Cited by 259Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsMedicinal Plants and Neuroprotection

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Apolipoprotein E, gender, and Alzheimer’s disease: an overlooked, but potent and promising interaction

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Ungar, Leo, Altmann, Andre, Greicius, Michael D.·2014·Brain Imaging and Behavior

DOI 10.1007/s11682-013-9272-xPMC PMC4282773

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Abstract

Alzheimer's disease (AD) is an increasingly prevalent, fatal neurodegenerative disease that has proven resistant, thus far, to all attempts to prevent it, forestall it, or slow its progression. The ε4 allele of the Apolipoprotein E gene (APOE4) is a potent genetic risk factor for sporadic and late-onset familial AD. While the link between APOE4 and AD is strong, many expected effects, like increasing the risk of conversion from MCI to AD, have not been widely replicable. One critical, and commonly overlooked, feature of the APOE4 link to AD is that several lines of evidence suggest it is far more pronounced in women than in men. Here we review previous literature on the APOE4 by gender interaction with a particular focus on imaging-related studies.

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Authors: Ungar, L., Altmann, A., & Greicius, M. D.
Affiliations: Stanford Medicine (US)
Corresponding author: Ungar, Leo
ORCID: Greicius, Michael D.
Venue: Brain Imaging and Behavior
Publisher: Springer Science and Business Media LLC
Published: 2013-11-30
Volume: 8
Issue: 2
Pages: 262-273
ISSN: 1931-7557 (ISSN-L)
1931-7565
DOI: 10.1007/s11682-013-9272-x
PMC: PMC4282773
OpenAlex: W2007870551
Semantic Scholar: a36142356acf18bedeb996827856502949b3d3b7
Cited by: 246
References: 140
Citations by year: 2026: 17 · 2025: 25 · 2024: 42 · 2023: 21 · 2022: 14 · 2021: 29 · 2020: 24 · 2019: 22 · 2018: 19 · 2017: 10 · 2016: 12 · 2015: 8 · 2014: 3
FWCI: 0.89
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Brain Imaging and Behavior (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
UCL Discovery (University College London) (submittedVersion)
Funders: National Institute of Neurological Disorders and Stroke (R01NS073498)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
Keywords: Alzheimer's disease, apolipoprotein E, APOE ε4, sex differences, gender interaction, genetic risk factors, mild cognitive impairment, neuroimaging
MeSH terms: Alzheimer Disease, Animals, Female, Humans, Male, Sex Factors, Genetic Predisposition to Disease, Apolipoprotein E4

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Apolipoprotein E, gender, and Alzheimer’s disease: an overlooked, but potent and promising interaction

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