Dose response biology of resveratrol in obesity
Open accessAbstract
Obesity is a major health problem throughout the world, and it is increasing both in prevalence and severity. Pharmaceutical approaches developed for the treatment of obesity, despite short-term benefits, often are associated with rebound weight gain after the cessation of drug use and serious side effects deriving from the medication can occur. Resveratrol has been well recognized as an anti-obesity substance for its lipid-lowering function as well as calorie-restriction effect. This polyphenol induces hormetic dose responses in a wide range of biological models, affecting numerous endpoints of biomedical and therapeutic significance. From an hormetic standpoint, we will discuss the potential relevance of resveratrol in the management of obesity and related comorbid conditions, emphasizing its ability to control simultaneously various pathological mechanisms associated with obesity.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Dietary resveratrol supplementation has anti-obesity effects, potentially by mimicking metabolic effects of long-term caloric restriction and improving adipose tissue function and insulin sensitivity in obese models.
“Recent studies have also revealed anti-obesity effects of dietary resveratrol supplementation [82, 83], potentially by mimicking the metabolic effects of long-term caloric restriction [84] and improving adipose tissue function and insulin sensitivity in obese model [85].”
From Mitochondrial Adaptation in Skeletal Muscle: Impact of Obesity, Caloric Restriction, and Dietary Compounds (2024) · cites this paper as [85]
Molecular targets of resveratrol include PGC1α, SIRT1, NFκB, AMPK, FoxO3, and PPARγ, which are responsible for modulating mitochondrial activity.
“Studies have demonstrated the characterization of molecular targets of resveratrol, including PGC1α, SIRT1, NFκB, AMPK, FoxO3, and PPARγ [16, 61, 85, 89], that are responsible for modulating mitochondrial activity.”
From Mitochondrial Adaptation in Skeletal Muscle: Impact of Obesity, Caloric Restriction, and Dietary Compounds (2024) · cites this paper as [85]
Resveratrol can influence gene expression by inducing changes that mimic those seen under calorie restriction conditions.
“In particular, resveratrol can influence gene expression by inducing changes that mimic those seen under calorie restriction conditions [12].”
From The Role of Resveratrol Administration in Human Obesity (2021) · cites this paper as [12]
Resveratrol may affect the activity of AMPK, SIRT-1, and PGC-1α, all altered in the metabolic abnormalities present in patients with obesity.
“Resveratrol may affect the activity of various intracellular targets such as adenosine monophosphate-activated protein kinase (AMPK), the deacetylating enzyme sirtuin-1 (SIRT-1), and the peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α), all altered in the metabolic abnormalities present in patients with obesity [12,13].”
From The Role of Resveratrol Administration in Human Obesity (2021) · cites this paper as [12]
Resveratrol-induced AMPK phosphorylation appears to be high-dose dependent.
“However, resveratrol-induced AMPK phosphorylation appears to be high-dose dependent [12].”
From The Role of Resveratrol Administration in Human Obesity (2021) · cites this paper as [12]
Phosphorylation of AMPK hinders adipogenesis.
“This is an important finding since the phosphorylation state of AMPK represents a signal for adipogenesis and its phosphorylation hinders this metabolic pathway [12].”
From The Role of Resveratrol Administration in Human Obesity (2021) · cites this paper as [12]
In in-vitro experiments, resveratrol concentrations range from 5-100 μM, with 50 μM most commonly used.
“In in-vitro experiments, resveratrol concentrations range from 5–100 µM, although the concentration of 50 µM is the most commonly used [12].”
From The Role of Resveratrol Administration in Human Obesity (2021) · cites this paper as [12]
During resveratrol supplementation, there is a dose-dependent response between the amount administered and its Cmax.
“During supplementation, there is a dose-dependent response between the amount of resveratrol administered and its Cmax.”
