships linking cadmium accumulation to cadmium tolerance and zinc and citrate accumulation in lettuce
Zorrig, W., Rouached, A., Shahzad, Z., et al. (2010) · Journal of Plant Physiology · doi:10.1016/j.jplph.2010.04.012 · Cited by 83
Nickel accumulation by Hybanthus floribundus
Severne, B. C. (1974) · Nature · doi:10.1038/248807a0 · Cited by 83
Two mulberry phytochelatin synthase genes confer zinc/cadmium tolerance and accumulation in transgenic Arabidopsis and tobacco
Fan, W., Guo, Q. Q., Liu, C., Liu, X., Zhang, M., Long, D., Xiang, Z., & Zhao, A. (2017) · Gene · doi:10.1016/j.gene.2017.12.042 · Cited by 83
Cd - tolerance of maize, rye and wheat seedlings
Wójicik, M., & Tukendorf, A. (1999) · Acta Physiologiae Plantarum · doi:10.1007/s11738-999-0063-3 · Cited by 82
Enhancing the first enzymatic step in the histidine biosynthesis pathway increases the free histidine pool and nickel tolerance in Arabidopsis thaliana
Wycisk, K. A., Kim, E. J., Schroeder, J. I., & Krämer, U. (2004) · FEBS Letters · doi:10.1016/j.febslet.2004.10.086 · Cited by 82
Selection on Synthesis Cost Affects Interprotein Amino Acid Usage in All Three Domains of Life
Swire, J. S. (2007) · Journal of Molecular Evolution · doi:10.1007/s00239-006-0206-8 · Cited by 81
Genetic Dissection of Histidine Biosynthesis in Arabidopsis
Muralla, R., Sweeney, C., Stepansky, A., et al. (2007) · PLANT PHYSIOLOGY · doi:10.1104/pp.107.096511 · Cited by 80
Function and Regulation of the Plant COPT Family of High-Affinity Copper Transport Proteins
Puig, S. (2014) · Advances in Botany · doi:10.1155/2014/476917 · Cited by 79
The Occurrence of the Amino Acid Nicotianamine in Plants and Microorganisms. A Reinvestigation
Rudolph, A., Becker, R., Scholz, G., et al. (1985) · Biochemie und Physiologie der Pflanzen · doi:10.1016/s0015-3796(85)80036-6 · Cited by 79
Phloem translocation of Fe, Cu, Mn, and Zn in Ricinus seedlings in relation to the concentrations of nicotianamine, an endogenous chelator of divalent metal ions, in different seedling parts
Stephan, U. W., Schmidke, I., & Pich, A. (1994) · Plant and Soil · doi:10.1007/bf00008060 · Cited by 79
Heterologous Expression of a Nelumbo nucifera Phytochelatin Synthase Gene Enhances Cadmium Tolerance in Arabidopsis thaliana
Liu, Z., Gu, C., Chen, F., Yang, D., Wu, K., Chen, S., Jiang, J., & Zhang, Z. (2011) · Applied Biochemistry and Biotechnology · doi:10.1007/s12010-011-9461-2 · Cited by 78
Nicotianamine forms complexes with Zn(ii)in vivo
Trampczynska, A., Küpper, H., Meyer‐Klaucke, W., Schmidt, H., & Clemens, S. (2009) · Metallomics · doi:10.1039/b913299f · Cited by 77
Phenotyping 60 populations of Noccaea caerulescens provides a broader knowledge of variation in traits of interest for phytoextraction
Sterckeman, T., Cazes, Y., Gonneau, C., & Sirguey, C. (2017) · Plant and Soil · doi:10.1007/s11104-017-3311-0 · Cited by 77
Cytosolic Action of Phytochelatin Synthase
Blum, R., Meyer, K. C., Wünschmann, J., Lendzian, K. J., & Grill, E. (2010) · PLANT PHYSIOLOGY · doi:10.1104/pp.109.149922 · Cited by 76
A Highly Sensitive, Quick and Simple Quantification Method for Nicotianamine and 2′-Deoxymugineic Acid from Minimum Samples Using LC/ESI-TOF-MS Achieves Functional Analysis of These Components in Plants
Kakei, Y., Yamaguchi, I., Kobayashi, T., et al. (2009) · Plant and Cell Physiology · doi:10.1093/pcp/pcp141 · Cited by 76
Adaptation to high zinc depends on distinct mechanisms in metallicolous populations of Arabidopsis halleri
Schvartzman, S., Corso, M., Fataftah, N., Scheepers, M., Nouet, C., Bosman, B., Carnol, M., Motté, P., Verbruggen, N., & Hanikenne, M. (2018) · New Phytologist · doi:10.1111/nph.14949 · Cited by 76
Purification and characterization of nicotianamine synthase from Fe-deficient barley roots
Higuchi, K., Kanazawa, K., Nishizawa, N., et al. (1995) · Springer eBooks · doi:10.1007/978-94-011-0503-3_5 · Cited by 75
