Cited by 259Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsMedicinal Plants and Neuroprotection

The DOI matches its Crossref record; 140 of the 140 references it cites were found in a registry or an index.

Apolipoprotein E, gender, and Alzheimer’s disease: an overlooked, but potent and promising interaction

Open access

Ungar, Leo, Altmann, Andre, Greicius, Michael D.·2014·Brain Imaging and Behavior

DOI 10.1007/s11682-013-9272-xPMC PMC4282773

Open this paper in CoChat — free account

Abstract

Alzheimer's disease (AD) is an increasingly prevalent, fatal neurodegenerative disease that has proven resistant, thus far, to all attempts to prevent it, forestall it, or slow its progression. The ε4 allele of the Apolipoprotein E gene (APOE4) is a potent genetic risk factor for sporadic and late-onset familial AD. While the link between APOE4 and AD is strong, many expected effects, like increasing the risk of conversion from MCI to AD, have not been widely replicable. One critical, and commonly overlooked, feature of the APOE4 link to AD is that several lines of evidence suggest it is far more pronounced in women than in men. Here we review previous literature on the APOE4 by gender interaction with a particular focus on imaging-related studies.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1007/s11682-013-9272-x

Cites

140 of 140 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

The diagnosis of dementia due to Alzheimer's disease: Recommendations from the National Institute on Aging‐Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease
McKhann, G. M., Knopman, D. S., Chertkow, H., Hyman, B. T., Jack, C. R., Kawas, C. H., Klunk, W. E., Koroshetz, W. J., Manly, J. J., Mayeux, R., et al. (2011) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2011.03.005 · Cited by 18,657
The diagnosis of mild cognitive impairment due to Alzheimer's disease: Recommendations from the National Institute on Aging‐Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease
Albert, M. S., DeKosky, S. T., Dickson, D., Dubois, B., Feldman, H. H., Fox, N. C., Gamst, A., Holtzman, D. M., Jagust, W. J., Petersen, R. C., et al. (2011) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2011.03.008 · Cited by 10,152 · cited 1×
“In AD research, the field has adopted several imaging and CSF protein biomarkers that can be used alone, or in conjunction with clinical information, to guide research and improve diagnostic accuracy (Albert et al. 2011; McKhann et al. 2011; Sperling et al. 2011).”
Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families
Corder, E. H., Saunders, A. M., Strittmatter, W. J., Schmechel, D. E., Gaskell, P. C., Small, G. W., Roses, A. D., Haines, J. L., & Pericak-Vance, M. A. (1993) · Science · doi:10.1126/science.8346443 · Cited by 9,429
Toward defining the preclinical stages of Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease
Sperling, R. A., Aisen, P. S., Beckett, L. A., Bennett, D. A., Craft, S., Fagan, A. M., Iwatsubo, T., Jack, C. R., Kaye, J., Montine, T. J., et al. (2011) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2011.03.003 · Cited by 7,155
The American Journal of Human Genetics
S., J. (1950) · Population · doi:10.2307/1523704 · Cited by 5,124
Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.
Strittmatter, W. J., Saunders, A. M., Schmechel, D., Pericak-Vance, M., Enghild, J., Salvesen, G. S., & Roses, A. D. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.5.1977 · Cited by 4,268
Clinical and biomarker changes in dominantly inherited Alzheimer's disease
Bateman, R. J., Xiong, C., Benzinger, T. L. S., Fagan, A. M., Goate, A., Fox, N. C., Marcus, D. S., Cairns, N. J., Xie, X., Blazey, T. M., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1202753 · Cited by 3,814
Association of apolipoprotein E allele ϵ4 with late‐onset familial and sporadic Alzheimer's disease
Saunders, A. M., Strittmatter, W. J., Schmechel, D., St. George-Hyslop, P. H., Pericak-Vance, M. A., Joo, S. H., Rosi, B. L., Gusella, J. F., Crapper-MacLachlan, D. R., Alberts, M. J., et al. (1993) · Neurology · doi:10.1212/wnl.43.8.1467 · Cited by 3,786
Default-mode network activity distinguishes Alzheimer’s disease from healthy aging: evidence from functional MRI
Greicius, M. D., Srivastava, G., Reiss, A. L., & Menon, V. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308627101 · Cited by 3,684
Self-citation
The Diagnosis of Mild Cognitive Impairment due to Alzheimer’s Disease: Recommendations from the National Institute on Aging-Alzheimer’s Association Workgroups on Diagnostic Guidelines for Alzheimer’s Disease
Albert, M., DeKosky, S. T., Dickson, D. W., Dubois, B., Feldman, H., Fox, N. C., Gamst, A. C., Holtzman, D. M., Jagust, W. J., Petersen, R. C., et al. (2013) · FOCUS The Journal of Lifelong Learning in Psychiatry · doi:10.1176/appi.focus.11.1.96 · Cited by 2,643
Cerebrospinal fluid biomarker signature in Alzheimer's disease neuroimaging initiative subjects
Shaw, L. M., Vanderstichele, H., Knapik‐Czajka, M., Clark, C. M., Aisen, P. S., Petersen, R. C., Blennow, K., Soares, H., Simon, A., Lewczuk, P., et al. (2009) · Annals of Neurology · doi:10.1002/ana.21610 · Cited by 2,065
Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease
Corder, E. H., Saunders, A. M., Risch, N. J., Strittmatter, W. J., Schmechel, D. E., Gaskell, P. C., Rimmler, J. B., Locke, P. A., Conneally, P. M., Schmader, K. E., et al. (1994) · Nature Genetics · doi:10.1038/ng0694-180 · Cited by 1,920
Vitamin E and Donepezil for the Treatment of Mild Cognitive Impairment
Petersen, R. C., Thomas, R. G., Grundman, M., Bennett, D., Doody, R., Ferris, S., Galasko, D., Jin, S., Kaye, J., Levey, A., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa050151 · Cited by 1,844
A 24-week, double-blind, placebo-controlled trial of donepezil in patients with Alzheimer's disease
