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Cited by 267

The DOI matches its Crossref record; 162 of the 162 references it cites were found in a registry or an index.

Angiogenesis as a hallmark of solid tumors - clinical perspectives

Open access
Majidpoor, Jamal, Mortezaee, Keywan·2021·Cellular Oncology
DOI 10.1007/s13402-021-00602-3
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Abstract

BACKGROUND: Angiogenesis is a key and early step in tumorigenesis, and is known as a hallmark of solid tumors and a key promoter of tumor recurrence. Unlike normal tissue vessels, the architecture of the tumor vasculature is abnormal, being leaky, tortuous, fragile and blind-ended. Perivascular cells are either detached or absent, causing reduction of vascular integrity, an increase in vessel immaturity, incoherent perfusion, defective functionality and enhanced tumor dissemination and metastasis. The abnormal tumor vasculature along with the defective tumor vessel functionality finally causes bouts of hypoxia and acidity in the tumor microenvironment (TME), further reinvigorating tumor aggression. Interstitial hypertension or high interstitial fluid pressure (IFP) is an outcome of tumor hyper-permeability. High IFP can be a barrier for either effective delivery of anti-cancer drugs toward the TME or accumulation of drugs within the tumor area, thus promoting tumor resistance to therapy. Some tumors do, however, not undergo angiogenesis but instead undergo vessel co-option or vascular mimicry, thereby adding another layer of complexity to cancer development and therapy. CONCLUSIONS: Combination of anti-angiogenesis therapy with chemotherapy and particularly with immune checkpoint inhibitors (ICIs) is a promising strategy for a number of advanced cancers. Among the various approaches for targeting tumor angiogenesis, vascular normalization is considered as the most desired method, which allows effective penetration of chemotherapeutics into the tumor area, thus being an appropriate adjuvant to other cancer modalities.

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Metadata

Authors
Majidpoor, J., & Mortezaee, K.
Venue
Cellular Oncology
Publisher
Springer Science and Business Media LLC
Published
2021-04-09
Volume
44
Issue
4
Pages
715-737
ISSN
  • 1570-5870 (ISSN-L)
  • 2211-3428
  • 2211-3436
DOI
10.1007/s13402-021-00602-3
OpenAlex
W3140673583
Cited by
267
References
162
FWCI
11.61
Type
journal article
Language
en
Open access
gold

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