The Effect of Sulfated (1→3)-α-l-Fucan from the Brown Alga Saccharina cichorioides Miyabe on Resveratrol-Induced Apoptosis in Colon Carcinoma Cells
Open accessAbstract
Accumulating data clearly indicate that the induction of apoptosis by nontoxic natural compounds is a potent defense against the development and progression of many malignancies, including colon cancer. Resveratrol and the fucoidans have been shown to possess potent anti-tumor activity in vitro and in vivo. The aim of the present study was to examine whether the combination of a fucoidan from the brown alga Saccharina cichorioides Miyabe and resveratrol would be an effective preventive and/or therapeutic strategy against colon cancer. Based on NMR spectroscopy and MALDI-TOF analysis, the fucoidan isolated and purified from Saccharina cichorioides Miyabe was (1→3)-α-l-fucan with sulfate groups at C2 and C4 of the α-l-fucopyranose residues. The fucoidan enhanced the antiproliferative activity of resveratrol at nontoxic doses and facilitated resveratrol-induced apoptosis in the HCT 116 human colon cancer cell line. Apoptosis was realized by the activation of initiator caspase-9 and effector caspase-7 and -3, followed by the cleavage of PARP. Furthermore, significant inhibition of HCT 116 colony formation was associated with the sensitization of cells to resveratrol by the fucoidan. Taken together, these results demonstrate that the combination of the algal fucoidan with resveratrol may provide a potential therapy against human colon cancer.
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Fucoidan from S. cichorioides enhanced antiproliferative activity of resveratrol at nontoxic doses and facilitated resveratrol-induced apoptosis in HCT116 cells.
“The fucoidan from S. cichorioides enhanced the antiproliferative activity of resveratrol at nontoxic doses and facilitated the resveratrol-induced apoptosis in the HCT116 cell line.”
From Anticancer and Cancer Preventive Properties of Marine Polysaccharides: Some Results and Prospects (2013) · cites this paper as [59]
Fucoidans may enhance the anticancer action of some low molecular weight compounds.
“Fucoidans may enhance the anticancer action of some low molecular weight compounds.”
From Anticancer and Cancer Preventive Properties of Marine Polysaccharides: Some Results and Prospects (2013) · cites this paper as [59]
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Anticancer and Cancer Preventive Properties of Marine Polysaccharides: Some Results and Prospects
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Self-citation
- Authors
- Vishchuk, O., Ermakova, S., & Zvyagintseva, T.
- Affiliations
- Russian Academy of Sciences (RU)
- Laboratory of Enzyme Chemistry, G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch, Russian Academy of Sciences, 159 100-Let Vladivostoku Ave., Vladivostok 690022, Russian Federation
- Corresponding author
- Vishchuk, Olesia
- ORCID
- Ermakova, Svetlana
- Venue
- Marine Drugs
- Publisher
- MDPI AG
- Published
- 2013-01-21
- Volume
- 11
- Issue
- 1
- Pages
- 194-212
- ISSN
- 1660-3397 (ISSN-L)
- PMC
- PMC3564167
- OpenAlex
- W2060899601
- Cited by
- 50
- References
- 50
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 2 · 2023: 5 · 2022: 5 · 2021: 1 · 2020: 4 · 2019: 3 · 2018: 6 · 2017: 2 · 2016: 7 · 2015: 5 · 2014: 2 · 2013: 3
- FWCI
- 8.64
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Marine Drugs (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Russian Foundation for Basic Research
- Russian Academy of Sciences
- Topics
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Natural product bioactivities and synthesis
- Physical Sciences › Earth and Planetary Sciences › Oceanography › Marine and coastal plant biology
- Keywords
- brown algae, resveratrol, colon cancer, apoptosis, HCT116 cells, caspase activation, PARP cleavage, antiproliferative activity, combination therapy, marine polysaccharides
- MeSH terms
- Resveratrol, Phaeophyceae, Antineoplastic Agents, Carcinoma, Colonic Neoplasms, Humans, Magnetic Resonance Spectroscopy, Polysaccharides, Stilbenes, Sulfuric Acid Esters, Apoptosis, Caspases, HCT116 Cells, Cell Line, Tumor, Cell Proliferation
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