Rogers, S. L., Farlow, M. R., Doody, R. S., Mohs, R., Friedhoff, L. T., & Donepezil Study Group* (1998) · Neurology · doi:10.1212/wnl.50.1.136 · Cited by 1,618
Distinct patterns of brain activity in young carriers of the APOE -ε4 allele
Filippini, N., MacIntosh, B. J., Hough, M. G., Goodwin, G. M., Frisoni, G. B., Smith, S. M., Matthews, P. M., Beckmann, C. F., & Mackay, C. E. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0811879106 · Cited by 1,613
Preclinical Evidence of Alzheimer's Disease in Persons Homozygous for the ε4 Allele for Apolipoprotein E
Reiman, E. M., Caselli, R. J., Yun, L. S., Chen, K., Bandy, D., Minoshima, S., Thibodeau, S. N., & Osborne, D. (1996) · New England Journal of Medicine · doi:10.1056/nejm199603213341202 · Cited by 1,366
Patterns of Brain Activation in People at Risk for Alzheimer's Disease
Bookheimer, S. Y., Strojwas, M. H., Cohen, M. S., Saunders, A. M., Pericak-Vance, M. A., Mazziotta, J. C., & Small, G. W. (2000) · New England Journal of Medicine · doi:10.1056/nejm200008173430701 · Cited by 1,328
International Journal of Geriatric Psychiatry
Robinson, L., Hutchings, D., Dickinson, H. O., Corner, L., Beyer, F., Finch, T. L., Hughes, J., Vanoli, A., Ballard, C. G., & Bond, J. (2006) · International Journal of Geriatric Psychiatry · doi:10.1002/(issn)1099-1166 · Cited by 1,301
Human ApoE isoforms differentially regulate brain amyloid-β peptide clearance
Castellano, J. M., Kim, J., Stewart, F. R., Jiang, H., DeMattos, R. B., Patterson, B. W., Fagan, A. M., Morris, J. C., Mawuenyega, K. G., Cruchaga, C., et al. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3002156 · Cited by 1,242 · cited 2×
“Cell culture and animal models have identified potential pathogenic mechanisms related to betaamyloid clearance, tau hyperphosphorylation, and synaptic function, among others (Brecht et al. 2004; Castellano et al. 2011; Dumanis et al. 2009).”
Intermediate phenotypes and genetic mechanisms of psychiatric disorders
Meyer-Lindenberg, A., & Weinberger, D. R. (2006) · Nature reviews. Neuroscience · doi:10.1038/nrn1993 · Cited by 1,216
Frequent amyloid deposition without significant cognitive impairment among the elderly
Aizenstein, H. J., Nebes, R. D., Saxton, J. A., Price, J. C., Mathis, C. A., Tsopelas, N. D., Ziolko, S. K., James, J. A., Snitz, B. E., Houck, P. R., et al. (2008) · Archives of Neurology · doi:10.1001/archneur.65.11.1509 · Cited by 1,059
Selective changes of resting-state networks in individuals at risk for Alzheimer’s disease
Sorg, C., Riedl, V., Mühlau, M., Calhoun, V. D., Eichele, T., Läer, L., Drzezga, A., Förstl, H., Kurz, A., Zimmer, C., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0708803104 · Cited by 1,036
2012 Alzheimer's disease facts and figures Alzheimer's Association ∗
Thies, W. H., & Bleiler, L. (2012) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2012.02.001 · Cited by 1,014
Functional brain abnormalities in young adults at genetic risk for late-onset Alzheimer's dementia
Reiman, E. M., Chen, K., Alexander, G. E., Caselli, R. J., Bandy, D., Osborne, D., Saunders, A. M., & Hardy, J. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2635903100 · Cited by 977
Efficacy and safety of rivastigmine in patients with Alzheimer's disease: international randomised controlled trial Commentary: Another piece of the Alzheimer's jigsaw
Rosler, M., Anand, R., Cicin-Sain, A., Gauthier, S., Agid, Y., Dal-Bianco, P., Stahelin, H. B., Hartman, R., Gharabawi, M., & Bayer, T. (1999) · BMJ · doi:10.1136/bmj.318.7184.633 · Cited by 943
Untitled work
Raskind (2000) · doi:10.1212/wnl.54.12.2261 · Cited by 870
The Genetics of Alzheimer Disease: Back to the Future
Bertram, L., Lill, C. M., & Tanzi, R. E. (2010) · Neuron · doi:10.1016/j.neuron.2010.10.013 · Cited by 834
APOE predicts amyloid‐beta but not tau Alzheimer pathology in cognitively normal aging
Morris, J. C., Roe, C. M., Xiong, C., Fagan, A. M., Goate, A. M., Holtzman, D. M., & Mintun, M. A. (2010) · Annals of Neurology · doi:10.1002/ana.21843 · Cited by 830
The Genetics of Alzheimer's Disease
Bertram, L., & Tanzi, R. E. (2012) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-385883-2.00008-4 · Cited by 794
Cerebral metabolic and cognitive decline in persons at genetic risk for Alzheimer’s disease
Small, G. W., Ercoli, L. M., Silverman, D. H. S., Huang, S.-C., Komo, S., Bookheimer, S. Y., Lavretsky, H., Miller, K., Siddarth, P., Rasgon, N. L., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.090106797 · Cited by 790
Fibrillar amyloid-β burden in cognitively normal people at 3 levels of genetic risk for Alzheimer's disease
Reiman, E. M., Chen, K., Liu, X., Bandy, D., Yu, M., Lee, W., Ayutyanont, N., Keppler, J., Reeder, S. A., Langbaum, J. B. S., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0900345106 · Cited by 785
Apolipoprotein E Status as a Predictor of the Development of Alzheimer's Disease in Memory-Impaired Individuals
Petersen, R. C. (1995) · JAMA · doi:10.1001/jama.1995.03520400044042 · Cited by 783
A phase 2 multiple ascending dose trial of bapineuzumab in mild to moderate Alzheimer disease
Salloway, S., Sperling, R., Gilman, S., Fox, N. C., Blennow, K., Raskind, M., Sabbagh, M., Honig, L. S., Doody, R., van Dyck, C. H., et al. (2009) · Neurology · doi:10.1212/wnl.0b013e3181c67808 · Cited by 753
Altered functional connectivity in early Alzheimer's disease: A resting‐state fMRI study
Wang, K., Liang, M., Wang, L. Y., Tian, L., Zhang, X., Li, K., & Jiang, T. (2006) · Human Brain Mapping · doi:10.1002/hbm.20324 · Cited by 737
Efficacy of rosiglitazone in a genetically defined population with mild-to-moderate Alzheimer’s disease
Risner, M. E., Saunders, A. M., Altman, J. F. B., Ormandy, G. C., Craft, S., Foley, I. M., Zvartau-Hind, M. E., Hosford, D. A., Roses, A. D., & for the Rosiglitazone in Alzheimer's Disease Study Group (2006) · The Pharmacogenomics Journal · doi:10.1038/sj.tpj.6500369 · Cited by 686