From The Role of Resveratrol Administration in Human Obesity (2021) · cites this paper as [12]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Resveratrol improves health and survival of mice on a high-calorie diet
Baur, J. A., Pearson, K. J., Price, N. L., Jamieson, H. A., Lerin, C., Kalra, A., Prabhu, V. V., Allard, J. S., Lopez-Lluch, G., Lewis, K., et al. (2006) · Nature · doi:10.1038/nature05354 · Cited by 4,290 · see citing works
Plant Polyphenols: Chemical Properties, Biological Activities, and Synthesis
Quideau, S., Deffieux, D., Douat, C., & Pouységu, L. (2011) · Angewandte Chemie International Edition · doi:10.1002/anie.201000044 · Cited by 2,753 · see citing works
Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-γ
Picard, F., Kurtev, M. V., Chung, N., Topark‐Ngarm, A., Senawong, T., de Oliveira, R. M., Leid, M. E., McBurney, M. W., & Guarente, L. (2004) · Nature · doi:10.1038/nature02583 · Cited by 1,943 · see citing works
Price, N. L., Gomes, A. P., Ling, A. J. Y., Duarte, F. V., Martin-Montalvo, A., North, B. J., Agarwal, B., Ye, L., Ramadori, G., Teodoro, J. S., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.04.003 · Cited by 1,602 · see citing works
Timmers, S., Konings, E., Bilet, L., Houtkooper, R. H., van de Weijer, T., Goossens, G. H., Hoeks, J., van der Krieken, S., Ryu, D., Kersten, S., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.10.002 · Cited by 1,320 · see citing works
Novel insights of dietary polyphenols and obesity
Wang, S. F., Moustaïd‐Moussa, N., Chen, L., Mo, H., Shastri, A. A., Su, R., Bapat, P., Kwun, I., & Shen, C. (2013) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2013.09.001 · Cited by 903 · see citing works
Calabrese, V., Cornelius, C., Dinkova‐Kostova, A. T., Calabrese, E. J., & Mattson, M. P. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.3074 · Cited by 803 · see citing works
Self-citationObesity and Cardiovascular Disease
Poirier, P., Giles, T. D., Bray, G. A., Hong, Y., Stern, J. S., Pi-Sunyer, X., & Eckel, R. H. (2006) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000216787.85457.f3 · Cited by 726 · see citing works
Brown, V. A., Patel, K. R., Viskaduraki, M., Crowell, J. A., Perloff, M., Booth, T. D., Vasilinin, G., Sen, A., Schinas, A. M., Piccirilli, G., et al. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-2364 · Cited by 691 · see citing works
Barger, J. L., Kayo, T., Vann, J. M., Arias, E. B., Wang, J., Hacker, T. A., Wang, Y., Raederstorff, D., Morrow, J. D., Leeuwenburgh, C., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002264 · Cited by 580 · see citing works
High-Dose Resveratrol Supplementation in Obese Men
Poulsen, M. M., Vestergaard, P. F., Clasen, B. F., Radko, Y., Christensen, L. P., Stødkilde-Jørgensen, H., Møller, N., Jessen, N., Pedersen, S. B., & Jørgensen, J. O. L. (2013) · Diabetes · doi:10.2337/db12-0975 · Cited by 455 · see citing works
Almeida, L., Vaz‐da‐Silva, M., Falcão, A. C., Soares, E., Costa, R., Loureiro, A. I., Fernandes‐Lopes, C., Rocha, J., Nunes, T., Wright, L. C., et al. (2009) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200800177 · Cited by 427 · see citing works
Cellular stress responses, hormetic phytochemicals and vitagenes in aging and longevity
Calabrese, V., Cornelius, C., Dinkova‐Kostova, A. T., Iavicoli, I., Paola, R. D., Koverech, A., Cuzzocrea, S., Rizzarelli, E., & Calabrese, E. J. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2011.11.002 · Cited by 420 · see citing works
Self-citationResveratrol: Its Biologic Targets and Functional Activity
Pervaiz, S., & Holme, A. L. (2009) · Antioxidants and Redox Signaling · doi:10.1089/ars.2008.2412 · Cited by 411 · see citing works
