Greater amygdala activity and dorsomedial prefrontal–amygdala coupling are associated with enhanced inflammatory responses to stress
Open accessAbstract
Psychological stress is implicated in the etiology of many common chronic diseases and mental health disorders. Recent research suggests that inflammation may be a key biological mediator linking stress and health. Nevertheless, the neurocognitive pathways underlying stress-related increases in inflammatory activity are largely unknown. The present study thus examined associations between neural and inflammatory responses to an acute laboratory-based social stressor. Healthy female participants (n=31) were exposed to a brief episode of stress while they underwent an fMRI scan. Blood samples were taken before and after the stressor, and plasma was assayed for markers of inflammatory activity. Exposure to the stressor was associated with significant increases in feelings of social evaluation and rejection, and with increases in levels of inflammation. Analyses linking the neural and inflammatory data revealed that heightened neural activity in the amygdala in response to the stressor was associated with greater increases in inflammation. Functional connectivity analyses indicated that individuals who showed stronger coupling between the amygdala and the dorsomedial prefrontal cortex (DMPFC) also showed a heightened inflammatory response to the stressor. Interestingly, activity in a different set of neural regions was related to increases in feelings of social rejection. These data show that greater amygdala activity in response to a stressor, as well as tighter coupling between the amygdala and the DMPFC, are associated with greater increases in inflammatory activity. Results from this study begin to identify neural mechanisms that might link stress with increased risk for inflammation-related disorders such as cardiovascular disease and depression.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Increases in cytokine activity and amygdala responsivity to stress exposure are associated with greater social disconnection and depressed mood, as well as cognitive disturbance and increased fatigue.
“Importantly, these increases in cytokine activity and amygdala responsivity to stress exposure are also associated with greater social disconnection and depressed mood (Muscatell et al, 2015), as well as cognitive disturbance and increased fatigue (Harrison et al, 2009b).”
From Inflammation in Fear- and Anxiety-Based Disorders: PTSD, GAD, and Beyond (2017) · cites this paper as Muscatell et al, 2015
The Results (section 3.2) report increased feelings of social rejection after the stressor, and the Discussion (section 4) links amygdala activity to increased IL-6. But the Discussion attributes changes in social rejection to a different set of brain regions, and the study does not report an association of these stress responses with depressed mood. Cognitive disturbance and fatigue are attributed to Harrison et al., not to this source. (LLM, conf=0.87)
Experimental — accuracy not yet measuredHeightened amygdala response to stress is associated with increased IL-6 production.
“This heightened amygdala response to stress is associated with increased IL-6 production (Inagaki et al, 2012;Muscatell et al, 2015).”
From Inflammation in Fear- and Anxiety-Based Disorders: PTSD, GAD, and Beyond (2017) · cites this paper as Muscatell et al, 2015
Exposure to a laboratory stressor that increases IL-6 concentrations peripherally was associated with increased functional connectivity between the dorsomedial PFC and the amygdala in a manner that was correlated with IL-6.
“Finally, exposure to a laboratory stressor that increases IL-6 concentrations peripherally was associated with increased functional connectivity between the dorsomedial PFC and the amygdala in a manner that was correlated with IL-6 (Muscatell et al, 2015).”
From Inflammation in Fear- and Anxiety-Based Disorders: PTSD, GAD, and Beyond (2017) · cites this paper as Muscatell et al, 2015
Peripheral levels of IL-6 were associated with increased activation of the amygdala and increased functional connectivity between the amygdala and dorsomedial prefrontal cortex in response to negative social feedback.
“peripheral levels of IL-6 were associated with increased activation of the amygdala and increased functional connectivity between the amygdala and dorsomedial prefrontal cortex (dmPFC) in response to negative social feedback (Muscatell et al., 2015).”
From The interplay between stress, inflammation, and emotional attention: relevance for depression (2019) · cites this paper as Muscatell et al., 2015
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
1 retracted
Kumar, S., Karrunakaran, C. M., Rao, M. R. K., & Balasubramanian, M. P. (2011) · Journal of Carcinogenesis · doi:10.4103/1477-3163.75458 · Cited by 35 · see citing works
RetractedThe cognitive control of emotion
OCHSNER, K., & GROSS, J. (2005) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2005.03.010 · Cited by 4,495 · see citing works
Psychological Stress and Disease
Cohen, S., Janicki-Deverts, D., & Miller, G. E. (2007) · JAMA · doi:10.1001/jama.298.14.1685 · Cited by 3,168 · see citing works
Emotional processing in anterior cingulate and medial prefrontal cortex
Etkin, A., Egner, T., & Kalisch, R. (2011) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2010.11.004 · Cited by 3,059 · cited 2× · see citing works
“Furthermore, a growing body of human research suggests that there is increased functional connectivity between DMPFC and threat-related limbic structures during negative emotional states and among individuals with mood disorders (Etkin et al., 2011).”
Associations of depression with C-reactive protein, IL-1, and IL-6: a meta-analysis.
Howren, M. B., Lamkin, D. M., & Suls, J. (2009) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3181907c1b · Cited by 2,766 · see citing works
Causal Relationship Between Stressful Life Events and the Onset of Major Depression
Kendler, K. S., Karkowski, L. M., & Prescott, C. A. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.6.837 · Cited by 2,486 · cited 1× · see citing works
“Psychological stress is implicated in the onset and progression of many common and costly chronic diseases, including cardiovascular disease, chronic pain conditions, and major depressive disorder (Cohen et al., 2007; Kendler et al., 1999; Steptoe and Kivimäki, 2012).”
