Effects of resveratrol on obesity-related inflammation markers in adipose tissue of genetically obese rats
Abstract
Objective The aim of this study was to examine whether resveratrol might represent a promising therapeutic tool with which to combat adipose tissue chronic inflammation in a model of genetic obesity and to link its anti-inflammatory activity with its effect on body fat reduction.Methods Twenty 6-wk-old male Zucker (fa/fa) rats were randomly distributed into two experimental groups. Resveratrol (RSV) was given orally (15 mg/kg body weight/d in RSV group) by means of an orogastric catheter for 6 wk. Enzyme activities were measured spectrophotometrically or fluorimetrically. Gene and protein expressions were analyzed by reverse transcriptase polymerase chain reaction and Western blot respectively. Cytokine concentrations and the activity of nuclear factor κ-light-chain-enhancer of activated β cells (NF-κB) were measured by using commercial kits.Results RSV reduced the weight of internal adipose tissues. In epididymal depot glucose-6P-dehydrogenase, acetyl-CoA carboxylase activities, as well as lipoprotein lipase expression and activity were reduced by RSV. The expression of hormone-sensitive lipase was increased, and that of the cluster of differentiation 36 was reduced. Serum concentrations of tumor necrosis factor-α, monocyte chemoattractant protein 1, and C-reactive protein were lower in the RSV-treated group than in the control group. Protein expression of interleukin-6 and the activity of NF-κB, were decreased by RSV.Conclusion The present results provide evidence that fatty acid uptake and lipolysis are metabolic pathways involved in the response of adipose tissue to RSV. This polyphenol modulates plasma cytokine levels partially by reducing macrophage infiltration in adipose tissue and inhibiting NF-κB activity.
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Animal studies, mainly in rats, have shown a reduction of abdominal fat, lipoprotein lipase, and ACC activities after treatment with resveratrol.
“Other animal studies, mainly conducted in rats, have shown a reduction of abdominal fat, lipoprotein lipase, and ACC activities after treatment with resveratrol [20,21,22].”
From The Role of Resveratrol Administration in Human Obesity (2021) · cites this paper as [21]
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- Authors
- Gómez-Zorita, S., Fernández-Quintela, A., Lasa, A., Hijona, E., Bujanda, L., & Portillo, M. P.
- Affiliations
- University of the Basque Country (ES)
- Corresponding author
- Portillo, María P.
- Venue
- Nutrition
- Publisher
- Elsevier BV
- Published
- 2013-11
- Volume
- 29
- Issue
- 11-12
- Pages
- 1374-1380
- ISSN
- 0899-9007 (ISSN-L)
- OpenAlex
- W1992046875
- Cited by
- 79
- References
- 55
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 3 · 2023: 2 · 2022: 6 · 2021: 6 · 2020: 4 · 2019: 4 · 2018: 8 · 2017: 7 · 2016: 13 · 2015: 11 · 2014: 8
- FWCI
- 4.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministerio de Ciencia e Innovación (AGL2008-01005-ALI)
- Ministerio de Economía y Competitividad (AGL2011-27406-ALI)
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Keywords
- resveratrol, genetic obesity, adipose tissue inflammation, NF-κB, lipolysis, fatty acid uptake, hormone-sensitive lipase, CD36, lipoprotein lipase, acetyl-CoA carboxylase, glucose-6-phosphate dehydrogenase, TNF-α, MCP-1, interleukin-6, C-reactive protein, macrophage infiltration, polyphenols, fat loss, Zucker rats
- MeSH terms
- Resveratrol, Acetyl-CoA Carboxylase, Adipose Tissue, Animals, Body Weight, C-Reactive Protein, Fatty Acids, Glucosephosphate Dehydrogenase, Inflammation, Lipolysis, Male, Obesity, Rats, Zucker, Stilbenes, Tumor Necrosis Factor-alpha, Interleukin-6, NF-kappa B, Chemokine CCL2, Rats, Adiponectin
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