Efficacy and safety of galantamine in patients with mild to moderate Alzheimer's disease: multicentre randomised controlled trial
Wilcock, G. K., Lilienfeld, S., & Gaens, E. (2000) · BMJ · doi:10.1136/bmj.321.7274.1445 · Cited by 623
Comparing predictors of conversion and decline in mild cognitive impairment
Landau, S. M., Harvey, D., Madison, C. M., Reiman, E. M., Foster, N. L., Aisen, P. S., Petersen, R. C., Shaw, L. M., Trojanowski, J. Q., Jack, C. R., et al. (2010) · Neurology · doi:10.1212/wnl.0b013e3181e8e8b8 · Cited by 616
Apolipoprotein E Type 4 Allele and Cerebral Glucose Metabolism in Relatives at Risk for Familial Alzheimer Disease
Small, G. W. (1995) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1995.03520360056039 · Cited by 604
Longitudinal Modeling of Age-Related Memory Decline and the APOE ε4 Effect
Caselli, R. J., Dueck, A. C., Osborne, D., Sabbagh, M. N., Connor, D. J., Ahern, G. L., Baxter, L. C., Rapcsak, S. Z., Shi, J., Woodruff, B. K., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0809437 · Cited by 528
Functional connectivity tracks clinical deterioration in Alzheimer's disease
Damoiseaux, J. S., Prater, K. E., Miller, B. L., & Greicius, M. D. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.06.024 · Cited by 520
Self-citation
ApoE-4 and Age at Onset of Alzheimer's Disease: The NIMH Genetics Initiative
Blacker, D., Haines, J. L., Rodes, L., Terwedow, H., Go, R. C. P., Harrell, L. E., Perry, R. T., Bassett, S. S., Chase, G., Meyers, D., et al. (1997) · Neurology · doi:10.1212/wnl.48.1.139 · Cited by 479
The Public Health Impact of Alzheimer's Disease, 2000–2050: Potential Implication of Treatment Advances
Sloane, P. D., Zimmerman, S. I., Suchindran, C., Reed, P. S., Wang, L., Boustani, M. A., & Sudha, S. (2002) · Annual Review of Public Health · doi:10.1146/annurev.publhealth.23.100901.140525 · Cited by 467
Declining brain activity in cognitively normal apolipoprotein E ɛ4 heterozygotes: A foundation for using positron emission tomography to efficiently test treatments to prevent Alzheimer's disease
Reiman, E. M., Caselli, R. J., Chen, K., Alexander, G. E., Bandy, D., & Frost, J. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.061509598 · Cited by 467
APOE4 Allele Disrupts Resting State fMRI Connectivity in the Absence of Amyloid Plaques or Decreased CSF Aβ42
Sheline, Y. I., Morris, J. C., Snyder, A. Z., Price, J. L., Yan, Z., D’Angelo, G., Liu, C., Dixit, S., Benzinger, T. L. S., Fagan, A. M., et al. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.3987-10.2010 · Cited by 444
β-Amyloid burden in healthy aging: Regional distribution and cognitive consequences
Rodrigue, K. M., Kennedy, K. M., Devous, M. D., Rieck, J. R., Hebrank, A. C., Diaz-Arrastia, R., Mathews, D., & Park, D. C. (2012) · Neurology · doi:10.1212/wnl.0b013e318245d295 · Cited by 419
Neuron-Specific Apolipoprotein E4 Proteolysis Is Associated with Increased Tau Phosphorylation in Brains of Transgenic Mice
Brecht, W. J., Harris, F. M., Chang, S., Tesseur, I., Yu, G.-Q., Xu, Q., Dee Fish, J., Wyss-Coray, T., Buttini, M., Mucke, L., et al. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.4315-03.2004 · Cited by 403
APOE -ε4 count predicts age when prevalence of AD increases, then declines: The Cache County Study
Breitner, J. C. S., Wyse, B. W., Anthony, J. C., Welsh-Bohmer, K. A., Steffens, D. C., Norton, M. C., Tschanz, J. T., Plassman, B. L., Meyer, M. R., Skoog, I., et al. (1999) · Neurology · doi:10.1212/wnl.53.2.321 · Cited by 397
Genetic counseling and testing for Alzheimer disease: Joint practice guidelines of the American College of Medical Genetics and the National Society of Genetic Counselors
Goldman, J. S., Hahn, S. E., Catania, J. W., Larusse-Eckert, S., Butson, M. B., Rumbaugh, M., Strecker, M. N., Roberts, J. S., Burke, W., Mayeux, R., et al. (2011) · Genetics in Medicine · doi:10.1097/gim.0b013e31821d69b8 · Cited by 393
Clinical and Biomarker Changes in Dominantly Inherited Alzheimer's Disease
(2012) · New England Journal of Medicine · doi:10.1056/nejmx120056 · Cited by 385
Update on the Magnetic Resonance Imaging core of the Alzheimer's Disease Neuroimaging Initiative
Jack, C. R., Bernstein, M. A., Borowski, B., Gunter, J. L., Fox, N. C., Thompson, P. M., Schuff, N. W., Krüger, G., Killiany, R., DeCarli, C. S., et al. (2010) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2010.03.004 · Cited by 379
Education, activity, health, blood pressure and apolipoprotein E as predictors of cognitive change in old age: A review
Anstey, K., & Christensen, H. (2000) · Gerontology · doi:10.1159/000022153 · Cited by 377
Estrogen use, APOE, and cognitive decline: Evidence of gene–environment interaction
Yaffe, K., Haan, M., Byers, A., Tangen, C., & Kuller, L. (2000) · Neurology · doi:10.1212/wnl.54.10.1949 · Cited by 371
Isoform-specific effects of human apolipoprotein E on brain function revealed in ApoE knockout mice: Increased susceptibility of females
Raber, J., Wong, D., Buttini, M., Orth, M., Bellosta, S., Pitas, R. E., Mahley, R. W., & Mucke, L. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.18.10914 · Cited by 364 · cited 5×
“The original study of transgenic APOE4 mice demonstrated this interaction, finding that female but not male transgenic APOE4 mice show impairments in memory and learning in special tasks (Raber et al. 1998).”
Influential
Prevalence of Apolipoprotein E4 Genotype and Homozygotes (APOE e4/4) among Patients Diagnosed with Alzheimer’s Disease: A Systematic Review and Meta-Analysis
Ward, A., Crean, S., Mercaldi, C. J., Collins, J. M., Boyd, D., Cook, M. N., & Arrighi, H. M. (2012) · Neuroepidemiology · doi:10.1159/000334607 · Cited by 349
Alzheimer's Prevention Initiative: A Plan to Accelerate the Evaluation of Presymptomatic Treatments
Reiman, E. M., Langbaum, J. B. S., Fleisher, A., Caselli, R. J., Chen, K., Ayutyanont, N., Quiroz, Y. T., Kosik, K. S., Lopera, F. J., & Tariot, P. N. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-0059 · Cited by 340