Cytokine Pathways and Joint Inflammation in Rheumatoid Arthritis
Choy, E., & Panayi, G. S. (2001) · New England Journal of Medicine · doi:10.1056/nejm200103223441207 · Cited by 2,248 · see citing works
Slavich, G. M., & Irwin, M. R. (2014) · Psychological Bulletin · doi:10.1037/a0035302 · Cited by 2,206 · cited 1× · see citing works
“Indeed, psychological stressors can induce increases in inflammation (Slavich and Irwin, 2014; Kiecolt-Glaser et al., 2003; Rohleder, 2014; Steptoe et al., 2007), which might contribute to the development of disease (Capuron and Miller, 2004; Choy and Panayi, 2001; DellaGiola and Hannestad, 2010;…”
Self-citationLeDoux, J., Iwata, J., Cicchetti, P., & Reis, D. (1988) · The Journal of Neuroscience · doi:10.1523/jneurosci.08-07-02517.1988 · Cited by 1,580 · see citing works
Gender differences in depression
Nolen-Hoeksema, S. (2001) · Current Directions in Psychological Science · doi:10.1111/1467-8721.00142 · Cited by 1,474 · see citing works
McLaren, D. G., Ries, M. L., Xu, G., & Johnson, S. C. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.03.068 · Cited by 1,445 · see citing works
Neurobiological Basis of Failure to Recall Extinction Memory in Posttraumatic Stress Disorder
Milad, M. R., Pitman, R. K., Ellis, C. B., Gold, A. L., Shin, L. M., Lasko, N. B., Zeidan, M. A., Handwerger, K., Orr, S. P., & Rauch, S. L. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.06.026 · Cited by 1,339 · see citing works
Stress and cardiovascular disease
Steptoe, A., & Kivimäki, M. (2012) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2012.45 · Cited by 1,321 · see citing works
Steptoe, A., Hamer, M., & Chida, Y. (2007) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2007.03.011 · Cited by 1,278 · see citing works
Chronic stress and age-related increases in the proinflammatory cytokine IL-6.
Kiecolt-Glaser, J. K., Preacher, K. J., MacCallum, R. C., Atkinson, C., Malarkey, W. B., & Glaser, R. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1531903100 · Cited by 1,220 · cited 1× · see citing works
“Indeed, psychological stressors can induce increases in inflammation (Slavich and Irwin, 2014; Kiecolt-Glaser et al., 2003; Rohleder, 2014; Steptoe et al., 2007), which might contribute to the development of disease (Capuron and Miller, 2004; Choy and Panayi, 2001; DellaGiola and Hannestad, 2010;…”
Sierra-Mercado, D., Padilla-Coreano, N., & Quirk, G. J. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2010.184 · Cited by 1,190 · see citing works
Eisenberger, N. I. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3231 · Cited by 1,016 · see citing works
Self-citationFirst, M. B., Spitzer, R. L., Gibbon, M., & Williams, J. B. W. (1997) · American Psychiatric Press eBooks · Cited by 983 · see citing works
A mechanism converting psychosocial stress into mononuclear cell activation
Bierhaus, A., Wolf, J., Andrassy, M., Rohleder, N., Humpert, P. M., Petrov, D., Ferstl, R., von Eynatten, M., Wendt, T., Rudofsky, G., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0438019100 · Cited by 926 · see citing works
Reciprocal regulation of the neural and innate immune systems
Irwin, M. R., & Cole, S. W. (2011) · Nature Reviews Immunology · doi:10.1038/nri3042 · Cited by 910 · see citing works
Self-citationSex differences in stress responses: social rejection versus achievement stress
Stroud, L. R., Salovey, P., & Epel, E. S. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01333-1 · Cited by 797 · see citing works
Vidal-Gonzalez, I., Vidal-Gonzalez, B., Rauch, S. L., & Quirk, G. J. (2006) · Learning & Memory · doi:10.1101/lm.306106 · Cited by 705 · see citing works
Social rejection shares somatosensory representations with physical pain
Kross, E., Berman, M. G., Mischel, W., Smith, E. E., & Wager, T. D. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1102693108 · Cited by 689 · see citing works
A functional MRI study of human amygdala responses to facial expressions of fear versus anger.
Whalen, P. J., Shin, L. M., McInerney, S. C., Fischer, H., Wright, C. I., & Rauch, S. L. (2001) · Emotion · doi:10.1037/1528-3542.1.1.70 · Cited by 660 · see citing works
Functional anatomical abnormalities in limbic and prefrontal cortical structures in major depression
Drevets, W. C. (2000) · Progress in Brain Research · doi:10.1016/s0079-6123(00)26027-5 · Cited by 659 · see citing works
Miller, G., Chen, E., & Cole, S. W. (2009) · Annual Review of Psychology · doi:10.1146/annurev.psych.60.110707.163551 · Cited by 591 · see citing works
Eisenberger, N. I., & Cole, S. W. (2012) · Nature Neuroscience · doi:10.1038/nn.3086 · Cited by 590 · see citing works
Self-citationCytokines and psychopathology: Lessons from interferon-α
Capuron, L., & Miller, A. H. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.02.009 · Cited by 562 · see citing works
Burgos-Robles, A., Vidal-Gonzalez, I., & Quirk, G. J. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.0378-09.2009 · Cited by 530 · see citing works
Stimulation of systemic low-grade inflammation by psychosocial stress.