Copper in xylem and phloem saps from rice (Oryza sativa): the effect of moderate copper concentrations in the growth medium on the accumulation of five essential metals and a speciation analysis of copper-containing compounds
Ando, Y., Nagata, S., Yanagisawa, S., & Yoneyama, T. (2012) · Functional Plant Biology · doi:10.1071/fp12158 · Cited by 74
Histidine‐mediated xylem loading of zinc is a species‐wide character in N occaea caerulescens
Kozhevnikova, A. D., Seregin, I. V., Erlikh, N. T., Shevyreva, T. A., Andreev, I. M., Verweij, R. A., & Schat, H. (2014) · New Phytologist · doi:10.1111/nph.12816 · Cited by 74
Self-citation
Localization and functional characterization of metal-binding sites in phytochelatin synthases
Maier, T. H. P., Yu, C., K�llertz, G., & Clemens, S. (2003) · Planta · doi:10.1007/s00425-003-1091-7 · Cited by 74
Schizosaccharomyces pombeas a model for metal homeostasis in plant cells: the phytochelatin‐dependent pathway is the main cadmium detoxification mechanism
Clemens, S., & Simm, C. (2003) · New Phytologist · doi:10.1046/j.1469-8137.2003.00811.x · Cited by 74
Characterization of the high affinity Zn transporter from Noccaea caerulescens, NcZNT1, and dissection of its promoter for its role in Zn uptake and hyperaccumulation
Milner, M. J., Craft, E., Yamaji, N., Koyama, E., Ma, J. F., & Kochian, L. V. (2012) · New Phytologist · doi:10.1111/j.1469-8137.2012.04144.x · Cited by 73
Transcriptional regulation of Arabidopsis thaliana phytochelatin synthase ( AtPCS1 ) by cadmium during early stages of plant development
Lee, S., & Korban, S. S. (2002) · Planta · doi:10.1007/s00425-002-0821-6 · Cited by 73
Contrasting effects of nicotianamine synthase knockdown on zinc and nickel tolerance and accumulation in the zinc/cadmium hyperaccumulator A rabidopsis halleri
Cornu, J., Deinlein, U., Höreth, S., Braun, M., Schmidt, H., Weber, M., Persson, D. P., Husted, S., Schjoerring, J. K., & Clemens, S. (2014) · New Phytologist · doi:10.1111/nph.13237 · Cited by 73
Accumulation mechanisms and heavy metal tolerance of a nickel hyperaccumulator
Gabbrielli, R., Mattioni, C., & Vergnano, O. (1991) · Journal of Plant Nutrition · doi:10.1080/01904169109364266 · Cited by 72
A proteomics approach to investigate the process of Zn hyperaccumulation in Noccaea caerulescens ( J & C . Presl) F . K . Meyer
Schneider, T., Persson, D. P., Husted, S., Schellenberg, M., Gehrig, P., Lee, Y., Martinoia, E., Schjoerring, J. K., & Meyer, S. (2013) · The Plant Journal · doi:10.1111/tpj.12022 · Cited by 71
Local and systemic signaling of iron status and its interactions with homeostasis of other essential elements
Gayomba, S. R., Zhai, Z., Jung, H., & Vatamaniuk, O. K. (2015) · Frontiers in Plant Science · doi:10.3389/fpls.2015.00716 · Cited by 70
γ‐Glutamylcysteinylglutamic acid ‐ a new homologue of glutathione in maize seedlings exposed to cadmium
Meuwly, P., Thibault, P., & Rauser, W. E. (1993) · FEBS Letters · doi:10.1016/0014-5793(93)80858-r · Cited by 69
Azetidine-2-carboxylic acid derivatives from seeds of Fagus silvatica L. and a revised structure for nicotianamine
Kristensen, I., & Larsen, P. O. (1974) · Phytochemistry · doi:10.1016/0031-9422(74)80243-8 · Cited by 67
The use of the model species Arabidopsis halleri towards phytoextraction of cadmium polluted soils
Meyer, C.-L., & Verbruggen, N. (2012) · New Biotechnology · doi:10.1016/j.nbt.2012.07.009 · Cited by 67
Facilitated citrate-dependent iron translocation increases rice endosperm iron and zinc concentrations
Wu, T., Gruissem, W., & Bhullar, N. K. (2018) · Plant Science · doi:10.1016/j.plantsci.2018.02.002 · Cited by 66
Nickel translocation via the phloem in the hyperaccumulator Noccaea caerulescens (Brassicaceae)
Deng, T., Tang, Y., van der Ent, A., Sterckeman, T., Echevarria, G., Morel, J., & Qiu, R. (2016) · Plant and Soil · doi:10.1007/s11104-016-2825-1 · Cited by 65
Cd2+ and Pb2+ complexation by glutathione and the phytochelatins
