Cited by 166Seaweed-derived Bioactive CompoundsNatural Antidiabetic Agents StudiesPolysaccharides Composition and Applications

In vitro and in vivo hypoglycemic effects of brown algal fucoidans

Shan, Xindi, Liu, Xin, Hao, Jiejie, Cai, Chao, Fan, Fei, Dun, Yunlou, Zhao, Xiaoliang, Liu, Xiaoxiao +2 more·2016·International Journal of Biological Macromolecules

Abstract

The inhibition of α-glucosidase is an effective therapeutic approach for type 2 diabetes mellitus that involves decreasing postprandial hyperglycemia. In the present study, the α-glucosidase and α-amylase inhibitory effects of 11 fucoidans extracted from different brown seaweeds were evaluated. Although no significant α-amylase inhibition was observed, fucoidan from Fucus vesiculosus (FvF) showed the highest α-glucosidase inhibitory activity, with an IC50 value of 67.9 μg/mL. In addition, FvF at a concentration of 200 μg/mL displayed very mild cytotoxicity to IEC-6 cells as indicated by the MTT assay. An in vivo study indicated that FvF decreased the fasting blood glucose and hemoglobin A1c (HbA1c) levels of db/db mice, with minimal effect on their weight. Therefore, our present in vitro and in vivo studies demonstrated that FvF could be a promising α-glucosidase inhibitor for the treatment of type 2 diabetes mellitus.

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Crossref · 10.1016/j.ijbiomac.2015.11.036

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  • Algae are a good source of dietary fibers because of non-digestible polysaccharides in the algal cell wall, which possess antioxidant, hypoglycemic, antiviral, antitumor, and anti-inflammatory activities due to fucoidan and laminarin.

    “Algae are considered as a good source of dietary fibers because of the presence of non-digestible polysaccharides in the algal cell wall (Figure 3) [11]. It has been shown that they possess activities, like antioxidant [12], hypoglycemic [13], antiviral [14,15], antitumor [16], and anti-inflammatory due to the presence of fucoidan and laminarin [17].”

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Authors
Shan, X., Liu, X., Hao, J., Cai, C., Fan, F., Dun, Y., Zhao, X., Liu, X., Li, C., & Yu, G.
Affiliations
Ocean University of China (CN)
Corresponding author
Yu, Guangli
Venue
International Journal of Biological Macromolecules
Publisher
Elsevier BV
Published
2016-01
Volume
82
Pages
249-255
ISSN
0141-8130 (ISSN-L)
OpenAlex
W2181076115
Cited by
166
References
48
Citations by year
2026: 6 · 2025: 11 · 2024: 26 · 2023: 11 · 2022: 15 · 2021: 22 · 2020: 17 · 2019: 22 · 2018: 20 · 2017: 7 · 2016: 9
FWCI
18.65
Type
journal article
Language
en
Open access
closed
Locations
  • International Journal of Biological Macromolecules (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Marine Science Research Centers (U1406402)
  • Marine Scientific Research in the Public Interest (201005024)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Polysaccharides Composition and Applications
Keywords
fucoidan, brown algae, Fucus vesiculosus, α-glucosidase inhibition, α-amylase inhibition, type 2 diabetes, hypoglycemic effect, postprandial hyperglycemia, db/db mice, fasting blood glucose, HbA1c, cytotoxicity, IEC-6 cells, dietary fiber
MeSH terms
Phaeophyceae, alpha-Amylases, alpha-Glucosidases, Animals, Blood Glucose, Cell Survival, Enzyme Inhibitors, Epithelial Cells, Hypoglycemic Agents, Male, Magnetic Resonance Spectroscopy, Polysaccharides, Seaweed, Mice, Rats

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