Rohleder, N. (2014) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000049 · Cited by 497 · see citing works
A Role for the Human Dorsal Anterior Cingulate Cortex in Fear Expression
Milad, M. R., Quirk, G. J., Pitman, R. K., Orr, S. P., Fischl, B., & Rauch, S. L. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.04.032 · Cited by 485 · see citing works
Neural sensitivity to social rejection is associated with inflammatory responses to social stress
Slavich, G. M., Way, B. M., Eisenberger, N. I., & Taylor, S. E. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1009164107 · Cited by 418 · see citing works
Self-citationBlack sheep get the blues: a psychobiological model of social rejection and depression
Slavich, G. M., O’Donovan, A., Epel, E. S., & Kemeny, M. E. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.01.003 · Cited by 362 · see citing works
Self-citationRohleder, N., Schommer, N. C., Hellhammer, D. H., Engel, R., & Kirschbaum, C. (2001) · Psychosomatic Medicine · doi:10.1097/00006842-200111000-00016 · Cited by 276 · see citing works
The evolutionary significance of depression in Pathogen Host Defense (PATHOS-D)
Raison, C. L., & Miller, A. H. (2013) · Molecular Psychiatry · doi:10.1038/mp.2012.2 · Cited by 253 · cited 1× · see citing works
“…and Irwin, 2014; Kiecolt-Glaser et al., 2003; Rohleder, 2014; Steptoe et al., 2007), which might contribute to the development of disease (Capuron and Miller, 2004; Choy and Panayi, 2001; DellaGiola and Hannestad, 2010; Raison and Miller, 2013; The Emerging Risk Factors Collaboration, 2010).”
The neural sociometer: brain mechanisms underlying state self-esteem
Eisenberger, N. I., Inagaki, T. K., Muscatell, K. A., Byrne Haltom, K. E., & Leary, M. R. (2011) · Journal of Cognitive Neuroscience · doi:10.1162/jocn_a_00027 · Cited by 199 · see citing works
Self-citationDickerson, S. S., Gable, S. L., Irwin, M. R., Aziz, N., & Kemeny, M. E. (2009) · Psychological Science · doi:10.1111/j.1467-9280.2009.02437.x · Cited by 197 · see citing works
Self-citationRobinson, O. J., Charney, D. R., Overstreet, C. M., Vytal, K. E., & Grillon, C. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.11.096 · Cited by 196 · see citing works
The relation among stress, adrenalin, interleukin 6 and acute phase proteins in the rat
Gool, J. V., van Vugt, H., Helle, M., & Aarden, L. A. (1990) · Clinical Immunology and Immunopathology · doi:10.1016/0090-1229(90)90034-n · Cited by 179 · see citing works
Inflammatory cytokines, socioeconomic status, and acute stress responsivity
Steptoe, A., Owen, N., Kunz-Ebrecht, S., & Mohamed‐Ali, V. (2002) · Brain Behavior and Immunity · doi:10.1016/s0889-1591(02)00030-2 · Cited by 176 · see citing works
A critical review of human endotoxin administration as an experimental paradigm of depression.
DellaGioia, N., & Hannestad, J. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.07.014 · Cited by 175 · see citing works
Biomarkers of PTSD: Neuropeptides and immune signaling
Baker, D. G., Nievergelt, C. M., & O’Connor, D. T. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.02.027 · Cited by 172 · see citing works
Induction of plasma interleukin-6 by circulating adrenaline in the rat
DeRijk, R. H., Boelen, A., Tilders, F. J. H., & BERKENBOSCH, F. (1994) · Psychoneuroendocrinology · doi:10.1016/0306-4530(94)90005-1 · Cited by 139 · see citing works
SHERIDAN, J. F., STARK, J. L., AVITSUR, R., & PADGETT, D. A. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb05455.x · Cited by 137 · see citing works
Tengstrand, B., Ahlmén, M., & Hafström, I. (2004) · PubMed · Cited by 127 · see citing works
Kop, W. J., Weissman, N. J., Zhu, J., Bonsall, R. W., Doyle, M. F., Stretch, M. R., Glaes, S. B., Krantz, D. S., Gottdiener, J. S., & Tracy, R. P. (2008) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2007.11.006 · Cited by 117 · see citing works
The telencephalic limbic system and experimental gastric pathology: A review
Henke, P. G. (1982) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(82)90047-1 · Cited by 114 · see citing works
Stroud, C. B., Davila, J., Hammen, C., & Vrshek-Schallhorn, S. (2011) · Journal of Abnormal Psychology · doi:10.1037/a0021659 · Cited by 103 · see citing works
A social neuroscience perspective on stress and health.