Yoshino, J., Conte, C., Fontana, L., Mittendorfer, B., Imai, S., Schechtman, K. B., Gu, C. C., Kunz, I., Fanelli, F. R., Patterson, B. W., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.09.015 · Cited by 381 · see citing works
Dietary phytochemicals and their potential effects on obesity: A review
González-Castejón, M., & Rodríguez‐Casado, A. (2011) · Pharmacological Research · doi:10.1016/j.phrs.2011.07.004 · Cited by 375 · see citing works
Neurohormetic phytochemicals: low-dose toxins that induce adaptive neuronal stress responses
Mattson, M. P., & Cheng, A. (2006) · Trends in Neurosciences · doi:10.1016/j.tins.2006.09.001 · Cited by 356 · see citing works
Jeon, B. T., Jeong, E. A., Shin, H. J., Lee, Y., Lee, D. H., Kim, H. J., Kang, S. S., Cho, G. J., Choi, W. S., & Roh, G. S. (2012) · Diabetes · doi:10.2337/db11-1498 · Cited by 352 · see citing works
Risks and safety of polyphenol consumption
Mennen, L. I., Walker, R., Bennetau-Pelissero, C., & Scalbert, A. (2005) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/81.1.326s · Cited by 340 · see citing works
Resveratrol induces apoptosis and inhibits adipogenesis in 3T3‐L1 adipocytes
Rayalam, S., Yang, J., Ambati, S., Della‐Fera, M. A., & Baile, C. A. (2008) · Phytotherapy Research · doi:10.1002/ptr.2503 · Cited by 294 · see citing works
Wong, R. H. X., Howe, P. R. C., Buckley, J. D., Coates, A. M., Kunz, I., & Berry, N. M. (2011) · Nutrition, Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2010.03.003 · Cited by 277 · see citing works
Tomé‐Carneiro, J., Gonzálvez, M., Larrosa, M., Yáñez-Gascón, M. J., García‐Almagro, F. J., Ruiz‐Ros, J. A., Tomás-Barberán, F. A., García‐Conesa, M., & Espı́n, J. C. (2012) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-012-6427-8 · Cited by 241 · see citing works
Eduardo Fuentes, Q., Fuentes, F., Vilahur, G., Badimón, L., & Palomo, I. F. (2013) · Mediators of Inflammation · doi:10.1155/2013/136584 · Cited by 208 · see citing works
Antioxidant Effects of Resveratrol in Cardiovascular, Cerebral and Metabolic Diseases
Carrizzo, A., Forte, M., Damato, A., Trimarco, V., Salzano, F., Bartolo, M., Maciag, A., Puca, A. A., & Vecchione, C. (2013) · Food and Chemical Toxicology · doi:10.1016/j.fct.2013.07.021 · Cited by 203 · see citing works
Mechanisms of endothelial dysfunction in obesity.
Avogaro, A., & de Kreutzenberg, S. V. (2005) · Clinica Chimica Acta · doi:10.1016/j.cccn.2005.04.020 · Cited by 188 · see citing works
Causes and consequences of adult obesity: health, social and economic impacts in the United States
Wellman, N. S., & Friedberg, B. A. (2002) · Asia Pacific Journal of Clinical Nutrition · doi:10.1046/j.1440-6047.11.s8.6.x · Cited by 181 · see citing works
Lee, J., Jo, D., Park, D., Chung, H. Y., & Mattson, M. P. (2014) · Pharmacological Reviews · doi:10.1124/pr.113.007757 · Cited by 154 · see citing works
Kang, L., Wang, H., Yuan, A., Baolin, L., & Fang, H. (2010) · Biochimie · doi:10.1016/j.biochi.2010.02.024 · Cited by 118 · see citing works
Panickar, K. S. (2012) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201200431 · Cited by 114 · see citing works
Barrajón‐Catalán, E., Herranz‐López, M., Joven, J., Segura‐Carretero, A., Alonso‐Villaverde, C., Menéndez, J. A., & Micol, V. (2014) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-07320-0_11 · Cited by 106 · see citing works
Resveratrol in metabolic health: an overview of the current evidence and perspectives
Poulsen, M. M., Jørgensen, J. O. L., Jessen, N., Richelsen, B., & Pedersen, S. B. (2013) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12141 · Cited by 95 · see citing works
Sun, Y., Li, J., Xiao, N., Wang, M., Kou, J., Qi, L., Huang, F., Liu, B., & Liu, K. (2014) · Pharmacological Research · doi:10.1016/j.phrs.2014.07.006 · Cited by 90 · see citing works
Resveratrol and cardiovascular health – Promising therapeutic or hopeless illusion?