Apolipoprotein E4 Causes Age- and Tau-Dependent Impairment of GABAergic Interneurons, Leading to Learning and Memory Deficits in Mice
Andrews-Zwilling, Y., Bien-Ly, N., Xu, Q., Li, G., Bernardo, A., Yoon, S. Y., Zwilling, D., Yan, T. X., Chen, L., & Huang, Y. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.4040-10.2010 · Cited by 326
Update on the biomarker core of the Alzheimer's Disease Neuroimaging Initiative subjects
Trojanowski, J. Q., Vandeerstichele, H., Korecka, M., Clark, C. M., Aisen, P. S. S., Petersen, R. C., Blennow, K., Soares, H. D., Simon, A. J., Lewczuk, P., et al. (2010) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2010.03.008 · Cited by 309
Human APOE Isoform-Dependent Effects on Brain β-Amyloid Levels in PDAPP Transgenic Mice
Bales, K. R., Liu, F., Wu, S., Lin, S., Koger, D., DeLong, C., Hansen, J. C., Sullivan, P. M., & Paul, S. M. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.0887-09.2009 · Cited by 274
Sex, Apolipoprotein E ε4 Status, and Hippocampal Volume in Mild Cognitive Impairment
Fleisher, A. (2005) · Archives of Neurology · doi:10.1001/archneur.62.6.953 · Cited by 268
Gender Modulates the APOE 4 Effect in Healthy Older Adults: Convergent Evidence from Functional Brain Connectivity and Spinal Fluid Tau Levels
Damoiseaux, J. S., Seeley, W. W., Zhou, J., Shirer, W. R., Coppola, G., Karydas, A., Rosen, H. J., Miller, B. L., Kramer, J. H., Greicius, M. D., et al. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.0305-12.2012 · Cited by 267
Self-citation
Hippocampal volumes in cognitively normal persons at genetic risk for Alzheimer's disease
Reiman, E. M., Uecker, A., Caselli, R. J., Lewis, S., Bandy, D., De Leon, M. J., De Santi, S., Convit, A., Osborne, D., Weaver, A., et al. (1998) · Annals of Neurology · doi:10.1002/ana.410440226 · Cited by 266
Detection of PCC functional connectivity characteristics in resting-state fMRI in mild Alzheimer’s disease
ZHANG, H., WANG, S., XING, J., LIU, B., Ma, Z., Yang, M., ZHANG, Z., & Teng, G. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.08.012 · Cited by 261
The Biphasic Relationship between Regional Brain Senile Plaque and Neurofibrillary Tangle Distributions: Modification by Age, Sex, and APOE Polymorphism
CORDER, E. H., GHEBREMEDHIN, E., TAYLOR, M. G., THAL, D. R., OHM, T. G., & BRAAK, H. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1297.005 · Cited by 254 · cited 3×
“In the few recent studies that have examined this interaction between APOE4 and gender, female, but not male, APOE4 carriers have shown more pronounced AD-like changes in neuroimaging, neuropathological, and neuropsychological measures when compared to their APOE3 homozygous peers (Corder et al. 2004; Damoiseaux et al…”
Effect of APOE genotype on amyloid plaque load and gray matter volume in Alzheimer disease
Drzezga, A., Grimmer, T., Henriksen, G., Mühlau, M., Perneczky, R., Miederer, I., Praus, C., Sorg, C., Wohlschläger, A., Riemenschneider, M., et al. (2009) · Neurology · doi:10.1212/wnl.0b013e3181a2e8d0 · Cited by 248
Gender difference in apolipoprotein E-associated risk for familial Alzheimer disease: a possible clue to the higher incidence of Alzheimer disease in women.
Payami, H., Zareparsi, S., Montee, K. R., Sexton, G. J., Kaye, J. A., Bird, T. D., Yu, C. E., Wijsman, E. M., Heston, L. L., Litt, M. J., et al. (1996) · PubMed Central · Cited by 248
Age effects on atrophy rates of entorhinal cortex and hippocampus
Du, A., Schuff, N. W., Chao, L. L., Kornak, J., Jagust, W. J., Kramer, J. H., Reed, B., Miller, B. L., Norman, D. M., Chui, H. C., et al. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.03.021 · Cited by 241
Apolipoprotein E and cognitive performance
Raber, J., Wong, D., Yu, G.-Q., Buttini, M., Mahley, R. W., Pitas, R. E., & Mucke, L. (2000) · Nature · doi:10.1038/35006165 · Cited by 237
Effect of APOE ε4 Status on Intrinsic Network Connectivity in Cognitively Normal Elderly Subjects
Machulda, M. M., Jones, D. T., Vemuri, P., McDade, E., Avula, R. T. V., Przybelski, S. A., Boeve, B. F., Knopman, D. S., Petersen, R. C., & Jack, C. R. (2011) · Archives of Neurology · doi:10.1001/archneurol.2011.108 · Cited by 229
Protection against Alzheimer's disease with apoE ∈2
Talbot, C., Lendon, C., Craddock, N., Shears, S., Morris, J., & Goate, A. (1994) · The Lancet · doi:10.1016/s0140-6736(94)92557-7 · Cited by 225
ApoE4 Decreases Spine Density and Dendritic Complexity in Cortical Neurons In Vivo
Dumanis, S. B., Tesoriero, J. A., Babus, L. W., Nguyen, M. T., Trotter, J. H., Ladu, M. J., Weeber, E. J., Turner, R. S., Xu, B., Rebeck, G. W., et al. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.4026-09.2009 · Cited by 220
Alzheimer disease: new concepts on its neurobiology and the clinical role imaging will play
Jack, C. R. (2012) · Radiology · doi:10.1148/radiol.12110433 · Cited by 211 · cited 3×
“…signal (plaque deposition) in the PCC, medial prefrontal cortex, and temporoparietal cortex; reduced functional connectivity between the PCC, temporoparietal cortex, and hippocampus; reduced CSF levels of betaamyloid ; and increased CSF levels of tau and p-tau (Jack 2012; Trojanowski et al. 2010).”
Temporal lobe functional activity and connectivity in young adult APOE ɛ4 carriers
Dennis, N. A., Browndyke, J. N., Stokes, J., Need, A., Burke, J. R., Welsh‐Bohmer, K. A., & Cabeza, R. (2010) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2009.07.003 · Cited by 201
Treatment outcome of tacrine therapy depends on apolipoprotein genotype and gender of the subjects with Alzheimer's disease
Farlow, M. R., Lahiri, D. K., Poirier, J., Davignon, J., Schneider, L., & Hui, S. L. (1998) · Neurology · doi:10.1212/wnl.50.3.669 · Cited by 199
Differential effects of the APOE genotype on brain function across the lifespan