Muscatell, K. A., & Eisenberger, N. I. (2012) · Social and Personality Psychology Compass · doi:10.1111/j.1751-9004.2012.00467.x · Cited by 101 · see citing works
Self-citationMurphy, M. L. M., Slavich, G. M., Rohleder, N., & Miller, G. E. (2013) · Clinical Psychological Science · doi:10.1177/2167702612455743 · Cited by 92 · see citing works
Self-citationGianaros, P. J., Hariri, A. R., Sheu, L. K., Muldoon, M. F., Sutton-Tyrrell, K., & Manuck, S. B. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.10.007 · Cited by 85 · see citing works
Gender differences in stimulated cytokine production following acute psychological stress
Prather, A. A., Carroll, J., Fury, J. M., McDade, K. K., Ross, D. C., & Marsland, A. L. (2008) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2008.11.004 · Cited by 80 · see citing works
LaFleur, B., Lee, W., Billheimer, D. D., Lockhart, C., Liu, J., & Merchant, N. B. (2011) · Journal of Carcinogenesis · doi:10.4103/1477-3163.79681 · Cited by 39 · see citing works
Inagaki, M., Akechi, T., Okuyama, T., Sugawara, Y., Kinoshita, H., Shima, Y., Terao, K., Mitsunaga, S., Ochiai, A., & Uchitomi, Y. (2013) · Supportive Care in Cancer · doi:10.1007/s00520-013-1767-x · Cited by 21 · see citing works
Flagged first, then by citations
1 of the 56 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
The role of inflammation in depression: from evolutionary imperative to modern treatment target
Miller, A. H., & Raison, C. L. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2015.5 · Cited by 3,942 · see citing works
Effects of stress on the development and progression of cardiovascular disease
Kivimäki, M., & Steptoe, A. (2018) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2017.189 · Cited by 1,197 · see citing works
Inflammation in Fear- and Anxiety-Based Disorders: PTSD, GAD, and Beyond
Michopoulos, V., Powers, A., Gillespie, C. F., Ressler, K. J., & Jovanovic, T. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.146 · Cited by 786 · see citing works
The Pathogenesis of Sepsis and Potential Therapeutic Targets
Huang, M., Cai, S., & Su, J. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20215376 · Cited by 776 · see citing works
The Role of Inflammation in Cardiovascular Disease
Henein, M. Y., Vancheri, S., Longo, G., & Vancheri, F. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232112906 · Cited by 766 · see citing works
Marsland, A. L., Walsh, C., Lockwood, K., & John-Henderson, N. A. (2017) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2017.01.011 · Cited by 691 · see citing works
Tawakol, A., Ishai, A., Takx, R. A., Figueroa, A. L., Ali, A., Kaiser, Y., Truong, Q. A., Solomon, C. J., Calcagno, C., Mani, V., et al. (2017) · The Lancet · doi:10.1016/s0140-6736(16)31714-7 · Cited by 636 · see citing works
Imaging the Role of Inflammation in Mood and Anxiety-related Disorders
Felger, J. C. (2017) · Current Neuropharmacology · doi:10.2174/1570159x15666171123201142 · Cited by 432 · see citing works
Slavich, G. M., & Sacher, J. (2019) · Psychopharmacology · doi:10.1007/s00213-019-05326-9 · Cited by 383 · see citing works
Self-citationNeuroinflammation mechanisms of neuromodulation therapies for anxiety and depression
Guo, B., Zhang, M., Hao, W., Wang, Y., Zhang, T., & Liu, C. (2023) · Translational Psychiatry · doi:10.1038/s41398-022-02297-y · Cited by 389 · see citing works
Sex differences in the neuro-immune consequences of stress: Focus on depression and anxiety
Bekhbat, M., & Neigh, G. N. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.02.006 · Cited by 359 · see citing works
Septic-Associated Encephalopathy: a Comprehensive Review
Mazeraud, A., Righy, C., Bouchereau, E., Benghanem, S., Bozza, F. A., & Sharshar, T. (2020) · Neurotherapeutics · doi:10.1007/s13311-020-00862-1 · Cited by 344 · see citing works
Life Stress and Health: A Review of Conceptual Issues and Recent Findings
Slavich, G. M. (2016) · Teaching of Psychology · doi:10.1177/0098628316662768 · Cited by 300 · see citing works
Self-citationHow the brain connects in response to acute stress: A review at the human brain systems level
van Oort, J., Tendolkar, I., Hermans, E. J., Mulders, P. C. R., Beckmann, C. F., Schene, A. H., Fernández, G., & van Eijndhoven, P. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.10.015 · Cited by 249 · see citing works
Psychosocial stress and cardiovascular disease
Dar, T., Radfar, A., Abohashem, S., Pitman, R. K., Tawakol, A., & Osborne, M. T. (2019) · Current Treatment Options in Cardiovascular Medicine · doi:10.1007/s11936-019-0724-5 · Cited by 248 · see citing works
Hill, M. N., Campolongo, P., Yehuda, R., & Patel, S. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2017.162 · Cited by 239 · see citing works
