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Lipids and membrane-associated proteins in autophagy

Li, Linsen, Tong, Mindan, Fu, Yuhui, Chen, Fang, Zhang, Shen, Chen, Hanmo, Ma, Xi, Li, Defa, Liu, Xiaoxia, Zhong, Qing·2021·Protein & Cell
DOI 10.1007/s13238-020-00793-9PMC PMC8225772
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Abstract

Autophagy is essential for the maintenance of cellular homeostasis and its dysfunction has been linked to various diseases. Autophagy is a membrane driven process and tightly regulated by membrane-associated proteins. Here, we summarized membrane lipid composition, and membrane-associated proteins relevant to autophagy from a spatiotemporal perspective. In particular, we focused on three important membrane remodeling processes in autophagy, lipid transfer for phagophore elongation, membrane scission for phagophore closure, and autophagosome-lysosome membrane fusion. We discussed the significance of the discoveries in this field and possible avenues to follow for future studies. Finally, we summarized the membrane-associated biochemical techniques and assays used to study membrane properties, with a discussion of their applications in autophagy.

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Cited by

Sorted by citations

Metadata

Authors
Li, L., Tong, M., Fu, Y., Chen, F., Zhang, S., Chen, H., Ma, X., Li, D., Liu, X., & Zhong, Q.
Venue
Protein & Cell
Publisher
Oxford University Press (OUP)
Published
2020-11-05
Volume
12
Issue
7
Pages
520-544
ISSN
  • 1674-800X
  • 1674-8018
DOI
10.1007/s13238-020-00793-9
PMC
PMC8225772
Cited by
88
References
14
Language
en
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