Filippini, N., Ebmeier, K. P., MacIntosh, B. J., Trachtenberg, A. J., Frisoni, G. B., Wilcock, G. K., Beckmann, C. F., Smith, S. M., Matthews, P. M., & Mackay, C. E. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.08.009 · Cited by 195
Alzheimer's Disease, Apolipoprotein E4, and Gender
Payami, H. (1994) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1994.03510410028015 · Cited by 190
Androgens Protect against Apolipoprotein E4-Induced Cognitive Deficits
Raber, J., Bongers, G., LeFevour, A., Buttini, M., & Mucke, L. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-12-05204.2002 · Cited by 187
Evidence for an Interaction between Apolipoprotein E Genotype, Gender, and Alzheimer Disease
Bretsky, P., Buckwalter, J. G., Seeman, T. E., Miller, C. A., Poirier, J., Schellenberg, G. D., Finch, C. E., & Henderson, V. W. (1999) · Alzheimer Disease & Associated Disorders · doi:10.1097/00002093-199910000-00007 · Cited by 183
Cerebrospinal fluid β-amyloid1–42 and tau in control subjects at risk for Alzheimer’s disease: The effect of APOE ε4 allele
Sunderland, T., Mirza, N., Putnam, K. T., Linker, G., Bhupali, D., Durham, R., Soares, H., Kimmel, L., Friedman, D., Bergeson, J., et al. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.07.021 · Cited by 179
Apolipoprotein E ϵ4 Count Affects Age at Onset of Alzheimer Disease,but Not Lifetime Susceptibility: The Cache County Study
Khachaturian, A. S. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.5.518 · Cited by 176
A gender difference in the association between APOE genotype and age-related cognitive decline
Mortensen, E. L., & Høgh, P. (2001) · Neurology · doi:10.1212/wnl.57.1.89 · Cited by 171
Increased Hippocampal Default Mode Synchronization during Rest in Middle-Aged and Elderly APOE ε4 Carriers: Relationships with Memory Performance
Westlye, E. T., Lundervold, A., Rootwelt, H., Lundervold, A. J., & Westlye, L. T. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.1230-11.2011 · Cited by 170
Aβ-independent roles of apolipoprotein E4 in the pathogenesis of Alzheimer's disease
Huang, Y. (2010) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2010.04.004 · Cited by 170
Hippocampal, amygdalar, and global brain atrophy in different apolipoprotein E genotypes
den Heijer, T., Oudkerk, M., Launer, L. J., van Duijn, C. M., Albert Hofman, D., & Breteler, M. M. B. (2002) · Neurology · doi:10.1212/wnl.59.5.746 · Cited by 169
Longitudinal change in hippocampal volume as a function of apolipoprotein E genotype
Moffat, S. D., Szekely, C. A., Zonderman, A. B., Kabani, N. J., & Resnick, S. M. (2000) · Neurology · doi:10.1212/wnl.55.1.134 · Cited by 169
Apolipoprotein E, survival in Alzheimer's disease patients, and the competing risks of death and Alzheimer's disease
Corder, E. H., Saunders, A. M., Strittmatter, W. J., Schmechel, D. E., Gaskell, P. C., Rimmler, J. B., Locke, P. A., Conneally, P. M., Schmader, K. E., Tanzi, R. E., et al. (1995) · Neurology · doi:10.1212/wnl.45.7.1323 · Cited by 169
Understanding the association of apolipoprotein E4 with Alzheimer disease: clues from its structure
Zhong, N., & Weisgraber, K. H. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.r800009200 · Cited by 159
APOE genotype and cognitive functioning in a large age-stratified population sample.
Jorm, A. F., Mather, K. A., Butterworth, P., Anstey, K. J., Christensen, H. M., & Easteal, S. (2007) · Neuropsychology · doi:10.1037/0894-4105.21.1.1 · Cited by 158
Memory performance in healthy elderly without Alzheimer’s disease: effects of time and apolipoprotein-E
Mayeux, R. P., Small, S. A., Tang, M., Tycko, B., & Stern, Y. (2001) · Neurobiology of Aging · doi:10.1016/s0197-4580(01)00223-8 · Cited by 156
Serial MRI and CSF biomarkers in normal aging, MCI, and AD
Vemuri, P., Wiste, H. J., Weigand, S. D., Knopman, D. S., Trojanowski, J. Q., Shaw, L. M., Bernstein, M. A., Aisen, P. S., Weiner, M., Petersen, R. C., et al. (2010) · Neurology · doi:10.1212/wnl.0b013e3181e7ca82 · Cited by 154
Accelerated decline in apolipoprotein E-ϵ4 homozygotes with Alzheimer's disease
Craft, S., Teri, L., Edland, S. D., Kukull, W. A., Schellenberg, G., McCormick, W. C., Bowen, J. D., & Larson, E. B. (1998) · Neurology · doi:10.1212/wnl.51.1.149 · Cited by 152
Disease Tracking Markers for Alzheimer's Disease at the Prodromal (MCI) Stage
Drago, V., Babiloni, C., Bartrés‐Faz, D., Caroli, A., Bosch, B., Hensch, T., Didic, M., Klafki, H., Pievani, M., Jovicich, J., et al. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-0043 · Cited by 144
A prospective study of the clinical utility of ApoE genotype in the prediction of outcome in patients with memory impairment
Tierney, M. C., Szalai, J. P., Snow, W. G., Fisher, R. H., Tsuda, T., Chi, H., McLachlan, D. R. C., & George‐Hyslop, P. S. (1996) · Neurology · doi:10.1212/wnl.46.1.149 · Cited by 144
Middle-aged human apoE4 targeted-replacement mice show retention deficits on a wide range of spatial memory tasks.
Bour, A., Grootendorst, J., Vogel, E., Kelche, C., Dodart, J.-C., Bales, K., Moreau, P.-H., Sullivan, P. M., & Mathis, C. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.05.008 · Cited by 141
Postmenopausal hormone therapy and cognitive outcomes: The Women's Health Initiative Memory Study (WHIMS)
Coker, L. H., Espeland, M. A., Rapp, S. R., Legault, C., Resnick, S. M., Hogan, P. E., Gaussoin, S. A., Dailey, M., & Shumaker, S. A. (2009) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2009.11.007 · Cited by 140
Effect of gender and apolipoprotein E genotype on response to anticholinesterase therapy in Alzheimer's disease
MacGowan, S. H., Wilcock, G. K., & Scott, M. (1998) · International Journal of Geriatric Psychiatry · doi:10.1002/(sici)1099-1166(199809)13:9 · Cited by 139
Sex differences in the association of the apolipoprotein E epsilon 4 allele with incidence of dementia, cognitive impairment, and decline
Beydoun, M. A., Boueiz, A., Abougergi, M. S., Kitner-Triolo, M. H., Beydoun, H. A., Resnick, S. M., O'Brien, R., & Zonderman, A. B. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.05.017 · Cited by 139