The interplay between stress, inflammation, and emotional attention: relevance for depression
Maydych, V. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00384 · Cited by 193 · see citing works
How inflammation affects the brain in depression: a review of functional and structural MRI studies
Han, K.-M., & Ham, B.-J. (2021) · Journal of Clinical Neurology · doi:10.3988/jcn.2021.17.4.503 · Cited by 187 · see citing works
Tawakol, A. A., Osborne, M. T., Wang, Y., Hammed, B. S. A., Tung, B., Patrich, T., Oberfeld, B., Ishai, A., Shin, L. M., Nahrendorf, M., et al. (2019) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2019.04.042 · Cited by 183 · see citing works
Won, E., & Kim, Y. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186546 · Cited by 184 · see citing works
The role of the immune system in posttraumatic stress disorder
Katrinli, Ş., Oliveira, N. C. D. S., Felger, J. C., Michopoulos, V., & Smith, A. K. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-02094-7 · Cited by 177 · see citing works
The role of depressive subtypes within the neuroinflammation hypothesis of major depressive disorder
Woelfer, M., Kasties, V., Kahlfuss, S., & Walter, M. (2019) · Neuroscience · doi:10.1016/j.neuroscience.2018.03.034 · Cited by 171 · see citing works
Neuroanatomy of sepsis-associated encephalopathy
Heming, N., Mazeraud, A., Verdonk, F., Bozza, F. A., Chrétien, F. C., & Sharshar, T. (2017) · Critical Care · doi:10.1186/s13054-017-1643-z · Cited by 167 · see citing works
Musculoskeletal pain and exercise—Challenging existing paradigms and introducing new
Smith, B. E., Hendrick, P., Bateman, M., Holden, S., Littlewood, C., Smith, T. O., & Logan, P. (2019) · British Journal of Sports Medicine · doi:10.1136/bjsports-2017-098983 · Cited by 166 · see citing works
Kraynak, T. E., Marsland, A. L., Wager, T. D., & Gianaros, P. J. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.07.013 · Cited by 165 · see citing works
Ginty, A. T., Kraynak, T. E., Fisher, J. P., & Gianaros, P. J. (2017) · Autonomic Neuroscience · doi:10.1016/j.autneu.2017.03.003 · Cited by 168 · see citing works
Sepsis‐Induced Brain Dysfunction: Pathogenesis, Diagnosis, and Treatment
Pan, S., Lv, Z., Wang, R., Shu, H., Yuan, S., Yu, Y., & Shang, Y. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/1328729 · Cited by 160 · see citing works
Kim, Y., & Won, E. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.04.020 · Cited by 157 · see citing works
Dysregulation of inflammation, neurobiology, and cognitive function in PTSD: an integrative review
Quiñones-Cordero, M. M., Gallegos, A. M., Lin, F. V., & Heffner, K. L. (2020) · Cognitive Affective & Behavioral Neuroscience · doi:10.3758/s13415-020-00782-9 · Cited by 161 · see citing works
Therapeutic Implications of Brain–Immune Interactions: Treatment in Translation
Miller, A. H., Haroon, E., & Felger, J. C. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.167 · Cited by 152 · see citing works
Muscatell, K. A., Moieni, M., Inagaki, T. K., Dutcher, J. M., Jevtic, I., Breen, E. C., Irwin, M. R., & Eisenberger, N. I. (2016) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2016.03.022 · Cited by 146 · see citing works
Self-citationLong-term consequences of childhood maltreatment: altered amygdala functional connectivity
Jedd, K., Hunt, R. H., Cicchetti, D., Hunt, E., Cowell, R. A., Rogosch, F. A., Toth, S. L., & Thomas, K. M. (2015) · Development and Psychopathology · doi:10.1017/s0954579415000954 · Cited by 149 · see citing works
Targeting HMGB1 for the treatment of sepsis and sepsis-induced organ injury
Deng, C., Zhao, L., Yang, Z. P., Shang, J., Wang, C., Shen, M., Jiang, S., Tian, L., Di, W., Chen, Y., et al. (2021) · Acta Pharmacologica Sinica · doi:10.1038/s41401-021-00676-7 · Cited by 135 · see citing works
The neuroscience of social feelings: mechanisms of adaptive social functioning
Eslinger, P. J., Anders, S., Ballarini, T., Boutros, S., Krach, S., Mayer, A. V., Moll, J., Newton, T. L., Schroeter, M. L., de Oliveira-Souza, R., et al. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.05.028 · Cited by 130 · see citing works
Inflammation‐driven brain and gut barrier dysfunction in stress and mood disorders
Doney, E., Cadoret, A., Dion‐Albert, L., Lebel, M., & Ménard, C. (2021) · European Journal of Neuroscience · doi:10.1111/ejn.15239 · Cited by 130 · see citing works
Mental Stress and Cardiovascular Health—Part I
Vancheri, F., Longo, G., Vancheri, E., & Henein, M. Y. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11123353 · Cited by 137 · see citing works
Hu, P., Lü, Y., Pan, B., & Zhang, W. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231911076 · Cited by 134 · see citing works
Mehta, N. D., Haroon, E., Xu, X., Woolwine, B. J., Li, Z., & Felger, J. C. (2018) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2018.07.026 · Cited by 116 · see citing works