Tang, P. C., Ng, Y.-F., Ho, S., Gyda, M., & Chan, S. (2014) · Pharmacological Research · doi:10.1016/j.phrs.2014.08.001 · Cited by 87 · see citing works
Gómez-Zorita, S., Fernández-Quintela, A., Lasa, A., Hijona, E., Bujanda, L., & Portillo, M. P. (2013) · Nutrition · doi:10.1016/j.nut.2013.04.014 · Cited by 79 · see citing works
Zhang, X.-H., Huang, B., Choi, S.-K., & Seo, J. (2012) · Nutrition Research and Practice · doi:10.4162/nrp.2012.6.4.286 · Cited by 73 · see citing works
Kwon, J. Y., Seo, S. G., Yue, S., Cheng, J., Lee, K. W., & Kim, K. (2012) · Nutrition Research · doi:10.1016/j.nutres.2012.06.014 · Cited by 66 · see citing works
Dose response biology: The case of resveratrol
Calabrese, E. J., Mattson, M. P., & Calabrese, V. (2010) · Human & Experimental Toxicology · doi:10.1177/0960327110383641 · Cited by 55 · see citing works
Self-citationMitocans, a class of emerging anti‐cancer drugs
Ralph, S. J., & Neužil, J. (2009) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200890054 · Cited by 38 · see citing works
Kang, N. E., Ha, A. W., Kim, J. Y., & Kim, W. K. (2012) · Nutrition Research and Practice · doi:10.4162/nrp.2012.6.6.499 · Cited by 38 · see citing works
Obesity and cardiovascular dysfunction: A role for resveratrol?
Naderali, E. K. (2008) · Obesity Research & Clinical Practice · doi:10.1016/j.orcp.2008.10.005 · Cited by 26 · see citing works
Catterall, F. S., Souquet, J., Cheynier, V., de Pascual‐Teresa, S., Santos‐Buelga, C., Clifford, M. N., & Ioannides, C. (2000) · Environmental and Molecular Mutagenesis · doi:10.1002/(sici)1098-2280(2000)35:2 · Cited by 24 · see citing works
An adipocentric perspective of resveratrol as a calorie restriction mimetic
Barger, J. L. (2013) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12212 · Cited by 18 · see citing works
Bracale, R., Petroni, M. L., Davinelli, S., Bracale, U. M., Scapagnini, G., Carruba, M. O., & Nisoli, E. (2014) · PLoS ONE · doi:10.1371/journal.pone.0098244 · Cited by 18 · see citing works
Self-citationPHARMACEUTICAL TREATMENT OF OBESITY
Blackburn, G. L., Miller, D. L., & Chan, S. (1997) · Nursing Clinics of North America · doi:10.1016/s0029-6465(22)02695-0 · Cited by 10 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Anti-Obesity Effects of Polyphenol Intake: Current Status and Future Possibilities
Boccellino, M., & D’Angelo, S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21165642 · Cited by 265 · see citing works
Ageing: from inflammation to cancer
Leonardi, G. C., Accardi, G., Monastero, R., Nicoletti, F., & Libra, M. (2018) · Immunity & Ageing · doi:10.1186/s12979-017-0112-5 · Cited by 241 · see citing works
Maresin 1 mitigates liver steatosis in ob/ob and diet-induced obese mice
Laiglesia, L. M., Lorente‐Cebrián, S., Martínez‐Fernández, L., Sáinź, N., Prieto-Hontoria, P. L., Burrell, M. A., Rodríguez‐Ortigosa, C. M., Martínez, J. A., & Moreno-Aliaga, M. J. (2017) · International Journal of Obesity · doi:10.1038/ijo.2017.226 · Cited by 167 · see citing works
The Role of Resveratrol Administration in Human Obesity
Mongioì, L. M., La Vignera, S., Cannarella, R., Cimino, L., Compagnone, M., Condorelli, R. A., & Calogero, A. E. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094362 · Cited by 71 · see citing works