On Jim Watson's APOE status: genetic information is hard to hide
Nyholt, D. R., Yu, C., & Visscher, P. M. (2008) · European Journal of Human Genetics · doi:10.1038/ejhg.2008.198 · Cited by 137
The effects of APOE on the functional architecture of the resting brain
Trachtenberg, A. J., Filippini, N., Ebmeier, K. P., Smith, S. M., Karpe, F., & Mackay, C. E. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.07.059 · Cited by 133
Age and Apolipoprotein E*4 Allele Effects on Cerebrospinal Fluid β-Amyloid 42 in Adults With Normal Cognition
Peskind, E. R., Li, G., Shofer, J., Quinn, J. F., Kaye, J. A., Clark, C. M., Farlow, M. R., DeCarli, C., Raskind, M. A., Schellenberg, G. D., et al. (2006) · Archives of Neurology · doi:10.1001/archneur.63.7.936 · Cited by 131
The apolipoprotein E ε2 allele is associated with an increased risk of early‐onset alzheimer's disease and a reduced survival
van Duijn, C. M., de Knijff, P., Wehnert, A., Voecht, J. D., Bronzova, J., Havekes, L. M., Albert Hofman, D., & Broeckhoven, C. V. (1995) · Annals of Neurology · doi:10.1002/ana.410370510 · Cited by 130
The absence of an apolipoprotein ϵ4 allele is associated with a more aggressive form of Alzheimer's disease
Stern, Y., Brandt, J., Albert, M., Jacobs, D. M., Liu, X., Bell, K. L., Marder, K. S., Sano, M. C., Albert, S. M., Castenada, C. D., et al. (1997) · Annals of Neurology · doi:10.1002/ana.410410510 · Cited by 127
Effects of Age, Sex, and Ethnicity on the Association Between Apolipoprotein E Genotype and Alzheimer Disease: A Meta-analysis
Farrer, L. A. (1997) · JAMA · doi:10.1001/jama.1997.03550160069041 · Cited by 124 · cited 4×
“In studies with long-lived subjects, the APOE4 effect is detectable in age of onset but is diminished in terms of overall risk, such that beyond age 80 there is little additional risk attributable to APOE4 (Blacker et al. 1997; Dickson et al. 2008; Farrer et al. 1997; Khachaturian et al. 2004).”
Influential
Predictive Utility of Apolipoprotein E Genotype for Alzheimer Disease in Outpatients With Mild Cognitive Impairment
Devanand, D. P., Pelton, G. H., Zamora, D., Liu, X., Tabert, M. H., Goodkind, M. S., Scarmeas, N., Braun, I. M., Stern, Y., & Mayeux, R. P. (2005) · Archives of Neurology · doi:10.1001/archneur.62.6.975 · Cited by 122
Gender and age modify the association between APOE and AD-related neuropathology
Ghebremedhin, E., Schultz, C., Thal, D. R., Rüb, U., Ohm, T. G., Braak, E., & Braak, H. (2001) · Neurology · doi:10.1212/wnl.56.12.1696 · Cited by 108
Differential Cross-Sectional and Longitudinal Impact of APOE Genotype on Hippocampal Volumes in Nondemented Older Adults
Jak, A. J., Houston, W. S., Nagel, B. J., Corey‐Bloom, J., & Bondi, M. W. (2007) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000101340 · Cited by 107
Reduced size of right hippocampus in 39- to 80-year-old normal subjects carrying the apolipoprotein E ϵ4 allele
Tohgi, H., Takahashi, S., Kato, E., Homma, A., Niina, R., Sasaki, K., Yonezawa, H., & Sasaki, M. (1997) · Neuroscience Letters · doi:10.1016/s0304-3940(97)00743-x · Cited by 102
No ɛ4 gene dose effect on hippocampal atrophy in a large MRI database of healthy elderly subjects
Lemaître, H., Crivello, F., Dufouil, C., Grassiot, B., Tzourio, C., Alpérovitch, A., & Mazoyer, B. M. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2004.10.016 · Cited by 102
Postmenopausal hormone therapy, timing of initiation, APOE and cognitive decline
Kang, J. H., & Grodstein, F. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.10.007 · Cited by 90
Apolipoprotein E ε4 Allele Is Unrelated to Cognitive or Functional Decline in Alzheimer’s Disease: Retrospective and Prospective Analysis
Kleiman, T., Zdanys, K. F., Black, B. T., Rightmer, T., Grey, M. A., Garman, K. S., MacAvoy, M. G., Gelernter, J. E., & van Dyck, C. H. (2006) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000093316 · Cited by 90
Specifically Progressive Deficits of Brain Functional Marker in Amnestic Type Mild Cognitive Impairment
Bai, F., Watson, D. R., Shi, Y., Wang, Y., Yue, C., YuhuanTeng, Wu, D., Yuan, Y., & Zhang, Z. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024271 · Cited by 85
Apolipoprotein E Phenotypes, Dementia and Mortality in a Prospective Population Sample
Tilvis, R. S., Strandberg, T. E., & Juva, K. (1998) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1998.tb03805.x · Cited by 83
Presence or absence of at least one epsilon 4 allele and gender are not predictive for the response to donepezil treatment in Alzheimer's disease.
Rigaud, A., Traykov, L. D., Latour, F., Couderc, R., Moulin, F., & Forette, F. (2002) · Pharmacogenetics · doi:10.1097/00008571-200207000-00009 · Cited by 82
Effects of ApoE-ɛ4 allele load and age on the rates of grey matter and hippocampal volumes loss in a longitudinal cohort of 1186 healthy elderly persons
Crivello, F., Lemaître, H., Dufouil, C., Grassiot, B., Delcroix, N., Tzourio‐Mazoyer, N., Tzourio, C., & Mazoyer, B. M. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2009.12.116 · Cited by 78
Apolipoprotein E Genotype is Associated with Temporal and Hippocampal Atrophy Rates in Healthy Elderly Adults: A Tensor-Based Morphometry Study1
Lu, P. H., Thompson, P. M., Leow, A., Lee, G. J., Lee, A., Yanovsky, I., Parikshak, N., Khoo, T., Wu, S., Geschwind, D. H., et al. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-101398 · Cited by 70
Working memory deficits in healthy APOE epsilon 4 carriers
Reinvang, I., Winjevoll, I. L., Rootwelt, H., & Espeseth, T. (2009) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2009.10.018 · Cited by 64
APOE genotype and survival in men and women with Alzheimer’s disease
Forno, G. D., Carson, K. A., Brookmeyer, R., Troncoso, J. C., Kawas, C. H., & Brandt, J. (2002) · Neurology · doi:10.1212/wnl.58.7.1045 · Cited by 62