Future Directions in Peer Relations Research
Prinstein, M. J., & Giletta, M. (2020) · Journal of Clinical Child & Adolescent Psychology · doi:10.1080/15374416.2020.1756299 · Cited by 116 · see citing works
Parrott, J. M., Redus, L., & O’Connor, J. C. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0590-y · Cited by 112 · see citing works
Neural mechanisms linking social status and inflammatory responses to social stress
Muscatell, K. A., Dedovic, K., Slavich, G. M., Jarcho, M. R., Breen, E. C., Bower, J. E., Irwin, M. R., & Eisenberger, N. I. (2016) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsw025 · Cited by 108 · see citing works
Self-citationMiklowitz, D. J., Portnoff, L. C., Armstrong, C. C., Keenan‐Miller, D., Breen, E. C., Muscatell, K. A., Eisenberger, N. I., & Irwin, M. R. (2016) · Psychiatry Research · doi:10.1016/j.psychres.2016.04.120 · Cited by 104 · see citing works
Self-citationNeuroanatomy and Physiology of Brain Dysfunction in Sepsis
Mazeraud, A., Pascal, Q., Verdonk, F., Heming, N., Chrétien, F. C., & Sharshar, T. (2016) · Clinics in Chest Medicine · doi:10.1016/j.ccm.2016.01.013 · Cited by 105 · see citing works
The Ketogenic Diet and Cardiovascular Diseases
Dyńka, D., Kowalcze, K., Charuta, A., & Paziewska, A. (2023) · Nutrients · doi:10.3390/nu15153368 · Cited by 113 · see citing works
Sepsis-Associated Brain Dysfunction: A Review of Current Literature
Czempik, P. F., Pluta, M. P., & Krzych, Ł. J. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17165852 · Cited by 99 · see citing works
Clark, U. S., Miller, E. R., & Hegde, R. R. (2017) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2017.11.011 · Cited by 102 · see citing works
Nusslock, R., Brody, G. H., Armstrong, C. C., Carroll, A., Sweet, L. H., Yu, T., Barton, A. W., Hallowell, E. S., Chen, E., Higgins, J. P., et al. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.03.968 · Cited by 100 · see citing works
The Impact of Mental Stress on Cardiovascular Health—Part II
Henein, M. Y., Vancheri, S., Longo, G., & Vancheri, F. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11154405 · Cited by 104 · see citing works
Zhou, X., Zhang, F., Hu, X., Chen, J., Tang, R., Zheng, K., & Song, Y. (2016) · Brain Research · doi:10.1016/j.brainres.2016.12.018 · Cited by 96 · see citing works
Biological Markers in Anxiety Disorders
Łoś, K., & Waszkiewicz, N. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10081744 · Cited by 97 · see citing works
The impact of stress on epidermal barrier function: an evidence‐based review
Maarouf, M., Maarouf, C. L., Yosipovitch, G., & Shi, V. Y. (2019) · British Journal of Dermatology · doi:10.1111/bjd.17605 · Cited by 92 · see citing works
Ge, F., Yuan, M., Li, Y., & Zhang, W. (2020) · Psychiatry Investigation · doi:10.30773/pi.2019.0112 · Cited by 92 · see citing works
Kim, Y., Amidfar, M., & Won, E. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.06.008 · Cited by 91 · see citing works
Role of Inflammation in Depression and Treatment Implications
Felger, J. C. (2018) · Handbook of experimental pharmacology · doi:10.1007/164_2018_166 · Cited by 92 · see citing works
Neural pathways of embarrassment and their modulation by social anxiety
Müller‐Pinzler, L., Gazzola, V., Keysers, C., Sommer, J. B., Jansen, A., Frässle, S., Einhäuser, W., Paulus, F. M., & Krach, S. (2015) · NeuroImage · doi:10.1016/j.neuroimage.2015.06.036 · Cited by 82 · see citing works
Antika, L. D., Tasfiyati, A. N., Hikmat, H., & Septama, A. W. (2022) · Zeitschrift für Naturforschung C · doi:10.1515/znc-2021-0193 · Cited by 77 · see citing works
Socioeconomic influences on brain function: implications for health
Muscatell, K. A. (2018) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13862 · Cited by 72 · see citing works
Self-citationSepsis: developing new alternatives to reduce neuroinflammation and attenuate brain injury
Meneses, G., Cárdenas, G., Espinosa, A., Rassy, D., Pérez‐Osorio, I. N., Bárcena, B., Fleury, A., Besedovsky, H. O., Fragoso, G., & Sciutto, E. (2018) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13985 · Cited by 72 · see citing works
Kang, D. O., Eo, J. S., Park, E., Nam, H. S., Song, J. W., Park, Y. H., Park, S. Y., Na, J. O., Choi, C. U., Kim, E. J., et al. (2020) · European Heart Journal · doi:10.1093/eurheartj/ehaa1095 · Cited by 69 · see citing works
Neural Mechanisms Linking Emotion with Cardiovascular Disease
Kraynak, T. E., Marsland, A. L., & Gianaros, P. J. (2018) · Current Cardiology Reports · doi:10.1007/s11886-018-1071-y · Cited by 68 · see citing works
Zhang, H., Ding, L., Shen, T., & Peng, D. (2019) · General Psychiatry · doi:10.1136/gpsych-2019-100084 · Cited by 67 · see citing works
Scopoletin ameliorates anxiety-like behaviors in complete Freund’s adjuvant-induced mouse model
Luo, L., Sun, T., Yang, L., Liu, A., Liu, Q.-Q., Tian, Q., Wang, Y., Zhao, M., & Yang, Q. (2020) · Molecular Brain · doi:10.1186/s13041-020-0560-2 · Cited by 68 · see citing works
Neuroinflammation, Early-Life Adversity, and Brain Development
Andersen, S. L. (2022) · Harvard Review of Psychiatry · doi:10.1097/hrp.0000000000000325 · Cited by 70 · see citing works
Early adversity, neural development, and inflammation
Chiang, J. J., Taylor, S. E., & Bower, J. E. (2015) · Developmental Psychobiology · doi:10.1002/dev.21329 · Cited by 65 · see citing works
Self-citationHeart rate variability is associated with psychosocial stress in distinct social domains
Lischke, A., Jacksteit, R., Mau‐Moeller, A., Pahnke, R., Hamm, A. O., & Weippert, M. (2018) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2018.01.005 · Cited by 67 · see citing works
Lopez, R. B., Denny, B. T., & Fagundes, C. P. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.10.019 · Cited by 64 · see citing works
Links between inflammation, amygdala reactivity, and social support in breast cancer survivors
Muscatell, K. A., Eisenberger, N. I., Dutcher, J. M., Cole, S. W., & Bower, J. E. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.09.008 · Cited by 60 · see citing works
Self-citationDisruption of Neural Homeostasis as a Model of Relapse and Recurrence in Late-Life Depression
Andreescu, C., Ajilore, O., Aizenstein, H. J., Albert, K. M., Butters, M. A., Landman, B. A., Karim, H. T., Krafty, R. T., & Taylor, W. D. (2019) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2019.07.016 · Cited by 56 · see citing works
Dedoncker, J., Vanderhasselt, M., Ottaviani, C., & Slavich, G. M. (2021) · Neuroscience and Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.02.010 · Cited by 49 · see citing works
Self-citationKemp, G. M., Altimimi, H. F., Nho, Y., Heir, R., Klyczek, A., & Stellwagen, D. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01737-x · Cited by 57 · see citing works
Byrne, M. L., Whittle, S., & Allen, N. B. (2016) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000311 · Cited by 52 · see citing works
Inflammation and dimensions of reward processing following exposure to the influenza vaccine
Boyle, C. C., Kuhlman, K. R., Dooley, L. N., Haydon, M. D., Robles, T. F., Ang, Y., Pizzagalli, D. A., & Bower, J. E. (2018) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2018.11.024 · Cited by 52 · see citing works
Self-citationMilligen, B. A. L.-V., Verhoeven, J. E., Schmaal, L., van Velzen, L. S., Révész, D., Black, C. N., Han, L. K. M., Horsfall, M., Batelaan, N. M., van Balkom, A. J. L. M., et al. (2019) · BMC Psychiatry · doi:10.1186/s12888-019-2404-0 · Cited by 51 · see citing works
Dedovic, K., Slavich, G. M., Muscatell, K. A., Irwin, M. R., & Eisenberger, N. I. (2016) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2016.00064 · Cited by 50 · see citing works
Self-citationMolecular insights into the therapeutic promise of targeting HMGB1 in depression
Rana, T., Behl, T., Mehta, V., Uddin, M. S., & BUNGAU, S. G. (2020) · Pharmacological Reports · doi:10.1007/s43440-020-00163-6 · Cited by 49 · see citing works
Hobson, J. M., Moody, M. D., Sorge, R. E., & Goodin, B. R. (2022) · Neurobiology of Pain · doi:10.1016/j.ynpai.2022.100101 · Cited by 47 · see citing works
Li, J., Huang, S., Huang, W., Wang, W., Wen, G., Gao, L., Fu, X., Wang, M., Weihai, L., Kwan, H. Y., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.14160 · Cited by 48 · see citing works
Labrenz, F., Ferri, F., Wrede, K. H., Forsting, M., Schedlowski, M., Engler, H., Elsenbruch, S., Benson, S., & Costantini, M. (2018) · NeuroImage · doi:10.1016/j.neuroimage.2018.09.056 · Cited by 46 · see citing works
Gupta, S., & Guleria, R. S. (2022) · Cells · doi:10.3390/cells11132034 · Cited by 48 · see citing works
Vecchiarelli, H. A., Gandhi, C. P., Gray, J. M., Morena, M., Hassan, K. I., & Hill, M. N. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.07.026 · Cited by 45 · see citing works
S100B blood levels and childhood trauma in adolescent inpatients
Falcone, T., Janigro, D., Lovell, R. E., Simon, B., Brown, C. A., Herrera, M., Myint, A.-M., & Anand, A. (2014) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2014.12.002 · Cited by 42 · see citing works
Swartz, J. R., Prather, A. A., & Hariri, A. R. (2017) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2017.01.024 · Cited by 42 · see citing works
Peters, A. T., Ren, X., Bessette, K. L., Goldstein, B. I., West, A. E., Langenecker, S. A., & Pandey, G. N. (2019) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2019.03.030 · Cited by 41 · see citing works
Brain–body pathways linking racism and health.