Jacquart, A., Brayner, R., Chahine, J. E. H., et al. (2016) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2016.09.002 · Cited by 65
The Nicotianamine Synthase Gene Is a Useful Candidate for Improving the Nutritional Qualities and Fe-Deficiency Tolerance of Various Crops
Nozoye, T. (2018) · Frontiers in Plant Science · doi:10.3389/fpls.2018.00340 · Cited by 65
Paralogs and mutants show that one DMA synthase functions in iron homeostasis in rice
Bashir, K., Nozoye, T., Nagasaka, S., Rasheed, S., Miyauchi, N., Seki, M., Nakanishi, H., & Nishizawa, N. K. (2017) · Journal of Experimental Botany · doi:10.1093/jxb/erx065 · Cited by 64
Nicotianamine synthase 2 localizes to the vesicles of iron‐deficient rice roots, and its mutation in the YXX φ or LL motif causes the disruption of vesicle formation or movement in rice
Nozoye, T., Nagasaka, S., Bashir, K., et al. (2013) · The Plant Journal · doi:10.1111/tpj.12383 · Cited by 63
Phytochelatin homologs induced in hairy roots of horseradish
Kubota, H., Sato, K., Yamada, T., et al. (2000) · Phytochemistry · doi:10.1016/s0031-9422(99)00493-8 · Cited by 63
Drosophila ABC Transporter, DmHMT-1, Confers Tolerance to Cadmium
Sooksa-nguan, T., Yakubov, B., Kozlovskyy, V. I., Barkume, C. M., Howe, K. J., Thannhauser, T. W., Rutzke, M. A., Hart, J. J., Kochian, L. V., Rea, P. A., et al. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m806501200 · Cited by 63
The bifunctional transporter‐receptor IRT 1 at the heart of metal sensing and signalling
Cointry, V., & Vert, G. (2019) · New Phytologist · doi:10.1111/nph.15826 · Cited by 63
Essential and Detrimental — an Update on Intracellular Iron Trafficking and Homeostasis
Vigani, G., Solti, Ï., Thomine, S. ⁄. B., & Philippar, K. (2019) · Plant and Cell Physiology · doi:10.1093/pcp/pcz091 · Cited by 62
Characterizing the Crucial Components of Iron Homeostasis in the Maize Mutants ys1 and ys3
Nozoye, T., Nakanishi, H., & Nishizawa, N. K. (2013) · PLoS ONE · doi:10.1371/journal.pone.0062567 · Cited by 61
Influence of CdCl2 and CdSO4 supplementation on Cd distribution and ligand environment in leaves of the Cd hyperaccumulator Noccaea (Thlaspi) praecox
Koren, Š., Arčon, I., Kump, P., Nečemer, M., & Vogel‐Mikuš, K. (2013) · Plant and Soil · doi:10.1007/s11104-013-1617-0 · Cited by 61
Biomolecular approaches to understanding metal tolerance and hyperaccumulation in plants
Corso, M., & García de la Torre, V. S. (2020) · Metallomics · doi:10.1039/d0mt00043d · Cited by 60
Nuclear micro-probe analysis of Arabidopsis thaliana leaves
Ager, F. J., Ynsa, M. D., Domı&#x;nguez-Solı&#x;s, J. R., López-Martı&#x;n, M. C., Gotor, C., & Romero, L. C. (2003) · Nuclear Instruments and Methods in Physics Research Section B Beam Interactions with Materials and Atoms · doi:10.1016/s0168-583x(03)01046-2 · Cited by 57
Two Purine Biosynthetic Enzymes That Are Required for Cadmium Tolerance in Schizosaccharomyces pombe Utilize Cysteine Sulfinate in Vitro
Juang, R., McCue, K. F., & Ow, D. W. (1993) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1993.1367 · Cited by 57
Current Market Trends in Phytoremediation
Glass, D. J. (1999) · International Journal of Phytoremediation · doi:10.1080/15226519908500001 · Cited by 57
Multi-element bioimaging of Arabidopsis thaliana roots
Persson, D. P., Chen, A., Aarts, M. G. M., et al. (2016) · PLANT PHYSIOLOGY · doi:10.1104/pp.16.00770 · Cited by 57
Intra-specific variation in zinc, cadmium and nickel hypertolerance and hyperaccumulation capacities in Noccaea caerulescens
Kozhevnikova, A. D., Seregin, I. V., Aarts, M. G. M., & Schat, H. (2020) · Plant and Soil · doi:10.1007/s11104-020-04572-7 · Cited by 56
Self-citation
Induction ofIRT1by the nickel-induced iron-deficient response in Arabidopsis
Nishida, S., Aisu, A., & Mizuno, T. (2012) · Plant Signaling & Behavior · doi:10.4161/psb.19263 · Cited by 55
Changes in glutathione content of maize seedlings exposed to cadmium
Rauser, W. E. (1987) · Plant Science · doi:10.1016/0168-9452(87)90190-7 · Cited by 55