Integrating ADNI results into Alzheimer's disease drug development programs
Cummings, J. L. (2010) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.03.016 · Cited by 59
Apolipoprotein E genotype and progression of Alzheimer's disease: the Rotterdam Study
Slooter, A. J. C., Houwing‐Duistermaat, J. J., van Harskamp, F., Cruts, M., Broeckhoven, C. V., Breteler, M. M. B., Albert Hofman, D., Stijnen, T., & van Duijn, C. M. (1999) · Journal of Neurology · doi:10.1007/s004150050351 · Cited by 56
Accelerated Memory Decline in Alzheimer's Disease With Apolipoprotein ϵ4 Allele
Hirono, N., Hashimoto, M., Yasuda, M., Kazui, H., & Mori, E. (2003) · Journal of Neuropsychiatry · doi:10.1176/jnp.15.3.354 · Cited by 54
Aging, Estrogens, and Episodic Memory in Women
Henderson, V. W. (2009) · Cognitive and Behavioral Neurology · doi:10.1097/wnn.0b013e3181a74ce7 · Cited by 52
Apolipoprotein E 4 and impaired episodic memory in community-dwelling elderly people: a marked sex difference. The Hordaland Health Study
Lehmann, D. J. (2006) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2005.077818 · Cited by 52
Predicting memory decline in normal elderly: Genetics, MRI, and cognitive reserve
Tupler, L. A., Krishnan, K., Greenberg, D. L., Marcovina, S. M., Payne, M. E., MacFall, J. R., Charles, H. C., & Doraiswamy, P. M. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.07.001 · Cited by 50
Apolipoprotein E ε4 and Change in Cognitive Functioning in Community-Dwelling Older Adults
Swan, G. E., Lessov‐Schlaggar, C. N., Carmelli, D., Schellenberg, G. D., & Rue, A. L. (2005) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/0891988705281864 · Cited by 48
Variability of age at onset in siblings with familial Alzheimer disease
Gómez-Tortosa, E., Barquero, M. S., Barón, M., Sainz, M. J., Manzano, S., Payno, M., Ros, R., Almaraz, C., Gómez-Garré, P., & Jiménez-Escrig, A. (2007) · Archives of Neurology · doi:10.1001/archneur.64.12.1743 · Cited by 47
Impairments in spatial memory retention of GFAP-apoE4 female mice
VANMEER, P., Acevedo, S. F., & Raber, J. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.10.024 · Cited by 45
Behavioral phenotype and BDNF differences related to apoE isoforms and sex in young transgenic mice
Reverte, I., Klein, A. B., Ratner, C., Domingo, J. L., & Colomina, M. T. (2012) · Experimental Neurology · doi:10.1016/j.expneurol.2012.06.015 · Cited by 41
Medial temporal lobe dysfunction during encoding and retrieval of episodic memory in non-demented APOE ε4 carriers
Kukolja, J., Thiel, C. M., Eggermann, T., Zerres, K., & Fink, G. R. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.03.044 · Cited by 40
Reduced hippocampal activity during encoding in cognitively normal adults carrying the APOE ɛ4 allele
Adamson, M. M., Hutchinson, J. B., Shelton, A. L., Wagner, A. D., & Taylor, J. L. (2011) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2011.04.022 · Cited by 34
Alzheimer's disease genetics: lessons to improve disease modelling
Guerreiro, R. J., & Hardy, J. (2011) · Biochemical Society Transactions · doi:10.1042/bst0390910 · Cited by 33
Sex Differences in Presynaptic Density and Neurogenesis in Middle-Aged ApoE4 and ApoE Knockout Mice
Rijpma, A., Jansen, D., Arnoldussen, I. A. C., Fang, X. T., Wiesmann, M., Mutsaers, M. P. C., Dederen, P. J. W. C., Janssen, C. I. F., & Kiliaan, A. J. (2013) · Journal of Neurodegenerative Diseases · doi:10.1155/2013/531326 · Cited by 32
Informed choice in direct-to-consumer genetic testing for Alzheimer and other diseases: lessons from two cases
Messner, D. A. (2011) · New Genetics and Society · doi:10.1080/14636778.2011.552300 · Cited by 29
Do apolipoprotein E genotype and educational attainment predict the rate of cognitive decline in normal aging? A 12-year follow-up of the Maastricht Aging Study.
Gerven, P. W. M. V., van Boxtel, M. P. J., Ausems, E. E. B., Bekers, O., & Jolles, J. (2012) · Neuropsychology · doi:10.1037/a0028685 · Cited by 29
APOE 4 increases the risk of progression from amnestic mild cognitive impairment to Alzheimer's disease among ethnic Chinese in Taiwan
Wang, P.-N., Hong, C.-J., Lin, K. N., Liu, H.-C., & Chen, W.-T. (2010) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2010.209122 · Cited by 27
Glucose metabolism and gray-matter concentration in apolipoprotein E ε4 positive normal subjects
Samuraki, M., Matsunari, I., Chen, W., Shima, K., Yanase, D., Takeda, N., Matsuda, H., & Yamada, M. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.11.020 · Cited by 21
Neuropsychiatric symptoms, apolipoprotein E gene, and risk of progression to cognitive impairment, no dementia and dementia: the Aging, Demographics, and Memory Study (ADAMS)
Beaudreau, S. A., Fairchild, J. K., Spira, A. P., Lazzeroni, L. C., & O'Hara, R. M. (2012) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.3868 · Cited by 17
Clinical trial methodologies for disease-modifying therapeutic approaches
Aisen, P. S. S. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.09.008 · Cited by 16
A genomic scan for age at onset of alzheimer's disease in 437 families from the NIMH genetic initiative
Dickson, M. R., Li, J., Wiener, H. W., Perry, R. T., Blacker, D., Bassett, S. S., & Go, R. C. P. (2008) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30689 · Cited by 14
Should the ApoE genotype be a covariate for clinical trials in Alzheimer disease?
Farlow, M. R. (2010) · Alzheimer s Research & Therapy · doi:10.1186/alzrt39 · Cited by 14
Accelerated Memory Decline in Alzheimer's Disease With Apolipoprotein 4 Allele
Hirono, N. (2003) · Journal of Neuropsychiatry · doi:10.1176/appi.neuropsych.15.3.354 · Cited by 12
P1–256: APOE genotype by gender interaction revealed in CSF biomarkers and clinical conversion rates in the ADNI database
Altmann, A., Tian, L., Henderson, V. W., & Greicius, M. D. (2013) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2013.05.481 · Cited by 2
Self-citation