Muscatell, K. A., Alvarez, G., Bonar, A. S., Cardenas, M. N., Galvan, M. J., Merritt, C., & Starks, M. D. (2022) · American Psychologist · doi:10.1037/amp0001084 · Cited by 39 · see citing works
Self-citationSwartz, J. R., Prather, A. A., Iorio, C., Bogdan, R., & Hariri, A. R. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.129 · Cited by 38 · see citing works
Community violence and cellular and cytokine indicators of inflammation in adolescents
Finegood, E. D., Chen, E., Kish, J. L., Vause, K. J., Leigh, A. K. K., Hoffer, L. C., & Miller, G. E. (2020) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2020.104628 · Cited by 39 · see citing works
Exaggerated amygdala response to threat and association with immune hyperactivity in depression
Boukezzi, S. C., Costi, S., Shin, L. M., Kim‐Schulze, S., Cathomas, F., Collins, A. B., Russo, S. J., Morris, L. S., & Murrough, J. W. (2022) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2022.05.015 · Cited by 39 · see citing works
Brick by Brick: Building a Transdiagnostic Understanding of Inflammation in Psychiatry
Thylur, D. S., & Goldsmith, D. R. (2022) · Harvard Review of Psychiatry · doi:10.1097/hrp.0000000000000326 · Cited by 40 · see citing works
McClintock, C. H., Worhunsky, P. D., Balodis, I. M., Sinha, R., Miller, L., & Potenza, M. N. (2019) · Current Behavioral Neuroscience Reports · doi:10.1007/s40473-019-00195-0 · Cited by 37 · see citing works
Lu, H., Surkan, P. J., Irwin, M. R., Treisman, G. J., Breen, E. C., Sacktor, N. C., Stall, R. D., Wolinsky, S. M., Jacobson, L. P., & Abraham, A. G. (2019) · American Journal of Epidemiology · doi:10.1093/aje/kwz190 · Cited by 35 · see citing works
Self-citationDutcher, J. M., Boyle, C. C., Eisenberger, N. I., Cole, S. W., & Bower, J. E. (2020) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2020.105114 · Cited by 35 · see citing works
Self-citationPerspectives on the complex links between depression and dementia
Hakim, A. M. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.821866 · Cited by 33 · see citing works
Yuan, J. P., Ho, T. C., Coury, S. M., Chahal, R., Colich, N. L., & Gotlib, I. H. (2022) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2022.07.007 · Cited by 31 · see citing works
Wagels, L., Votinov, M., Kellermann, T., Konzok, J., Jung, S., Montag, C., Schneider, F. W., Eisert, A., Beyer, C., & Habel, U. (2019) · Neuropharmacology · doi:10.1016/j.neuropharm.2019.01.006 · Cited by 31 · see citing works
Gassen, J., & Hill, S. E. (2019) · Social and Personality Psychology Compass · doi:10.1111/spc3.12471 · Cited by 30 · see citing works
Mehta, N. D., Stevens, J. S., Li, Z., Fani, N., Gillespie, C. F., Ravi, M., Michopoulos, V., & Felger, J. C. (2022) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2022.06.013 · Cited by 31 · see citing works
Neuroimmune Mechanisms and Sex/Gender-Dependent Effects in the Pathophysiology of Mental Disorders
Kokkosis, A. G., & Tsirka, S. E. (2020) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.120.266163 · Cited by 28 · see citing works
Yang, H., Koh, E., & Kang, Y. (2021) · Biomolecules · doi:10.3390/biom11050708 · Cited by 31 · see citing works
Davis, L. L., & Hamner, M. B. (2024) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2024.1356563 · Cited by 32 · see citing works
Integrating Pathophysiology in Migraine: Role of the Gut Microbiome and Melatonin
Anderson, G. (2019) · Current Pharmaceutical Design · doi:10.2174/1381612825666190920114611 · Cited by 28 · see citing works
- Authors
- Muscatell, K. A., Dedovic, K., Slavich, G. M., Jarcho, M. R., Breen, E. C., Bower, J. E., Irwin, M. R., & Eisenberger, N. I.
- Affiliations
- University of California, Los Angeles (US)
- Loras College (US)
- Corresponding author
- Eisenberger, Naomi I.
- ORCID
- Venue
- Brain, Behavior, and Immunity
- Publisher
- Elsevier BV
- Published
- 2015-01
- Volume
- 43
- Pages
- 46-53
- ISSN
- 0889-1591 (ISSN-L)
- PMC
- PMC4368432
- OpenAlex
- W1968731032
- Cited by
- 240
- References
- 56
- Citations by year
- 2026: 18 · 2025: 24 · 2024: 12 · 2023: 12 · 2022: 45 · 2021: 19 · 2020: 21 · 2019: 22 · 2018: 18 · 2017: 20 · 2016: 18 · 2015: 9 · 2014: 2
- FWCI
- 8.01
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Brain Behavior and Immunity (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion, cc-by-nc-nd)
- Funders
- National Alliance for Research on Schizophrenia and Depression (NARSAD) Young Investigator Award (NIE)
- UCLA Cousins Center for Psychoneuroimmunology Seed Grant (NIE)
- UCLA Clinical & Translational Science Institute (CTSI) Seed Grant (NIE)
- NIH/National Center for Advancing Translational Science (NCATS) UCLA CTSI (UL1TR000124)
- NIA/NIH (AG028748)
- Canadian Institutes of Health Research Post-Doctoral Research Fellowship (KD)
- National Science Foundation Graduate Research Fellowship (KAM)
- NIH Pre-Doctoral Institutional Training Grant (MH015750)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- psychological stress, inflammation, amygdala, dorsomedial prefrontal cortex, social stress, social rejection, social evaluation, plasma inflammatory markers, cardiovascular disease, depression
- MeSH terms
- Adolescent, Amygdala, Emotions, Female, Humans, Inflammation, Magnetic Resonance Imaging, Neural Pathways, Stress, Psychological, Tumor Necrosis Factor-alpha, Biomarkers, Interleukin-6, Prefrontal Cortex, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