Alvarado, J. L., Leschot, A., Olivera‐Nappa, Á., Salgado, A. M., Rioseco, H., Ana, C. L. D., & Pilar Vigil, P. (2016) · BioMed Research International · doi:10.1155/2016/9070537 · Cited by 70 · see citing works
Arzola-Paniagua, M. A., López, E., Calvo-Vargas, C. G., & Guevara-Cruz, M. (2016) · Obesity · doi:10.1002/oby.21523 · Cited by 62 · see citing works
Navarro‐Orcajada, S., Conesa, I., Vidal-Sánchez, F. J., Matencio, A., Albaladejo-Maricó, L., García‐Carmona, F., & López-Nicolás, M. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2045558 · Cited by 60 · see citing works
Cytoprotective Polyphenols Against Chronological Skin Aging and Cutaneous Photodamage
Davinelli, S., Bertoglio, J. C., Polimeni, A., & Scapagnini, G. (2018) · Current Pharmaceutical Design · doi:10.2174/1381612823666171109102426 · Cited by 57 · see citing works
Self-citationDavinelli, S., & Scapagnini, G. (2016) · High Blood Pressure & Cardiovascular Prevention · doi:10.1007/s40292-016-0149-0 · Cited by 55 · see citing works
Self-citationGenovese, C., Davinelli, S., Mangano, K., Tempera, G., Nicolosi, D., Corsello, S., Vergalito, F., Tartaglia, E., Scapagnini, G., & Marco, R. D. (2017) · Journal of Chemotherapy · doi:10.1080/1120009x.2017.1393587 · Cited by 49 · see citing works
Self-citationPleiotropic Effects of Eugenol: The Good, the Bad, and the Unknown
Aburel, O. M., Pavel, I. Z., Dănilă, M. D., Lelcu, T., Roi, A., Lighezan, R., Muntean, D. M., & Rusu, L. C. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/3165159 · Cited by 47 · see citing works
Davinelli, S., Melvang, H. M., Andersen, L. P., Scapagnini, G., & Nielsen, M. E. (2019) · Marine Drugs · doi:10.3390/md17070382 · Cited by 42 · see citing works
Self-citationLee, Y., Yang, W., Kim, H. Y., Min, B., Caturla, N., Jones, J., Park, Y., Lee, Y., & Kim, S. (2018) · Nutrients · doi:10.3390/nu10091204 · Cited by 38 · see citing works
Shamseddin, A., Crauste, C., Durand, E., Villeneuve, P., Dubois, G., Durand, T., Vercauteren, J., & Veas, F. (2017) · European Journal of Lipid Science and Technology · doi:10.1002/ejlt.201700171 · Cited by 34 · see citing works
Jun, L., Tao, Y.-X., Geetha, T., & Babu, J. R. (2024) · Current Nutrition Reports · doi:10.1007/s13668-024-00555-7 · Cited by 27 · see citing works
Davinelli, S., Nicolosi, D., Cesare, C. D., Scapagnini, G., & Marco, R. D. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9040987 · Cited by 23 · see citing works
Self-citationPlant-Derived Nutraceuticals Involved in Body Weight Control by Modulating Gene Expression
Vrânceanu, M., Hegheş, S. C., Cozma-Petruț, A. P., Banc, R., Stroia, C. M., Raischi, V., Miere, D., Popa, D., & Filip, L. A. (2023) · Plants · doi:10.3390/plants12122273 · Cited by 19 · see citing works
Chen, L., Wang, T., Chen, G., Wang, N., Gui, L., Dai, F., Fang, Z., Zhang, Q., & Lu, Y. (2017) · Endocrine · doi:10.1007/s12020-016-1212-2 · Cited by 19 · see citing works
Safahani, M., Aligholi, H., Noorbakhsh, F., Djalali, M., Pishva, H., Mousavi, S. M. M., Alizadeh, L., Gorji, A., & Koohdani, F. (2018) · European Journal of Nutrition · doi:10.1007/s00394-018-1715-0 · Cited by 16 · see citing works
The anti-obesity effects of resveratrol on the 3T3-L1 adipocytes
Molani‐Gol, R., & Rafraf, M. (2023) · International Journal for Vitamin and Nutrition Research · doi:10.1024/0300-9831/a000784 · Cited by 11 · see citing works
Yang, R.-F., Zhang, H.-L., Wang, Z.-C., Liu, X.-Y., & Lin, Z. (2018) · Immunity & Ageing · doi:10.1186/s12979-018-0119-6 · Cited by 10 · see citing works
Kumar, V., Thakur, A. K., Verma, S., Yadav, V., & Chatterjee, S. S. (2015) · TANG [HUMANITAS MEDICINE] · doi:10.5667/tang.2014.0026 · Cited by 8 · see citing works
Lifespan and Healthspan Extension by Nutraceuticals: An Overview
Davinelli, S., & Scapagnini, G. (2019) · Springer eBooks · doi:10.1007/978-3-030-20762-5_11 · Cited by 6 · see citing works
Self-citationFrom covalent bonds to eco-physiological pharmacology of secondary plant metabolites
Chatterjee, S. S. (2015) · Biochemical Pharmacology · doi:10.1016/j.bcp.2015.07.037 · Cited by 6 · see citing works
Autophagy in Obesity and Type 2 Diabetes: Beyond the Protective Paradigm
Angarita-Planchez, M. E., Sánchez-Rodríguez, P., Múnera‐Rodríguez, A. M., Leiva‐Castro, C., Benítez-Márquez, J. M., Reina-Pérez, I., Palomares, F., & López-Enríquez, S. (2026) · Current Obesity Reports · doi:10.1007/s13679-026-00716-5 · Cited by 6 · see citing works
Vasdev, N., Gupta, T., Bain, A., Kalyane, D., Polaka, S., & Tekade, R. K. (2025) · AAPS PharmSciTech · doi:10.1208/s12249-025-03085-9 · Cited by 5 · see citing works
Effects of Resveratrol on Cognitive Functions
Hühn, S., & Witte, A. V. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-805376-8.00024-1 · Cited by 2 · see citing works
Yeger, H. (2015) · Journal of Cell Communication and Signaling · doi:10.1007/s12079-015-0285-7
Nutritional Regulation of Metabesity
Ajayi, E. I. O., Molehin, O. R., Adefegha, S. A., Fakayode, A. E., Oladele, J. O., & Samuel, O. A. (2021) · Healthy ageing and longevity · doi:10.1007/978-3-030-83017-5_27
Nutraceuticals as Interventional Tools for the Management of Obesity in Aging
Tomtheelnganbee, E., Sah, P., Syiem, D., & Sharma, R. (2026) · Healthy ageing and longevity · doi:10.1007/978-3-032-24097-2_23
Sowmya, G. S., Shanmugam, Y., Arumugam, V., & Ramasamy, J. (2026) · Pharmacological Research - Modern Chinese Medicine · doi:10.1016/j.prmcm.2026.100882
- Authors
- Scapagnini, G., Davinelli, S., Kaneko, T., Koverech, G., Koverech, A., Calabrese, E. J., & Calabrese, V.
- Affiliations
- University of Molise (IT)
- Oregon Health & Science University (US)
- University of Catania (IT)
- University of Massachusetts Amherst (US)
- University of Sannio (IT)
- Corresponding author
- Calabrese, Vittorio
- ORCID
- Venue
- Journal of Cell Communication and Signaling
- Publisher
- Wiley
- Published
- 2014-11-12
- Volume
- 8
- Issue
- 4
- Pages
- 385-391
- ISSN
- 1873-9601 (ISSN-L)
- 1873-961X
- PMC
- PMC4390800
- OpenAlex
- W2056059444
- Cited by
- 31
- References
- 44
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 1 · 2023: 2 · 2022: 1 · 2021: 3 · 2020: 2 · 2019: 2 · 2018: 5 · 2017: 5 · 2016: 3 · 2015: 3
- FWCI
- 1.87
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Journal of Cell Communication and Signaling (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Archivio Istituzionale della Ricerca - Università degli Studi del Molise (submittedVersion)
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Keywords
- resveratrol, obesity, hormesis, dose-response relationship, polyphenols, anti-obesity, lipid lowering, caloric restriction, obesity-related comorbidities
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