Phytochelatin Synthesis Promotes Leaf Zn Accumulation ofArabidopsis thalianaPlants Grown in Soil with Adequate Zn Supply and is Essential for Survival on Zn-Contaminated Soil
Kühnlenz, T., Hofmann, C., Uraguchi, S., Schmidt, H., Schempp, S., Weber, M., Lahner, B., Salt, D. E., & Clemens, S. (2016) · Plant and Cell Physiology · doi:10.1093/pcp/pcw148 · Cited by 55
The Missing Link in Plant Histidine Biosynthesis: Arabidopsismyoinositol monophosphatase-like2Encodes a Functional Histidinol-Phosphate Phosphatase
Petersen, L. N., Marineo, S., Mandalà, S., et al. (2009) · PLANT PHYSIOLOGY · doi:10.1104/pp.109.150805 · Cited by 54
Structural element responsible for the Fe(III)–phytosiderophore specific transport by HvYS1 transporter in barley
Harada, E., Sugase, K., Namba, K., Iwashita, T., & Murata, Y. (2007) · FEBS Letters · doi:10.1016/j.febslet.2007.08.011 · Cited by 54
Comparative analyses of phytochelatin synthase ( PCS ) genes in higher plants
Filiz, E., Saracoglu, I. A., Özyiğit, İ. İ., & Yalçın, B. (2019) · Biotechnology & Biotechnological Equipment · doi:10.1080/13102818.2018.1559096 · Cited by 54
Heavy metal specificity of cellular tolerance in two hyperaccumulating plants, Arabidopsis halleri and Thlaspi caerulescens
Marqués, L. P., Cossegal, M., Bodin, S., Czernic, P., & Lebrun, M. (2004) · New Phytologist · doi:10.1111/j.1469-8137.2004.01178.x · Cited by 53

Research works printed but not linked: 5

Callahan DL, Kolev SD, O’Hair RAJ, Baker AJM (2005) The detection of nicotianamine in nickel hyperaccumulating plants. In: Lombi E (ed) Proceedings of the 8th International Conference on the Biogeochemistry of Trace Elements (ICOBTE). Adelaide, Australia: CSIRO Land and Water Adelaide, pp 822–823
Ernst WHO (1999) Effects of heavy metals in plants at the cellular and organismic level. In: Schuurmann G, Markert B (ed) Ecotoxicology. Ecological Fundamentals, Chemical Exposure and Biological Effects. Wiley Publishing House. Heidelberg. pp 587–620
Ingle RA (2011) Histidine biosynthesis. The arabidopsis book. American Society of Plant Biologists 9:1–9
Minguzzi C, Vegnano O (1948) Il contenuto di nichel nelle ceneri di Alyssum bertelonii. Desv Atti Soc Toscana Sci Nat 55:49–74
Reeves RD, Baker AJM (2000) Metal-accumulating plants. In: Raskin I, Ensley BD (eds) Phytoremediation of toxic metals: using plants to clean up the environment. Wiley, New York, pp 193–229

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Authors: Seregin, I. V., & Kozhevnikova, A. D.
Affiliations: Timiryazev Institute of Plant Physiology (RU)
Corresponding author: Seregin, I. V.
ORCID: Seregin, I. V.
Kozhevnikova, A. D.
Venue: Photosynthesis Research
Publisher: Springer Science and Business Media LLC
Published: 2020-07-11
Volume: 150
Issue: 1-3
Pages: 51-96
ISSN: 0166-8595 (ISSN-L)
1573-5079
DOI: 10.1007/s11120-020-00768-1
OpenAlex: W3041383585
Cited by: 73
References: 481
Citations by year: 2026: 13 · 2025: 10 · 2024: 15 · 2023: 9 · 2022: 13 · 2021: 11 · 2020: 2
FWCI: 0.74
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Photosynthesis Research (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Micronutrient Interactions and Effects
Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant nutrient uptake and metabolism
Physical Sciences › Environmental Science › Pollution › Heavy metals in environment
Keywords: low molecular weight ligands, metal homeostasis, metal hyperaccumulation, nicotianamine, histidine, phytochelatins, phytosiderophores, organic acids, metal transport, metal detoxification, metal sequestration, metal tolerance, phytoremediation, phytomining, biofortification, micronutrient uptake, ionomics
MeSH terms: Homeostasis, Ligands, Metals, Plants, Plant Physiological Phenomena

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Low-molecular-weight ligands in plants: role in metal homeostasis and hyperaccumulation

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