Sorted by citations

2016 Alzheimer's disease facts and figures
Alzheimer's Association (2016) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2016.03.001 · Cited by 5,069
2023 Alzheimer's disease facts and figures
(2023) · Alzheimer's & Dementia · doi:10.1002/alz.13016 · Cited by 3,212
2024 Alzheimer's disease facts and figures
(2024) · Alzheimer's & Dementia · doi:10.1002/alz.13809 · Cited by 2,536
2019 Alzheimer’s disease facts and figures.
Alzheimer's Association (2019) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2019.01.010 · Cited by 2,461
2022 Alzheimer's disease facts and figures
Anonymous (2022) · Alzheimer s & Dementia · doi:10.1002/alz.12638 · Cited by 2,469

See all 259

Authors: Ungar, L., Altmann, A., & Greicius, M. D.
Affiliations: Stanford Medicine (US)
Corresponding author: Ungar, Leo
ORCID: Greicius, Michael D.
Venue: Brain Imaging and Behavior
Publisher: Springer Science and Business Media LLC
Published: 2013-11-30
Volume: 8
Issue: 2
Pages: 262-273
ISSN: 1931-7557 (ISSN-L)
1931-7565
DOI: 10.1007/s11682-013-9272-x
PMC: PMC4282773
OpenAlex: W2007870551
Semantic Scholar: a36142356acf18bedeb996827856502949b3d3b7
Cited by: 246
References: 140
Citations by year: 2026: 17 · 2025: 25 · 2024: 42 · 2023: 21 · 2022: 14 · 2021: 29 · 2020: 24 · 2019: 22 · 2018: 19 · 2017: 10 · 2016: 12 · 2015: 8 · 2014: 3
FWCI: 0.89
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Brain Imaging and Behavior (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
UCL Discovery (University College London) (submittedVersion)
Funders: National Institute of Neurological Disorders and Stroke (R01NS073498)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
Keywords: Alzheimer's disease, apolipoprotein E, APOE ε4, sex differences, gender interaction, genetic risk factors, mild cognitive impairment, neuroimaging
MeSH terms: Alzheimer Disease, Animals, Female, Humans, Male, Sex Factors, Genetic Predisposition to Disease, Apolipoprotein E4

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Apolipoprotein E, gender, and Alzheimer’s disease: an overlooked, but potent and promising interaction

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks